History Database Research Articles

Development and internal validation of a clinical risk score to predict incident renal and pulmonary tumours in people with tuberous sclerosis complex

ObjectiveThis study aims to develop and internally validate a clinical risk score to predict incident renal angiomyolipoma (AML) and pulmonary lymphangioleiomyomatosis (LAM) in people with tuberous sclerosis complex (TSC).Study designData...

Abstract C078: Optimizing exposure science to understand disparities: the Bayview Hunters Point residential history study

Abstract Background: Understanding environmental impacts on local cancer burden requires accurate documentation of residential histories. Collection of residential history data is challenging because individuals may have difficulty recalling addresses over decades, or the detailed dates living at each location. In addition, some communities may have different concepts of where they live versus their home address. Recently, Surveillance Epidemiology and End Results (SEER) data was linked to LexisNexis longitudinal residential history database, which could address some of these challenges. As part of a larger effort to understand the impact of environmental exposures in Bayview Hunters Point (BVHP), we compared the oral residential histories against commercially available data found in LN. We hypothesized that for communities with limited financial mobility, who live in multi-generational households or have diverse definitions of “home,” commercially available data sets may fail to capture accurate residential histories and has implications for studying environmental exposures and cancer. Methods: After institutional IRB approval, community advocates helped identify long term (>20 years) BVHP residents. Group interviews, including a friend/family member to support detailed recall of residential history, were conducted. Interviews elicited residential histories (RH) with addresses and concepts of ‘home.’ Participant-reported RH were compared against records in LexisNexis (LN). We used three levels of identifiers to locate participant records: 1. Name and Date of Birth (DOB); 2. Name, DOB, and middle initial and aliases; 3. Name, DOB, augmented name, and alternate family members’ addresses. Participants were categorized by the amount of data required to find the LN record; and those who could not be located at all. Qualitative data was analyzed using Dedoose Version 7.0.23 (2016), Los Angeles, California. Results: The study included 20 participants who lived on average 40 years in BVHP. Of those, 90% were African American. The majority (65%) were female with an average age of 61. LN records for 4 participants (20%) were identified using minimal identifiers; five (25%) required inclusion of aliases. Nearly half (n=8 (40%)) required search terms that included aliases and an alternative address, highlighting the difference between where people “live” versus where they “stay;” and suggesting the importance of differences in definitions of ‘home.’ Three (15%) participants’ records could not be found in LN. Conclusion: In a historically redlined community situated at one of the country’s most contaminated superfund sites, LN data was limited in capturing complete RH. The NCI’s recent linkage of SEER with LN residential history data relies on assumptions about financial mobility and multigenerational households. The dataset may fail to capture exposures when locations where people “stay” differ from their permanent address. Our results suggest that SEER-LN data to evaluate environmental exposures should be used with caution. Citation Format: Chinomnso Okorie, Dalila Adofo, Michael Bennett, Debora Oh, Galen Joseph, Scarlett Gomez, Kim F. Rhoads. Optimizing exposure science to understand disparities: the Bayview Hunters Point residential history study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C078.

The Foundation to Advance Brain Rehabilitation: Organization, History, and Collaborative Database.

To describe the history, organization, goals, and data management procedures of the Foundation to Advance Brain Rehabilitation (FABR). Postacute brain injury rehabilitation following acute inpatient care. FABR was incorporated in 2019 with a primary mission to advance brain rehabilitation through scientific and strategic analysis of industry-wide data. Contributing FABR member organizations include Bancroft NeuroRehab, Collage Rehabilitation Partners, On With Life, Pate NeuroRehabilitation, and Shepherd Center. These organizations contribute demographic, admission, discharge, and follow-up data on persons served in 5 types of intensive posthospital brain injury rehabilitation programs (neurobehavioral residential, neurorehabilitation residential, home and community neurorehabilitation, day treatment, and outpatient) and 3 types of supported living programs (neurobehavioral residential, residential, and community-based) to a collaborative database managed by Inventive Software Solutions. Inventive Software Solutions provides FABR researchers with a dataset that is de-identified both for participant and organizational identifying information.

Jewish women dermatologists who escaped the perils of National Socialism: Triumph over adversity

The period of National Socialism (1933-1945), including the Holocaust and World War II, has had a profound impact on dermatology. We have identified Jewish women dermatologists who escaped the perils of National Socialism, document their struggles, and describe their contribution to medicine and dermatology. Medical, history, and media databases were searched. Relevant contributions in languages other than English were translated into English. Fourteen dermatologists were identified, and for seven, there was sufficient information to describe their lives in more detail: Helen Ollendorff-Curth (née Ollendorff) (1899-1982), Bertha Ottenstein (1891-1956), Sidonie Fürst (1891-1973), Marianne Bauer (née Jokl) (1885-1980), Hedwig Fischer (née Hoffmann) (1888-1983), Vera Shukhman (1900-1987) and Lili Farkas (1899–1992). The challenges that confronted the dermatologists were sizeable. Status as a woman, antisemitism, persecution in various forms during National Socialism, murder of family and dermatology colleagues, untimely death of family members in other ways, loss of jobs and status, the stress of relocation, and myriad obstacles in a newly adopted country were among hurdles that they faced; nevertheless, collectively, the seven dermatologists could make a range of contributions in clinical, academic, and administrative areas. The dermatologists displayed courage, tenacity, and determination and served as role models of resilience for current and future generations of women in the dermatology field.

Impact of Seismic Geohazards on water supply systems and pipeline performance: Insights from the 2023 Kahramanmaras Earthquakes

This study delves into the profound repercussions of geohazards on water supply systems, specifically in the aftermath of the Kahramanmaras earthquakes. The influence of these geohazards was far-reaching, impacting a vast geographical expanse affected by the seismic events. The primary focus of this investigation centers on the provinces of Adiyaman, Gaziantep, and Hatay, providing representative damage examples from the earthquake-affected areas. The study illustrates various types of pipe failures induced by geohazards such as fault displacements, landslides, and liquefaction. The analysis encompasses diverse cases of damage, starting from the water resources, progressing through issues at transmission lines, and extending to challenges faced by pumping and treatment facilities. Key aspects of damages and geohazards are presented, shedding light on the intricate dynamics of these interactions. It is crucial to note the scarcity of real cases in the existing literature, emphasizing the need for extensive site investigations and dedicated research endeavors to construct a comprehensive database of case histories in this domain. This study addresses this gap, contributing valuable insights into the tangible impacts of geohazards on water supply systems. By comprehending and effectively addressing the risks associated with geohazards, water supply organizations can fortify the safety and resilience of their infrastructure. The findings presented herein offer a foundation for informed decision-making and strategic planning, fostering a proactive approach to mitigate potential damages and enhance the overall robustness of water supply systems in regions prone to seismic events and associated geohazards.

Lessons learned in migrating from one commercial genetics decision-support tool to another: Assessment of data integrity and utilization readiness.

e23232 Background: Rapid advancements in health information technology have greatly influenced how clinicians engage with patient health data. In the context of clinical genetics, the electronic health record (EHR) often contains a wide array of data to identify patients at elevated risk for hereditary cancer syndromes. However, these data often exist in multiple forms and disparate locations, which in the presence of numerous commercial EHR solutions, results in significant variations in how institutions codify genetic data. Furthermore, within an institution, there is often internal pressure to migrate from one support tool to another, necessitating a focus on data integrity during such a transition. Methods: Fred Hutchinson Cancer Center (Fred Hutch) is a large academic cancer care center associated with the University of Washington. Between July and December 2023, the Fred Hutch Clinical Cancer Genetics and Genetic Counseling Service migrated their family history database from commercial pedigree software, Progeny, to another commercial pedigree and decision-support tool, CancerIQ. Following completion of the data migration on more than 13,000 patient records, study team planned to review a total of 500 randomly selected patient charts in both support tools. Each chart was reviewed to determine: (1) the presence of genetic intake information, (2) the presence and results of genetic testing, if available, and (3) whether the patient met National Comprehensive Cancer Network (NCCN) criteria for testing. A chart was noted to be concordant between the two support tools if there was agreement in all three of the above. Results: So far, a total of 240 patient charts were reviewed between the two support tools. Of these, 226 (94.2%) were noted to be fully concordant. Of the 14 charts that were noted to be discordant, the distribution of the discordant data was: 5 charts differed on whether genetic testing had been ordered, 5 charts differed on the results of the testing (often omitting one or more variants), and 4 differed on whether the patient met NCCN criteria for testing. Conclusions: At our institution, there was high data integrity following migration from one commercial and pedigree-generating software solution to another. While these results can ease clinician concerns following such support tools transitions, it also highlights areas for improvement in how family and patient genetic data is recorded.

Healthcare 5.0: A secure and distributed network for system informatics in medical surgery

IntroductionHealth records serve not only as a database of a patient's health history and treatment process but also as a crucial tool for doctors to diagnose and treat patients. However, the storage and sharing of these records are sensitive issues as they involve maintaining patient privacy and ensuring data transparency, security, and interoperability between different parties. Challenges to achieving these goals in the current surgical process can impact the allocation of medical resources and surgical outcomes. MethodsThis article proposes a healthcare 5.0 framework for medical surgery that deploys a secure and distributed network using Blockchain to demonstrate transactions between different parties in the orthopedic surgery process. The proposed network uses the Hyperledger Composer platform for deployment, and a patient-doctor-supplier orthopedic surgery network is designed and implemented to enable the safe sharing of medical records. ResultsA benchmarking tool was implemented for analyzing different scenarios of applying blockchain technology to orthopedic surgery. The application of blockchain technology to orthopedic surgery presents a promising solution for data sharing and supply chain management in the field. The integration of blockchain with cloud storage and hybrid encryption ensures secure and efficient storage of Electronic Health Record (EHR) and Personal Health Record (PHR) data. By leveraging the tamper-proof nature of blockchain and addressing concerns regarding centralized data storage, this scenario demonstrates enhanced security, improved access efficiency, and privacy protection in medical data sharing. ConclusionsThe article demonstrates the feasibility of using an IoT-based blockchain network in orthopedic surgery, which can reduce medical errors and improve data interoperability among different parties. This unique application of blockchain enables secure sharing of medical records, ensuring transparency, security, and interoperability. The network design may also be applicable to other surgeries and medical applications in the future.

Framework for BIM-Based Repair History Management for Architectural Heritage

This research addresses the challenges faced in collecting and managing repair history information for architectural heritage due to its distribution among different institutions. To overcome this problem, this study proposes a building information modeling (BIM)-based repair history management framework that links non-formal repair details of architectural heritage to BIM. This framework was applied to the case study of the Great Hero Hall of Sudeoksa Temple in Yesan, South Korea. A repair history database in the form of structured data adhering to the historic building information modeling standard was utilized. The proposed framework effectively syncs the repair history database with BIM to preserve architectural heritage and streamline repair history information updates as well as management. Integrated heritage BIM is anticipated to furnish a thorough knowledge base for architectural heritage, comprising non-geometric details and formal information models, thus enhancing building maintenance planning. Ultimately, the benefits and limitations of the suggested framework and methodologies are deliberated for further implementation.

Medconnect (Android App): Linking Doctors, Patients, and Prescriptions Digitally

Abstract: Medconnect, an innovative Android application, emerges as a transformative platform within the healthcare sector, seamlessly bridging the communication gap between doctors, patients, and pharmacies. This application introduces a novel approach to managing prescriptions digitally, ensuring accuracy, enhancing medication adherence, and streamlining the healthcare experience. With functionalities like e-prescriptions, real-time appointment scheduling, and a comprehensive medical history database, Medconnect prioritizes patient care and data security. The integration of advanced technologies facilitates a more efficient healthcare delivery system, reduces the potential for prescription errors, and promotes a collaborative environment between healthcare providers and patients. By embodying the principles of accessibility, reliability, and user-centric design, Medconnect stands at the forefront of digital healthcare innovation, promising a future where managing health and wellness is more integrated and intuitive.

(337) Microsurgical Varicocelectomy Improves Seminal Parameters in Infertile Men: 10-year Experience in a University Hospital

Abstract Introduction Varicocele is the most common treatable cause of male infertility. Although the exact mechanisms by which varicocele causes infertility have not been fully identified, there is evidence of an improvement in seminal parameters and pregnancy rates after varicocelectomy, especially if the technique is performed with an operating microscope Objective This study seeks to compare pre- and post-operative seminal and hormonal parameters of infertile patients undergoing microsurgical varicocelectomy in a local cohort Methods Retrospective analytical study of male patients with a diagnosis of infertility and clinical varicocele, who underwent microsurgical varicocelectomy in a University Hospital, between April 2013 - April 2023. Demographic variables, varicocele grade and laterality, reproductive hormone levels, seminal parameters and postoperative complications were collected from the clinical history database. Pre and postoperative seminal parameters and reproductive hormones were compared using non-parametric statisticians were used for data analysis with the Jamovi Software. P<0.05 was considered statistically significant Results There were 136 varicocelectomies in the period, 56 patients were excluded due to incomplete data collection and finally 80 patients were analyzed. Median age was 34.5 years (IQR 31-38), with a median infertility duration of 2 years (IQR 1-4). All patents had primary infertility. The median testicular volume was 15 cc (IQR 15-20 cc). 82.5% of varicoceles were Grade ≥2, 70.6% patients presented left varicocele and 28% were bilateral. Of the reproductive hormones, only FSH showed a statistically significant decrease of the pre- and post-operative median values, being 5.8 IU/L (IQR 3.9-8.9) and 2.7 IU/L (IQR 2.5-2.9) (p=0.001), respectively. Median sperm concentration before and after surgery was 7 million/mL (IQR 2-23) and 18 million/mL (IQR 3.3-73.5), respectively (p=0.02). Median preoperative and postoperative sperm progressive motility was 29% (IQR 15-48) and 40% (IQR 27-60), respectively (p=0.004). Seminal volume and normal morphology did not show significative changes after surgery. Only 2 patients (2.5%) presented a grade 1 Clavien-Dindo postoperative complication (mild infection of surgical site) Conclusions In this study, infertile patients with a clinical diagnosis of varicocele showed a statistically significant improvement in sperm concentration and progressive motility and a significant decrease in FSH levels after microsurgical varicocelectomy. The reduction of this pituitary hormone may reflect an improvement in testicular spermatogenesis Disclosure No.

The role of the TSC Alliance in advancing therapy development: a patient organization perspective.

Tuberous sclerosis complex (TSC) is a genetic disease leading to malformations, or tubers, in the cerebral cortex and growth of tumors, most frequently in the brain, heart, kidneys, skin, and lungs. Changes in the brain caused by TSC usually have the biggest negative impact on quality of life. Approximately 85% of individuals with TSC have epilepsy, and TSC-associated neuropsychiatric disorders (TAND) affect nearly all individuals with TSC in some way. TSC Alliance's research strategy is built upon both funding and catalyzing research. Through grants, the organization provides funding directly to researchers through a competitive application process. The organization has also built a set of resources available to researchers worldwide, including a Natural History Database, Biosample Repository, and Preclinical Consortium. These resources catalyze research because they are available to qualified academic or industry researchers around the world, enabling an almost unlimited number of scientists to access data and resources to enable and accelerate research on TSC. This research strategy continues to be shaped by the needs and priorities of the TSC community, working toward a future where everyone affected by TSC can live their fullest lives.

Wide-spread dispersal in a deep-sea brooding polychaete: the role of natural history collections in assessing the distribution in quill worms (Onuphidae, Annelida)

BackgroundModern integrative taxonomy-based annelid species descriptions are detailed combining morphological data and, since the last decades, also molecular information. Historic species descriptions are often comparatively brief lacking such detail. Adoptions of species names from western literature in the past led to the assumption of cosmopolitan ranges for many species, which, in many cases, were later found to include cryptic or pseudocryptic lineages with subtle morphological differences. Natural history collections and databases can aid in assessing the geographic ranges of species but depend on correct species identification. Obtaining DNA sequence information from wet-collection museum specimens of marine annelids is often impeded by the use of formaldehyde and/or long-term storage in ethanol resulting in DNA degradation and cross-linking.ResultsThe application of ancient DNA extraction methodology in combination with single-stranded DNA library preparation and target gene capture resulted in successful sequencing of a 110-year-old collection specimen of quill worms. Furthermore, a 40-year-old specimen of quill worms was successfully sequenced using a standard extraction protocol for modern samples, PCR and Sanger sequencing. Our study presents the first molecular analysis of Hyalinoecia species including the previously known species Hyalinoecia robusta, H. tubicloa, H. artifex, and H. longibranchiata, and a potentially undescribed species from equatorial western Africa morphologically indistinguishable from H. tubicola. The study also investigates the distribution of these five Hyalinoecia species. Reassessing the distribution of H. robusta reveals a geographical range covering both the Atlantic and the Indian Oceans as indicated by molecular data obtained from recent and historical specimens.ConclusionOur results represent an example of a very wide geographical distribution of a brooding deep-sea annelid with a complex reproduction strategy and seemingly very limited dispersal capacity of its offspring, and highlights the importance of molecular information from museum specimens for integrative annelid taxonomy and biogeography.

Description of maternal and neonatal adverse events in pregnant people immunised with COVID-19 vaccines during pregnancy in the CLAP NETWORK of sentinel sites: nested case–control analysis of the immunization-associated risk – a study protocol

IntroductionCOVID-19 is associated with higher morbimortality in pregnant people compared with non-pregnant people. At present, the benefits of maternal immunisation are considered to outweigh the risks, and therefore, vaccination is...

Corpus Linguistics Strategies for Identifying Accepted Theories in Early Modern England

The paper investigates the applicability of corpus linguistics to the construction of a database of intellectual history. Working with the Royal Society Corpus (RSC), it presents a series of corpus queries that can aid with computationally identifying potential instances of communal theory acceptance in England during the period of 1665-1800. These queries allowed to identify a set of noun-adjective pairs potentially synonymous with “accepted theory” and retrieve around 1,400 excerpts potentially indicative of instances of communal theory acceptance. The paper also discusses some strategies for identifying the epistemic agent, as well as the RSC’s place within the broader historical context. Finally, I argue that, in addition to exploring corpus linguistics strategies, methodologies for interpreting computationally retrieved data should also be developed.

한국사 디지털 자료의 활용 현황과 과제

In this article, we reviewed several issues focusing on the current situation and assignment of using Korean history digital materials. In particular, limited to Korean history materials, we examined the current use and use of digital materials, as well as research for new expansion, from a historical perspective.
 First, we discussed what role existing historical research could play in digitizing Korean history materials and what its historical significance was.
 Next, in order to check the current state of utilization of Korean history digital materials, we used and analyzed the contents of the Korean history database of the National Institute of Korean History, which provides a variety of contents to date. The contents were largely examined through lists by era and type, which expanded the existing Korean history database data as much as possible, and also gave a glimpse of the expansion of non-literary data rather than literary data.
 Next, as a starting point for the expansion of digital materials on Korean history, we sufficiently reviewed existing research results and raised the need to find new solutions. Among them, the field of ‘History electronic maps’ based on computerized historical information, the development strategy of the classic anthology system through computerization of Korean ancient texts, big data work using digital materials with the help of computers, visual materials and media. We observed that there are attempts to supplement the gaps in literature through data.
 In addition, the writer attempted to address the issue of utilizing image data from old texts centered on 『Samguksagi』 and 『Samgukyusa』, namely, ‘Edition bibliography 板本書誌學’ as an alternative.

On the Category ofReligion: A Taxonomic Analysis of a Large-Scale Database

AbstractThe Database of Religious History is a large-scale digital humanities project dedicated to capturing scholarly perspectives on the history of religious groups across the globe. Analysis of the current state of the data shows a remarkable consistency between a taxonomic tree generated from the entries submitted by our expert contributors and larger assumptions within religious studies as they pertain to the similarities and differences between religious groups. Additionally, there is broad agreement between how experts answer questions and the tags they use to categorize their own entries, demonstrating a consistency between top-down and bottom-up approaches to describing religious groups. We see both of these results as affirming a commensurable understanding of the category of religion while demonstrating the value of these types of large-scale quantitative analyses for answering larger questions within the field.

Concepts of multi-level dynamical modelling: understanding mechanisms of squamous cell carcinoma development in Fanconi anemia.

Fanconi anemia (FA) is a rare disease (incidence of 1:300,000) primarily based on the inheritance of pathogenic variants in genes of the FA/BRCA (breast cancer) pathway. These variants ultimately reduce the functionality of different proteins involved in the repair of DNA interstrand crosslinks and DNA double-strand breaks. At birth, individuals with FA might present with typical malformations, particularly radial axis and renal malformations, as well as other physical abnormalities like skin pigmentation anomalies. During the first decade of life, FA mostly causes bone marrow failure due to reduced capacity and loss of the hematopoietic stem and progenitor cells. This often makes hematopoietic stem cell transplantation necessary, but this therapy increases the already intrinsic risk of developing squamous cell carcinoma (SCC) in early adult age. Due to the underlying genetic defect in FA, classical chemo-radiation-based treatment protocols cannot be applied. Therefore, detecting and treating the multi-step tumorigenesis process of SCC in an early stage, or even its progenitors, is the best option for prolonging the life of adult FA individuals. However, the small number of FA individuals makes classical evidence-based medicine approaches based on results from randomized clinical trials impossible. As an alternative, we introduce here the concept of multi-level dynamical modelling using large, longitudinally collected genome, proteome- and transcriptome-wide data sets from a small number of FA individuals. This mechanistic modelling approach is based on the "hallmarks of cancer in FA", which we derive from our unique database of the clinical history of over 750 FA individuals. Multi-omic data from healthy and diseased tissue samples of FA individuals are to be used for training constituent models of a multi-level tumorigenesis model, which will then be used to make experimentally testable predictions. In this way, mechanistic models facilitate not only a descriptive but also a functional understanding of SCC in FA. This approach will provide the basis for detecting signatures of SCCs at early stages and their precursors so they can be efficiently treated or even prevented, leading to a better prognosis and quality of life for the FA individual.

Evaluation of case-based reasoning to estimate liquefaction manifestation

This article develops a framework for and explores the use of case-based reasoning (CBR) to predict seismically induced liquefaction manifestation. CBR is an artificial intelligence process that solves new problems using the known answers to similar past problems. CBR sorts a database of case histories based on their similarity to a design case and predicts the outcome of the design case as the observed outcome of the most similar case history or majority outcome of the most similar case histories. Two databases of liquefaction case histories are used to develop and validate numerous CBR models. Different input parameters and aspects of the CBR method and their influence on the predictive capability of the models are evaluated. Some of the developed CBR models were shown to have a better predictive power than currently existing models. However, more research is needed to refine these models before they can be used in practice. Nevertheless, this study shows the potential of CBR as a method to estimate liquefaction manifestation and suggests several avenues of future research.

Insights from liquefaction ejecta case histories for the 2010–2011 Canterbury earthquakes

A database of detailed liquefaction ejecta case histories for the 2010–2011 Canterbury earthquakes is interrogated. More than 50 mm of ejecta-induced settlement occurred at thick, clean sand sites shaken by PGA6.1 = 0.35–0.70 g (wherein PGA6.1 is the peak ground acceleration for a Mw 6.1 earthquake), whereas ejecta-induced settlement at highly stratified silty soil sites did not exceed 10 mm even when PGA6.1 exceeded 0.45 g. Cone penetration test-based liquefaction-induced damage indices that do not consider soil-system response effects, such as post-shaking hydraulic mechanisms, overestimate the severity of ejecta at stratified silty soil sites. Considering post-shaking hydraulic mechanisms captures the lack of ejecta at stratified silty soil sites. It also improves the estimation of ejecta severity at clean sand sites with severe-to-extreme ejecta. Strongly shaken clean sand sites that did not produce ejecta typically had thick strata with high tip resistances, thick non-liquefiable crusts, or deeper non-liquefiable strata overlying liquefiable strata. Ejecta-induced fissures formed in the non-liquefiable crust during the Feb 2011 earthquake which liquefied soil at depth could exploit to produce ejecta during the Jun 2011 earthquake. When significant ejecta formed on the roads, elevated adjacent ground with houses typically had negligible ejecta.

CARACTERIZACIÓN DE LA DIETA EN PERFILES BIOQUÍMICOS Y ANTROPOMÉTRICOS CON ANÁLISIS DE COMPONENTES PRINCIPALES EN OBESOS EN GUAYAQUIL-ECUADOR

Objectives: To determine the characterization of the diet in biochemical and anthropometric profiles with principal component analysis in obese Ecuadorian patients. Methods: Descriptive, comparative, longitudinal studies; we had access to the institutional health clinical history database and a study group was formed, they were offered a low-carbohydrate diet. The sample consisted of 110 obese patients from the Hospital of Guayaquil-Ecuador. Results: The patients were between the ages of 25 to 65 years. The results showed a significant loss of BMI (kg/m2) (Δ-2.6±1.9) (p<0.001), waist circumference (cm) (Δ-5.1±4.7) (p<0.001), body fat (%) (Δ-3.6±3.6) (p<0.001), triglycerides (mg/dL) (Δ-25.4±72.9) (p<0.001) and glucose (mg/dL) (Δ-6.8±9.6) (p<0.001). Conclusion: The low carbohydrate diet reduces BMI, waist circumference, body fat, triglycerides and glucose in obese patients.