In view of the lack of research on the failure mode and seismic behavior of high-performance insulation walls utilizing lightweight concrete as the structural material, this study presents experimental findings from a seismic behavior investigation of prefabricate foamed concrete composite walls (PFCCWs) for passive house in China. The PFCCWs incorporate low thermal conductivity and high-strength foamed concrete, polyurethane, decorative magnesium straw slabs to provide excellent thermal and mechanical properties for prefabricated passive houses in hot summer and cold winter area. The seismic behavior of PFCCWs under different influence factors were elaborated using quasi-static test data and observation of external damage. The lightweight and porous nature of foamed concrete leads to significant crack formation during failure. The findings suggest that the skin effect of magnesium straw slabs and polyurethane impedes crack development and improve the load-bearing capacity with ductility enhancement. Additionally, reducing the aspect ratio and substituting post-cast column concrete with common concrete are effective to improve the seismic behavior. The window opening changes the worst damage area of the wall and notably weakens the seismic behavior. The enhanced integrity of cast-in-place wall leads to the difference in the failure mechanism and increases in load-bearing and deformation capacities. Meanwhile, design suggestions for the foamed concrete insulation walls are also proposed by comparing the failure mode and hysteretic response of various wall types.