With the rapid advance of wide-field surveys it is increasingly important to perform combined cosmological probe analyses. We present a new pipeline for simulation-based multi-probe analyses, which combines tomographic large-scale structure (LSS) probes (weak lensing and galaxy clustering) with cosmic microwave background (CMB) primary and lensing data. These are combined at the C ℓ-level, yielding 12 distinct auto- and cross-correlations. The pipeline is based on UFalconv2, a framework to generate fast, self-consistent map-level realizations of cosmological probes from input lightcones, which is applied to the CosmoGridV1 N-body simulation suite. It includes a non-Gaussian simulation-based covariance for the LSS tracers, several data compression schemes, and a neural network emulator for accelerated theoretical predictions. We validate the pipeline by comparing the simulations to these predictions, and our derived constraints to earlier analyses. We apply our framework to a simulated 12×2 pt tomographic analysis of KiDS, BOSS, and Planck, and forecast constraints for a ΛCDM model with a variable neutrino mass. We find that, while the neutrino mass constraints are driven by the CMB data, the addition of LSS data helps to break degeneracies and improves the constraint by up to 35%. For a fiducial Mν = 0.15 eV, a full combination of the above CMB+LSS data would enable a 3σ constraint on the neutrino mass. We explore data compression schemes and find that MOPED outperforms PCA and is made robust using the derivatives afforded by our automatically differentiable emulator. We also study the impact of an internal lensing tension in the CMB data, parametrized by AL , on the neutrino mass constraint, finding that the addition of LSS to CMB data including all cross-correlations is able to mitigate the impact of this systematic. UFalconv2 and a MOPED compressed Planck CMB primary + CMB lensing likelihood are made publicly available.[UFalconv2: https://cosmology.ethz.ch/research/software-lab/UFalcon.html, compressed Planck CMB primary + CMB lensing likelihood: https://github.com/alexreevesy/planck_compressed.]
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