The Four-Dimensional Data Assimilation module (FDDA) is used in combination with the WRF model for the analysis of two case studies of high tide (on 4 April 2019 and on 12 November 2019) that affected the Venice Lagoon in the recent past. The system is implemented in the perspective of an operational use for nowcasting of 10 m wind, which will be part of a numerical system aimed at the forecast of the sea level height in the Venice Lagoon. The procedure involves the assimilation of data from meteorological surface stations distributed within the Venice Lagoon and in the open northern Adriatic Sea in front of the lagoon, as well asthe radiosonde profiles available within the simulation domain. The two cases were selected considering that the real-time forecasts missed their evolution, and the sea level height was significantly underpredicted. The comparison of the simulated wind with the observations shows a fairly good agreement over short time scales (1–2 h) in both cases; hence, the WRF-FDDA system represents a promising tool and a possibly valuable support to the decision makers in case of high tide in the Venice Lagoon.