Waste pickers in Dar Es Salaam play a great role in managing wastes, however; their health and safety status is not documented with certainty. The objective of the study was to assess the health and safety risks among informal solid waste pickers. The study deployed interview and questionnaire to collect data. The study revealed that most waste pickers are poor and marginalized social groups. The health and safety status of waste pickers is affected by long working hours, repetitive movement for picking waste, walking long distances carrying heavy bags of recyclables, and working on hazardous environments without personal protective gears. The most common health and safety risks were musculoskeletal diseases, accidents and injuries. The waste pickers' vulnerability to the hazards is exacerbated by inadequate awareness on health and safety problems, lack of personal protective equipment and medical insurances. Formal recognition of waste pickers, educational support on health and safety including the use of personal protective equipment (PPE), and medical insurances are needed to lessen their exposure to various risks. The government and private sector are encouraged to invest in waste recycling activities which create employment opportunities while protecting the environment. At the same time, they should pay attention to waste pickers who, despite the challenges they face, form an integral part on successful recycling activities.