Due to its special material composition, formation environment, and special structure, loess usually shows different engineering and dynamic characteristics from ordinary soil. Based on previous research results, this paper studies the Haiyuan loess. It is found that: (1) the variation coefficients of various physical properties (except for the liquid index) of loess in the region are relatively stable, but the mechanical properties are relatively discrete; (2) the correlation among natural water content, void ratio, and density is high, but the correlation between mechanical properties is poor; (3) the consolidation ratio, effective confining pressure, and dynamic shear modulus ratio change in direct proportion, while the damping ratio changes in the opposite direction with increasing shear strain; and (4) in this paper, the recommended model of shear wave velocity and burial depth of loess in the study area is given. Compared with the example, the error is smaller and more reliable. (5) The characteristic period of the seismic response spectrum of the loess soil layer is not sensitive to the change in the damping ratio, and the change amplitude is small.