Damp-heat Type Research Articles

Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type

Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type

Application of the Theory of "Treating the Future Disease" in Spleen and Stomach Damp-heat Type Chronic Atrophic Gastritis: an Investigation

Application of the Theory of "Treating the Future Disease" in Spleen and Stomach Damp-heat Type Chronic Atrophic Gastritis: an Investigation

基于三焦辨证探讨急性期湿热型 特应性皮炎的分型及论治

基于三焦辨证探讨急性期湿热型 特应性皮炎的分型及论治

加味白头翁汤灌肠联合针灸治疗湿热下注型 溃疡性结肠炎的临床观察

加味白头翁汤灌肠联合针灸治疗湿热下注型 溃疡性结肠炎的临床观察

Shunt value of HPV E6/E7 mRNA examination in damp-heat type ASCUS.

Shunt value of HPV E6/E7 mRNA examination in damp-heat type ASCUS.

Study on the mechanism of Huangqin Decoction on rats with ulcerative colitis of damp-heat type base on mtDNA, TLR4, p-PI3K, p-Akt protein expression and microbiota

Ethnopharmacological relevanceHuangqin decoction (HQD), composed of Scutellaria(Huangqin), Peony(Shaoyao), Liquorice(Gancao) and Jujube(Dazao), is a traditional Chinese medicine prescription, originated from treatise on Febrile Diseases, has the functions of clearing heat, stopping benefits and relieving pain. It is the original prescription for treating heat and relieving dysentery, and is commonly used in clinic for diarrhea and other diseases. In ulcerative colitis, damp-heat syndrome is the most common. However, its mechanism of action is not completely clear. Aims of the reviewThe purpose of the research is to investigate the protective effect of HQD on ulcerative colitis rats and the regulation effect of mitochondrial DNA, TLR4, p-Akt, p-PI3K protein and microbiota. Materials and methodsThe effects of HQD anti-UC were investigated by fluorescence quantitative PCR, cytokine level and histopathological analysis in DSS-induced ulcerative colitis (UC) rats. The content of mtDNA in colon epithelial cells of rats in each group was detected by fluorescence quantitative PCR, p-PI3K, p-Akt and TLR4 protein expressions in colon tissues of rats in each group were detected by Western blotting. IL-6, IL-17 and IL-23 inflammatory factors were detected by ELISA. The effect of HQD on intestinal microbiota of rats with ulcerative colitis was studied by high-throughput sequencing technology, and the correlation between mtDNA level and inflammatory factors as well as protein expression in colonic epithelium of rats with ulcerative colitis was analyzed by SPSS23.0. ResultsHQD significantly alleviated UC symptoms by improving the mucosal intestinal epithelial cell structure, mental state, hair gloss, fecal occult blood, lamina propria intestinal glands and inflammatory cell infiltration. And HQD reduced the pro-inflammatory cytokines in the colonic epithelium of UC rats Production of IL-6, IL-17 and IL-23. The HE stained section of colon tissue showed a complete intestinal epithelial mucosal layer structure. The structure of epithelial cells was more normal and abundant. There were more goblet cells in lamina propria adenoma, which improved the infiltration of inflammatory cells. HQD significantly inhibited the mtDNA content in rat colonic epithelial tissue, and significantly inhibited the expression of TLR4, p-PI3K and p-Akt inflammatory signaling pathways. The results of the microbiota experiment showed that the abundance of HQD in the phylum Firmicutes increased, and the number of Bacteroides phylum decreased (p < 0.05). At the genus level, HQD significantly increased Lactobacillus and Firmicutes Bacteroides, while Treponema and Bacteroides were significantly reduced (p < 0.05). ConclusionHQD has a certain protective effect on rats with damp heat ulcerative colitis. Its mechanism may be related to regulating the expression of p-PI3K, p-Akt and TLR4 proteins, mitochondrial DNA as well as microbiota.

Effect of Shugan Jianpi Recipe Combined with Cross Moxibustion on Biochemical Examination Indexes and Total Score of TCM Symptoms in Patients with Spleen-Stomach Damp-Heat Diarrhea Irritable Bowel Syndrome.

Objective To explore the effect of Shugan Jianpi recipe combined with cross moxibustion on biochemical examination indexes and total score of TCM symptoms in patients with spleen-stomach damp-heat diarrhea irritable bowel syndrome (IBS). Methods Sixty patients with spleen-stomach damp-heat diarrhea (IBS) treated in our hospital from January 2019 to September 2021 were enrolled. The patients were randomly assigned into the control group and study group. The control group was treated with Chang Shugan Jianpi recipe, and the study group was treated with Shugan Jianpi recipe combined with cross moxibustion. The curative effect, single symptom score, total score of TCM clinical symptoms, plasma gastrointestinal hormone level, IBS-QOL score, and recurrence were compared. Results First of all, we compared the curative effects. The study group was significantly effective in 24 cases, effective in 5 cases, and ineffective in 1 case, and the effective rate was 96.67%. In the control group, 13 cases were markedly effective, 10 cases were effective, and 7 cases were ineffective, and the effective rate was 76.67%. The effective rate of the study group was higher compared to the control group (P < 0.05). Secondly, the individual symptom scores were compared. Compared between the two groups, the scores of diarrhea times, stool characteristics, abdominal pain, and abdominal distension in the study group were lower compared to the control group (P < 0.05). After treatment, the total score of TCM clinical symptoms decreased. Compared between the two groups, the total score of TCM clinical symptoms in the study group was lower compared to the control group at 1 week, 2 weeks, and 4 weeks after treatment (P < 0.05). After treatment, the levels of 5-HT and VIP decreased. The levels of 5-HT and VIP in the study group were lower compared to the control group (P < 0.05). The scores of anxieties, health worry, behavioral disorder, social reaction, somatic intention, interpersonal relationship, dietary concern, and sexual behavior in the study group were lower compared to the control group. The IBS-QOL scores were significantly lower compared to the control group (P < 0.05). Finally, we compared the recurrence. The recurrence rate in the study group was lower compared to the control group (P < 0.05). Conclusion The prescription combined with cross moxibustion has the effect of soothing the liver and invigorating the spleen, resolving dampness and stomach, and can reduce the main clinical symptoms of patients with diarrhea IBS of spleen-stomach damp-heat type, and the overall effect is significant. It can also enhance the emotional state of anxiety and depression and achieve the overall psychological and physical balance and health state, and the recurrence rate is low, which can be further applied in clinic.

Observation and nursing of a patient with constipation of damp-heat type treatment by acupoint massage

Observation and nursing of a patient with constipation of damp-heat type treatment by acupoint massage

Clinical Application of Lichiqufengzhiyang Decoction in Patients with Perianal Eczema of Damp-heat Type

Clinical Application of Lichiqufengzhiyang Decoction in Patients with Perianal Eczema of Damp-heat Type

Clinical observation of Tongfeng decoction combined with celecoxib for the acute gouty arthritis with damp-heat and blood stasis type

Objective To explore clinical efficacy and safety of Tongfeng decoction combined with celecoxib for the acute gouty arthritis of damp-heat with blood stasis type. Methods According to the random indicator method, 193 of patients with acute gouty arthritis of damp-heat with blood stasis type in our hospital from 2014 January to January 2017 were divided into control group (n=96) and treatment group (n=97). Patients of control group were treated with celecoxib, while treatment group were treated with Tongfeng decoction combined with celecoxib. The two groups were treated for 14 days. Clinical curative effect was evaluated after treatment. The joint pain score, joint function score and quality of life score of the two groups before and after treatment were compared. The BUA, ESR, DD, IL-1 and CRP of the two groups before and after treatment were compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of observation group was 93.81% (91/97), which was significantly higher than the control group 73.96% (71/96), and the difference was statistically significant (χ2=14.109, P<0.01). After treatment, the joint pain (1.1 ± 0.4 vs. 2.4 ± 0.8, t=13.984), joint function score (0.7 ± 0.6 vs. 1.3 ± 0.9, t=5.451) in the treatment group were lower than those in the control group (P<0.05). The quality of life score (39.7 ± 9.3 vs. 32.5 ± 8.6, t=5.623) in the treatment group were higher than that in the control group (P<0.05). After treatment, the BUA (302.47 ± 50.72 μmol/L vs. 395.21 ± 69.63 μmol/L, t=10.584), ESR (11.63 ± 4.05 mm/h vs. 24.87 ± 10.49 mm/h, t=11.589), DD (0.43 ± 0.21 mg/L vs. 0.95 ± 0.71 mg/L, t=6.914), IL-1 (12.03 ± 2.62 ng/L vs. 19.31 ± 3.25 ng/L, t=17.140) and CRP (6.11 ± 2.40 mg/L vs. 11.84 ± 5.49 mg/L, t=9.411) in the treatment group were lower than those in the control group (P<0.05). There was no significantly difference of the adverse reaction rates of the two groups during treatment (χ2=0.216, P=0.642). Conclusions Tongfeng decoction combined with celecoxib for treatment of acute gouty arthritis of damp-heat with blood stasis type showed a good efficacy and low adverse reactions, and it can improve the joint function and quality of life, reduce the BUA. Key words: Arthritis, Gouty; Damp-heat with blood stasis type; Tongfeng decoction; Celecoxib; Clinical Study

Constitutional types of Chinese medicine of primary bile reflux gastritis among different season: a cross-sectional study

Objective To investigate the constitutional types of Chinese medicine of primary bile reflux gastritis among different seasons. Methods Data of gastroscopy center during August 2015 to July 2016 were analyzed. A total of 603 patients were diagnosed as primary bile reflux gastritis. After gastroscopy, the standardized constitution in Chinese medicine questionnaire was used to evaluation the scores of all kinds of constitutional types. The Constitutional types of Chinese medicine of primary bile reflux gastritis among different seasons were analyzed. Results Among all seasons, the positive detection rate showed significant difference (χ2=13.041, P=0.005), and summer group showed the highest among the four seasons (23.38% vs. 17.63%, χ2=12.414, P<0.001). Among all seasons, constitutional types of Chinese medicine of primary bile reflux gastritis had significant difference (χ2=37.441, P<0.001). Damp-heated type had significant difference among seasons (χ2=8.472, P=0.037), especially during the summer (χ2=5.847, P=0.016). Conclusions The summer may have more primary bile reflux gastritis chance to be diagnosed as primary bile reflux gastritis. Yang-deficiency type, Gentleness type, Qi-deficiency type and damp-heat type were more common in primary bile reflux gastritis patients. Key words: Bile reflux; Gastritis; Constitutional types of Chinese medicine; Seasons

Clinical observation of acupuncture at Zhiyang (GV 9) Bazhen points combined with pantoprazole for gastroesophageal reflux cough with damp-heat type

On the basic treatment, to observed the effect difference between acupuncture at Zhiyang (GV 9) Bazhen points combined with pantoprazole and simple pantoprazole for gastroesophageal reflux cough with damp-heat type. A total of 102 patients were randomly assigned into an observation group and a control group, 51 cases in each group. The patients in the two groups were given domperidone tablets (10 mg each time, 3 times a day). The patients in the control group were treated with pantoprazole capsule (40 mg each time, once a day). On the basis of the control group, the patients in the observation group were treated with Zhiyang (GV 9) Bazhen points, once a day, 5 times a week. All the treatment was given for 8 weeks. The indexes were observed before and after treatment, including cough symptom at daytime and nighttime scores, TCM symptom (heartburn, acid regurgitation, chest pain, epigastric pain, throat discomfort) scores and quality of life scores of cough questionnaire in Leicester (physiological, psychological and social aspects). The clinical effects were compared. After treatment, the daytime and nighttime cough scores, TCM symptom (heartburn, acid regurgitation, chest pain, epigastric pain, throat discomfort) scores were lower, and the quality of life scores of cough questionnaire in Leicester (physiological, psychological and social aspects) were higher than those before treatment in the two groups (all P<0.05), with better results in the observation group (all P<0.05). The total effective rate of the observation group was 94.1% (48/51), which was better than 80.4% (41/51) of the control group (P<0.05). On the basic treatment, acupuncture at Zhiyang (GV 9) Bazhen points combined with pantoprazole can improve TCM symptoms, such as cough, of the patients with gastroesophageal reflux cough with damp-heat type, and improve their quality of life.

Correspondence analysis between traditional Chinese medicine (TCM) syndrome differentiation and histopathology in colorectal cancer

IntroductionDefining Traditional Chinese medicine (TCM) syndrome is considered the key therapeutical principle of TCM. The present study was to explore the correlation between TCM syndrome differentiation and histopathology in colorectal cancer (CRC). MethodsA total of 180 patients were differentiated into 5 TCM syndrome types, including accumulated damp-heat type (ADH), deficiency of both qi and blood type (DBQB), deficiency of liver and kidney yin type (DLKY), deficiency of spleen and kidney yang type (DSKY) and qi stagnation due to spleen deficiency type (QSSD). They were also differentiated into pathologic types, including adenocarcinoma, mucous carcinoma, signet ring cell carcinoma and anaplastic carcinoma. Moreover, the expression of protein 53 (P53), cluster of differentiation 44 (CD44), non-metastasis 23 (nm23), proliferating cell nuclear antigen (PCNA) and B-cell lymphoma-2 (Bcl-2) was detected by immunohistochemistry in 61 patients. Finally, the correspondence analysis between TCM syndrome differentiation and histopathology or pathological molecular markers was conducted. ResultsChi-square test of independence showed that TCM syndrome types correlated with pathological types (χ2=33.456, P=0.001), while not with molecular markers (χ2=7.344, P=0.834). Correspondence analysis showed that the distances between adenocarcinoma and QSSD or DLKY were the shortest among the distances of adenocarcinoma with other TCM syndrome types. Moreover, distances between mucinous carcinoma and ADH, signet ring cell carcinoma and ADH, anaplastic carcinoma and DBQB were the shortest among all the types. ConclusionTCM syndrome differentiation is strongly correlated with histopathology of colorectal cancer. TCM syndrome differentiation may be used as a supplement in the diagnosis of CRC.

Observation on clinical therapeutic effect of Liyao granule in the treatment of damp-heat syndrome type lumber intervertebral disc protrusion

Objective To observe the clinical curative effect of Liyao granule for treatment of damp-heat syndrome type lumber intervertebral disc protrusion.Methods Totally 60 patients with dampheat syndrome type lumber intervertebral disc protrusion were randomly divided into two groups:treatment group (Liyao granule plus foundation therapy,n=30) and control group (Fenbid plus foundation therapy,n=30).After two courses of treatment,VAS score and general clinical efficacy were observed.Result Compared with the treatment before,after 2 courses of treatment,VAS score of two groups were decreased (P＜0.01); the general efficacy of treatment group and control group were 86.7％ and 90％ respectively; however,there was no significant statistical difference between two groups in VAS score and general efficacy (P＞0.05).Conclusion Liyao granule has short-term analgesic effect on damp-heat syndrome type lumber intervertebral disc protrusion,the same as Fenbid. Key words: Liyao granule; Damp-heat syndrome type; Lumber intervertebral disc Protrusion

Clinical observation on side effects of various Tripterygium wilfordii preparations

Objective: To observe the side effects of various Tripterygium wilfordii (TW) preparations in treating rheumatoid arthritis (RA).Methods: The total of 271 patients with RA were treated with various TW preparations to observe the occurrence of side effects.Results: The influence on reproductive system with TW preparations extracted from the TW leaves (Leino ester tablet, LE) was milder than that extracted from the roots (TW tablets and TW polyglycoside tablets, TWP). In the TWP group, the rate of side effect of 60 mg daily was higher than that of 30 mg daily,P < 0.01. The main effects on digestive system and irregular menstruation occurred before 50 years in age, while it was kidney impairment after the age of 50. Those side effects occurred within the first ten years in long-term application. The side effects of TWP produced in the Damp-Heat Stagnation type of RA was much lower than Liver and Kidney Yin Deficiency type of RA,P < 0.05.Conclusion: TW Leino ester tablet is indicated for young woman, and small dosage of TWP tablet is indicated for maintenance therapy, particularly to the Damp-Heat type of RA.