The orthotropic anisotropy of sedimentary rocks has a significant impact on the force and deformation behavior of the project. In this paper, radial pressurization tests were carried out in the borehole in a typical northern karst area to obtain the deformation properties and orthotropic anisotropy of the rock masses. The test results showed that the deformation modulus and elastic modulus of the limestone rocks in the dam site area obeyed normal distribution. The deformation modulus was basically larger than the proposed deformation modulus of Class II rocks (10 GPa). The deformation behavior and anisotropy degree of the limestone showed a weak correlation with the elevation, but a strong correlation with the development density of the rock joints. The larger development density of the rock in the right bank test section leads to a larger degree of orthotropic anisotropy and frequency of occurrence.