Daily Cholesterol Intake Research Articles

Decrease of cholesterol content in cereal products containing animal-based components

AbstractThe daily intake of excessive cholesterol plays an important role in the incidence of cardiovascular diseases (CVD), while the main contributors are foods of animal origin. However, animal-based foods are also common components of many cereal products, which can then play a role of hidden cholesterol source. Thus, this study aims to decrease cholesterol content in three types of commonly consumed cereal products (biscuits, pasta, and muffins) by replacing original animal-based components (milk and eggs) with the same components, from which the cholesterol was removed using β-cyclodextrin treatment procedure. The cholesterol content in the original and treated samples was then analyzed using the validated HPLC–UV method. So, while the cholesterol content in the original biscuits, pasta, and muffins was observed at 329.2, 1117.1, and 487.2 mg/kg levels, the same products containing low cholesterol animal-based components exhibited a considerable decrease in cholesterol content by 93.1, 91.6, and 89.5%, respectively. The optimum β-cyclodextrin level was observed at 4.0, 10.0, and 2.0% (w/w) for butter, egg melange, and milk, respectively. Furthermore, it is notable that the β-cyclodextrin treatment procedure itself did not significantly change the organoleptic profiles of the cereal products, such as colour, culinary, and texture properties. Therefore, it can be concluded that the application of animal-based low cholesterol components in cereal food products could be one of the effective tools in the overall strategy to decrease the total daily cholesterol intake. Thus, this study presents a novel strategy that could have substantial health benefits in relation to the incidence of CVD.

Associations between Cholesterol Intake, Food Sources and Cardiovascular Disease in Chinese Residents.

Cholesterol is a nutrient commonly found in the human diet. The relationship between dietary cholesterol, its sources, and cardiovascular disease (CVD) is still a topic of debate. This study aimed to investigate the association between dietary cholesterol, its sources, and cardiovascular events in a Chinese population. The present study analyzed data from the China Health and Nutrition Survey (CHNS) cohort between 1991 and 2015. This study analyzed data from 3903 participants who were 40 years of age or older at baseline and had no history of cardiovascular disease, diabetes, or hypertension. During a median follow-up of 14 years, 503 cardiovascular disease events were identified through follow-up questionnaires administered every 2-3 years. The events included fatal and nonfatal coronary heart disease, stroke, heart failure, and other cardiovascular disease deaths. Cox regression was used to estimate risk ratios (HR) for CVD events after adjusting for demographic, socioeconomic, and behavioral factors. It was discovered that sources of dietary cholesterol varied among different subgroups of the population. The top three sources of cholesterol among all participants were eggs, red meat, and seafood, accounting for 57.4%, 28.2%, and 9.0% of total daily cholesterol intake, respectively. The present study found that there was a significant association between total dietary cholesterol intake, and the risk of developing cardiovascular disease (adjusted HR [95% CI]: total cholesterol (highest and lowest quartiles compared) 1.57 [1.17-2.11]). Cholesterol from poultry, seafood, and eggs was also significantly associated with a reduced risk of CVD (adjusted HR [95% CI]: poultry 0.18 [0.04-0.82], seafood 0.11 [0.02-0.54], and eggs 0.16 [0.03-0.73]). After adjusting for daily caloric intake, daily fat intake, and daily saturated fat intake, the previously observed association between red meat cholesterol and cardiovascular events (unadjusted HR [95% CI]: 0.44 [0.35-0.55]) was no longer statistically significant (adjusted HR [95% CI]: 0.21 [0.04-1.01]).

Synthesis of Effect Sizes on Dose Response from Ultra-Processed Food Consumption against Various Noncommunicable Diseases.

Ultra-processed foods (UPFs), according to the NOVA classification food system, are food products that are processed using advanced processing technology, which improves palatability and sensory quality. However, UPFs increase the daily intake of energy, sodium, sugar, and total fat (including saturated fat), and decrease the intake of fiber. This might trigger overweight and obesity, the initial stages of noncommunicable diseases (NCDs). However, the effect of UPF consumption on NCDs remains under debate. This study aimed to synthesize the effect size of UPF dose response on various NCDs by using a meta-analysis method. The main output was a hazard ratio (HR) and a 95% confidence interval (CI). Using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) selection guidelines, 18 research articles were chosen for further effect size synthesis. The results showed that UPF consumption significantly increased the daily intake of carbohydrates, added sugar, saturated fat, sodium, energy, cholesterol, and total fat; increases of 49.64, 40.78, 30.00, 27.76, 26.67, 25.69, and 15.77%, respectively, were observed. Moreover, with UPF consumption, the fiber intake was way below the daily dietary recommendation (DR), at -38.55%. Further, a 10% increment in UPF consumption significantly affects diabetes, cardiovascular diseases, obesity, and cancer (HR ± 95% CI: 1.115 ± 0.044, 1.096 ± 0.053, 1.068 ± 0.050, and 1.020 ± 0.020, respectively). Thus, limiting daily UPF consumption could help prevent obesity and various NCDs.

Dietary fats and serum lipids in relation to the risk of ovarian cancer: a meta-analysis of observational studies.

Although numerous epidemiological studies investigated the association between dietary fat intakes or serum lipid levels and ovarian cancer risk, a consistent and explicit conclusion for specific dietary fats or serum lipids that increase the risk of ovarian cancer is not available. In this study, a systematic review and meta-analysis were conducted to assess the key dietary fats and serum lipids that increased the risk of ovarian cancer. Databases such as PubMed, Web of Science, and EMBASE were searched for observational studies. A total of 41 studies met the inclusion criteria, including 18 cohort and 23 case-control studies (109,507 patients with ovarian cancer and 2,558,182 control/non-ovarian cancer participants). Higher dietary intakes of total fat (RR = 1.19, 95% CI = 1.06-1.33, I2 = 60.3%), cholesterol (RR = 1.14, 95% CI = 1.03-1.26, I2 = 19.4%), saturated fat (RR = 1.13, 95% CI = 1.04-1.22, I2 = 13.4%), and animal fat (RR = 1.21, 95% CI = 1.01-1.43, I2 = 70.5%) were significantly associated with a higher risk of ovarian cancer. A higher level of serum triglycerides was accompanied by a higher risk of ovarian cancer (RR = 1.33, 95% CI = 1.02-1.72, I2 = 89.3%). This meta-analysis indicated that a higher daily intake of total fat, saturated fat, animal fat, and cholesterol and higher levels of serum triglycerides were significantly associated with an increased risk of ovarian cancer.

DIETARY HABITS AND BODY COMPOSITION IN TUNISIAN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. About 50 % of diagnosed women are obese or overweight, suggesting that there is a possible link between abnormal dietary habits and PCOS. Objective: to compare the dietary intakes between women with PCOS and healthy controls. Design and method: A case-control study was performed. Women with PCOS and age-matched controls were recruited and asked to complete a questionnaire on their eating habits and a recall dietary diary, from which their caloric, macronutrients (carbohydrate, fat, protein, fiber), and micronutrients (folic acid, iron, calcium, sodium…) intakes were calculated. Systolic and diastolic blood pressure, anthropometric indexes (height, body weight, and body mass index (BMI), and body composition (lean mass and fat mass) were measured. Results: Sixteen women with PCOS and 8 controls were included. Mean age was 27.06 +/- 6.6 and 26.3 +/-5.9 years and BMI was 26.8 +/- 5 and 27.7+/- 7.8 kg/m2, respectively. We observed lower lean mass (45.6 vs 48.8 kg) and fat mass (23.6 vs 26.9 kg) in PCOS patients compared to controls. No significant difference in blood pressure was observed between the two groups. Both PCOS and control groups had similar energy (2114.1 vs 2155.6 kcal/d) and macronutrient intakes. In women with PCOS, the percentage of energy from fat was lower (35.2 vs 38.3%) and the percentage of energy from carbohydrates was slightly higher compared with normal controls (53.6 vs 51.3%). PCOS women had significantly higher zinc intake (8.6 vs 7.6 mg, p = 0.032). Daily cholesterol intake was higher in the PCOS group (281.3 mg versus 254.7 mg). All women had a low daily consumption of dietary fiber than the recommended value of 25 g. Conclusions: This study didn’t find major differences in macronutrient intake in PCOS patients compared to controls. Regarding micronutrients, a high zinc diet in PCOS patients could be a key observation. It could clear up PCOS pathophysiology, since zinc has major biological roles, as a catalyst, structural, and regulatory ion.

Nutrient Intake and Risk Factors for Metabolic Syndrome in Christian Orthodox Church Religious Fasters.

Studies regarding health effects of religious fasting have been increased during the last decade. Our aim was to investigate the impact of adherence to the periodic Christian Orthodox Church (COC) fasting on nutrient intake, body composition, and risk factors for metabolic syndrome (MetS). Four-hundred individuals aged 42.6 ± 17.0 years participated in this cross-sectional study. Two-hundred subjects followed the COC fasting since childhood or at least the last twelve consecutive years, and two-hundred subjects did not follow the COC fasting regimes or any other restrictive dietary pattern. Socioeconomic data, lifestyle habits, and physical activity data were collected. Nutritional assessment was performed via two 24 h recalls and a food frequency questionnaire. Anthropometric data and biochemical parameters were also measured. Fasters had a significantly lower daily intake of calories (1547 vs. 1662 kcals, p = 0.009), protein (52 vs. 59 g, p = 0.001), fat (82 vs. 89 g, p = 0.012), and cholesterol (147 vs. 178 g, p = 0.001) compared with non-fasters. Furthermore, fasters reported a healthier way of living, with lower rates of smoking and alcohol consumption (p < 0.001 and 0.002, respectively). Insulin and magnesium levels were significantly higher, whereas levels of urea, transaminases, glucose, and phosphorus were significantly lower, as was DBP in fasters versus non-fasters. Furthermore, MetS prevalence was non-significantly higher in non-faster compared with fasters. During a non-fasting period, individuals following the COC fasting recommendations reported lower intake of calories, protein, fat, and cholesterol compared with non-fasters. Fasters tended to have a healthier lifestyle pattern and a lower risk for MetS versus non-fasters. Some biochemical parameters also significantly differed between the two study groups. Further research is warranted to establish the long-term clinical impact of these findings.

Impact of the Cardiovascular Health Integrated Lifestyle Diet on nutritional profile and dietary compliance in Ukrainian pediatric patients with heterozygous familial hypercholesterolemia

Background. Hypercholesterolemia is a risk factor for atherosclerosis and cardiovascular disease; it is also a significant contributor to mortality from major adverse cardiovascular events. Medical nutrition therapy and proper physical activity level are all important parts of prevention strategy for patients with familial hypercholesterolemia (FH). The aim of our study was to determine the impact of the Cardiovascular Health Integrated Lifestyle Diet (CHILD-1) on the nutritional profile of patients with FH compared to the healthy peers and to identify possible deviations from the required daily nutrient intake. Materials and methods. Fifteen patients with FH included in the study were interviewed using an adapted Food Frequency Questionnaire. Their nutritional status was assessed with Anthro+ WHO software. The average daily intake of FETA nutrients and its possible correlation with other parameters were analyzed using SAS OnDemand for Academics software. Results. The results suggest a lack of complete dietary compliance in all age groups of patients. Patients with FH aged 5–9 years consumed more fat than recommended daily intake level. There was a significant deficit in vitamin D. Children with FH aged 10–14 years consumed less carbohydrates and fats per day, showed the deficiencies in protein, calcium, iron, iodine, zinc, vitamin D. Patients with FH aged 15–18 years had a slightly increased daily intake of cholesterol and vitamin D deficiency. This age group was the only to exceed the recommended daily cholesterol intake level. Age and gender had no effect on nutrient intake (p &gt; 0.05). A statistically significant gender difference in intake of certain nutrients was recorded at ages 5–9 and 10–14 years only in the group of patients with FH, with higher levels in male patients. Conclusions. The diets of patients with FH and healthy children in all age groups were unbalanced, containing little protein and many non-recommended ingredients. Non-adherence to dietary treatment in patients with FH is associated with a lack of motivation, inadequate education of children and parents and a general lack of medical attention. Treatment of these patients requires a multidisciplinary team with a family-oriented approach that is focused on self-management skills development in a child. The FH management guidelines should include provision of medical nutrition therapy and step-by-step monitoring of growth and development.

Adherence to the 2021 dietary guidelines of the European Society of Cardiology on cardiovascular disease prevention in residents of the Pomeranian Voivodeship with increased cardiovascular risk.

Good eating habits can reduce cardiovascular risk. The aim of this work was to verify the compliance with the new European Society of Cardiology (ESC) dietary guidelines in people with increased risk of cardiovascular disease. The study included 1244 current or former smokers (636 men and 608 women) at a mean (SD) age of 61.6 (6.4) years who volunteered for the MOLTEST BIS lung cancer prevention program. During the program, 49% of the patients were diagnosed with one of the following: arterial hypertension (AH), diabetes mellitus (DM), or coronary artery disease (CAD). The patients with lung cancer were excluded from the study. The participants completed a Food Frequency Questionnaire (FFQ‑6) and their food intake was assessed with a 24‑hour dietary recall method. Only 2% of the studied individuals declared consuming more than 2 servings of both fruits and vegetables every day, and only 3% of the respondents confirmed daily nut consumption. Most of them weighed too much, consumed too little fiber, and derived too much energy from total and saturated fats. The mean animal to plant protein ratio was higher than recommended, as was the omega‑6 to omega‑3 fatty acid ratio. Only 40% of the participants with AH, DM, or CAD had a daily cholesterol intake below 200 mg, and in only 12% of them less than 7% of total energy came from saturated fats. The smokers with increased cardiovascular risk did not comply with the 2021 ESC dietary recommendations. The most common error was inadequate consumption of vegetables, fruits, and nuts.

β-Cyclodextrin as the Key Issue in Production of Acceptable Low-Cholesterol Dairy Products.

The application of cyclodextrins in food technology is extensive due to their unique ability to form complexes with many bioactive substances. Consumption of dairy products is associated with an increased risk of cardiovascular diseases (CVD) due to its high content of saturated fatty acids and cholesterol, so the production of low-cholesterol content products would be one of the critical steps in CVD prevention with regards to lowered total daily cholesterol intake. To maintain consumer acceptance, organoleptic profiles of such products should be, in the optimal case, the same with comparison to original ones. So, this study deals with the development of set low cholesterol foods (milk, cream, butter, soft cheese, cottage cheese) by β-cyclodextrin treatment and the characterization of their organoleptic profiles such as color and textural characteristics. During the experiments, high effectivity of cholesterol removal was reached as follows: milk–97.3%, cream–95.6%, butter–95.6%, cottage cheese–97.9%, soft cheese–97.7%, while color differences varied from 0.25 to 1.13 and textural characteristics were not influenced by cholesterol removal as well. So, it can be concluded that the proposed procedure is enabled to be substantial for the production of a new assortment of low-cholesterol dairy products with considerable health benefits toward the incidence of CVD.

MO566: Relationship Between Cholesterol Intake and Development of Chronic Kidney Disease: A Community-Based Prospective Cohort Study

Abstract BACKGROUND AND AIMS Globally, the incidence and prevalence of CKD have been increased. Also, CKD DALYs and death due to CKD have been increased (DALYs: The disability-adjusted life-year).[1] CKD puts a lot of mental and economic burden on an individual’s life and lowers the quality of life.[2] As CKD progress, kidney-specific risk factor for cardiovascular events and disease are increased.[3] Dyslipidemia is generally known to be associated with the development and progression of chronic kidney disease.[4] However, it is unclear whether limiting cholesterol intake helps prevent CKD. Recent studies have reported that there is no association between cholesterol intake and cardiovascular disease.[5] The aim of our study is to analyze the relationship between cholesterol intake and the development of CKD in a general population. METHOD We included 9226 subjects without CKD from the Korean Genome and Epidemiology Study. The amount of daily cholesterol intake was assessed by food frequency questionnaire. The primary outcome was the development of CKD, which was defined as an estimated glomerular filtration rate (eGFR) of &amp;lt; 60 mL/min/1.73 m2 and/or proteinuria (≥1+). RESULTS The mean age was 55.7 ± 8.8 years and 39.6% of subjects were men. The cholesterol intake was only significantly correlated with serum HDL cholesterol but not with total and non-HDL cholesterol. Moreover, this significant relationship was disappeared after adjusting for daily fat intake. During median follow-up duration of 11.4 years, 778 (8.5%) CKD events occurred. In multivariable Cox analysis, serum total cholesterol was significantly associated with incident CKD (hazard ratio [HR] 1.005, 95% confidence interval [CI]: 1.003–1.007; P &amp;lt; 0.001). However, cholesterol intake was not associated with incident CKD both in subjects with dyslipidemia (HR: 1.001; 95% CI: 1.000–1.002; P = 0.205) and without dyslipidemia (HR: 0.999; 95% CI: 0.997–1.000; P = 0.134). CONCLUSION Cholesterol intake was not correlated with serum cholesterol levels with considering fat intake. In addition, cholesterol intake was not associated with increased risk of CKD in the general population. Therefore, it may not be necessary to limit cholesterol intake to prevent CKD in this population.

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41502 Does dietary fat composition predict short-term elevations in lipid levels in adults on a modified Atkins diet?

ABSTRACT IMPACT: Our work provides guidance on whether dietary fat intake influences serum cholesterol levels in response to ketogenic diet therapy in adults with epilepsy. OBJECTIVES/GOALS: The modified Atkins diet (MAD) is used in the management of drug-resistant epilepsy in adults. Some patients on MAD show an increase in serum levels of total cholesterol and low-density lipoprotein (LDL) cholesterol. We explored whether dietary fat composition predicts short-term elevations in serum lipid levels in diet-naive adults who begin MAD. METHODS/STUDY POPULATION: Participants self-reported their diet intake with 3-day food records at baseline, 1 month and 2 months. Food records were analyzed using Nutrition Data System for Research software. Fasting serum levels of total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides were also collected and LDL level calculated at baseline, 1 month, and 2 months. RESULTS/ANTICIPATED RESULTS: 38 patients submitted complete food records at each study visit (baseline, 1 month, and 2 month). Compared to baseline diet intake, there was a significant reduction in daily carbohydrate intake at 1 and 2 months (p&lt;0.001) and a significant increase in daily fat intake at 1 and 2 months (p&lt;0.001). There was also a significant increase in daily saturated fatty acid (SFA) intake at 1 and 2 months (p&lt;0.001), daily mono-unsaturated fatty acid (MUFA) intake at 1 and 2 months (p&lt;0.001), and daily cholesterol intake at 1 month (p&lt;0.05) and 2 months (p&lt;0.001), but no change in daily poly-unsaturated fatty acid (PUFA) intake over time. Compared to baseline, there was a significant increase in serum LDL at 1 month (p&lt;0.001) and 2 months (p&lt;0.01) and an increase in serum TC at 1 month (p&lt;0.01) but not 2 months. DISCUSSION/SIGNIFICANCE OF FINDINGS: Despite a significant increase in total fat, saturated fat and mono-unsaturated fat intake as well as an increase in total cholesterol and LDL levels following MAD initiation, dietary fat composition appears to minimally predict serum lipid values in the short term.

Dietary nutrients of relative importance associated with coronary artery disease: Public health implication from random forest analysis.

Dietary nutrients have significant effects on the risk of cardiovascular diseases. However, the results were not uniform across different countries. The study aims to determine the relative importance of dietary nutrients associated with coronary artery disease (CAD) among the Nepalese population. A hospital-based matched case-control study was carried out at Shahid Gangalal National Heart Center in Nepal. In the present study, patients with more than seventy percent stenosis in any main coronary artery branch in angiography were defined as cases, while those presenting normal coronary angiography or negative for stressed exercise test were considered controls. Dietary intakes of 612 respondents over the past 12 months were evaluated using a semi-quantitative customized food frequency questionnaire. In conditional regression model, the daily average dietary intake of β-carotene (OR: 0.54; 95%CI: 0.34, 0.87), and vitamin C (OR: 0.96; 95%CI: 0.93, 0.99) were inversely, whereas dietary carbohydrate (OR: 1.16; 95%CI: 1.1, 1.24), total fat/oil (OR: 1.47; 95%CI: 1.27, 1.69), saturated fatty acid (SFA) (OR: 1.2; 95%CI: 1.11, 1.3), cholesterol (OR: 1.01; 95%CI: 1.001, 1.014), and iron intakes (OR: 1.11; 95%CI: 1.03, 1.19) were positively linked with CAD. Moreover, in random forest analysis, the daily average dietary intakes of SFA, vitamin A, total fat/oil, β-carotene, and cholesterol were among the top five nutrients (out of 12 nutrients variables) of relative importance associated with CAD. The nutrients of relative importance imply a reasonable preventive measure in public health nutrients specific intervention to prevent CAD in a resource-poor country like Nepal. The findings are at best suggestive of a possible relationship between these nutrients and the development of CAD, but prospective cohort studies and randomized control trials will need to be performed in the Nepalese population.

Decrease of cholesterol content in milk by sorption onto β-cyclodextrin crosslinked with tartaric acid; considerations and implications

Abstract Elevated cholesterol intake can induce the development of cardiovascular diseases in man, especially with long term animal origin foods consumption. Therefore, this work deals with the possibility of cholesterol content decrease in milk applying β-cyclodextrin crosslinked with tartaric acid (βCDcTA) as a removal agent. Evaluation of statistic data on food consumption in the Slovak Republic in 2018 aimed at total cholesterol daily intake and effects of “milky” cholesterol content decrease on total cholesterol balance. During the experiments, various amounts of βCDcTA addition to milk were studied resulting in optimal 5 % addition resulting in the cholesterol content decrease by 85.4 % in comparison to original cholesterol content. For monitoring purposes, an HPLC method analysing cholesterol content in saponified milk was employed. The food consumption data analysis showed that total per capita daily cholesterol intake was 369.8 mg, from which 86 mg was assigned to the cholesterol contained in milk and dairy products while the application of cholesterol removal procedure could decrease the total per capita daily cholesterol intake to 296.3 mg (“milky” cholesterol amount equal to 12.6 mg), which in below the recommended value of 300 mg daily intake still valid in the Slovak Republic. This approach might prove as a meaningful step to weaken health problems associated with high long term intake of cholesterol contained in foods of animal origin.

4013 Does dietary fat composition predict short-term elevations in lipid levels in adults on a modified Atkins diet?

OBJECTIVES/GOALS: The modified Atkins diet (MAD) is used in the management of drug-resistant epilepsy in adults. Some patients on MAD show an increase in serum levels of total cholesterol and low-density lipoprotein (LDL) cholesterol. We explored whether dietary fat composition predicts short-term elevations in serum lipid levels in diet-naïve adults who begin MAD. METHODS/STUDY POPULATION: Participants self-reported their diet intake with 3-day food records at baseline, 1 month and 2 months. Food records were analyzed using Nutrition Data System for Research software. Fasting serum levels of total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides were also collected and LDL level calculated at baseline, 1 month, and 2 months. RESULTS/ANTICIPATED RESULTS: 38 patients submitted complete food records at each study visit (baseline, 1 month, and 2 month). Compared to baseline diet intake, there was a significant reduction in daily carbohydrate intake at 1 and 2 months months (p&lt;0.001). There was also a significant increase in daily saturated fatty acid (SFA) intake at 1 and 2 months (p&lt;0.001), daily mono-unsaturated fatty acid (MUFA) intake at 1 and 2 months (p&lt;0.001), and daily cholesterol intake at 1 month (p&lt;0.05) and 2 months (p&lt;0.001), but no change in daily poly-unsaturated fatty acid (PUFA) intake over time. Compared to baseline, there was a significant increase in serum LDL at 1 month (p&lt;0.001) and 2 months (p&lt;0.01) and an increase in serum TC at 1 month (p&lt;0.01) but not 2 months. DISCUSSION/SIGNIFICANCE OF IMPACT : Despite a significant increase in total fat, saturated fat and mono-unsaturated fat intake as well as an increase in total cholesterol and LDL levels following MAD initiation, dietary fat composition appears to minimally predict serum lipid values in the short term. CONFLICT OF INTEREST DESCRIPTION: Tanya McDonald has received speaking honoraria from Nutricia North America. Bobbie Henry-Barron receives grants from Johns Hopkins Institute for Clinical and Translational Research (ICTR) which is funded in part by Grant Number UL1 TR 001079 from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research, Nutricia and Vitaflo. Diane Vizthum receives grants from the Johns Hopkins Institute for Clinical and Translational Research (ICTR) which is funded in part by Grant Number UL1 TR 001079 from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Mackenzie C. Cervenka has received grant support from Nutricia North America, Vitaflo, Army Research Laboratory, The William and Ella Owens Medical Research Foundation and BrightFocus Foundation. She receives speaking honoraria from LivaNova, Epigenix, Nutricia North America and the Glut1 Deficiency Foundation and performs consulting with Nutricia North America and Sage Therapeutics and receives Royalties from Demos Health.

Association between dietary sodium, calcium, saturated fat and blood pressure in obese Egyptian adolescents

BackgroundOverweight/obesity, high dietary fat, sodium and low calcium intake are recognized as risk factors for primary hypertension in obese adults, children and adolescents.AimThe aim of this work was to assess the association between some dietary factors (fat, sodium, calcium) and blood pressure (BP) among obese Egyptian adolescents.Subjects and methodsSeventy-seven adolescents shared in this study. Their height and weight were reported. Body mass index (BMI) was calculated. Blood pressure was measured; the mean values were corrected for age and sex in the form of centile. Dietary interview consisting of 24 h recall was performed. Fasting blood glucose and serum lipid profile were determined.ResultsData revealed that, the percent of the prehypertensive was 42.86% and 38.80%, for boys and girls, no hypertensive cases were recorded. The mean values of their weight, DBP, and the serum lipid parameters were high compared to their controls; significant differences were found between the daily intake of calories, protein, carbohydrate, dietary fiber and cholesterol at p ≤ 0.05. The mean values of the daily intake of the vitamins and minerals were low in all groups compared to the RDAs, except sodium intake which was high in the prehypertensive boys and normal and prehypertensive girls.ConclusionThis study showed a high incidence of pre-hypertension among obese Egyptian adolescents, which is associated with high intake of sodium, saturated fat and cholesterol, along with low intake of calcium.

The Association between Depressive Mood and Cholesterol Levels in Korean Adolescents.

ObjectivePrevious studies have shown that there is a correlation between lipid levels and depressive mood, and that lipids could be useful biomarkers for depression. We conducted this study to clarify the association between lipid levels and depressive mood in adolescents, especially in community samples. MethodsWe analyzed data from the Korea National Health and Nutrition Examination Survey (KNHANES) that was conducted from 2013 to 2016. A total of 2,454 adolescents aged 12–18 years (1,273 boys, 1,181 girls) participated in the Survey. We conducted a cross-sectional study using multiple logistic regression, adjusting for age, household income, daily energy intake, daily fat intake, and daily cholesterol intake, to assess the association between depressive mood and serum lipid levels. ResultsDepressive mood was found in 8.7% of those included in the study. Borderline (110–129 mg/dL) and high (≥130 mg/dL) levels of low-density lipoprotein cholesterol (LDL-C) were significantly associated with depressive mood [Borderline level: odds ratio (OR)=5.55, 95% confidence interval (CI) 1.56–19.81, p=0.01; High level: OR=5.73, 95% CI 1.06–31.08, p=0.04]. However, this association was not found in girls. ConclusionOur findings indicate that depressive mood in boys is associated with higher LDL-C levels. Further investigation regarding this relationship and the underlying biological mechanisms is needed.

Association between the Frequency of Dining Out and the Risk of Obesity, Diabetes Mellitus, and Dyslipidemia among Korean Adults

ABSTRACTThis study aimed to clarify the association between the frequency of dining out and the risk of obesity, diabetes mellitus, and dyslipidemia among Korean adults. This cross-sectional study surveyed 640 participants aged 20–69 years in Korea. Daily intake of energy, fat, protein, and cholesterol significantly increased as the frequency of dining out increased (P < .001). Energy derived from carbohydrates significantly decreased with the frequency of dining out, while that derived from fat and protein increased (P < .001). Among participants who rarely dined out, the fully adjusted odds ratios (ORs) for hyperglycemia were significantly lower at 0.35 (95% CI, 0.16–0.76). Decreased risk of being hyperglycemia among participants who rarely dined out suggests that the frequency of dining out can be related to diabetes risk.

Eating Behaviors and Dietary Intakes of Older Adults: What We Eat in America, NHANES 2015–2016 (FS02-07-19)

ObjectivesIt is estimated that the number of older individuals in the U.S. will nearly double between 2020 and 2050 to over 80 million. This research examines eating behaviors and dietary intakes of older adults. MethodsNationally representative day 1 dietary data from 1684 adults ages 60+ participating in What We Eat in America (WWEIA), NHANES 2015–2016 were analyzed to estimate eating pattern behaviors and dietary intakes. The interviewer-administered 5-step USDA Automated Multiple-Pass Method (AMPM) was used to collect the 24-hour dietary recall. The WWEIA Food Categories were used to estimate the percentage who consumed vegetables or fruits. The Food Patterns Equivalents Database (FPED) was used to calculate added sugars intake. ResultsOn any given day, almost all older adults reported eating breakfast (92%) and dinner (94%) and fewer ate lunch (78%); two-thirds reported all three meals. Snacks were consumed by 94%, most commonly 3 to 4 times per day, and provided 20% of daily mean energy intake. In relation to energy, snacks provided more of the daily intakes of caffeine (33%), total sugar (32%), carbohydrates (23%), and calcium (21%). More than 2/3 of older adults consumed a vegetable, 1/3 of which were white potatoes, such as French fried, mashed, or baked potatoes. A fruit was reported by just over half of older adults, the most common being bananas (16%), followed by apples (12%), berries (11%), citrus (9%), melons (8%), and grapes (5%). Four out of ten older adults consumed at least one food or beverage from a restaurant and among these individuals, intake at restaurants provided 42% of their daily energy intake and about half of daily intakes of fat, saturated fat, cholesterol, and sodium. Mean daily intakes of added sugars and saturated fat each provided 12% of daily energy intake, exceeding the Dietary Guidelines for Americans recommendations of less than 10% of calories per day from each, as did sodium with mean daily intake of 3091 mg, exceeding the recommendation of less than 2300 mg. ConclusionsWith the number and proportion of older adults increasing in the U.S., understanding their eating behaviors and dietary intakes can inform strategies for well-being during this life stage. Funding SourcesUSDA, Agricultural Research Service.

Association between dietary sodium, calcium, saturated fat and blood pressure in obese Egyptian adolescents

BackgroundOverweight/obesity, high dietary fat, sodium and low calcium intake are recognized as risk factors for primary hypertension in obese adults, children and adolescents. AimThe aim of this work was to assess the association between some dietary factors (fat, sodium, calcium) and blood pressure (BP) among obese Egyptian adolescents. Subjects and methodsSeventy-seven adolescents shared in this study. Their height and weight were reported. Body mass index (BMI) was calculated. Blood pressure was measured; the mean values were corrected for age and sex in the form of centile. Dietary interview consisting of 24 h recall was performed. Fasting blood glucose and serum lipid profile were determined. ResultsData revealed that, the percent of the prehypertensive was 42.86% and 38.80%, for boys and girls, no hypertensive cases were recorded. The mean values of their weight, DBP, and the serum lipid parameters were high compared to their controls; significant differences were found between the daily intake of calories, protein, carbohydrate, dietary fiber and cholesterol at p ≤ 0.05. The mean values of the daily intake of the vitamins and minerals were low in all groups compared to the RDAs, except sodium intake which was high in the prehypertensive boys and normal and prehypertensive girls. ConclusionThis study showed a high incidence of pre-hypertension among obese Egyptian adolescents, which is associated with high intake of sodium, saturated fat and cholesterol, along with low intake of calcium.