The Lancang-Mekong River is the most important international river in Southeast Asia, and its water resources are invaluable for the survival of the inhabitants of the basin, while the climatic conditions have a significant impact on the production and livelihoods of the riparian countries. In this study, future climate change in the Lancang-Mekong River Basin (LMRB) was projected based on precipitation and temperature from CMIP6. First, a bias processing procedure was established to correct the initial bias of climate models using the Daily Bias Correction (DBC) method, and the performance of equal weighted averaging (EW) and Bayesian mode averaging (BMA) of multi-model ensembles was compared. The characteristics of future precipitation and temperature changes were projected in terms of mean climatology, seasonal variation and extreme events, respectively, from which the future trends of the four weather extremes (dry-cold, dry-hot, wet-cold and wet-hot) were projected. Evaluation based on mean climatology, daily frequency distribution, temporal change and its bias showed that the climate bias correction procedure has good performance. It was found that future precipitation in the LMRB will increase by 50–120 mm in the near future (2031–2050) and 150–400 mm in the far future (2061–2090), with higher increases in the upper Mekong River Basin (MRB), Lower MRB and Mekong Delta than in the Lancang River Basin (LRB) and middle MRB. Future increase in precipitation will occur mainly from June to October, while April and May will see a decrease by 10–30 mm, and the number of heavy precipitation days (R25, daily precipitation exceeding 25 mm) will increase by about 5 days in the eastern part of the lower and middle MRB. The mean temperature will increase by 1–3 °C in most parts of the LMRB, with the LRB experiencing an increase of about 3 °C higher than in the MRB. Future maximum and minimum daily temperatures will increase by 1–2 °C in the near future and by 2–5 °C in the far future. Dry-hot days will increase by about 20 days in the lower and middle MRB, and wet-hot days will increase significantly in the MRB, by 30–80 days in the near future and by 50–100 days in the far future.
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