The link between in-cylinder flow and subsequent combustion in a single-cylinder gasoline spark-ignition engine is analyzed via independent component analysis (ICA). Experimentally, the two in-plane components of the velocity are measured in the central cylinder plane by high-speed particle image velocimetry (PIV) with the engine running slightly lean at 1500 rpm in skip-fired mode. In 213 cycles, measurements are made during the late compression stroke before ignition with approximately 1° crank-angle temporal resolution. ICA then decomposes the set of 213 flow fields at each time step, yielding a set of “source” flow patterns—the independent components (IC). The temporal coherence between the ICs is then examined in a persistence analysis, comparing each IC with the one from the previous time step starting at ignition timing and going backwards in time. The results show which ICs persist how long throughout the compression stroke. To investigate the link between the ICs and combustion, the crank angle at which 10% of the fuel are burned (CA10) in each cycle is correlated with the extent to which a given IC can be found in each flow field. The most persistent IC can be traced over more than half of the 70 degrees crank angle over which images were acquired. The IC that correlates best with CA10 visually more resembles some of the flow features found in conditional averaging of fast-burning versus slow-burning cycles.