Cyclization Of Hydroxy Epoxide Research Articles

ChemInform Abstract: Palladium-Catalyzed Stereospecific Cyclization of Hydroxy Epoxides. Stereocontrolled Synthesis of cis- and trans-2-Alkenyl-3- hydroxytetrahydropyrans.

Abstract Stereospecific constructions of the cis- and trans-2-alkenyl-3-hydroxytetrahydropyrans have been achieved by the one-pot procedure of desilylation-palladium catalyzed cyclization of the silyl ethers of ω-hydroxy trans- and cis-γ,°-epoxy-α,β-unsaturated esters, respectively.

ChemInform Abstract: Cyclization of Hydroxy Epoxides Promoted by (Bu3Sn)2O/Lewis Acid: Efficient Synthesis of Oxepanes.

Abstract Cyclization of hydroxy epoxides mediated by a (Bu3Sn)2O/Lewis acid system proceeded via an SN2 process and exo mode to provide the corresponding seven-membered cyclic ethers in high yield.