The role of state structural regulation of the national economy in the conditions of the high volatility of economic cycles is substantiated. The key parameters of the system of state regulation of the economy in terms of permanent structural transformation and cyclical national economy are defined as the following: efficiency, balance of interests of all participants in economic relations, socialization and greening of economic processes. The evolution of basic theories of cyclical economic development is studied, and their main features in terms of factor influence on cyclicity and structural transformations in the system of the national economy are determined. The scientific and methodological approach to determining the content of structural changes in the national economy is determined as a transition from one paradigm of development and economic growth to another paradigm more adequate to the global challenges and domestic demands faced by society. The author's definitions of the structural-economic conceptual-categorical apparatus that reflects the transformation processes in the cyclical economy are suggested, in particular: the structure of the national economy (structural basis); structural changes (transformation, shifts); structural policy; structural reform (restructuring); structural crisis. The cyclical development of the economy is characterized, which is often accompanied by such undesirable parameters as discreteness, uncertainty, chaos, which affects economic growth and resilience of the national economy to recession shocks. Timely structural reform is determined to be the only vector to prevent it, including ensuring the availability of developed domestic markets, high competitiveness of domestic companies in global markets, high level of solvency of domestic consumers and efficient structure of the national economy. These factors will help reduce the level of negative effects arising from market fluctuations.