As security breaches are increasingly widely reported in today’s culture, cybersecurity is gaining attention on a global scale. Threat modeling methods (TMM) are a proactive security practice that is essential for pinpointing risks and limiting their impact. This paper proposes a hybrid threat modeling framework based on system-centric, attacker-centric, and risk-centric approaches to identify threats in Operational Technology (OT) applications. OT is made up of software and hardware used to manage, secure, and control industrial control systems (ICS), and its environments include factories, power plants, oil and gas refineries, and pipelines. To visualize the “big picture” of its infrastructure risk profile and improve understanding of the full attack surface, the proposed framework builds on several threat modeling methodologies: PASTA modeling, STRIDE, and attack tree components. Nevertheless, the continuity and stability of vital infrastructure will continue to depend heavily on legacy equipment. Thus, protecting the availability, security, and safety of industrial environments and vital infrastructure from cyberattacks requires operational technology (OT) cybersecurity. The feasibility of the proposed approach is illustrated with a case study from a real oil and gas production plant control system where numerous significant cyberattacks in recent years have targeted OT networks more frequently as hackers realized the possibility of disruption due to insufficient OT security, particularly for outdated systems. The proposed framework achieved better results in detecting threats and severity in the design of the case study system, helping to increase security and support cybersecurity assessment of legacy control systems.