Abstract Controlling and managing nuclear waste is a significant challenge due to the harmful effects of radioactive materials on human health. To address this, long-term storage solutions are essential. Artificial Intelligence (AI) and Machine Learning (ML) are being utilized to make nuclear waste management safer, more effective, and efficient. This paper evaluates various applications of AI and ML in the field of nuclear waste, covering aspects such as predictive maintenance, waste sorting, and classification. AI and ML enhance real-time monitoring of storage conditions and optimize waste handling procedures through advanced data processing capabilities. Implementing cutting-edge solutions is crucial to protect public health and the environment from radioactive waste. The purpose of this evaluation is to examine how AI and ML improve nuclear waste management processes. These technologies can reduce human exposure to harmful materials and increase the safety and efficiency of managing nuclear waste through advanced predictive capabilities. The introduction of AI and ML in nuclear waste management is driving significant changes and innovations, addressing current issues, and establishing new guidelines for future policies.