The patient was a Caucasian female, gravida iii, para ii, who had 1 abortion and developed hilar and cervical lymphadenopathy in 1957 at the age of 27. Biopsy of one of the lymph nodes in the neck established the diagnosis of Hodgkin’s disease. Radiation therapy resulted in a 2 year remission. From 1959 to 1962 she was treated with steroids, various chemotherapeutic drugs, and radiation. The disease appeared limited to the chest and neck. In January, 1962, the disease was in complete remission except for a pulmonary infiltrate and cough which persisted after irradiation of the chest. In February, 1962, she developed a painless nodule of the vulva which enlarged and then ulcerated and bled. She was seen initially by the Gynecology Service approximately 6 weeks after she first noticed the swelling. Examination revealed an ulcer measuring 6.5 cm. by 5 cm. and 1.5 cm. deep. It was located in the lower portion of the right labium majus close to the fourchette and covered the area of a right mediolateral episiotomy. The base was soft, reddish tan, velvety in appearance, nontender, partially covered by a yellow-white purulent exudate, and bled freely when touched. The edges of the ulcer were slightly raised with moderate surrounding inflammation and tenderness. The remainder of the rectal and pelvic examinations were normal. A biopsy was taken which revealed an ulcerated tumor composed of cells of polymorphous character infiltrating the dermis and