Cutaneous Histiocytic Sarcoma Research Articles

Cutaneous Histiocytic Sarcoma with Giant Cells in a Free-ranging Brush Rabbit (Sylvilagus bachmani).

A cutaneous mass in a free-ranging brush rabbit (Sylvilagus bachmani) was composed of neoplastic spindle to polygonal cells with multinucleated giant cells, which were positive for CD204 and negative for smooth muscle actin and desmin. Histiocytic sarcoma with giant cells was diagnosed; this neoplasm has not been reported previously in free-ranging lagomorphs.

13014 Primary cutaneous histiocytic sarcoma

We present the case of a 32-year-old African-American man with biopsy-proven primary cutaneous histiocytic sarcoma (PCHS) of the left nasal ala. The lesion had been present for 1.5 years and was asymptomatic. Biopsy of the nodule was originally diagnosed as granulocytic sarcoma, with further investigation revealing PCHS. Here we discuss the challenge of both diagnosis and treatment of a rare tumor on a cosmetically sensitive area without clear guidelines with regard to best-care practices. Histiocytic sarcoma is an extremely rare malignancy arising from mature histiocytes. PCHS is the cutaneous version of the disease, usually presenting as asymptomatic nodules, plaques, or subcutaneous tumors. PCHS localized to the skin confers a favorable prognosis with early intervention. Once metastasized, however, the prognosis is highly variable and treatment involves chemotherapy with possible stem cell transplant. Based on the limited cases reported in the literature, wide local excision is recommended, though specific surgical margins have not been detailed. There is a lack of data regarding the benefit of Mohs micrographic surgery. Biopsy is instrumental in differentiating PCHS from similarly presenting lesions. Histologically, PCHS has a predominantly spindled and pleomorphic appearance with hematoxylin and eosin staining, though monomorphic histiocytic appearance has been reported. High mitotic activity has been described. The phenotypic profile of PCHS includes positivity for CD45, CD2, CD14, CD68, CD163, and CD42. Negative markers include MXA, TCL1, CD30, CD117, CD8, CD34, CD123, CD83, langerin, S100, HMB45, CD3, CD5, CD7, and all B-cell markers.

Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient

Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient

Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus)

A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mass was composed of large round to polyhedral neoplastic cells with marked cytological atypia. The neoplastic cells were often binucleated or multinucleated. Immunohistochemically, the neoplastic cells were intensely positive for Iba1 and vimentin, but fewer neoplastic cells expressed E-cadherin. Nuclear immunoreactivity for Ki67 was detected in approximately 41% of the neoplastic cells. Metastasis to the left cervical lymph nodes was detected 6 months after the surgical excision. Based on clinical, histopathological and immunohistochemical findings, the present case was diagnosed as cutaneous histiocytic sarcoma. To the authors' knowledge cutaneous histiocytic disease has not been reported previously in lagomorphs.

Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas

Histiocytic sarcoma is a rare hematologic malignant neoplasia originating from histiocytic or dendritic cell clones. The lesions may be in nodal or extranodal sites, most commonly in the gastrointestinal tract. A small number of cases presents as unique cutaneous lesions. The definitive diagnosis is made by positivity for the immunohistochemical markers CD163, CD68, CD4 and lysozyme. The treatment is controversial, often with combined systemic chemotherapy. This is a case of cutaneous histiocytic sarcoma in an 82-year-old patient presenting two nodular lesions in the breast and right arm which were treated with simple excision and multidisciplinary follow-up, avoiding aggressive management and exhaustive investigations. Although most studies report aggressive evolution, the patient had good and stable clinical status during the twelve-month follow-up period.

Cutaneous histiocytic sarcoma: A case report

Cutaneous histiocytic sarcoma: A case report

Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping

A 9-month-old male Great Dane had progressive generalized nodular dermatopathy for several months. There were > 100 raised, alopecic, firm, painful nodules throughout the skin. Aspirates from several lesions yielded moderate numbers of irregularly round or polygonal to spindle-shaped cells with mild to moderate anisocytosis and few inflammatory cells, and the cytologic interpretation was proliferation of mesenchymal or histiocytic cells. On histopathologic examination, nodules were composed of densely packed sheets of round to spindle-shaped cells with mild anisokaryosis and low mitotic activity. Multifocal histiocytic sarcoma with a spindle-cell pattern was diagnosed based on morphologic features and intense expression of CD18. Additional immunophenotypic analysis on frozen sections of tissue confirmed the diagnosis of histiocytic sarcoma; expression of CD18, CD45, CD1a, CD11b, and CD11c, limited expression of Thy-1 (CD90) and CD80, and lack of expression of CD4, CD11d, and CD86 indicated that the cells were likely interstitial dendritic cells; a review of reactive and neoplastic dendritic cells is provided. Based on staging, internal organs were not affected. Sequential treatment with lomustine and doxorubicin failed to prevent progression of the cutaneous lesions, and the dog died 3 months after initial diagnosis. At necropsy, a focus of neoplastic cells was present in one lymph node, but except for skin other organs were not involved. The clinical presentation of histiocytic sarcoma may be unusual, and neoplastic cells may lack overt features of malignancy on cytologic and histopathologic examination. In some instances, immunophenotyping is required to differentiate histiocytic sarcoma from other histiocytic disorders.

Primary cutaneous histiocytic sarcoma

Primary cutaneous histiocytic sarcoma