Abstract We study the γ-ray signal emitted from dark matter (DM) pair annihilation in the Higgs portal Majorana fermion DM model. In the model, a Majorana fermion DM χ couples with the Standard Model (SM) Higgs field H through a higher-dimensional term $-{\cal L}\supset H^\dagger H \bar{\chi }\chi /\Lambda$, where Λ is a cutoff scale. The pair annihilation of χ through the above term produces the Higgs boson and the longitudinal modes of W, Z gauge bosons. The Milky Way dwarf spheroidal satellite galaxies (dSphs) are used as the most promising targets to search for the γ-ray signal of the model, due to high DM density and lack of astrophysical backgrounds. The Fermi Large Area Telescope (Fermi-LAT) is used for the search, for its high sensitivity. In this work, we use 14-year Fermi-LAT data from 16 dSphs, to constrain the DM pair annihilation cross section for the DM mass range from 125 GeV to 100 TeV.