CuS Nanocomposites Research Articles

Synthesis of Au/Ce2S3@CeO2/CuS nanocomposites for promoted catalytic performance in propargylamine conversion

A newly developed nanocomposite catalyst, Au/Ce2S3@CeO2/CuS, has been engineered for effective propargylamine synthesis through the A3 coupling reaction. The catalyst’s synthesis involved the targeted addition of 15 wt% CeO2 to the CuS sulfur precursor, leading to the formation of a Ce2S3 layer due to its lower solubility product constant (Ksp). This layer, along with 0.5 wt% Au nanoparticles, significantly increased the Ce3+ concentration (16.9 % to 33 %∼52 %), which can accelerate the Cu+/Cu2+ valence state changes, thereby promoting the activation of the alkynyl hydrogen to enhance propargylamine formation. After 2 h reaction, the Au/Ce2S3@CeO2/CuS catalyst achieved over 99 % conversion, nearly 55 % more than pure CuS (45.5 %). The Au/Ce2S3@CeO2/CuS nanocomposite also showed excellent recyclability (80 % retention after 5 cycles) and a high conversion rate of 222.5 mmol·g−1·h−1.

Enhanced performance of novel green synthesized CuS nanostructures decorated with Rh and Pd nanoparticles for energy generation and gas sensing applications

This article investigates the utilization of copper sulfide (CuS) based nanomaterials functionalized with rhodium (Rh) and palladium (Pd) nanoparticles for gas sensing and energy generation applications. CuS nanoparticles, known for their unique properties, were combined with Rh and Pd nanoparticles to enhance hydrogen (H2) gas sensing capabilities. Gas sensing experiments revealed that CuS/Rh/Pd nanocomposites exhibited the highest sensing response of 58.33% to H2, indicating the significant improvement in gas sensing properties due to the combined presence of Rh and Pd nanoparticles in CuS matrices. Moreover, temperature-dependent responses provided insights into optimal operating conditions for effective gas sensing with CuS-based nanocomposites. Comprehensive characterization studies including XPS, Raman, and morphology analysis confirmed the successful synthesis of CuS/Rh/Pd nanomaterials with high purity and desirable structural properties. Dye-sensitized solar cell (DSSC) performance studies demonstrated that CuS/Rh/Pd nanocomposites enhanced the efficiency by minimizing light over-absorption and improving photoanode stability. Overall, this study highlighted the potential of metal nanoparticle-decorated CuS nanocomposites for advanced gas sensing and energy generation applications, paving the way for the development of highly sensitive and efficient gas sensors and solar energy conversion technologies.

Preparation and Characterization of CuS Nanoparticles

This study focuses on producing Copper sulphide (CuS) nanoparticles via the sol–gel technique. Characterization methods such as X-ray diffraction (XRD), FTIR, UV spectroscopy, and PL spectroscopy were used to analyze the samples. Various Nanocomposites were created through sol–gel and electro-polishing techniques, yielding core-shell nanostructures via oxidation or sulfidation treatment. These CuS nanocomposites displayed distinct optical absorption peaks reflecting their structural characteristics. Notably, sol–gel methodologies successfully generated copper sulfide (CuS) nanoparticles sized between 30[Formula: see text]nm and 40[Formula: see text]nm. This result is verified by XRD data and field emission scanning electron microscope (FESEM) images in this study.

Studies of reduced graphene oxide (rGO)/CuS nanocomposite for supercapacitor applications

We have prepared CuS and CuS-rGO nanocomposites via the hydrothermal method. The physical properties of the synthesized materials were studied through x-ray diffraction and scanning electron microscopy. The supercapacitor characteristics were evaluated by cyclic voltammetric and galvanostatic charge–discharge studies. The cyclic voltammetric studies conform the pseudocapacitive nature of CuS and CuS-rGO electrodes. The specific capacitance of CuS was obtained as 207, 150, and 97 F/g at a current density of 0.5, 5, and 20 A/g, respectively. The rGO-CuS nanocomposite showed improved specific capacitance of 350, 251, and 149 F/g at current densities of 0.5, 5, and 20 A/g, respectively.

(Invited) Transition Metal Oxides and Sulfides for Supercapacitor Applications

Energy produced by renewable energy sources need to be stored till required. Therefore, the development of high energy density energy storage systems is required to fulfil the energy needs around the world without any significant environmental impact. Recently, energy storage devices such as rechargeable batteries, fuel cells, and supercapacitors have attracted significant attention owing to their diverse applications in hybrid electric vehicles, energy management, and smart portable electronic devices. Rechargeable batteries such as lithium-ion batteries have been widely employed for various commercial application ranging from consumer electronics to hybrid electric vehicles. However, rechargeable batteries possess high energy density but often suffers from slow charging/discharging, limited cycle life, high cost of Li metal, low power density, poor cycle life, and environmental issues. Currently, supercapacitors are becoming more popular to overcome the issues raised by Li on rechargeable batteries such as low power density and limited cycle life.Various transition metal-based materials such as oxides, sulfide, selenides, nitrides, phosphide are being used for supercapacitor applications due to their high theoretical specific capacitance abundant sources, and low cost. Transition metal oxides have attracted great attention of the researchers for supercapacitor applications because of their multiple oxidation states due to which multiple electrons transfer exists and discharge time extends, resulting in improving energy density in rapid Faraday redox reactions.Our group is actively engaged in studying supercapacitor behavior of various transition metal oxides, sulfides, and their composites with carbonaceous materials such as carbon nanotube, graphene oxide (GO), reduced graphene oxide(rGO), and carbon nanotubes (CNT). We have synthesized pure MnO2 and CuS along with their composites with graphene oxide and multiwall carbon nanotube (MWCNT). It was reported that the specific capacitance of CuS and CuS-GO nanocomposite was found to be 158 F/g and 250 F/g, respectively, at a current density of 0.5A/g. The specific capacitance of MnO2 and MnO2/MWCNT nanocomposite was found to be as 124 F/g and 145 F/g, respectively, at a current density of 0.5A/g. The detailed studies on electrochemical performances of various transition metal oxide/sulfides and their composite with carbonaceous materials will be presented at 242nd ECS Meeting.

Influence of nanocomposite (1-x)CdS/xCuS on optical characteristics of PVA/CMC/PEG blended polymer; effect of ratio (x)

PVA/CMC/PEG blended polymers loaded with (1-x)CdS/xCuS nanocomposites (x = 0, 0.3, 0.5, 0.7, 1) were formed applying the thermolysis and casting techniques. Rietveld analysis of synchrotron x-ray diffraction data measured for (1-x)CdS/xCuS manifested a single hexagonal phase CuS (x = 1.0) and biphasic structure, hexagonal and cubic, for CdS (x = 0.0); composite samples (x = 0.3, 0.5, and 0.7) exhibited the three phases with varied percentages. Average crystallite size for all nanofillers ranged 4–12 nm. The surface morphology and chemical compositions of the different blends were investigated using SEM and EDS techniques. The effect of loading PVA/CMC/PEG blends with multi phases CdS–CuS nanocomposite on the optical linear and nonlinear behaviors was explored using diffused reflectance technique. The direct and indirect optical band gaps (Eg) values determined for PVA/CMC/PEG are 5.62 and 5.18 eV, respectively, which reduced to (4.2, 4.5, 4.47, 4.56, 3.89) and (3.43, 3.9, 3.74, 3.98, 3.18) eV upon loading with (1-x)CdS-xCuS for x = 0, 0.3, 0.5, 0.7, and 1, respectively. The refractive index of all loaded blends increased non monotonically with (x) reached its highest value for λ ≥ 500 nm upon loading with x = 0.0 (CdS). The fluorescence (FL) intensity of the blended polymers nearly quenched upon loading with CuS (x = 1.0) and greatly enhanced for x = 0.5.

Controllable interface engineering of g-C3N4/CuS nanocomposite photocatalysts

The rational fabrication of an efficient photocatalyst with optimal interface engineering remains a huge challenge for the enhancement of photocatalytic perpformance. Herein, a sequence of multidimensional nanocomposites with different spatial interfaces, including point, and line or face-contact surface are controllable designed by horizontal growing diverse dimensional (0D, 1D,2D and 3D) copper sulfide (CuS) on 2D graphitic-carbon nitride (g-C 3 N 4 ) nanosheets. Physical and photochemical measurements demonstrate that the formation of an extraordinary 2D/2D face-to-face contact interface can not only enhance the specific surface area, visible light utilization, and photo-excited charge separation efficiency, but also elevate the density and lifetime of photo-generated carriers. The results of ultraviolet photoemission spectroscopy (UPS) and density functional theory (DFT) calculation also confirm that charge transfer tends to occur in face-to-face contact. Among the types of nanocomposites considered, 2D/2D g-C 3 N 4 /CuS has the smallest electron transfer barrier (Ф Be ) between active species, thereby displaying the maximum photocatalytic apparent rate constant, which is about 12 times larger than that of pristine g-C 3 N 4 . Most importantly, this work systematically investigates the relationship between microscopic interface structure and photocatalytic activity from the perspective of the optical, and electrical and energy levels, providing a new insight on the rational design of desired interface engineering towards efficient photocatalysts. • 2D/xD g-C3N4/CuS nanocomposites with different spatial interfaces were fabricated. • 2D/2D g-C3N4/CuS nanocomposite displays the optimal photocatalytic performance. • The concentration, lifetime and separation-efficiency of photogenerated carriers were tested. • The energy barrier between active species and catalysts was analyzed by UPS and DFT. • The photocatalytic mechanism of 2D/2D g-C3N4/CuS nanocomposites is proposed.

Chemical bath synthesis of Ag2S, CuS, and CdS nanoparticle-polymer nanocomposites: structural, linear, and nonlinear optical characteristics

In this study, CdS, CuS, and Ag2S nanoparticles (NPs) were synthesized by a chemical bath procedure in the presence of polyvinyl alcohol (PVA) as a polymer stabilizer. Morphological studies followed by X-ray diffraction (XRD) and atomic force microscopy (AFM) revealed monolithic and small size NPs. The average crystalline size of CdS, Ag2S, and CuS nanocomposites was 18.1, 26.7, and 21.7 nm, respectively. UV-Vis absorption and photoluminescence (PL) spectra of samples showed a near-infrared region (NIR) emission peak for CuS. The bandgap of samples measured using absorption data was 3.48, 2.75, and 2.30 eV for CdS, Ag2S, and CuS NPs, respectively. Nonlinear optical properties, including nonlinear refractive index and nonlinear absorption of the NPs, were measured by the Z-scan technique under a 632.8 nm wavelength He-Ne CW laser. PVA/Ag2S nanocomposite displayed reverse saturable absorbance (RSA) and self-focusing, while PVA/CdS and PVA/CuS displayed saturable absorbance and self-defocusing behavior under the chemical bath procedure synthesis.

Electrodeposited Alginate‐Based Green Synthesis of CuS Nanoparticles and Nanocomposite Films for Electrochemical and Colorimetric Detection

AbstractCuS nanoparticles (NPs) and CuS NPs/alginate nanocomposite films are prepared using a novel method based on the coordinated electrodeposition of alginate. This method exquisitely utilizes the coordination of alginate with Cu2+ ions to carry out the electrodeposition, and alginate as the stabilizer for CuS NPs and the major ingredient in the nanocomposite film. Thus, the method has many advantages such as facile operation, green route, mild conditions, and convenient post‐treatment. After the electrodeposition, a smooth and homogeneous film has been electrodeposited on the anodic electrode. Transmission electron microscopy observation reveals that there are nanoparticles (the average size of 6.0 nm) in the electrodeposited film. The results from spectral analysis further confirm the existence of CuS NPs. The CuS NPs/alginate nanocomposite film modified electrode can be directly constructed by taking advantage of the electrodeposition, which shows the electrochemical detection capability towards H2O2 and hydroquinone. The CuS NPs/alginate nanocomposite film also possesses the colorimetric detection capability toward H2O2 and dopamine. Therefore, this study offers a green and convenient method for fabricating CuS NPs and nanocomposite films, which is promising for applications in functional nanocomposites and detection fields.

Effect of a locust bean gum based gel electrolyte with nanocomposite additives on the performance of a dye-sensitized solar cell

In this study, we proposed Mn3O4 and Mn3O4·CuS nanocomposites as novel inorganic additives in locust bean gum (LBG) gel electrolytes for application in an aqueous dye-sensitized solar cell (DSSC).

Synthesis and characterization of magnetic iron sulfide (Fe-S)/CuS nanocomposite as a novel recyclable catalyst in photocatalyst removal of tetracycline from aqueous solutions

Synthesis and characterization of magnetic iron sulfide (Fe-S)/CuS nanocomposite as a novel recyclable catalyst in photocatalyst removal of tetracycline from aqueous solutions

Strategies for preparing TiO2/CuS nanocomposites with cauliflower-like protrusions for photocatalytic water purification

A simple and controllable method was developed to prepare TiO2/CuS nanocomposites with high photocatalytic efficiency.

Enhanced photo-catalytic degradation of natural organic matters (NOMs) with a novel fibrous silica-copper sulfide nanocomposite (KCC1-CuS)

The present study aims to test the degradation ability of KCC-1/CuS nanocomposite as a new photocatalyst for Humic acid (HA) degradation. The degradation process was accomplished using a photocatalytic reaction under irradiation by UV light A facile method applied for catalyst synthesis in different condition, and it was structurally and morphologically characterized, Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Energy-Dispersive X-ray Spectroscopy (EDX) and Thermo Gravimetric Analysis (TGA) which showed successful synthesis of KCC-1/CuS nanocomposite.The degradation process was examined as a function of pH (3–11), catalyst dose (0.005-0.1 g/L), contact time (0–90 min) and initial HA concentration (2–15 mg/L) under UV radiation. The results demonstrated that maximum degradation of HA was 89.5% in optimized environmental conditions including pH: 3, nanocomposite dosage: 0.1 g/L, contact time: up to 90 min and initial HA concentration: 2 mg/L.

Biocompatible copper sulfide-based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma.

Transcatheter arterial embolization has been considered as a promising targeted delivery approach for hepatocellular carcinoma (HCC). Currently, chemoembolization was the main treatment for unresectable HCC. However, the traditional chemoembolization treatment suffers from undesirable therapeutic effects and serious side-effects. In this study, the doxorubicin (DOX)-encapsulated and near-infrared (NIR)–responsible copper sulfide (CuS)–based nanotherapeutics was developed for magnetic resonance imaging (MRI)–guided chemo-photothermal therapy of HCC tumor in rats. The DOX-loaded CuS nanocomposites (DOX@BSA-CuS) demonstrated distinct NIR-triggered drug release behavior and high photothermal effect. In an orthotopic HCC rat model, DOX@BSA-CuS nanocomposites were selectively delivered to the tumor site via the intra-arterial transcatheter. The proposed DOX@BSA-CuS nanocomposites plus NIR laser irradiation exhibited significant tumor growth suppression performance. Moreover, the treatment progress can be monitored by MRI images. Finally, the preliminary toxicity estimate suggested the negligible side-effect of DOX@BSA-CuS nanocomposites during the therapeutic process. These results suggest the clinical translational potential possibility for imaging-guided arterial embolization with DOX@BSA-CuS nanocomposites for the treatment of HCC.

Surface-Confined Winding Assembly of Mesoporous Nanorods.

Bending and folding are important stereoscopic geometry parameters of one-dimensional (1D) nanomaterials, yet the precise control of them has remained a great challenge. Herein, a surface-confined winding assembly strategy is demonstrated to regulate the stereoscopic architecture of uniform 1D mesoporous SiO2 (mSiO2) nanorods. Based on this brand-new strategy, the 1D mSiO2 nanorods can wind on the surface of 3D premade nanoparticles (sphere, cube, hexagon disk, spindle, rod, etc.) and inherit their surface topological structures. Therefore, the mSiO2 nanorods with a diameter of ∼50 nm and a variable length can be bent into arc shapes with variable radii and radians, as well as folded into 60, 90, 120, and 180° angular convex corners with controllable folding times. Additionally, in contrast to conventional core@shell structures, this winding structure induces partial exposure and accessibility of the premade nanoparticles. The functional nanoparticles can exhibit large accessible surface and efficient energy exchanges with the surroundings. As a proof of concept, winding-structured CuS&mSiO2 nanocomposites are fabricated, which are made up of a 100 nm CuS nanosphere and the 1D mSiO2 nanorods with a diameter of ∼50 nm winding the nanosphere in the perimeter. The winding structured nanocomposites are demonstrated to have fourfold photoacoustic imaging intensity compared with the conventional core@shell nanostructure with an inaccessible core because of the greatly enhanced photothermal conversion efficiency (increased by ∼30%). Overall, our work paves the way to the design and synthesis of 1D nanomaterials with controllable bending and folding, as well as the formation of high-performance complex nanocomposites.

Magnetically recoverable nickel ferrite coated with CuS nanocomposite for degradation of metronidazole in photocatalytic and photo fenton like processes

ABSTRACT This study aims to investigate the efficacy of photocatalytic and Fenton-like photocatalytic processes using the FeNi3/SiO2/CuS nanocomposite in the removal of metronidazole (MNZ) from aqueous solutions in the presence of ultraviolet (UV) light. The desired magnetic nanocomposite was first synthesised and then characterised using electron microscopy (TEM), x-ray diffraction device (XRD), fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), energy dispersive spectroscopy (EDS), and scanning electron microscopy (FESEM). The effects of various physicochemical parameters on the degradation process like the initial MNZ concentrations, the nanocomposite dose, the hydrogen peroxide (H2O2) concentrations, the contact time, and the pH were investigated. According to TEM and FESEM analyses, it was found that the obtained nanoparticles tend to accumulate due to their magnetic properties; hence, the particle size (about 52 nm) was greater than that obtained from the Scherrer equation in the XRD analysis. VSM analysis results revealed that the studied nanocomposite was dispersed in water and could be easily separated by an external magnetic field in a short time, and then be easily re-dispersed with shaking slightly. The maximum removal efficiency was obtained by an exposure time of 200 min, pH of 7, MNZ concentration of 20 mg/L, and a catalyst dosage of 0.02 g/L in the photocatalytic degradation stage. Optimum conditions in the Fenton-like photo-catalytic stage were a pH of 7, a time of 180 min, MNZ concentration of 20 mg/L, a catalyst dose of 0.01 g/L, and an H2O2 concentration of 150 mg/L. The photocatalytic degradation of MNZ has followed the pseudo-first-order kinetic model. Results of catalyst recovery and recycling tests showed that the synthesised nanocomposite had a very high recovery and recycling capacity, with only a 5.05% reduction in contaminant degradation efficiency after six alternating cycles. In the Fenton-like photo-catalytic degradation stage, the difference of catalyst degradation percentage was very small among the cycles, showing a decrease of 2.84% from the first to the last cycles. Therefore, the magnetic nanocomposite synthesised in the photocatalytic and heterogeneous Fenton-like photocatalytic degradation of MNZ can be used as a suitable catalyst in the removal and degradation of resistant organic drugs contaminants.

Enhanced Thermoelectric Performance of Novel Reaction Condition-Induced Bi2S3-Bi Nanocomposites.

This is the first report on the enhanced thermoelectric (TE) properties of novel reaction-temperature (TRe) and duration-induced Bi2S3-Bi nanocomposites synthesized using a facile one-step polyol method. They are well characterized as nanorod composites of orthorhombic Bi2S3 and rhombohedral Bi phases in which the latter coats the former forming Bi2S3-Bi core-shell-like structures along with independent Bi nanoparticles. A very significant observation is the systematic reduction in electrical resistivity ρ with a whopping 7 orders of magnitude (∼107) with just reaction temperature and duration increase, revealing a promising approach for the reduction of ρ of this highly resistive chalcogenide and hence resolving the earlier obstacles for its thermoelectric application potentials in the past few decades. Most astonishingly, a TE power factor at 300 K of the highest Bi content nanocomposite pellet, made at 27 °C using ∼900 MPa pressure, is 3 orders of magnitude greater than that of hot-pressed Bi2S3. Its highest ZT at 325 K of 0.006 is over twice of that of similarly prepared CuS or Ag2S-based nanocomposites. A significantly improved TE performance potential near 300 K is demonstrated for these toxic-free and rare-earth element-free TE nanocomposites, making the present synthesis method as a pioneering approach for developing enhanced thermoelectric properties of Bi2S3-based materials without extra sintering steps.

Dual-stimuli responsive mesoporous copper (II) sulfide nanocomposite for chemo-photothermal synergistic therapy

A combination of chemo-photothermal therapy has recently emerged as a great potential cancer treatment due to enhanced therapeutic efficacy. Herein, we present a novel nanocomposite for chemo-photothermal synergistic therapy. The glutathione (GSH)-responsive mesoporous silica-coated copper sulfide (mesoporous CuS) nanocomposite was synthesized by co-condensation using tetraethyl orthosilicate (TEOS) and bis[3-(triethoxysilyl)propyl]tetrasulfide (BTES). Hyaluronic acid (HA) was functionalized on nanocarrier for drug leakage prevention, enzyme-triggered drug release and targeting moiety toward CD44 overexpressing cancer cells. The mesoporous CuS nanocomposite generated the heat for photothermal therapy in response to near-infrared (NIR) irradiation. The release of doxorubicin (Dox) from mesoporous CuS nanocomposite was controlled by dual-stimuli of response. We confirmed that mesoporous CuS nanocomposite was internalized to HeLa cells by CD44 receptor-mediated endocytosis and significantly enhanced anticancer effects due to the combination treatment. Therefore, we developed a tumor targeted dual-stimuli responsive drug delivery system for chemo-photothermal synergistic therapy. • GSH-responsive mesoporous silica coated CuS nanocomposites was prepared by in-situ co-condensation method using TEOS and BTES. • HA was functionalized on nanocarrier as a gate keeper and CD44 receptor targeting moiety. • Mesoporous CuS nanocomposite exhibited good photothermal effect and dual stimuli-responsive durg release property by GSH and HAase. • Mesoporous CuS nanocomposite enhanced therapeutic efficacy against cancer cell by chemo-photothermal combination treatment.

Novel, promising, and broadband microwave‐absorbing nanocomposite based on the graphite‐like carbon nitride/CuS

ABSTRACTIn this study, a broadband, intense, novel, and promising microwave‐absorbing nanocomposite was prepared using graphite‐like carbon nitride (g‐C3N4)/CuS suspended in poly(methyl methacrylate) (PMMA) medium. The g‐C3N4nanosheets were synthesized by heating the urea as well as the CuS nanoparticles, and g‐C3N4/CuS nanocomposites were prepared using a solvothermal method and then were separately molded by a PMMA solution to investigate their microwave‐absorbing characteristics. The Fourier transform infrared and X‐ray powder diffraction were used to characterize the g‐C3N4, CuS, and CuS/g‐C3N4nanostructures, which confirmed that the pure structure of the nanomaterials has been synthesized. The optical properties of the nanostructures were also investigated by diffuse reflection spectroscopy analysis. Accordingly, the Kubelka–Munk theory suggested significant narrow band gap for g‐C3N4/CuS nanocomposite (0.27 eV), facilitating electron jumping and conductive loss. The morphology of the structures was examined using field emission scanning electron microscopy micrographs, illustrating that the uniform hexagonal structures of the CuS nanoplates have been formed and the CuS two‐dimensional structures were uniformly distributed on the g‐C3N4nanosheets. Finally, the microwave‐absorbing properties of the CuS, g‐C3N4, and g‐C3N4/CuS were investigated by PMMA as a host. The microwave‐absorbing properties were evaluated using a vector network analyzer. The results illustrated that the maximum reflection loss of the g‐C3N4/PMMA nanocomposite was −71.05 dB at 14.90 GHz with a thickness of 2.00 mm, demonstrating a 1.70 GHz bandwidth >30 dB, as well as g‐C3N4/CuS/PMMA nanocomposite absorbed 7.30 GHz bandwidth of more than 10 dB with a thickness of 1.80 mm along the x‐ and ku‐band frequency. The obtained results introduced the PMMA as a capable microwave‐absorbing substrate. Besides, the g‐C3N4/CuS/PMMA nanocomposite demonstrated metamaterial property and abundant attenuation constant. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2020,137, 48430.

MXene-Ti3C2/CuS nanocomposites: Enhanced peroxidase-like activity and sensitive colorimetric cholesterol detection.

Nanomaterials with enzyme-like activity have attracted much attention recently. Herein, we report the synthesis of a new type of 2D MXene-Ti3C2/CuS nanocomposites with peroxidase-like activity using a simple hydrothermal approach. Significantly, compared with the individual MXene-Ti3C2 nanosheets or CuS nanoparticles, the MXene-Ti3C2/CuS nanocomposites show a synergistically enhanced peroxidase-like activity and can be used as an efficient mimetic peroxidase to catalyze the reaction of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2), causing a blue color change. Kinetic studies reveal that the MXene-Ti3C2/CuS nanocomposites have a higher catalytic activity to TMB than their single components, and the catalytic reaction follows the ping-pong mechanism. The MXene-Ti3C2/CuS nanocomposites are used for the colorimetric determination of cholesterol with a linear range of 10-100 μM and a limit of detection (LOD) of 1.9 μM. Our results show that the MXene-Ti3C2/CuS nanocomposites based colorimetric cholesterol biosensor is cost-effective, sensitive, and selective, which has potential application in H2O2 and cholesterol detection and clinic medicine diagnostics.