Direct Air Capture (DAC) is a rapidly evolving technology that extracts CO2 directly from ambient air. This study presents a comprehensive performance evaluation of integrating DAC in HVAC systems, which can reduce indoor CO2 concentration and improve energy efficiency of HVAC systems. The DAC equipment is modeled in Modelica based on isotherm and thermodynamic equations, and pressure drop curves of the CO2 sorbent described in literature. The model is validated with data from the literature, and then integrated into a typical HVAC system available in Modelica Buildings library. The HVAC system is a Variable Air Volume (VAV) with reheater system for a one-floor office building with standard ASHRAE 2006 control sequences. Demand control ventilation strategies are designed to reduce the outdoor air flowrates when indoor CO2 concentrations are lower than the threshold, which is to maximize the benefits of integrating DAC. Four cases are proposed to assess the impacts of integrating DAC and DCV in HVAC systems in 8 different ASHRAE climate zones in the USA. The results show that by integrating DAC unit into the HVAC system, the average indoor CO2 concentration can be significantly reduced by over 45 % against the baseline without a DAC unit. By integrating DCV, 0.39–21.66 % of annual energy savings and 226–9539 kg carbon emissions reduction are observed across different climate zones. The highest energy savings are found to be achieved with cold climatic conditions while the lowest energy savings occur with favorable weather.