Misinterpreted medical prescriptions had led to casualties due to the illegible cursive handwriting of medical practitioners. Many studies focused on this problem. However, the accuracy was unsatisfactory and needed improvement. The study evaluated the performance of the Canny edge detection with other preprocessing methods, including RGB to Grayscale Conversion, Binarization, and Inversion, which was used to process the images of cursive handwritten medical prescriptions using Alexnet Convolutional Recurrent Neural Network (ACoRNN). The CRNN model developed by previous researchers was used as the basis for comparison, and the researchers created a faster and more accurate model. The best combination of preprocessing methods for ACoRNN was with RGB to Grayscale Conversion, Binarization, Canny edge detection, and Inversion. The researchers’ model had faster preprocessing and testing time and achieved 90.76% average accuracy through five trials.