BackgroundA need exists for a unified curriculum framework for nurse educators, recognizing racism as a central driver of health inequities. PurposeThis paper provides nurse educators with a unifying curriculum framework that centers racism as a root cause of health inequity shaping SSDH. MethodsA critical examination of the social and structural determinants of health (SSDH) and Yob’s (2018) Framework for a Curriculum in Social Change was conducted, to develop a curriculum framework tailored to the intersection of SSDH and social change within nursing education. DiscussionThe “Nursing Education Integrating Social Change for Health Equity (NISCHE)” framework was developed as a comprehensive curriculum framework for SSDH and social change specifically tailored for nursing education. Practical examples of curricular activities across various settings are offered, thus illustrating implementation and potential impact. ConclusionBy centering racism in the curriculum framework and emphasizing its role in perpetuating health inequities, this paper advances a crucial agenda in nursing education.