Current Restrictions Research Articles

The Value of Life and Reproductive and Professional Autonomy.

This article considers John Harris' work on autonomy, specifically reproductive autonomy, outlined in The Value of Life and developed throughout his career. Harris often used the concept of reproductive autonomy to make the case for liberal approaches to developments in reproductive and genetic technologies. Harris argued that reproductive autonomy should be highly valued, and therefore we need compelling arguments to justify limiting it in anyway. When discussing reproductive autonomy, Harris focused mainly on restrictions on the potential users of reproductive technologies autonomy, that is, prospective parents. This article extends the discussion of autonomy and the appropriate limits to individuals exercising their autonomy to medical professionals working in this area. Given reproductive technologies have become part of routine medical practice, this article considers whether the current restrictions on both patients and clinicians, as imposed by regulators and professional guidelines, remain ethically justified.

Digital Currencies of Central Banks (CBDC) as a New Institution of Digital Money Circulation: Legal Essence, History, Foreign Experience

The article is devoted to the study of the genesis of the institute of digital currencies issued by central banks, motives and key stages of launching projects for their implementation. The article analyzes the cases of foreign countries in the field of launching their national digital currencies, compares approaches to the legal regulation of digital currencies of central banks and their types. Also, the possibilities for the cross-border use of CBDC and other digital tools in the context of current sanctions restrictions are explored. The article analyzes in detail the legal essence of digital currencies of central banks, and particularly the digital ruble, as well as the features of the legal technique of legislative acts regulating public relations in the field of introduction and circulation of the digital ruble.

Will Psychedelics Propel Your Career? Exploring the Potential Impact of Psychedelics on Work, Productivity and Well-Being

With growing research demonstrating the therapeutic potential of psychedelics such as psilocybin and MDMA in treating mental health conditions, interest is mounting around potential applications beyond health. This article explores emerging evidence on the impact of psychedelics in key domains relevant to careers and the workplace including creativity, focus, stress and burnout, leadership, teamwork, and well-being. It surveys both practitioner accounts and early research studying the effects of microdosing psychedelics on enhancing performance and career outcomes. While acknowledging current legal restrictions and the need for more research, implications are discussed for how individuals and organizations could ethically and responsibly approach psychedelics if regulations change. The goal is to begin a fact-based discussion on psychedelics' untapped potential to fuel growth, fulfillment and peak workplace functioning—if pursued prudently under proper guidance as the science continues to rapidly advance.

Detection and analysis of ship emissions using single-particle mass spectrometry: A land-based field study in the port of rostock, Germany

The regulation of ship emissions has become more restrictive due to their significant impact on global air quality, particularly in coastal regions. According to the International Maritime Organization (IMO) regulations, current restrictions mainly limit the sulfur content of the fuel mass to 0.5 % and 0.1 % respectively. In compliance with these regulations, exhaust SO2 cleaning systems (scrubbers) and new low-sulfur fuels are increasingly used. For comprehensive monitoring of ship emissions, advanced measurement techniques are demanded. Our study reports on the results of a land-based field campaign conducted in the port of Rostock, Germany. The chosen location strategically positions the measurement setup to capture all incoming and outgoing ships passing within a distance of up to 2 km. Potential ship exhaust plumes are indicated by rapid changes in particle number and size distribution monitored by an optical particle sizer (OPS) and a scanning mobility particle sizer (SMPS). Additionally, single-particle mass spectrometry (SPMS) was used to qualitatively characterize ambient single-particles (0.2–2.5 μm) by their chemical signatures. In a one-week time span, the exhaust plumes of 73 ships were identified. The high sensitivity of SPMS to transition metals and polycyclic aromatic hydrocarbons (PAH) in individual particles make it possible to distinguish between different marine fuels.

Energy-Based Medical Devices in Plastic Surgery: A Comparison of FDA-Approved Indications to Advertised Claims.

Lasers and energy-based devices are commonly employed in aesthetic medicine. In the United States, the FDA regulates lasers as medical devices, restricting marketing to approved indications and making off-label claims illegal. Despite this, no comprehensive analysis of off-label marketing prevalence exists. The authors of this study aim to compare the FDA-approved indications for 2 popular aesthetic lasers to their online advertising claims. Additionally, they seek to educate aesthetic providers on the current regulatory restrictions surrounding off-label advertising. FDA-approved indications for 2 lasers-helium plasma dermal resurfacing and 2940 nm fractional erbium-doped yttrium aluminum garnet-were obtained from the publicly available Establishment Registration & Device Listings Database. Online advertisements regarding the capabilities of each laser were collected from practice websites in the United States. Our analysis of 100 online claims for each laser revealed that more than half of the websites advertising helium plasma (n = 59) and 44 websites advertising fractional lasers made at least 1 off-label claim. Both plastic surgeons and nonplastic surgeons made at least 1 off-label claim, with no statistically significant difference between the groups. Despite FDA regulation of medical devices, online advertising regarding the indications and capabilities of popular medical lasers varies widely. Patients who seek information regarding aesthetic laser treatments may encounter inaccurate and differing claims for these treatments, potentially leading to false expectations and poor patient outcomes.

Effects of a Smartphone App-Based Intervention on Rheumatoid Arthritis Self-Management Efficacy: A Randomized Controlled Trial.

Self-management programs can help patients with rheumatoid arthritis develop strategies to address their disease-related problems. However, accessibility to traditional self-management programs is often limited. This study was developed to assess the effectiveness, feasibility, and acceptability of a smartphone-delivered self-management program application (app) for adults with rheumatoid arthritis. A two-arm (intervention vs. control) randomized controlled trial was used. Adult patients with rheumatoid arthritis were recruited from the rheumatology departments of a medical center. Study enrollment capabilities were limited by current pandemic restrictions. The patients who met the inclusion criteria and agreed to participate (N = 46) were enrolled as participants and randomly assigned either to the intervention group (n = 25), which received instructions on the use of a smartphone app designed to facilitate the self-management of rheumatoid arthritis, or to the control group (n = 21), which received instructions on related self-management only. The outcome variables were assessed at baseline and at 8 and 12 weeks. Differences in between-group outcomes over time were analyzed using generalized estimating equations. Feasibility and acceptability were also evaluated. Data were collected between August 1, 2020, and July 31, 2022. At baseline, no differences were detected between the two groups in terms of the demographic and disease characteristics of concern. Outcome measures for the intervention group improved significantly more than the control group for self-efficacy of pain at 8 weeks (B = 6.39, p < .05) and for both of self-efficacy of pain and self-management behavior at 12 weeks (B = 9.16, p < .05, and B = 4.25, p < .001, respectively). Factors related to app ease of use included limiting pop-ups and windows and having no time restrictions. Most of the participants reported the app as acceptable and easy to use, although challenges relating to using technology limited the usability of the app for some. The smartphone app was shown to improve self-efficacy of pain and self-management behaviors. However, an accurate assessment of the effectiveness of the app and generalizability of the findings is limited by the smaller-than-desired sample size due to the COVID-19 pandemic and technological challenges. A greater understanding of how to overcome technological challenges is needed to optimize the delivery of self-management programs via smartphone-based apps. Studies reevaluating this app on a larger sample size should be conducted.

The Devil is in the Details: Detection, Measurement and Lawfulness of Server-Side Tracking on the Web

As online privacy is cementing itself as one of the core pillars of the Internet, major changes are happening across many industries. On the technological side, users are pushing for more privacy-preserving technologies and rely on browsers and extensions that limit online tracking as much as possible. On the legal front, regulations like GDPR and the ePrivacy Directive in Europe have forced companies to change their practices and be more transparent about how they handle user data. For the ad industry, the end of third-party cookies planned for 2025 is having severe ramifications as the main source of data on which this industry is built on will be gone. In this tumultuous context, companies have come up with innovative ways to overcome current and future restrictions. A novel technique which has not received much attention called Server-side tracking (SST) moves its tracking logic away from the user's device onto an external server. In this work, our aim is to detect SST on the web and understand its lawfulness with respect to current legislation. We developed a methodology that relies on crawls spaced 2 years apart performed before and after the introduction of SST to identify trackers that moved behind SST domains and that are now hidden from view. Our results show that 389, out of 7,367 visited websites, track users behind a cloaked domain and that 28 websites perform Server-side tracking in a first-party capacity. We demonstrate that such a tracking technique can overcome the Same-Origin Policy and introduce security vulnerabilities. Together with a legal scholar, we also show that SST entails non-compliant practices and infringes the GDPR and the ePrivacy Directive.

2D and Quasi-2D Halide Perovskite-Based Resistive Switching Memory Systems

Resistive switching (RS) memory devices are gaining recognition as data storage devices due to the significant interest in their switching material, Halide perovskite (HP). The electrical characteristics include hysteresis in its current–voltage (I–V) relationship. It can be attributed to the production and migration of defects. This property allows HPs to be used as RS materials in memory devices. However, 3D HPs are vulnerable to moisture and the surrounding environment, making their devices more susceptible to deterioration. The potential of two-dimensional (2D)/quasi-2D HPs for optoelectronic applications has been recognized, making them a viable alternative to address current restrictions. Two-dimensional/quasi-2D HPs are created by including extended organic cations into the ABX3 frameworks. By adjusting the number of HP layers, it is possible to control the optoelectronic properties to achieve specific features for certain applications. This article presents an overview of 2D/quasi-2D HPs, including their structures, binding energies, and charge transport, compared to 3D HPs. Next, we discuss the operational principles, RS modes (bipolar and unipolar switching), in RS memory devices. Finally, there have been notable and recent breakthroughs in developing RS memory systems using 2D/quasi-2D HPs.

Towards practical artificial intelligence in Earth sciences

AbstractAlthough Artificial Intelligence (AI) projects are common and desired by many institutions and research teams, there are still relatively few success stories of AI in practical use for the Earth science community. Many AI practitioners in Earth science are trapped in the prototyping stage and their results have not yet been adopted by users. Many scientists are still hesitating to use AI in their research routine. This paper aims to capture the landscape of AI-powered geospatial data sciences by discussing the current and upcoming needs of the Earth and environmental community, such as what practical AI should look like, how to realize practical AI based on the current technical and data restrictions, and the expected outcome of AI projects and their long-term benefits and problems. This paper also discusses unavoidable changes in the near future concerning AI, such as the fast evolution of AI foundation models and AI laws, and how the Earth and environmental community should adapt to these changes. This paper provides an important reference to the geospatial data science community to adjust their research road maps, find best practices, boost the FAIRness (Findable, Accessible, Interoperable, and Reusable) aspects of AI research, and reasonably allocate human and computational resources to increase the practicality and efficiency of Earth AI research.

Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway.

Melatonin, the hormone of the pineal gland, possesses a range of physiological functions, and recently, its anticancer effect has become more apparent. A more thorough understanding of molecular alterations in the components of several signaling pathways as new targets for cancer therapy is needed because of current innate restrictions such as drug toxicity, side effects, and acquired or de novo resistance. The PI3K/Akt/mTOR pathway is overactivated in many solid tumors, such as breast and ovarian cancers. This pathway in normal cells is essential for growth, proliferation, and survival. However, it is an undesirable characteristic in malignant cells. We have reviewed multiple studies about the effect of melatonin on breast and ovarian cancer, focusing on the PI3K/Akt/mTOR pathway. Melatonin exerts its inhibitory effects via several mechanisms. A: Downregulation of downstream or upstream components of the signaling pathway such as phosphatase and tensin homolog (PTEN), phosphatidylinositol (3,4,5)-trisphosphate kinase (PI3K), p-PI3K, Akt, p-Akt, mammalian target of rapamycin (mTOR), and mTOR complex1 (mTORC1). B: Apoptosis induction by decreasing MDM2 expression, a downstream target of Akt, and mTOR, which leads to Bad activation in addition to Bcl-XL and p53 inhibition. C: Induction of autophagy in cancer cells via activating ULK1 after mTOR inhibition, resulting in Beclin-1 phosphorylation. Beclin-1 with AMBRA1 and VPS34 promotes PI3K complex I activity and autophagy in cancer cells. The PI3K/Akt/mTOR pathway overlaps with other intracellular signaling pathways and components such as AMP-activated protein kinase (AMPK), Wnt/β-catenin, mitogen-activated protein kinase (MAPK), and other similar pathways. Cancer therapy can benefit from understanding how these pathways interact and how melatonin affects these pathways.

Commercial fishery no-take zones for African penguins minimize fisheries losses at the expense of conservation gains

Abstract The African penguin population has declined precipitously in recent decades, and if current rates of decline persist, this species could become extinct in the wild by 2035. Resource extraction of small pelagic fish prey by the purse-seine fishery around African penguin breeding colonies has been identified as a demographically meaningful threat to African penguins. Consequently, long-term, effective no-take zones around breeding colonies have been endorsed by an expert panel of scientists constituted by the South African government. Here, we consider the six largest South African penguin colonies that currently hold 76% of the global population. We evaluate the adequacy of different no-take zone options using a trade-off mechanism recommended by the expert panel. For all six colonies except Bird Island, Algoa Bay, which is subject to the least fishing pressure, the current no-take zone delineations are assessed as having little benefit to the African penguin and little to no cost to the purse-seine fishery. Four of the six current no-take zones include ≤50% of the African penguins’ core foraging areas. Alternative no-take zones that approximate a more balanced trade-off offer more impactful alternatives to the current fisheries restrictions. Given the urgent need to implement evidence-based conservation interventions for the endangered African penguin, we recommend the substitution of the current no-take zones with those proposed herein.

A matter of choice: a cross-sectional study examining the impact of the overturning of Roe v Wade on U.S. medical students’ perceptions and career decisions

Background In June 2022, the Dobbs decision by the U.S. Supreme Court overturned federal abortion protections. In states with restrictive abortion laws such as Indiana, which also has the country’s largest medical school and the third worst maternal mortality rate, the impact of this ruling may be huge on the medical field. The purpose of this study was to analyze perceptions of medical students in Indiana in their third and fourth years of education after the Dobbs decision to assess if the state’s current abortion restrictions impact their career choice. Methods Between December 2022 and March 2023, an anonymous survey was carried out at Indiana University School of Medicine, which included questions about personal beliefs on abortion and the current abortion laws in Indiana, as well as priorities when choosing residency training and practice locations. Results Our survey found that four-fifths of medical students in Indiana disagreed with the Dobbs decision. While most students (71.4%) had not considered state abortion laws when selecting a medical school, since the Dobbs decision, 66.3% of third-year and 40.3% of fourth-year students indicated that they would take abortion laws into account when choosing a residency program. 47.5% of female students stated that they will be seeking residency in a state where abortion is legal and 55.3% of single students were more likely to leave Indiana to practice medicine. Conclusion Our research suggests that physicians who are more liberal in their views on abortion may now be much less likely to practice in conservative states which will compound the healthcare outcomes secondary to the Dobbs decision. We emphasize the role that abortion laws have in shaping the landscape of healthcare workforce and the need for a more nuanced understanding of how societal structures impact women's reproductive decisions and career paths in medicine.

Looking beyond duty hours: Offering a balanced quantitative-qualitative approach to resident burnout.

Burnout, stress and overwork are highly prevalent amongst junior training physicians worldwide, which explains the widespread phenomenon of physicians leaving the field and organised protests/strikes for better working conditions. Back in 2003, the mandatory duty hour restriction was a landmark intervention rolled out by the Accreditation Council for Graduate Medical Education that formally mandated limiting working hours of trainee residents to no more than 80 h per week, and not exceeding 24-h shifts with 6 added hours for education and handover. Nonetheless, 20 years later, this measure continues to be subject to multiple debates on its purported efficacy in achieving its intended objectives and fails to adequately prevent physician burnout and exodus. In our view, the current duty hour restriction model is, in and of itself, inadequate for combating burnout amongst medical residents for several reasons, including insignificant reduction in duty hours with suboptimal adherence/reporting, failure to account for off-site clinical and non-clinical duties, as well as nature of clinical work which typically involves high work intensity in less-than-optimal/unconducive work environments and significant psychoemotional stress. In this article, we offer our perspectives on pursuing a balanced approach towards both meaningful quantitative reduction in working hours as well as practical qualitative improvement in nature of clinical and non-clinical work that could collectively address resident burnout and improve work and training outcomes.

Exploring variations in the weight, size and shape of liquid hydrogen tanks for zero-emission fuel-cell vessels

We report an exploration of liquid hydrogen (LH2) tank technology, determining if improving LH2 tank weight, multiplicity or shape enables more hydrogen to be stored on hydrogen vessels. The improvements investigated are well beyond the current LH2 technology state-of-the-art. The platform for this study is a monohull H2 Baseline research vessel powered 100% by hydrogen.Regarding weight reductions, we found that the research vessel does not benefit significantly from large weight reductions of the LH2 tanks. A 50% reduction in mass of the inner pressure vessel led to a 3.1% reduction in the total research vessel weight. Reducing the LH2 tank weight to the asymptotic limit of zero results in a 7.1% reduction in the overall research vessel weight. This maritime application, while benefitting from a reduction in LH2 tank weight, is not a strong driver for LH2 tank weight improvements.The two large LH2 tanks of the H2 Baseline Vessel can be replaced with a multitude of smaller LH2 tanks. In two Multiplicity design variants, the total amount of stored LH2 was ∼5–9% less than that of the H2 Baseline Vessel, which does not motivate conducting the needed R&D that would drive the technology to smaller high-performing LH2 tanks.We did find a significant benefit to improving the shape of LH2 tanks, towards prismatic tanks that would better match the vessel hullform. Considering a “Shape Variant” that included space-consuming features such as tank connection spaces, manifolding and ventilation, we found a 26% improvement in stored LH2 compared to the H2 Baseline Vessel. The large improvement in storage capacity could warrant further LH2 tank R&D that can enable high performing prismatic LH2 tanks, such as pressure vessel steel developments allowing for higher strength/ductility at 20 K, improved insulation systems, methods for efficiently building prismatic tanks with insulation systems fit for 20 K service and flare-less techniques for managing heat leak (venting).The results are reviewed considering the current regulatory restrictions as well as prevailing limitations in LH2 tank manufacturing.

The Need for Age Restrictions on Sales of Nonalcoholic Beverages

This Viewpoint discusses the current restrictions of nonalcoholic beverage sales to minors across several states and the need for expansion of those restrictions.

Investigation into the Mental Health of Businesswomen in Afghanistan after August 2021

The shift of power to the Taliban had negatively affected the mental health of businesswomen due to the current restrictions on women. Therefore, this study aimed to evaluate the experience of mental health issues among businesswomen in Afghanistan after the Taliban came to power. We examined the mental health challenges they faced, what helped deal with them, and what might be helpful and effective in supporting the mental health of Afghan businesswomen in the future. In-depth semi-structured interviews were conducted from February 17, 2022, to February 29, 2022, with 14 businesswomen (Owner/CEO) based in Kabul, Herat, Mazar-e-Sharif, Kandahar, and Jalalabad. Data were analysed using thematic analysis appraising businesswomen's mental health experiences and coping strategies. Four themes were identified: Theme 1: Stress and anxiety, Theme 2: Restrictions as to the main source of stress and anxiety, Theme 3: Courage to work and religious beliefs as coping strategies to relieve their stress, and Them 4: Support and ease of restriction can be effective to businesswomen's mental health wellbeing. The study concluded that the mental health of businesswomen was affected as the Taliban took control of the government. Participants reported increased stress and anxiety levels, based mainly on restrictions imposed on women after the Taliban came to power. The most helpful coping strategy was self-motivation to continue their businesses. They also reported a need for financial and technical support. Our findings can help the government and organizations that support women and their economic activities to identify effective measures to support businesswomen in challenging times.

Relationships of the wild peanut species, section Arachis: A resource for botanical classification, crop improvement, and germplasm management.

Wild species are strategic sources of valuable traits to be introduced into crops through hybridization. For peanut, the 33 currently described wild species in the section Arachis are particularly important because of their sexual compatibility with the domesticated species, Arachis hypogaea. Although numerous wild accessions are carefully preserved in seed banks, their morphological similarities pose challenges to routine classification. Using a high-density array, we genotyped 272 accessions encompassing all diploid species in section Arachis. Detailed relationships between accessions and species were revealed through phylogenetic analyses and interpreted using the expertise of germplasm collectors and curators. Two main groups were identified: one with A genome species and the other with B, D, F, G, and K genomes. Species groupings generally showed clear boundaries. Structure within groups was informative, for instance, revealing the history of the proto-domesticate A. stenosperma. However, some groupings suggested multiple sibling species. Others were polyphyletic, indicating the need for taxonomic revision. Annual species were better defined than perennial ones, revealing limitations in applying classical and phylogenetic species concepts to the genus. We suggest new species assignments for several accessions. Curated by germplasm collectors and curators, this analysis of species relationships lays the foundation for future species descriptions, classification of unknown accessions, and germplasm use for peanut improvement. It supports the conservation and curation of current germplasm, both critical tasks considering the threats to the genus posed by habitat loss and the current restrictions on new collections and germplasm transfer.

Двойное и множественное гражданство в Российской Федерации: перспективы развития правового регулирования

Introduction. After the legislative distinction between the concepts of “dual citizenship” and “multiple citizenship”, predicting the prospects for the development of legal regulation of social relations emerging in the field of dual and multiple citizenship, as well as development of practical proposals to consolidate the legal status of persons with multiple citizenship in the Russian Federation, becomes relevant. Theoretical analysis. The author examined the legislation of the Russian Federation regulating the legal status of persons with dual and multiple citizenship, in particular, analyzed the current legislative restrictions and prohibitions established for this category of persons. Empirical analysis. The author studied the problem of exercising electoral rights by citizens of the Russian Federation with multiple citizenship, including the problem of renouncing the citizenship of a foreign state, and analyzed judicial practice on challenging decisions of election commissions of municipalities on the annulment of registration/refusal to register candidates for deputies. Results. The author proposes the concept of the Federal Law “On the legal status of persons with multiple citizenship in the Russian Federation”: legislative consolidation of the concept of “person with multiple citizenship”, formulation of the goals of establishing prohibitions for persons with multiple citizenship, establishment of additional prohibitions for persons with multiple citizenship in the sphere of the use of electoral rights, in particular, the ban on passive suffrage (the right to be elected) in municipal elections, the ban on active suffrage (the right to vote) for persons with multiple citizenship permanently residing outside the Russian Federation.

Investigating Food Allergen Labeling in Commercially Packaged Food Products

Background: In 2017, Turkey introduced Turkish Food Codex Regulation on labeling and providing food information to customers, which has been revised on a regular basis ever since. The purpose of this study was to survey food allergen information regarding foods and beverages sold in Turkey and the extent to which food allergens and precautionary allergen labeling (PAL) are emphasized in the products. Method: Thirteen food and drink categories were reviewed in five physical food stores and three online stores. A total of 1,010 foods and beverages were checked for allergens according to their labels. Results: 1,116 allergenic foods were identified in 59.7% of foods and beverages,. Gluten-containing cereals were clearly labelled in every food category, and milk received the highest number of declarations (30.55%), followed by gluten (27.42%), and tree nuts (9.67%). Snacks contained the most number of allergens (14.8%), followed by dairy products (13.8%), and baked products (12.4%). Conclusions: Accurate and understandable food allergy labeling is essential in avoiding food allergies. Food allergy labeling legislation especially The EU Regulation No. 1169/2011 establishes uniform rules for allergen labeling, which is one of the most stringent food regulations in the world. Current allergen labeling restrictions and policies need to be improved to reduce the risk of food hypersensitivity.

Travel Restrictions in Siargao: An Intervention for the Island’s Long-Term Sustainability

An overwhelming influx of tourists to a destination can create massive pressure. Siargao, a tourism-first island known as "Asia's Best Island" and the "Surfing Capital of the Philippines", is one of the favorite spots and has captivated the hearts of tourists around the world. This study investigated the efficacy of travel restrictions to ensure the island’s long-term sustainability. This descriptive research, using a quantitative approach, utilized snowball sampling. Data were gathered from 400 respondents from the National Capital Region. The findings revealed that Siargao is popularly known as one of the top attractions in the Philippines, and respondents are aware that excessive tourism may lead to site deterioration. Restrictions could be an effective intervention to achieve island conservation. Stakeholders can make a substantial contribution to conservation efforts by closely observing tourist demand and behavior to incorporate the current travel restrictions into strategies and, thereby, prevent traffic and destruction of natural sites when visitation levels return to normal. These restrictions could be an effective environmental conservation intervention; therefore, implementing these travel limitations is an effective way to ensure long-term gains that contribute to Siargao’s conservation goals. Considering this additional intervention, a thorough intervention, and its impact will greatly help determine the significance of the improvement. Thus, this pioneering study provides supporting statements to help Siargao rise to the top Philippine destination and ensure the long-term sustainability of tourism.