Current Opportunity Research Articles

Blood Management: A Current Opportunity in Perioperative Medicine.

The purpose of this viewpoint is to provide awareness of the current opportunities to enhance a high-value care approach to blood product transfusion. It provides a historical context to the evolution of blood management, as well as of the patient safety and high-value care movement. Leveraging current technology for enhanced education, as well as clinical decision support, is also discussed.

Distinguishing between translational science and translational research in CTSA pilot studies: A collaborative project across 12 CTSA hubs.

The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be "focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research." This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS. Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies. Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (t = 6.92, p < .001) by an expert panel. The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS' vision of TS.

LCA to evaluate the environmental opportunity cost of biological performances in finfish farming

PurposeMortality and suboptimal biological performance are a widespread problem in finfish farming. The associated losses constitute an environmental opportunity cost that needs to be thoroughly assessed to prioritize actions aiming at reducing the environmental impacts of finfish aquaculture. We here propose and demonstrate the use of a new parameterized and consequential LCA model of sea-trout production designed to assess the environmental opportunity costs of suboptimal biological performances, considering distinct mortalities and biological feed conversion ratios (FCRs) along the rearing process.MethodsPrimary data was collected in Danish and Italian farms to reconstitute the whole production process for sea-reared trouts. The level of detail allowed us to divide this production into seven different growth stages for which mortality and biological FCR can be assessed and modified. Excretion and valorization of fish sludge were modeled with a calibrated mass-balance model. Together with fish sludge, dead fish was modeled as valorized by anaerobic digestion. The foreground system was linked to the consequential version of ecoinvent 3.8 for which the embedded uncertainty was considered in Monte Carlo simulations. The model was used to assess the current environmental opportunity costs and evaluate the effect of losses happening at different timings along the rearing process.Results and discussionResults showed a low environmental opportunity cost for the current mortality rate of 5% as suppressing this mortality decreased impacts by 3.5 to 5% across impact categories. Decreasing the biological FCR decreased the environmental impacts proportionally. The timing of the losses was shown to greatly influence the environmental opportunity cost, and the same mortality rate happening in the late stages had substantially more impact than in the first stages. The valorization of the dead fish showed a negligible contribution to the reduction of impacts in the current system but showed a substantial contribution in the case of higher mortalities, such as observed for other farms and foreseen in the future.ConclusionThe model demonstrated that assessing an opportunity cost by multiplying the lost biomass by a unique impact factor constitutes an oversimplification neglecting the losses timing and the fact that fish biomass is not a marketable product. Even though the current environmental opportunity cost for losses appeared neglectable, suboptimal biological FCR should be tackled. The model and approach can be used to project trout farming within future disease regimes and assess the trade-offs regarding fish health issues and new treatments and practices.

Current Progress of COPD Early Detection: Key Points and Novel Strategies.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide, with approximately 70% to 80% of adults with COPD being undiagnosed. Patients with undiagnosed COPD are at increased risk of poor outcomes and a worsened quality of life, making early detection a crucial strategy to mitigate the impact of COPD and reduce the burden on healthcare systems. In the past decade, increased interest has been focused on the development of effective strategies and instrument for COPD early detection. However, identifying undiagnosed cases of COPD is still challenging. Both screening and case-finding approaches have been adopted to identify undiagnosed COPD, with case-finding being recommended by the 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline and the updated United States Preventive Services Task Force (USPTF) recommendation. Nonetheless, the approaches, criteria, and instruments used for early detection of COPD are varied. However, advances in the taxonomy and risk factors of COPD are continuously being investigated. It is important to continuously assess the current state of knowledge on COPD early detection, given the challenges associated with identifying undiagnosed COPD. This review aims to highlight recent advances in early detection of COPD. To discuss the current challenge and opportunity in COPD early detection, providing an overview of existing literature on COPD case-finding strategies, including the approaches, criteria for subjects, and instruments. The review also summarizes the current progress in COPD case-findings and proposes a COPD case-finding flowchart as an efficient method for identifying at risk COPD patients.

How Uncertain Promotions Affect Inaction Inertia in an Online Retail Context

ABSTRACT E-tailers often use different types of promotions to increase consumers’ willingness to buy. However, little research has been done to explore how to reduce inaction inertia caused by online promotions. Inaction inertia refers to the condition in which people who have missed a previously attractive opportunity are less likely to accept the current less attractive opportunity. This study explores how uncertainty, in combination with monetary and nonmonetary promotion types, impacts inaction inertia. The effect of the best possible outcome in an uncertain promotion is also examined. Two experiments are conducted in the context of online shopping to test the effects. The research findings can help e-tailers devise effective promotion strategies.

Beyond the horizon: immersive developments for animal ecology research

More diverse data on animal ecology are now available. This “data deluge” presents challenges for both biologists and computer scientists; however, it also creates opportunities to improve analysis and answer more holistic research questions. We aim to increase awareness of the current opportunity for interdisciplinary research between animal ecology researchers and computer scientists. Immersive analytics (IA) is an emerging research field in which investigations are performed into how immersive technologies, such as large display walls and virtual realityand augmented realitydevices, can be used to improve data analysis, outcomes, and communication. These investigations have the potential to reduce the analysis effort and widen the range of questions that can be addressed. We propose that biologists and computer scientists combine their efforts to lay the foundation for IA in animal ecology research. We discuss the potential and the challenges and outline a path toward a structured approach. We imagine that a joint effort would combine the strengths and expertise of both communities, leading to a well-defined research agenda and design space, practical guidelines, robust and reusable software frameworks, reduced analysis effort, and better comparability of results.

Early cochlear implantation in prelingual profound hearing loss in Italy, analyzed by means of a social media survey.

To assess newborn hearing screening (NHS) impact on timing of cochlear implant (CI) surgery of patients with prelingual bilateral profound hearing impairment (BPHI), in order to evaluate whether the NHS ultimately serves the needs of the target population in Italy. An online questionnaire was created to survey subjects affected by prelingual BPHL born between 1990 and 2018. Questions focused on age at BPHI diagnosis, first and second CI surgery (if performed), and the region in which the surgery was performed. The survey was distributed to potential participants via social media communities used by hearing impaired people or their family members for sharing advice and offering support. Responses were analyzed using descriptive statistics. Among the 318 respondents who completed the questionnaire, 276 (87%) reported having chosen CI surgery, 2/3 of them bilaterally. In the vast majority (97%) of cases the CI is used on a daily basis. Most of the people residing in the center (65%) and southern Italy (71%) had to move from their region of residence to perform the surgery. Late CI surgery was associated with failure to perform NHS (p = 0.007), birth before 2011 (p = 0.009), definitive diagnosis of BPHI after 6months of life (p = 0.002), and progressive hearing impairment (p < 0.001). The worldwide scientific approval of the NHS as the current best opportunity for early diagnosis and CI treatment for prelingual BPHI is confirmed by what patients and families reported via the online questionnaire used for this study. In recent years, early bilateral cochlear implantation has become increasingly available in Italy, but late diagnosis, progressive hearing loss, failure to perform the NHS and lack of follow-up are still open questions. A large proportion of families had to move from the region of residence to have their child undergo CI surgery, revealing inequalities in terms of geographical disparities. Social media has proved to be a valuable, fast and inexpensive tool for gathering information on the effectiveness of health prevention programs, involving a large sample of individuals in a short amount of time.

The income bond puzzle

The income bond puzzle

Preparing for the Next Leadership Position, Part 3: The Campus Interview

Preparing for the Next Leadership Position, Part 3: The Campus Interview

상가권리금 회수기회 보호규정의 개선방안

In Korea, self-employed people account for about 24% of the total number of employed people, so the proportion of them is especially high when compared to the world. Most of these self-employed businesses operate as tenants, but on May 13, 2015, five provisions were newly established in the Commercial Building Lease Protection Act, which mainly protects the opportunity to recover the premium, and on October 16, 2018, protection for tenants was strengthened. Nevertheless, criticism continues that it is still insufficient to protect tenants, and in reality, disputes are constantly occurring. The reason why premium disputes are constantly occurring is that the concept of the newly established premium as above is uncertain and does not play a practical role in protecting tenants. Therefore, in this study, the author critically analyzes the current premium collection opportunity protection regulations and proposes a legislative improvement plan that can more practically and stably protect the premium collection opportunity of commercial tenants.

Resilient edges — holistic coastal protection and lessons learned

This paper will provide the reader with a planning and engineering framework that addresses a broad range of dynamic coastal issues which are increasingly exacerbated by climate change. The exploration of our recent work in Charleston, South Carolina, will demonstrate how strategies can be implemented at a site-specific scale to tackle interconnected issues impacting community, infrastructure and environment. This will highlight the importance of how layered protection, ecological sensitivity, and holistic thinking to address coastal systems can facilitate innovative and thoughtful approaches to resilient coastal edge protection, resulting in effective long-term solutions that align with community character, robust ecosystems, and integrated infrastructure. Our involvement in a wide range of sea level rise projects has highlighted core principles to achieve coastal resilience. These include the need for rigorous site analysis to identify vulnerable communities and services, and proactive development of solutions to mitigate projected threats while supporting critical stormwater and transportation infrastructure. The goal is to prepare for the future without undermining current economic opportunity, quality of life, and connection to waterfronts.

Opening up mediation opportunities by engaging grassroots data: Adaptive and resilient feminist data activism in China

This article explores the dynamics and practices of feminist data activism that engages with grassroots data to archive cases of sexual violence in China. Drawing on Cammaert’s notion of the mediation opportunity structure, we investigate the mediation process of a feminist data campaign and activists’ communicative practices in contemporary China. By practicing data-activist research, our study shows that the data-based action repertoire opens up hybrid and contingent mediation opportunities for an anti-sexual violence campaign under the current political opportunity structure. We find the paradox of seeking visibility while refusing mainstream media coverage in activist tactics, which embodies a form of adaptive and resilient feminist data activism in the authoritarian context of China. This case study suggests that the dynamics of feminist data activism in China are configured by the tripartite interaction among the disruptive action repertoire, mediation opportunity structure, and political conditions.

Longitudinal molecular analysis of tumor exome and transcriptome to evaluate clonal evolution and identify novel therapeutic targets in thymoma.

e20624 Background: The rarity of thymic epithelial tumors has limited mechanistic understanding of tumor biology and the rational identification of potential therapeutic targets for patients with advanced disease. While the Cancer Genome Atlas Project enabled multi-omic profiling of thymic epithelial tumors, the majority of samples were early-stage and chemotherapy-naïve. Furthermore, next generation sequencing for patients with advanced disease often provides only a limited breadth of genome coverage. The genetic changes in thymic epithelial tumors that evolve through disease progression and treatment represent a current knowledge gap and opportunity for reassessment of new therapeutic targets. Methods: To address these points, we conducted whole exome and bulk RNA transcriptome sequencing for serially-collected FFPE archival tumor samples from a patient with Stage IVA, WHO B2/B3 thymoma using the BostonGene Tumor Portrait Test version 1.3. Samples analyzed include the initial primary tumor resected without induction treatment; two subsequent, metachronous pleural recurrences resected without any induction treatment; and a third pleural metastasis resected following two cycles of induction chemotherapy with Cisplatin/Adriamycin/Cyclophosphamide without interval radiographic evidence of treatment response. Results: Tumor characteristics were largely consistent with prior molecular studies, and without significant evidence of major clonal evolutionary changes based on single nucleotide polymorphisms, insertions/deletions or copy number alterations. Tumor mutational burden was recurrently low (&lt; 1 mutation per megabase) with stable microsatellite status. EGFR copy number gain was observed (+1 copy) across recurrent pleural resection specimens. While the degree of copy number gain did not change with disease progression, increasing EGFR transcript counts were observed and evaluated by IHC. Other notable therapeutic biomarkers included absent TGFB1 and present VEGFA expression. Collective RNA-based gene expression changes were compared with the Thymic TCGA cohort for reference. Conclusions: Our analysis illustrates the narrow clonal evolution of a thymic epithelial tumor through treatment—both with and without the selective pressures of induction chemotherapy. This suggests that the genomic features of advanced thymoma may reflect the treatment-naïve state as described in the TCGA, one marked by a low mutational burden but with recurrent copy number alterations in select genes. Complementary transcriptome sequencing identified EGFR expression as a promising therapeutic target for further study. Taken together, these findings illustrate the hypothesis-generating potential for deep molecular analysis with whole exome and transcriptome sequencing to improve the understanding of rare tumors.

Cryogenic signal amplification combined with helium-temperature MAS DNP toward ultimate NMR sensitivity at high field conditions

The low sensitivity of NMR spectroscopy is of historical concern in the field, and various approaches have been developed to mitigate this limitation. On the shoulder of giants, today one can routinely implement, for example, the pulse/Fourier transform NMR with the cross polarization together with the ultra-low temperature MAS DNP under high-field conditions. We show in this work this current opportunity should further be augmented by combining them with the cryogenic signal amplification. Our presented MAS DNP probe operates with the closed-cycle helium MAS system, and cools the internal preamplifier-duplexer module with the “return” helium gas on its way back to the compressor in the loop. The signal-to-noise (S/N) gain relative to the room-temperature measurements of a factor of 4.6 and 2.4 was found for the measurement using the cold- and room-temperature preamplifier, respectively, at the sample temperature of T = 20 K at B0 = 16.4 T. The ratio of these factors reveals ∼ two-fold sensitivity improvement that results purely from the introduction of the cold signal amplification, i.e., noise reduction. Together with the increase of the thermal Boltzmann polarization at low temperatures, the combined S/N gain of max. ∼70-fold is possible without DNP. The DNP enhancement factor of ∼40 as we found in this work for a microcrystalline MLF sample may be multiplied to this gain. We also demonstrated the sensitivity improvement with a 13C-detected 2D NCaCx spectrum, illustrating the generality of the S/N gain from combining DNP with the cold signal amplification.

The Current Constraints and Opportunity of Beekeeping in Ethiopia: A Review

The Current Constraints and Opportunity of Beekeeping in Ethiopia: A Review

Mango Peel Pectin: Recovery, Functionality and Sustainable Uses

Concerns regarding the overconsumption of natural resources has provoked the recovery of biopolymers from food processing biomass. Furthermore, the current market opportunity for pectin in other areas has increased, necessitating the search for alternative pectin resources. This is also a step towards the sustainable and circular green economy. Mango peel is the byproduct of agro-processing and has been used for high value-added components such as polysaccharide biopolymers. Pectin derived from the peel is yet to be exploited to its greatest extent, particularly in terms of its separation and physiochemical properties, which limit its applicability to dietary fiber in culinary applications. The functionality of the mango peel pectin (MPP) strongly depends on the molecular size and degree of esterification which highlight the importance of isolation and characterisation of pectin from this novel resource. This article therefore provides a useful overview of mango peel as a potential biomaterial for the recovery of MPP. Different extraction techniques and the integrated recovery were also discussed. The utilisation of MPP in different industrial schemes are also detailed out from different perspectives such as the pharmaceutical and biotechnology industries. This review convincingly expresses the significance of MPP, providing a sustainable opportunity for food and pharmaceutical development.

We need to talk about tracking - Practitioners' perspectives on assessment

The following article discusses the current opportunity within the early years sector to review and improve assessment processes, providing a context, current practices and points for reflection. This is the first article in a four-part series from David Meechan's current research.

COVID-19 Impact on Modern Virtual Pathology Education: Challenges and Opportunities

Background & Objective: Pathology education conventional methods have been disrupted by the Corona-Virus Disease 2019 (COVID-19) outbreak, compelling a re-evaluation of the means of educational interactions from the undergraduate to the postgraduate level. This commentary explores how the COVID-19 outbreak has challenged pathology education.Methods: We reviewed the current challenges and determined the potential implications of virtual technologies on modern pathology education for the future of pathology competency learning and assessment.Results & Conclusion: The challenges are partly due to transferring from in-person teaching to a virtual education. Other reasons are shifting away from discipline-based teaching to organ-system based in medical curriculum and additional pressures on pathology faculties, such as increased demand for pathology services, lack of time, and learning resources. Keeping the national standards in pathology education even in the constant disruptions from pandemic outbreaks are current challenges. Pathology expertise will need to use emergent technologies in providing educational material to ensure quality pathology education. However, virtualization of pathology education produces a value of digital pathology and web-based pathology training materials. Medical students could review clinical cases remotely with their supervisors and gain the pathology competencies necessary for clinical practice.We need new innovative strategies, and we suggested the following steps to take advantage of the current opportunity to meet the challenges: evaluating the available digital training materials for formal pathology education, investing in the virtual infrastructure for competency-based pathology education, expanding student/residents exposure to pathology educational cases through virtual platforms; applying digital pathology solutions for virtual pathology education.

Maintenance gravity window based opportunistic maintenance scheduling for multi-unit serial systems with stochastic production waits

This paper proposes an Opportunistic Maintenance (OM) scheduling model for the multi-unit serial system subject to random production waits. With the stochastic nature of production waits involved, the pre-scheduled Preventive Maintenance (PM) time for each unit changes from a specific time to a time window. To effectively group the PM activities of the units with a series of time windows, a new concept called Maintenance Gravity Window (MGW) is introduced and then a novel MGW based OM policy is developed. Whenever one of the units reaches its PM threshold or accepts a production wait to conduct PM, a PM opportunity for the system arises. At that time, all the other units, which also reach their own PM thresholds or accept this production wait, or whose gravity related to the current PM opportunity is within the MGW, will be preventively maintained together with this unit. The optimal MGW for the system is obtained by minimizing the total maintenance cost per unit time throughout the PM scheduling horizon. Finally, numerical examples and comparisons are illustrated to show the cost-effectiveness of the proposed MGW based OM policy.

Flattening the World of Pathology Education and Training and Shortening the Curve of Pathology Learning.

We review how the pandemic-related education disruption may interplay with pathology manpower worldwide and shifts in disease burden to identify workable solutions. Literature related to pathology education, pathology services in low-resource settings, and application of digital tools to pathology education was reviewed for trends and training gaps. Publications covering pathology manpower and cancer incidence worldwide were also included to assess needs. Pandemic-related virtual teaching has produced abundant online training materials. Pathology learning resources in low- to middle-income countries remain considerably constrained and dampen pathology manpower growth to meet current needs. Projected increases in disease burden toward the developing world thus pose a major challenge. Digital pathology resources have expanded and are beginning to appear beyond the developed countries. This circumstance offers a unique opportunity to leverage digital teaching resources to enhance and equitize training internationally, potentially sufficient to meet the rising wave of noncommunicable diseases. We propose four next steps to take advantage of the current opportunity: curate and organize digital training materials, invest in the digital pathology infrastructure for education and clinical care, expand student exposure to pathology through virtual electives, and develop further competency-based certification pathways.