Abstract Certain Aspergillus spp. release harmful byproducts known as aflatoxins. These carcinogenic toxins contaminate crops, such as groundnut, maize, and rice. This contamination poses a significant health risk and economic burden. Current control methods have limitations. This review explores the potential of silver nanoparticles (AgNPs) as a novel strategy to mitigate aflatoxin contamination (AC). The review highlights the advantages of AgNPs, such as (1) antimicrobial properties against Aspergillus flavus and Aspergillus parasiticus, the aflatoxin producers; (2) effectiveness at concentrations that do not inhibit fungal growth, potentially reducing aflatoxin production; and (3) potential for eco-friendly synthesis using plant extracts. The review also discusses the potential drawbacks of AgNPs viz. (a) environmental concerns regarding accumulation and impact on beneficial soil microbes; and (b) cytotoxicity towards various organisms, requiring further research on safety. Studies suggest AgNPs can inhibit aflatoxin synthesis by disrupting the transcription of aflatoxin biosynthesis genes, damaging the fungal cell membrane and causing leakage of cellular components, and interfering with the secondary metabolism pathway. The review concludes that AgNPs offer a promising approach for aflatoxin control. However, further research is needed to address cytotoxicity concerns and optimise their safe and effective application in agricultural settings.
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