Most modern microprocessors have one or two levels of on-chip caches to make things run faster, but this is not always the case. Most of the time, these caches are made of static random access memory cells. They take up a lot of space on the chip and use a lot of electricity. A lot of the time, low power is more important than several aspects. This is true for phones and tablets. Cache memory design for single bit architecture consists of six transistors static random access memory cell, a circuit of write driver, and sense amplifiers (such as voltage differential sense amplifier, current differential sense amplifier, charge transfer differential sense amplifier, voltage latch sense amplifier, and current latch sense amplifier, all of which are compared on different resistance values in terms of a number of transistors, delay in sensing and consumption of power. The conclusion arises that single bit six transistor static random access memory cell voltage differential sense amplifier architecture consumes 11.34 μW of power which shows that power is reduced up to 83%, 77.75% reduction in the case of the current differential sense amplifier, 39.62% in case of charge transfer differential sense amplifier and 50% in case of voltage latch sense amplifier when compared to existing latch sense amplifier architecture. Furthermore, power reduction techniques are applied over different blocks of cache memory architecture to optimize energy. The single-bit six transistors static random access memory cell with forced tack technique and voltage differential sense amplifier with dual sleep technique consumes 8.078 μW of power, i.e., reduce 28% more power that makes single bit six transistor static random access memory cell with forced tack technique and voltage differential sense amplifier with dual sleep technique more energy efficient.