This article presents a novel method for enabling energy-efficient and orientation-independent gravity compensation in active vibration isolation systems by taking advantage of the inherent negative stiffness of a hybrid reluctance actuator (HRA). Counteracting the gravitational force acting on the mover of an HRA with the position dependent force of the actuator’s integrated permanent magnet, the gravitational force can be compensated without the need for an additional actuation. An HRA-system with two translational degrees of freedom (DOF) is developed, comprising a permanent magnet for generating a constant biasing flux for both system axes and two actuator coils per axis for actively controlling the position of the mover. The system prototype has an actuation range of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula> 0.7 mm in both DOF, while enabling energy efficient gravity compensation of payloads up to 500 g by an additional current feedback control loop. Experiments demonstrate that the current consumption for compensation of a 500 g payload is reduced from 1.58 A to 10 mA, which corresponds to a reduction of the power consumption by a factor of 25 000.