Interest by the theme of spirituality in work is growing intensely in the last years, especially in the business world. In thecourse of my reflection, I will use the word enterprise understanding that every health institution is an enterprise. Something formerlyseen as a subject restricted to the organizational universe, as something religious or even mystic, is currently inserted as a strategicdimension, because it confers meaning to the mission of the enterprise and to the work of people. Studies show that enterprises thatalso develop the conscience linked to spirituality make much easier the development of the factors executives most want employees toachieve: motivation, performance, team spirit, efficient communication, quality, and focus in the client, in sum, “happy about what’sgoing on one’s own life”. After a brief conceptual panorama we will discuss some of the possible hindrances for the development ofbusiness spirituality, globalization for example. Then, focusing the crisis of humanism, we will consider contextualization of spiritualityin current enterprises. We will exemplify with the efforts of the government regarding humanization, which is in the last instance thecrucial point in communication. Health care is global and not only individualized. There is a system (an enterprise) that must be humanizedby communication, by conviviality, and it must develop material resources and train people so that that happens.