Current Coronavirus Disease 2019 Vaccine Research Articles

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden.

COVID-19 vaccine communication and advocacy strategy: a social marketing campaign for increasing COVID-19 vaccine uptake in South Korea

Research evidence suggests that communication is a powerful tool for influencing public opinion and attitudes toward various health-related issues, such as vaccine reluctance, provided it is well-designed and thoughtfully conducted. In particular, social marketing techniques that alter the target audience’s behaviors for the public good can substantially improve vaccine uptake if adopted as a communication strategy in immunization programs to counter public hesitancy. This study presents evidence from the Korean government’s current coronavirus disease 2019 (COVID-19) vaccination campaign, which successfully applied a social marketing approach. By the end of August 2022, South Korea had achieved high vaccine coverage, with 94.8% of the population (12+) receiving a second dose, 71.3% a third dose, and a fourth dose drive currently underway. There are five crucial factors to consider when preparing official communication for an immunization program: (i) a high degree of proactiveness, (ii) credibility, (iii) fighting misinformation, (iv) emphasizing social norms and prosocial behavior, and (v) coherence. Although using social marketing strategies may not be successful in all circumstances, the lessons learned and current implementation in Korea suggest their efficacy in fostering vaccine acceptance. This study offers valuable insights for government agencies and global public health practitioners to develop effective targeted campaign strategies that enhance the target population’s vaccination intention.

Potential Risk of Overlooking Biased Reporting of Vaccination against Novel Coronavirus Disease 2019: Lessons from Japan's Experience with the Human Papillomavirus Vaccine.

Vaccination is a crucial and evidence-based measure against novel coronavirus disease 2019 (COVID-19) implemented worldwide, including in Japan, where more than 67% of the population has received more than three doses of vaccination as of February 2023. Although some common adverse reactions of the vaccine, such as fever and arm pain, have been reported, serious adverse reactions resulting in death, such as myocarditis and Guillain-Barré syndrome, are rare. However, the biased reporting of the adverse reactions of the COVID-19 vaccine in the Japanese media has recently become more frequent, which is similar to the past biased reporting on the human papillomavirus (HPV) vaccine. Previously, the media's biased reporting on the HPV vaccine caused public mistrust in vaccines, leading to a drop in vaccination rates in Japan. Thus, overlooking the sensational reporting of the media on the current COVID-19 vaccine may potentially influence people's health behavior and awareness in the long run. Actually, experts worldwide agree that the COVID-19 vaccine is safe, and the media reports are inconsistent with the observations. Thus, it is necessary to urge the media to release accurate information to prevent tragedies caused by biased reporting. Moreover, it is essential to correct misinformation in reporting, disseminate accurate information from media outlets, such as Internet news and video-sharing sites, and promote awareness among people to support the vaccination rate against COVID-19.

Low acceptance rate of COVID-19 vaccination and reduced quality of life among heart transplant recipients during the COVID-19 pandemic.

To investigate the impact of the current coronavirus disease 2019 (COVID-19) pandemic on the quality of life (QoL) and status of COVID-19 vaccination in heart transplant recipients (HTRs). Patients who underwent allogeneic heart transplants between June 2006 and December 2019, who survived were selected from a follow-up registration form at our center. Data were collected using questionnaires in 2021, the QoL survey was conducted using the MOS 36-item Short-Form Health Survey (SF-36) and compared to the same time frame in 2019. The patients were divided into two groups: post-epidemic (A) and pre-epidemic (B) groups. We also recorded whether the participants had been vaccinated against COVID-19 (Beijing Sinovac COVID-19 vaccine). All the data obtained were analyzed. There were 88 patients who participated in the study. Only 12 (13.6%) were vaccinated. In terms of SF-36 scale assessments, after the outbreak of the COVID-19 pandemic, Group A scored lower in vitality [52.5(49.0, 58.0) vs.75.0(69.0, 79.0), p < .001], social functioning [54.0(50.5, 58.0)vs. 74.0(67.5, 78.0), p < .001], role emotional [58.5(55.0, 62.0)vs.67.0(63.0, 71.0), p < .001], and mental health [58.5(55.0, 62.0)vs. 76.0(72.0, 79.0), p < .001]. In Group A the mental component summary (MCS) significantly decreased [222.0(214.5, 230.0)vs.289.0(277.5, 299.5), p < .001]. The PCS and MCS of HTRs who had been vaccinated against COVID-19 were significantly higher than those who had not [PCS: 283.5(280.0, 287.0) vs.276.0(271.0, 279.0), p < .001; MCS: 245.0(141.5, 254.0) vs.220.0(213.5, 226.5), p < .001]. Low acceptance levels of COVID-19 vaccination were observed in the HTRs. The QoL of the HTRs decreased after the COVID-19 pandemic.

Determinants of COVID-19 Vaccine Acceptance Among the General Adult Population in Saudi Arabia Based on the Health Belief Model: A Web-Based Cross-Sectional Study.

BackgroundMany studies have been conducted worldwide and in the Kingdom of Saudi Arabia (KSA) during the current coronavirus disease 2019 (COVID-19) pandemic to assess the factors affecting COVID-19 vaccine acceptance. However, only some of these studies have adopted the Health Belief Model (HBM). This study aimed to assess the demographic characteristics and socio-psychological variables affecting the willingness to receive the COVID-19 vaccine among the general adult population in the KSA using the basic elements of the HBM.MethodsA cross-sectional survey-based study was conducted. A Google Form questionnaire comprising 30 questions was distributed electronically using social media platforms. A univariate analysis using chi-square testing identified candidate variables for the multivariate logistic regression at a p-value of <.05 at 95% confidence interval (CI) set as a cut-off point. Multivariate logistic regression analysis was used to determine the association between multiple predictor variables and the dichotomized COVID-19 vaccine acceptance variable.ResultsA total of 1939 individuals participated in the current study. More than 73% were willing to take the vaccine, while the rest were either not willing (14.6%) or not sure (12.1%). The results showed that men were 1.29 times more likely to receive the COVID-19 vaccine than women (odds ratio, or OR = 1.29, 95% CI = 1.01-1.64, p = .04); those who were or had been a healthcare worker (HCW) were 1.43 times more likely to receive the COVID-19 vaccine compared with those who had never been a HCW (OR = 1.43, 95% CI = 1.10-1.87, p = .01). We found that perceiving the risk of contracting COVID-19 (OR = 2.86, 95% CI = 1.47-5.55, p = .00) and perceiving the severity of the disease (OR = 2.07, 95% CI = 1.08-3.96, p = .03) were positively associated with the willingness to receive the vaccine. Perceived barriers such as ineffectiveness of the vaccine (OR = 0.28, 95% CI = 0.18-0.44, p < .001), or believing the vaccine is just a media advertisement (OR = 0.56, 95% CI = 0.35-0.87, p = .01) were negative predictors of acceptance of the vaccine. Moreover, perceiving the benefits, such as life going back to normal (OR = 2.28, 95% CI = 1.37-3.77, p = .00) and recognizing the importance of the annual flu vaccine (OR = 3.43, 95% CI = 2.29-5.14, p < .001), were found to be positive predictors of acceptance of the vaccine. Finally, we also found that cues to action were positively associated with vaccine acceptance, that is, participants who were encouraged by their doctors (OR = 1.75, 95% CI = 1.17-2.60, p = .01), and family members or friends (OR = 2.89, 95% CI = 1.94-4.32, p < .001) were more willing to receive the COVID-19 vaccine than those who were not.ConclusionsThe current study provides valuable insights into the determinants of vaccine acceptance and hesitancy based on the HBM from a cognitive perspective. This could be useful in helping the government establish public health programs aimed at addressing barriers and false beliefs among the adult population, which could enhance the public’s willingness to receive COVID-19 vaccines and, ultimately, accelerate achieving herd immunity.

Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design.

Coronavirus disease-2019 (COVID-19) is a pandemic with a high morbidity rate occurring over recent years. COVID-19 is caused by the severe acute respiratory syndrome causing coronavirus type-2 (SARS-CoV-2). COVID-19 not only challenged mankind but also gave scope to the evolution of various vaccine design technologies. Although these vaccines protected and saved many lives, with the emerging viral strains, some of the strains may pose a threat to the currently existing vaccine design that is primarily based on the wild type spike protein of SARS-CoV-2. To evaluate the risk involved from such mutant viral strains, we performed a systematic in silico amino acid substitution of critical residues in the receptor binding domain (RBD) of the spike protein. Our molecular modeling analysis revealed significant topological changes in the RBD of spike protein suggesting that they could potentially contribute to the loss of antigen specificity for the currently existing therapeutic antibodies/vaccines, thus posing a challenge to the current vaccine strategies that are based on wild type viral spike protein epitopes. The structural deviations discussed in this article should be considered carefully in the future vaccine design.

Erythema nodosum after COVID-19 vaccine.

The current coronavirus disease 2019 (COVID-19) pandemic is a global challenge with strong medical and socioeconomic implications. Hopes have been placed in the development of various vaccines. As the vaccination campaign is in progress, adverse effects need to be monitored closely. Possible side effects range from minor events to more serious manifestations. In this article, we describe two cases of erythema nodosum (EN) after COVID-19 vaccination in two previously healthy female patients of 59 and 51 years, respectively. Most of the usual etiologies of EN were excluded by laboratory testing. EN was successfully treated with corticosteroids. Remarkably, in the first case, a relapse occurred 48 hours after the second dose of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. In this case series, we describe two unusual occurrences of EN after vaccination with an mRNA COVID-19 vaccine and a viral vector vaccine, respectively, and we discuss the available related literature.

Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein.

The current coronavirus disease 2019 (COVID-19) vaccines are used to prevent viral infection by inducing neutralizing antibody in the body, but according to the existing experience of severe acute respiratory syndrome coronavirus (SARS) infection, T-cell immunity could provide a longer durable protection period than antibody. The research on SARS-CoV-2-specific T-cell epitope can provide target antigen for the development and evaluation of COVID-19 vaccines, which is conducive to obtain COVID-19 vaccine that can provide long-term protection. For screening specific T-cell epitopes, a SARS-CoV-2 S protein peptide library with a peptide length of 15 amino acids was synthesized. Through flow cytometry to detect percentage of IFN-γ+ T cells after mixed COVID-19 convalescent patients’ peripheral blood mononuclear cell with peptide library, seven peptides (P77, P14, P24, P38, P48, P74, and P84) that can be recognized by the T cells of COVID-19 convalescent patients were found. After excluding the nonspecific cross-reactions with unexposed population, three SARS-CoV-2-specific T-cell potential epitopes (P38, P48, and P84) were finally screened with the positive reaction rates between 15.4% and 48.0% in COVID-19 convalescent patients. This study also provided the HLA allele information of peptide-positive-response COVID-19 convalescent patients, thus predicting the population coverage of these three potential epitopes. Some HLA alleles showed higher frequency of occurrence in COVID-19 patients than in total Chinese population but no HLA alleles related to the T-cell peptide response and the severity of COVID-19. This research provides three potential T-cell epitopes that are helpful for the design and efficacy evaluation of COVID-19 vaccines. The HLA information provided by this research supplies reference significance for subsequent research such as finding the relation of HLA genotype with disease susceptibility.

Lessons for the future-psychosocial perspectives of vaccine literacy among beneficiaries at a COVID-19 vaccination center in a tertiary teaching hospital in Punjab, Northern India: A qualitative analysis

Background: Due to the unprecedented magnitude of the current Coronavirus disease 2019 (COVID-19) pandemic, vaccine development was fast-tracked; yet, there were barriers to vaccination uptake. Aim and Objectives: The objectives of this study were to understand the factors promoting vaccination and the barriers to vaccination, to explore the infection prevention and control practices followed after vaccination. Materials and Methods: A qualitative study using in depth interviews, both face to face and telephonic; among beneficiaries willing to participate and given at least one dose of COVID-19 vaccine in the institutions’ vaccination center, stratified sampling technique was used. Informed consent was obtained. Absolute confidentiality was ensured. The interviews were recorded and transcribed verbatim and validated by back translation into vernacular. The results obtained were analyzed using framework approach and categorized into themes and subthemes and valid conclusions drawn. Results: Various factors promoting willingness for vaccination and barriers perceived by the participants in their community, social, and occupational setting have been revealed in the present study. Availability of vaccine along with clear and accurate information can go a long way in overcoming vaccine hesitancy and promoting vaccine literacy. Conclusion: Clear and accurate information should be disseminated. The role of social media, mass media, and dissemination of information by word of mouth cannot be undermined. It is hoped that results of the present study will aid in formulating future vaccination programs.

Understanding the continuous vaccination of the COVID-19 vaccine: an empirical study from China

ABSTRACT Vaccination for the novel coronavirus disease 2019 (COVID-19) provides an effective approach for the general improvement of social safety and individual health. However, given that the current COVID-19 vaccine can only work for a period of time, the continuous vaccination of the vaccine will be particularly important. Using the Health Action Process Approach (HAPA) Model, Expectation Confirmation Model (ECM) and vaccine hesitancy (VH) theory, this research evaluates the continuous vaccination for COVID-19. This research selected Chinese survey platform to recruit respondents and conducted online surveys. A total of 768 Chinese individuals who were vaccinated participated in the survey, and 561 responses were effective after screening. Six valuable and novel findings are identified through this research. First, perceived efficacy has a positive significant impact on vaccination intention, but the positive effects of outcome expectancy and risk perception on vaccination intention are not significant. Second, social positive cues play a significant role in promoting vaccination intention. Third, VH has a negative significant influence on vaccination intention. Fourth, vaccination behavior produces a positive significant effect on perceived usefulness and satisfaction, respectively. Fifth, perceived usefulness exerted a positive significant impact on satisfaction and continuous vaccination, respectively. Sixth, satisfaction has no positive significant influence on continuous vaccination. Our theoretical model, which is the main contribution of this research, indicates that individual continuous vaccination is a process from motivation to intention, and from intention to behavior, and then from behavior to continuous vaccination.

Effect of Counseling Regarding COVID-19 Vaccine on Pregnant Women's Acceptance to Take the Vaccine

Background: Covid19 vaccine remain the most important strategy for Curbing infections and disease severity in the current coronavirus disease 2019 (COVID-19) pandemic. Lack of knowledge about the vaccine's mechanism of action was related to low vaccine acceptance in pregnant women. Aim: To evaluate the effect of counseling regarding covid19 vaccine on pregnant women's acceptance to take the vaccine. Design : Quasi experimental research design was used in this study. Setting: It was conducted at Sohag university hospital in antenatal clinic. Sample: purposive sample of 100 pregnant women. Tools: Three tools were used in this study, (1) structured interviewing questionnaire, (2) knowledge assessment sheet, (3) acceptance assessment sheet. Results: There is highly statistical significance difference between pre & posttest regarding total knowledge and acceptance of studied pregnant women regarding covid19 vaccine p-value 0.001. Conclusion: There was an improvement in the knowledge and acceptance of covid19 vaccine following the counseling program Recommendations: The nurses should provide counseling to pregnant women to increase their knowledge and correct misconceptions regarding COVID- 19 vaccine

Current COVID-19 vaccine epidemiology and dentistry

The coronavirus disease 2019 (COVID-19) vaccine story is continuously unfolding. Since our previous COVID-19 commentaries, much new information has transpired on the subject, and here we revisit this topic, which has practical implications for all stakeholders in dentistry, as well as the public. This article, on current vaccine epidemiology, provides an account of why vaccines fail in general, and the particular concerns in relation to the new Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related ‘variants of concern’. Issues related to vaccine failure are fundamentally dichotomous in nature, appertaining either to the vaccine strain (type) per se, and/or the numerous endogenous factors of the vaccine recipient/vaccinee. Societal factors such as vaccine hesitancy and its impact on herd immunity appear to overarch the long-term goal of total or partial global suppression of SARS-CoV-2, and its eventual endemicity. CPD/Clinical Relevance: To describe the reasons for the failure of currently administered COVID-19 vaccines, particularly in relation to the advent of the SARS-CoV-2 ‘variants of concern’, and discuss implications for clinical dental practice.

Fake news and fallacies: Exploring vaccine hesitancy in South Africa.

Historically, vaccine hesitancy (VH) has been a thorn in the side of public health efforts to contain and eradicate infectious diseases. This phenomenon is magnified in light of the current coronavirus disease 2019 (COVID-19) pandemic. Surveys conducted across South Africa since the outbreak of COVID-19 demonstrate the complexity of factors that contribute towards VH in this population. Amidst the negative press that the COVID-19 vaccine has received, especially across social media, understanding and combatting VH remains important to achieve herd immunity. This article aims to shed light on key factors fuelling COVID-19 VH in South Africa and provides a framework from which to address this problem.

Sociodemographic and Behavioral Predictors of COVID-19 Vaccine Hesitancy in Pakistan.

BackgroundThe current coronavirus disease 2019 (COVID-19) pandemic continues with resurgent second and third waves worldwide. Vaccination is one of several measures that are needed to end this pervasive threat. Pakistan, however, has a relatively low rate of routine vaccine acceptance. Our study aimed to determine the proportion and predictors of COVID-19 vaccine hesitancy (VH) among adults in Pakistan.MethodsAn online cross-sectional study was conducted from December 27, 2020 to March 6, 2021. Non-probability sampling was applied to recruit study participants through social media platforms (ie, Facebook and Twitter) and through free messaging services (WhatsApp). Stata 16 was used to generate descriptive statistics and logistic regression models for identifying predictive variables of vaccine hesitancy. A p-value of <0.05 was considered strong evidence against the null hypothesis.ResultsOut of 1014 participants, 35.8% (n=363) were hesitant about receiving the COVID-19 vaccine. Reasons for VH included concerns about side effects (42.4%), belief in conspiracy theories (20.1%), perceived inefficacy of the vaccine (13.2%), and perceived protection through precautionary measures (12.6%). Urban residency (AOR 2.34, 95% CI 1.54–3.57), reservations about vaccine safety (AOR 3.29, 95% CI 1.68–6.44), uncertainty about vaccine efficacy (AOR 2.70, 95% CI 1.50–4.86), failure of the vaccine to reduce hospitalization and death (AOR 6.36, 95% CI 4.01–10.22), and unfelt need for vaccination awareness among public (AOR 2.02, 95% CI 1.28–3.14) were associated with higher rates of VH. At least one chronic disease (AOR 0.60, 95% CI 0.39–0.92), knowing someone infected with COVID-19 (AOR 0.56, 95% CI 0.39–0.81), and trusting information from the ministry of health (AOR 0.64, 95% CI 0.41–0.99) and physicians (AOR 0.27, 95% CI 0.13–0.53) were found to be associated with lower rates of COVID-19 VH.ConclusionMore than one third of survey participants were VH. COVID-19 vaccine uptake in Pakistan can be improved through targeted health education strategies and planned interventions that address the barriers identified in the present study.

Prioritizing 'equity' in COVID-19 vaccine distribution through Global Health Diplomacy.

With over 4 million deaths worldwide, the current coronavirus disease 2019 (COVID-19)pandemic is regarded as one of the worst pandemics in history. With its wider devastating consequences, even so-called affluent countries could not provide full coverage for COVID-19vaccines and medications to all of their citizens. Against this backdrop, the main aim of this article is to examine how Global Health Diplomacy (GHD) can play a role in prioritizing vaccine equity in the global health agenda in the fight against COVID-19. The majority of developed countries’ healthcare systems have been exposed and have reached a tipping point.After the completion of eighteen months of the pandemic, only five countries were able to produce vaccines for the treatment of COVID-19. This pandemic has divided the world into two blocs: those with vaccines, such as the United States, the United Kingdom, Russia, China, and India; and those without, such as the rest of the world. The greatest challenges are vaccine inequalities, inequities and distribution, which undermine the global economic recovery. Many poor countries are still waiting for the initial doses to be delivered to their citizens, while some rich nations are planning for booster doses. GHD plays a critical role in establishing successful global collaborations, funding mechanisms and ensuring international cooperation through the combined efforts of all stakeholders. Besides, global solidarity is necessary to lessen the wider gaps between the vaccination status of rich and poor nations. Therefore, through GHD, the vaccine gaps and inequities can be addressed to strengthen global health security and accelerate global economic recovery.

High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries.

Vaccination could be an effective strategy for slowing the spread of the current coronavirus disease 2019 (COVID-19) pandemic. Vaccine hesitancy could pose a serious problem for COVID-19 prevention, due to the spread of misinformation surrounding the ongoing pandemic. The aim of this study was to assess the attitudes towards the prospective COVID-19 vaccines among the general public in Jordan, Kuwait and other Arab countries. We also aimed to assess the association between COVID-19 vaccine acceptance and conspiracy beliefs. This study used an online survey distributed in December 2020, with items assessing conspiracies regarding COVID-19’s origin and vaccination. Attitudes towards COVID-19 vaccines were assessed using the Vaccine Conspiracy Belief Scale (VCBS), with higher scores indicating a greater belief in vaccine conspiracy. A total of 3414 respondents completed the survey, the majority being residents of Jordan (n = 2173, 63.6%), Kuwait (n = 771, 22.6%) and Saudi Arabia (n = 154, 4.5%). The acceptance rates for COVID-19 and influenza vaccines were 29.4% and 30.9%, respectively. Males, respondents with higher educational levels and those with histories of chronic disease had higher rates of COVID-19 vaccine acceptance. Beliefs that COVID-19 vaccines are intended to inject microchips into recipients and that the vaccines are related to infertility were found in 27.7% and 23.4% of respondents, respectively. Higher VCBS scores were found among females, respondents with lower educational levels and respondents relying on social media platforms as the main source of information. The high rates of vaccine hesitancy in Jordan and Kuwait, among other Arab countries, are alarming. They could hinder the proper control of COVID-19 in the region. The harmful effect of COVID-19 misinformation and conspiracy beliefs was manifested in vaccine hesitancy. This may represent a massive obstacle to the successful control of the pandemic. A reliance on social media as the main source of information about COVID-19 vaccines was associated with vaccine hesitancy. This should alert governments, policy makers and the general public to the importance of vigilant fact checking.

An overview of current COVID-19 vaccine platforms.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic that emerged in December 2019 in Wuhan city, China. An effective vaccine is urgently needed to protect humans and to mitigate the economic and societal impacts of the pandemic. Despite standard vaccine development usually requiring an extensive process and taking several years to complete all clinical phases, there are currently 184 vaccine candidates in pre-clinical testing and another 88 vaccine candidates in clinical phases based on different vaccine platforms as of April 13, 2021. Moreover, three vaccine candidates have recently been granted an Emergency Use Authorization by the United States Food and Drug Administration (for Pfizer/BioNtech, Moderna mRNA vaccines, and Johnson and Johnson viral vector vaccine) and by the UK government (for University of Oxford/AstraZeneca viral vector vaccine). Here we aim to briefly address the current advances in reverse genetics system of SARS-CoV-2 and the use of this in development of SARS-CoV-2 vaccines. Additionally, we cover the essential points concerning the different platforms of current SARS-CoV-2 vaccine candidates and the advantages and drawbacks of these platforms. We also assess recommendations for controlling the COVID-19 pandemic and future pandemics using the benefits of genetic engineering technology to design effective vaccines against emerging and re-emerging viral diseases with zoonotic and/or pandemic potential.

Immunological considerations for COVID-19 vaccine strategies.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a century. It is widely believed that prepandemic normalcy will never return until a safe and effective vaccine strategy becomes available and a global vaccination programme is implemented successfully. Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, we discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and the ways in which COVID-19 vaccine strategies may evolve over the next few years.

Understanding COVID-19 Vaccines and Their Development.

Understanding COVID-19 Vaccines and Their Development.

COVID-19 Vaccine Hesitancy in Jordan is Becoming an Obstacle Toward Achieving Immunity

Background: Vaccination is currently considered the major hope to slow down the spread of the current coronavirus disease 2019 (COVID-19) pandemic. Currently, the biggest obstacle against mass vaccination is that people are reluctant to take the vaccine. Objective: The aim of this study is to assess the acceptance and hesitancy towards the COVID-19 vaccine among the general population in Jordan. In addition, the study explores the possible causes of vaccine refusal and the possible associated factors. Methods: The study was conducted by using an online survey distributed in March 2021. It is composed of items that assess the respondent characteristics and their acceptance to the vaccine. Results: A total of 3728 respondents completed the survey. The majority of respondents 60.5% (n = 2255) didn’t register to the platform to take the vaccine, most of them (54.77% were not convinced with the effectiveness of the vaccine). People who work in the health care sector and people with chronic diseases were found to be more likely to receive the vaccine, whereas previously COVID-19 infected and possibly exposed patients both showed hesitancy to sign up for the vaccine. Conclusion: The effectiveness and safety of different vaccines should be widely available to the general population, and be scientifically explained in a simple trustful way. In addition, more awareness programs probably need to target the hesitant groups, including the previously infected patients.