Current Advances In Development Research Articles

Targeting thyroid diseases with TSH receptor analogs

The thyroid-stimulating hormone (TSH) receptor (TSHR) is a major regulator of thyroid function and growth, and is the key antigen in several pathological conditions including hyperthyroidism, hypothyroidism, and thyroid tumors. Various effective treatment strategies are currently available for many of these clinical conditions such as antithyroid drugs or radioiodine therapy, but they are not devoid of side effects. In addition, treatment of complications of Graves’ disease such as Graves’ ophthalmopathy is often difficult and unsatisfactory using current methods. Recent advances in basic research on both in vitro and in vivo models have suggested that TSH analogs could be used for diagnosis and treatment of some of the thyroid diseases. The advent of high-throughput screening methods has resulted in a group of TSH analogs called small molecules, which have the potential to be developed as promising drugs. Small molecules are low molecular weight compounds with agonist, antagonist and, in some cases, inverse agonist activity on TSHR. This short review will focus on current advances in development of TSH analogs and their potential clinical applications. Rapid advances in this field may lead to the conduct of clinical trials of small molecules related to TSHR for the management of Graves’ disease, thyroid cancer, and thyroid-related osteoporosis in the coming years.

Targeting thyroid diseases with TSH receptor analogs

The thyroid-stimulating hormone (TSH) receptor (TSHR) is a major regulator of thyroid function and growth, and is the key antigen in several pathological conditions including hyperthyroidism, hypothyroidism, and thyroid tumors. Various effective treatment strategies are currently available for many of these clinical conditions such as antithyroid drugs or radioiodine therapy, but they are not devoid of side effects. In addition, treatment of complications of Graves’ disease such as Graves’ ophthalmopathy is often difficult and unsatisfactory using current methods. Recent advances in basic research on both in vitro and in vivo models have suggested that TSH analogs could be used for diagnosis and treatment of some of the thyroid diseases. The advent of high-throughput screening methods has resulted in a group of TSH analogs called small molecules, which have the potential to be developed as promising drugs. Small molecules are low molecular weight compounds with agonist, antagonist and, in some cases, inverse agonist activity on TSHR. This short review will focus on current advances in development of TSH analogs and their potential clinical applications. Rapid advances in this field may lead to the conduct of clinical trials of small molecules related to TSHR for the management of Graves’ disease, thyroid cancer, and thyroid-related osteoporosis in the coming years.

New initiatives in building human‐computer interfaces

PurposeThis paper aims to review current advances in development of human‐computer interfaces.Design/methodology/approachA general review and survey of selected research and development topics.FindingsIllustrates the multi‐ and trans‐disciplinary natures of studies in cybernetics, systems and management science with a view to further research and development activity.Practical implicationsThe choice of reviews provides the awareness of the current trends in these areas of endeavour.Originality/valueThe reviews are selected from a global database and give a studied assessment of current research and development initiatives.

Current Advances in Development of Material in the Field of Wiring in Japan

AbstractThis paper presents the current advances in the development of materials in the field of telecommunication wiring together with the background which created the need for the new technologies. The background is somewhat unique to the current socio-economical situation of Japan. The key technical areas, which are addressed in this paper, are; (1) fibers for transmission of over 1 Tbps by utilizing WDM (wavelength division multiplexing), (2) fibers for fiber amplifiers to replace repeaters within trunk lines, (3) high density cables with over 1000 fiber counts, (4) ABF (air blown fiber) for access system, (5) plastic optical fibers wiring in premises or offices operating at the transmission speed of over 200 Mbps.