Curative Factors Research Articles

An exploration of the postural, location- and social contact- related sub-characteristics of inactive but awake behaviour as a depression-like indicator in mice

Inactive behaviour is essential to life. However, specific forms of inactivity may be indicative of compromised welfare in certain captive conditions. Inactive but awake behaviour (IBA - spontaneous, motionless awake behaviour without interacting with the surroundings) has been documented in some species and may be associated with poor welfare and negatively valenced affective states. In our previous work in laboratory mice, we have identified environmental risk factors (non-enriched housing) and curative factors (antidepressant drug Venlafaxine) for IBA and we hypothesise that greater levels of IBA may represent a depression-like state in this species. Here we aimed to identify which specific sub-characteristics of IBA would show construct validity as a depression-like state by exploring the posture (i.e. lying, curled lying or sitting), social contact position (i.e. in physical contact with a cage mate or not) and location of mice while performing the behaviour during two experiments (respectively investigating the aetiology and the curative factors of IBA). In both experiments we expected that more IBA would be displayed in standard (non-enriched) laboratory cages, compared with large highly-enriched cages and that a move from a highly-enriched to a non-enriched cage would increase IBA, while the opposite treatment would result in a decrease. In our second experiment (curative factors investigation), we predicted that less IBA would be displayed by mice that voluntarily ingested an antidepressant (Venlafaxine) versus a placebo. Because we could not control the number of instances of each IBA sub-characteristic we measured and we had no a priori predictions about which IBA sub-characteristics would match our general IBA treatment predictions, we compared the effect size and the direction of the effect between our treatment groups to explore which of the sub-characteristics matched our general IBA predictions. Overall, we found little variation in the location IBA was performed, with the majority being seen in the nest. Across treatment comparisons in both experiments, overall, the largest effect sizes were measured for IBA performed when in contact with the cage mate and performed when lying and both characteristics generally matched the direction of our treatment-related predictions. We suggest that future work should perform more detailed analyses of the specific characteristics of IBA by identifying behavioural sequences and the co-occurrence of the sub-characteristics to obtain a more complete picture of IBA as a depression-like indicator.

Audit of risk factors of drug-sensitive, drug-resistant tuberculosis disease, a case-control study of patients registered under NTEP, Gujarat.

Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acquisition. A comparative cross-sectional study recruited 350 bacteriologically confirmed TB patients registered under the National Tuberculosis Elimination Program (NTEP) in Gujarat, India, and 300 matched participants without active/past TB. Multinomial logistic regression analyzed risk factors for 200 drug-sensitive and 150 drug-resistant TB cases compared to participants without active or past TB. Key factors independently associated with higher adjusted odds ratios (aOR) of both TB types included low socioeconomic status (SES) (drug-sensitive TB: aOR 1.7, 95% CI 1.2-2.5; drug-resistant TB: aOR 2.2, 95% CI 1.3-3.7), crowding (>5 persons/room) (drug-sensitive TB: aOR 1.6, 95% CI 1.1-2.3; drug-resistant TB: aOR 1.9, 95% CI 1.2-2.9), undernutrition (drug-sensitive TB: aOR 1.6, 95% CI 1.1-2.3; drug-resistant TB: aOR 2.0, 95% CI 1.2-3.2), smoking (drug-sensitive TB: aOR 1.5, 95% CI 1.0-2.3; drug-resistant TB: aOR 1.7, 95% CI 1.1-2.7), and indoor air pollution (drug-sensitive TB: aOR 1.5, 95% CI 1.0-2.2; drug-resistant TB: aOR 1.8, 95% CI 1.2-2.8). Marked social determinants and clinical risks drive heightened susceptibility for both TB types in India, while prior inadequate treatment and nosocomial exposures selectively enable additional drug resistance. Holistic prevention policies jointly targeting transmission, vulnerability, and curative factors are imperative.

Philosophies Teori Konsep Keperawatan Jean Watson Caring

Background: Jean Watson nurse theorist and nursing professor known for the “Philosophy and Theory of Transpersonal Care.” She has also written many books, including Nursing: The Philosophy and Science of Caring. Watson's studies of caring have been integrated into education and patient care in nursing schools and healthcare facilities around the world. Jean Watson was born Margaret Jean Harmon and raised in Welch, West Virginia, Watson is known for seeing the unified science of caring, examining the role of the nurse through the lens of a worldview of harmony, belonging, and connection. In caring theory, values, knowledge and caring practices are integrated with the healing process from within and the patient's life experiences, thus requiring the art of healing-care and a framework called carative factors. These factors are complementary, but different from curative factors. Curative is developed by doctors, while carative is developed by nurses. Caring behavior can determine the moral values ??of nurses. In addition, caring behavior in nursing care can determine the level of client satisfaction in receiving health services. It can be said that caring is a wholehearted attitude or behavior given by a nurse to a client with a sense of care, attention and attention to the patient's emotions to create a therapeutic relationship. This causes patients to feel comfortable, safe and relieved because of the reduction in stress they feel due to suffering from an illness.

Psychosomatic states and their correlation with letting-go: two newly evaluated core factors for investigating the therapeutic effect of spa treatment.

Spa therapy (aka crenobalneotherapy) has been the object of criticism due to insufficient evidence of its effectiveness. While further effectiveness studies are needed, others are also required to better evaluate the curative factors involved during spa therapy that may contribute to the effectiveness. The current study used specific scales to investigate two possible curative factors: the psychosomatic state and the letting-go of patients with mental disorders after 3 weeks of spa therapy. The Saujon Psychosomatic Questionnaire (SPQ) and the Quantified Assessment of Fluidity of Consciousness Questionnaire (QACF) evaluate psychosomatic state and letting-go, respectively. The Hospital Anxiety and Depression Scale (HAD) and the Insomnia Severity Index (ISI) evaluate depression and anxiety symptoms and insomnia symptoms, respectively. Sixty-five subjects (57 women (87.69%); 8 men), with a mean age of 56.9 (± 9.7) years, were included. SPQ and QAFC scores improved significantly before and after the 3 weeks of spa therapy. Improvement in HAD and ISI scores was significantly correlated with SPQ and QACF scores. These preliminary results suggest that the induced psychosomatic state and the letting-go induced by spa treatment with bubbling baths, jet showers, pool bathing and massage could help patients to become more available and more able to change their psychophysiological state.

Long-Term Group Nature-Assisted Therapy for Veterans Diagnosed with Chronic PTSD

ABSTRACT Posttraumatic stress disorder (PTSD) is common among veterans. However, many veterans who deal with this condition avoid therapy, and innovative therapeutic solutions are needed. The current article presents a case study of combining nature and group therapy in a long-term, group adventure therapy program for veterans with chronic PTSD. Qualitative data were collected during four focus groups with 10 participants. Thematic content analysis was employed to conceptualize this intervention’s therapeutic components. Three main themes were identified, highlighting how this program enhanced participants’ skills in coping with PTSD avoidance symptoms, because group relations constituted a platform for promoting rehabilitation efforts. Nature was described as a pivotal curative factor, providing added value to this therapeutic model. These findings suggest nature-assisted therapy is a promising supplementary intervention, particularly for clients who fail to gain sufficient improvement via other individual or trauma-focused therapies.

Judges' Considerations in Granting Permission to Underage Marriage Applications at the Luwuk Religious Court

This study discusses judges’ considerations in granting requests for underage marriages permission at the Luwuk Religious Court. This study used a qualitative method. The data was collected through direct observation, in-depth interviews, and written document analysis. The data, then, was analyzed using thematic analysis to find themes from the data. The results of this study show that the procedure for submitting a marriage dispensation at the religious court is the same as the mechanism for filing other application cases. Increasing the minimum age for marriage for women to 19 years impacted the increase cases of underage marriage dispensation applications at the Religious Courts. The filing of a underage marriage dispensation case in the Religious Courts was caused by preventive and curative factors. The basis used by the judge in deciding the application for underage marriage dispensation is based on the theory of law enforcement. Then there must be considerations encouraging the judge to grant the application for underage marriage dispensations. The factors considered by judges in determining the dispensation of marriage were also related to psychological, health, educational, and economic factors. These four factors were taken into serious consideration by the judge in determining the dispensation of marriage. Based on the results, we recommend the religious courts should be more selective in examining, considering, and determining applications for underage marriage dispensation to prevent social conflicts and the impact of these decisions to society.

Nanocarriers for Active Ingredients of Chinese Medicine (AIFCM) Used in Gastrointestinal Cancer Therapy

Active ingredients of Chinese medicine (AIFCM) are pharmacological substances taken from traditional Chinese medicine that show promise in treating gastrointestinal cancer. Compared with traditional chemotherapeutic drugs, AIFCM have advantages such as multi-target and multi-level treatment of gastrointestinal cancer. Nanocarriers have the following advantages, better bioavailability, passive or active targeting of tumor sites and responsive release of drugs. The use of nanocarriers for delivery of AIFCM in treatment of gastrointestinal cancer, can overcome the disadvantages of some AIFCM, such as insolubility and low bioavailability. In this review, we first outline the background on gastrointestinal cancer, main curative factors and conventional therapeutic approaches. Then, the mechanisms for AIFCM in gastrointestinal cancer therapy are presented in the following four aspects: gene regulation, immune modulation, cellular pathway transduction, and alteration of intestinal flora. Thirdly, preparation of various nanocarriers and results when combining AIFCM in gastrointestinal cancer are presented. Fourth, application of novel targeted nanocarriers and responsive nanocarriers in gastrointestinal tumors is further introduced. Finally, the application of AIFCM in the treatment of gastrointestinal cancer is summarized and prospected, hoping to shed some light on the nanocarrier-bound AIFCM in the treatment of gastrointestinal cancer.

Group Psychotherapy: Development of a Successful Group

Group psychotherapy is a complex and integrative task that is designed to assist patients to better understand their problems and focus on creating change. Effective group therapy is characterized by the concept that the group functions as the agent of change. Primary among those concepts are curative factors that are used to intentionally facilitate group development and member change. In addition, there is an establishment of group norms that help leader and group members to function efficiently. A fully functioning group develops group cohesion, establishes goals that fit each individual member and the group as a whole, and effectively screens group members to enhance therapeutic productivity. This review contains 2 tables and 24 references. Key Words: curative factors, instillation of hope, development of socializing techniques, stages of group development, cohesiveness, norms in group therapy, group goals, screening group members

Cognition for coaches: A curriculum for coaches working in physical activity programming for veterans

ABSTRACT Veterans returning home from duty are affected in ways which are both visible and unseen. More importantly, veterans transitioning back to civilian life are susceptible to a loss of social support and isolation from their communities. Based on the success of sport as a curative factor for wounded veterans, this curriculum framework seeks to prepare coaches to appropriately train and coach athletes who are wounded veterans. Additionally, this curriculum conceptualizes the coach as the gatekeeper for enhancing a sense of community and social capital among participants by increasing his or her awareness of participant personalities and identities, in conjunction with their military experiences as well as those associated with reentry into civilian life.

Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation.

Objective Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Our aim was to assess the prognostic significance of primary curative resection factors in recurrent HCC patients undergoing radiofrequency ablation therapy (RFA). Methods In this retrospective study, we assessed 235 patients who underwent limited RFA of HCC recurrences (tumors ≤ 5 cm; nodules ≤ 3) after primary curative resection. Factors of primary curative resection were collected, and overall survival and recurrence-free survival were evaluated by the Kaplan-Meier method. Univariate and multivariate analyses were used to identify significant prognostic factors. Results After a median follow-up of 36 months, 54 patients died, and 128 patients had hepatic recurrence. On univariate analyses, patients whose primary tumors were less differentiated (p = 0.032 and p = 0.048) and required less time to recur (p = 0.013 and p = 0.001) after curative resection displayed poorer overall survival and higher recurrence rates following RFA. On multivariate analyses, the pathologic tumor grade (p = 0.026 and p = 0.038) and recurrence-free survival after primary curative resection (p = 0.028 and p < 0.001) emerged as independent risk factors of survival and HCC recurrence. Conclusions Primary tumor differentiation and time to recurrence after curative resection are viable prognostic factors of overall survival and further recurrence risk in patients undergoing RFA of recurrent HCC.

THE RELATIONSHIP BETWEEN JEAN WATSON'S THEORY OF HELPING TRUST WITH PATIENT SATISFACTION

Background: Fostering a trusting relationship between nurses and patients is the development of one of the curative caring factors because it is closely related to the acceptance of positive and negative feelings of patients when receiving services from nurses. The quality of a person's relationship with others is an element that determines the caring behavior of a nurse (Sartika, 2011). Nurses must be patient, generous, willing to provide assistance to patients voluntarily and be able to communicate, work and be responsible for their duties and rights when acting (Nursalam, 2013).Objectives: The purpose of this study was to determine Jean Watson's theory of helping trust with patient satisfaction in the inpatient room in The Government Hospital of Tangerang Regency.Methods: The research design used in this study is descriptive correlation using the Cross-Sectional approach. The population used in this study were patients treated in the inpatient rooms of Government Hospital of Tangerang Regency amounting to 80 people. The sampling method used is the non-probability sampling method. The sampling technique in this research is purposive sampling. The sample used in this study were 65 respondents. This research instrument using a questionnaire. The analysis used the Chi square test with a significance level α &lt; 0.05.Results: Jean Watson's helping trust relationship both 13 respondents (34.2%) and those who were not satisfied were 1 respondent (3.7%). the results of the analysis obtained OR = 25.35 means that patients who claim helping trust relationship Jean Watson have a 25.35 times chance expressed satisfied. Chi square test results obtained p value 0.001 so that it can be concluded that there is a significant relationship between Jean Watson’s theory of helping trust relationship with patient satisfaction in class III inpatient room at The Government Hospital of Tangerang Regency.Conclusion: Patient satisfaction depends on the quality of nursing services. Service is said to be good if in fact the nurse provides the needs according to the patient's condition and the patient's response to service can be disappointing or satisfying. Further research is expected that nurses can provide assistance to the relationship of trust to patients so that patients can feel safe and comfortable when nurses take nursing actions to patients. Further researchers can use other research methods either qualitatively or add other variables so that the helping trust relationship between nurses and patients can be well developed. Keywords: Helping Trust Relationship, Patient, Satisfaction, Jean Watson.

Nutritional Counseling Protocol for Colorectal Cancer Patients after Surgery Improves Outcome

Incidences of colorectal cancer (CRC) have continued to grow. Surgery is the main treatment and the only curative factor is nutritional status, which has an enormous influence on postoperative evolution. This study proposes a protocol for nutritional intervention beginning preoperatively and lasting up to three months postoperatively. Twenty patients with confirmed diagnosis of colon adenocarcinoma who underwent resection surgery were included. Anthropometric and food intake data–assessed through two 24-hour recalls, one weekday and one weekend–were collected at baseline, one month postoperative (PO), and three months PO. Anthropometric evaluation showed a decrease in the first month PO in weight, BMI, Hand grip strength, and arm circumference (P < 0.05), but these parameters recovered after 3 mo, PO and concomitant with the increase in protein and dietary fiber intake. In addition, collateral symptoms, such as abdominal distension, abdominal pain, and post prandial fullness, decreased between baseline and three months postoperative (P < 0.05). The nutritional counseling protocol for patients undergoing surgery due to CRC was positive in the recovery of nutritional status and improve of symptoms.

Could Putting the Mesenchymal Stem Cells Technology into Practice Be an Optimistic Therapy for The Critically Ill COVID-19?

COVID-19 comes to light, quickly developing status. Daily, we know more about the human new coronavirus (HCoV19), which is extremely infective with heavy pneumonia connected with fast virus reproduction. Emerging in Wuhan China 31 December 2019, the contemporary COVID-19 outbreak has quickly overripe taking place directly between individuals so contagion extending to be a world health emergency at present on pandemic level. The pandemic has had deep impacts on everyday lifetime towards numerous of the world. Presently no therapy, no specified remedies or inoculations are ready to treat the patients with COVID-19 pollution and investigators here and there the globe are jostling to recognize present medication or synthesis that could be functional versus it. Therefore, there is a great unmet requirement for a secure and efficient therapy for COVID-19 contaminated cases, particularly the serious cases. What types of therapies might now assist? What are the lab craft strategies to restraining coronavirus? Ago mid-February, one tactic that has acquired rising attraction is stem cell therapy, curing that have often been saw as a potential magic bullet by despairing patients suffering from degenerative incurable conditions. In plentiful of these diseases, truth has so far to coincide with the hype. The cell based-therapy doings by supporting the body’s precocious refractory reply in an orientation that could goal the coronavirus. Now stem cell-based therapy for COVID-19 is earning incentive in China. The tally of the world emergency has visible governments frequently proclamation the company global to develop in the search for a cure, and the Australian corporate Mesoblast – a global commander in cell-based therapies for a lot of illnesses – are earned recently the approval to start clinical trials of their possess stem cell based product against COVID-19. Taking into consideration that generality of the dead sick people were produced by serious inflammation reaction, it is extremely demanding to advance efficient curative factors and strategies for that cases. I present an accurate lab modality in preparing mesenchymal stem cells (MSCs) which might be a perfect option to cure the seriously sick novel COVID-19 cases. Beneath this situation, I suppose that blood derived MSCs generated from the critically ill novel COVID-19 patient itself (autologous) suggested as a treatment for him. Therefore, my viewpoint spots a modern curative strategy.

Landscape and geographical characteristics of the resorts of Imereti

The article considers the resort climatic resources of Imereti. The main climatic characteristics of the Resorts are determined and a map of the resorts and resort areas of Imereti is developed. The thermal characteristics of summer and winter are given in accordance with the classification of Kaygorodov. The spa and curative factors of the main resorts are considered. The physicochemical properties of water, their composition and medicinal properties are indicated. In article resort climatic resources of Imeretia are considered. The attention that in the world isn't a lot of places where in rather small territory so many various landscapes are located is focused: from damp subtropics, to the Alpine mountain meadows. It is proved that a relief of mountain landscapes, the coast of the Black Sea, Mineral water and climate – a natural basis of development of resort economy of the region.

Vicissitudes in Winnicottian Theory on the Origins of Aggression: Between Dualism and Monism and from Back to Front

Reading Winnicott’s writings in reverse order reveals a major unacknowledged turning-point in his thinking. Based on the unveiling of this development it is proposed that: 1) It is only in his late writings that Winnicott makes a wholehearted shift to a monistic view of psychic energy, 2) The paradoxical joining of two opposing forces, taken together with the unification of “primitive love” and “motility” into a single energy source, as suggested in “The use of an object,” was the missing step that enabled Winnicott’s final shift to monistic thinking, 3) This shift allows to identify motility as the energetic origin of human behavior, and 4) Restoring the connection between aggression and motility is a major curative factor.

Prevention Considerations in Cardiovascular Diseases regarding the premature mortality reduction

Introduction. Cardiovascular diseases are recognized as worldwide (1) and national public health issue (2, 3). This is argued by having a leading position in the structure of general mortality and disability, the substantial loss of quality of life and the health system needs for increased costs. Prevention and control of cardiovascular disease has become one of the priority directions for global and national noncommunicable disease control strategies developed to reduce premature mortality (1, 5). The major cardiovascular diseases mortality was identified some aspects of premature mortality among the adult population in the Republic of Moldova. Overall decrease of mortality due to cardiovascular diseases among adults (-5.9%) has been accompanied by a relatively slower decrease in premature mortality (-2.4%) in the Republic of Moldova (6). Primary, secondary and tertiary prevention measures are essential in reducing the burden of cardiovascular disease and contribute to improving cardiovascular health at the population level. Nature is helping people to maintain their health through mechanisms much closer to them than pharmaceutical ones through the curative action of the various natural factors that form the climate of the respective territorial area. Material and method. There is a descriptive study based on statistical data of the World Health Organization and official vital statistics of the Republic of Moldova. Results and discussions. The climatic conditions of Moldova are favorable to cardiovascular prevention and rehabilitation. Moldova is located in the temperate continental climate influenced by the proximity of the Black Sea and the interference of warm-humid air from the Mediterranean. The annual air temperatures average in the country is 9,30C. In the Republic of Moldova the warm weather with a confortable temperature lasts 175 days and the relative humidity oscillates in the average from 66 to 87%. The country's thermal regime is the most important curative factor for treating chronic diseases and opportunity for the amplification of medical rehabilitation programs for patients with cardiovascular diseases. Application of methods based on the action of climatic factors in cardiovascular rehabilitation process contributes to its efficiency. Increasing the role of tertiary prevention is a good practice for the quality improvement of medical services for this category of patients. By making appropriate, timely and complex measures of primary, secondary and tertiary prevention cardiovascular disease can be substantially prevented. Conclusions. Strengthening cardiovascular prevention centered on a complex approach to all its primary, secondary, and tertiary components is an opportunity to reduce premature mortality in the population. Key words: Cardiovascular diseases, prevention, premature mortality,

La relazione terapeutica nella tradizione psicoanalitica

La discussione sulla teoria psicoanalitica dei fattori terapeutici viene brevemente rivista, a partire dalla posizione di Freud, attraverso i Simposi sui fattori curativi ai due Congressi dell'International Psychoanalytic Association (IPA) di Marienbad nel 1936 e di Edimburgo nel 1961 (dove vi fu un punto di svolta), fino alle posizioni all'interno della psicoanalisi contemporanea. Contrariamente a quanto in genere si creda, Freud dava molta importanza al ruolo della relazione tra paziente e terapeuta, da lui ritenuta un potente agente terapeutico. In effetti, Freud non solo oscillava costantemente tra l'idea di considerare l'interpretazione cognitiva come il principale fattore curativo e l'idea che, invece, la relazione terapeutica avesse un ruolo importante, ma in diverse occasioni ha ammesso apertamente che la relazione con il paziente ed altri fattori emotivi (come identificazione, modellizzazione, ecc.) rivestivano un'importanza molto maggiore nel determinare il cambiamento del paziente.

Ibuka Institution and Group Therapy Curative Factors in Healing Psychological Problems of Women Sexually Violated During 1994 Genocide Against Tutsi in Rwanda

Ibuka Institution and Group Therapy Curative Factors in Healing Psychological Problems of Women Sexually Violated During 1994 Genocide Against Tutsi in Rwanda

Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications.

The development of natural phospholipids for nanostructured drug delivery systems has attracted much attention in the past decades. Lecithin that was derived from naturally occurring in soybeans (SL) has introduced some auspicious accomplishments to the drug carrying aspect, like effectual encapsulation, controlled release, and successful delivery of the curative factors to intracellular regions in which they procure these properties from their flexible physicochemical and biophysical properties, such as large aqueous center and biocompatible lipid, self-assembly, tunable properties, and high loading capacity. Despite the almost perfect properties as a drug carrier, liposome is known to be quite quickly eliminated from the body systems. The surface modification of liposomes has been investigated in many studies to overcome this drawback. In this review, we intensively discussed the surface-modified liposomes that enhancing the targeting, cellular uptake, and therapeutic response. Moreover, the recent applications of soy lecithin-derived liposome, focusing on cancer treatment, brain targeting, and vaccinology, are also summarized.

THE IMPLICIT ANALYST: QUALITIES OF SALIENCE

More than fifty years ago, in “The Curative Factors in Psycho-Analysis,” Sacha Nacht wrote, “It is what the analyst is rather than what he says that matters” (his emphasis). This article focuses on what I believe is the main thrust of Nacht’s statement: the analyst’s personal attributes, her ways of relating formed by her organizing principles that operate at an implicit, procedural level, manifesting in what we recognize in common parlance as her personality. Eight specific, implicit qualities of the analyst’s personality are delineated, which, from my subjective perspective, are salient for psychotherapy and which may, or may not, find common ground with other practitioners as well, regardless of the analyst’s theoretical persuasion. Perspectives on salience will be different from analyst to analyst, although I believe not entirely different, given that we are all members of the human phylogeny. This article is not prescriptive; the qualities identified reflect my personal perspective of implicit qualities of the analyst beneficial to psychotherapy. As well, some tenets of psychoanalytic training and theory that may facilitate these qualities are discussed.