ABSTRACT This study proposes a multidimensional framework for the assessment of cultural heritage vulnerability to flood hazards. In this framework, cultural heritage is framed within a landscape approach drawing on the concept of the historic urban landscape as a physical entity, a lived space and a layered socio-economic environment. In such manner, this study emphasises that climate change disturbs both tangible and intangible aspects of cultural heritage – such as social systems and daily life practices – by modifying the material conditions that sustain them. Thus, the proposed framework integrates built and natural heritage with area-based vulnerability and socio-economic deprivation, considering households’ exposure to flood risk. The analysis follows a spatial and quantitative approach using open geospatial data available at the statistical unit level. The data are processed and analysed employing QGIS software and statistical analysis. Results confirm that cultural heritage vulnerability is highly associated with socio-economic deprivation and area-based vulnerability. The understanding of this interrelation is key to the identification of historic urban landscape qualities and priority areas for reconstruction and social support.