The article presents materials on the testing of a polyvalent vaccine. It was found that after double immunization of cattle with a polyvalent vaccine against infectious rhinotracheitis, viral diarrhea, respiratory syncytial, parainfluenza-3, rota-and coronavirus infection, no hematological changes in the body and violations of physiological functions were detected in the vaccinated animals. Animal husbandry is constantly developing. For the further development of this industry, new and old technologies of animal breeding are used in various cattle breeding enterprises. Livestock breeders are faced with various tasks to increase milk yields, weight gain in young animals, the safety of livestock, and the quality of livestock products. Given that cattle can get sick with various infectious and non-infectious diseases, this problem is very urgent. However, the tasks you can perform by providing cattle complete balanced feed for protein, vitamins, trace elements, introduction of new technologies in breeding, raising productivity and preservation of animals through the creation of improving the breed characteristics of the animal [1, 2, 3]. One of the main tasks facing the breeders is to increase milk yield in cows producing healthy calves, increase their viability, safety and weight gain in fattening [4, 5]. Numerous researchers have found that various infectious diseases in calves caused by pathogenic viruses and bacteria cause huge economic damage to animal husbandry. Infectious diseases are the most dangerous, as they cause mass diseases, deaths, negatively affect the health of animals, reduce the receipt of low-quality products from them. It is known from various literature sources that in case of violation of zoohygienic rules when keeping calves, in particular, crowding of animals, drafts, not timely cleaning of manure, cleaning of premises and feeders leads to the accumulation of various microorganisms in livestock premises, both viruses and bacteria. As a result, a significant accumulation of pathogenic microorganisms leads to the emergence of infectious diseases in calves [6,7, 9].