This article examines how leaders can apply concepts from complexity theory to take a systems-based approach to navigating organizational complexity. It first defines key ideas from complexity science such as complexity theory, which views organizations as existing in a state of productive tension at the "edge of chaos" rather than under pure control, a systems approach that recognizes organizations as interconnected networks of interdependent parts, and complex adaptive systems characterized by self-organization. The article then discusses how leaders can establish clear yet flexible goals and direction, loosen central control to allow decentralized experimentation, promote transparency, and embrace diversity to foster conditions for bottom-up self-organization. It also explores developing networked mindsets through cross-functional teams, relationship building, and transparent information sharing to enhance emergent coordination. Additionally, the article emphasizes cultivating attentiveness to subtle changes and disturbances by establishing early warning systems and experimenting quickly, as well as nurturing an adaptive culture through innovation, reskilling, and rapid pilot-based learning to sustainably renew the organization amid nonlinearity and uncertainty.