Cross-domain Knowledge Research Articles

Using cross-domain knowledge augmentation to explore comorbidity in electronic health records data

Research concentrating on specific diseases or employing single datasets, such as medical histories and thematic data, has garnered considerable attention. However, there has been limited investigation into comorbidities. Although some ad-hoc methods have been utilized in the medical field, there is a scarcity of systematic approaches to address this challenge. The task of expressing patient features using heterogeneous and cross-domain data presents considerable difficulties. Directly mapping this data into a matrix frequently results in issues such as high dimensionality, sparsity, redundancy, and noise. Additionally, given the critical role of supervisory information in medicine, acquiring accurate information is paramount. To address these issues, we propose an enhanced clustering method that capitalizes on cross-domain knowledge augmentation. This method can iteratively learn clustering outcomes and cross-domain knowledge. The cross-domain knowledge matrix produced by our approach can be interpreted as a measure of similarity between instances across domains. We validate our proposed model in real-world electronic health records (EHR) data, and achieve significant performance improvement compared to the baseline method, successfully completing the task of exploring comorbidity. Due to the privacy of EHR data, we also conduct extensive experiments on the publicly available datasets DBLP and UCI. The experimental results show that our algorithm is superior to the baseline algorithm and has strong generality.

Enhancing few-shot lifelong learning through fusion of cross-domain knowledge

Humans can continually solve new problems with a few examples and enhance their learned knowledge by incorporating new ones. Few-shot lifelong learning (FSLL) has been presented to mimic human learning ability. However, they overlook the significance of cross-domain knowledge and little effort has been made to investigate it. In this paper, we explore the effects of cross-domain knowledge in FSLL and propose a new framework to enhance the model’s ability by fusing cross-domain knowledge into the learning process. Moreover, we investigate the impact of both debiased and non-debiased models in the FSLL context for the first time. Compared with previous works, our setting presents a unique challenge: the model should continually learn new knowledge from cross-domain few-shot data and update its existing knowledge by fusing new knowledge throughout its lifelong learning process. To address this challenge, the proposed framework focuses on learning and updating while migrating the well-known issues of forgetting and overfitting. The framework comprises three key components designed for learning cross-domain knowledge: the Debiased Base Learning strategy, Knowledge Acquisition, and Knowledge Update. The superiority of the framework is validated on mini-ImageNet, CIFAR-100, OfficeHome, and Meta-Dataset. Experiments show that the proposed framework exhibits the capability to perform in cross-domain situations and also achieves state-of-the-art performance in the non-cross-domain situation.

Federating cross-domain BIM-based knowledge graph

Despite decades of the digitization of the construction industry, interoperability challenges prevail. One of which is the lack of sufficient integration between domain-specific BIM models. Therefore, the paper proposes a novel methodology for federating cross-domain BIM-based knowledge graphs. The approach leverages the integration of multiple models into a single knowledge graph, aiming to bridge the existing gaps in data exchange and enhance the semantic richness of building information models. Through a detailed exploration of existing data exchange mechanisms, popular ontologies, and schema limitations, this research addresses the interoperability dilemma. A practical demonstration, encapsulated in the “LBD-Online-Merge” demo application, validates the methodology’s efficacy in real-world scenarios, illustrating its potential to revolutionize building operations management and data preparation for the operational phase of a building’s lifecycle. This study significantly contributes to the academic and practical discourse by providing a robust framework for achieving a more integrated, intelligent building information management ecosystem, setting a new benchmark for future research and applications in constructing semantically rich digital twins of the built environment.

Enhancing Recommendation Diversity and Novelty with Bi-LSTM and Mean Shift Clustering

In the digital age, personalized recommendation systems have become crucial for information dissemination and user experience. While traditional systems focus on accuracy, they often overlook diversity, novelty, and serendipity. This study introduces an innovative recommendation system model, Time-based Outlier Aware Recommender (TOAR), designed to address the challenges of content homogenization and information bubbles in personalized recommendations. TOAR integrates Neural Matrix Factorization (NeuMF), Bidirectional Long Short-Term Memory Networks (Bi-LSTM), and Mean Shift clustering to enhance recommendation accuracy, novelty, and diversity. The model analyzes temporal dynamics of user behavior and facilitates cross-domain knowledge exchange through feature sharing and transfer learning mechanisms. By incorporating an attention mechanism and unsupervised clustering, TOAR effectively captures important time-series information and ensures recommendation diversity. Experimental results on a news recommendation dataset demonstrate TOAR’s superior performance across multiple metrics, including AUC, precision, NDCG, and novelty, compared to traditional and deep learning-based recommendation models. This research provides a foundation for developing more intelligent and personalized recommendation services that balance accuracy with content diversity.

KGFabric: A Scalable Knowledge Graph Warehouse for Enterprise Data Interconnection

Based on the diversified application scenarios at Ant Group, we built the Ant Knowledge Graph Platform (AKGP). It has constructed numerous domain-specific knowledge graphs related to merchants, companies, accounts, products, and more. AKGP manages trillions of structured knowledge graphs, serving search, recommendation, risk control and other businesses. However, as the demand increasing for various workloads such as graph pattern matching, graph representation learning, and cross-domain knowledge reuse, the existing warehouse systems based on relational DBMS or graph databases are unable to meet the requirements. To address these issues, we propose KGFabric, an industrial-scale knowledge graph management system built on the distributed file system (DFS). KGFabric offers a nearline knowledge storage engine that utilizes a Semantic-enhanced Programmable Graph (SPG) model, which is compatible with the Labeled Property Graph (LPG) model. The data is persistently stored in DFS, such as HDFS, which leverages the POSIX file system API, making it suitable for deployment in multi-cloud environment at low cost. KGFabric provides a native graph-based and hybrid storage format that can serve as a shared backend for parallel graph computing systems, significantly accelerating the analysis of multi-workload. Additionally, KGFabric includes a graph fabric framework that minimizes data duplication and guarantees data security. KGFabric is able to manage Peta-scale data and has supported graph fabric and analysis with over 100 billion relations at Ant Group. We conduct experiments on various datasets to evaluate the performance of KGFabric. Compared with popular relational DBMS and graph databases, the storage space for semantic relations is reduced by over 90%. The performance of graph fabric improves by 21× in real-world workloads. In multi-hop semantic graph analysis, KGFabric enhances performance by 100×.

Co-creation in action: Bridging the knowledge gap in artificial intelligence among innovation champions

The increasing significance of artificial intelligence (AI) in various industries highlights the necessity for industry leaders and professionals to comprehend and gain knowledge about AI. The urgency for AI literacy is more critical than ever due to the potential unethical use of AI resulting from insufficient knowledge. This issue is particularly crucial for educators because they need to understand and adapt to the impact of AI within educational institutions, with some needing to use and become literate in AI, given that students now have increased access to public AI tools. This research presents a multi-phase study to address the issue of bridging the knowledge gap in AI by conducting co-creation with innovation champions, illustrated by a case of Generative AI innovation in a K-12 school. Using action design research, we engaged experienced teachers who are experts in pedagogical innovation to co-create a generative AI-enhanced platform at a leading K-12 education institution known for its pedagogical innovation in Australia. The findings reveal that champions enhance their knowledge through their subject-matter expertise, organizational knowledge, and AI knowledge gained through external exposure and experience. The study also highlights the key elements that facilitate a cross-domain knowledge exchange platform, enabling champions to be exposed to and experience AI technological learning, leading to shifts in their understanding and perception of AI. The initially unaware and sceptical champions become more aware and capable of articulating more technical AI knowledge rooted in a shared value. This research demonstrates how co-creation serves as a pathway for learning AI, particularly among K-12 teachers who are innovation champions. It underscores the impact of experiential and organizational learning on AI collaborative learning and behavioral intentions. Additionally, the study presents that aligning organizational and personal visions and values can influence perceptions about AI technologies, enhancing the discourse on AI and education innovation.

Cross-Domain Knowledge Transfer for Sustainable Heterogeneous Industrial Internet-of-Things Networks.

In this article, a novel cross-domain knowledge transfer method is implemented to optimize the tradeoff between energy consumption and information freshness for all pieces of equipment powered by heterogeneous energy sources within smart factory. Three distinct groups of use cases are considered, each utilizing a different energy source: grid power, green energy source, and mixed energy sources. Differing from mainstream algorithms that require consistency among groups, the proposed method enables knowledge transfer even across varying state and/or action spaces. With the advantage of multiple layers of knowledge extraction, a lightweight knowledge transfer is achieved without the need for neural networks. This facilitates broader applications in self-sustainable wireless networks. Simulation results reveal a notable improvement in the 'warm start' policy for each equipment, manifesting as a 51.32% increase in initial reward compared to a random policy approach.

A patent retrieval method and system based on double classification

As one of the most prominent carriers of knowledge, patents can provide masses of cross-domain knowledge to support the innovative design process of products. However, there is a major problem faced by most patent-aided innovation design systems, that is, identifying and providing patents related to design requirements from a multitude of cross-domain patents. To address this problem, a patent retrieval method based on double classification is proposed in this study, and a corresponding patent-aided innovative design prototype system is also developed. Firstly, the functional attributes are extracted from design requirements and expanded to different fields based on functional bases, by which the primary patent sets are constructed via classifying cross-domain patents. Secondly, technical features are mined from the primary patent sets with the topic model, which is used to classify the primary patent sets in turn and construct the secondary patent sets, hence, corresponding patents can be obtained to solve the design problems. Finally, a patent-aided prototype system is developed based on the proposed method. On the basis of the system, the hole plug of irradiated samples of nuclear reactor pressure vessel has undergone innovative design, which verifies the feasibility and practicability of both the method and system.

Cross-domain knowledge collaboration for blending-target domain adaptation

Unsupervised domain adaptation (UDA) avoids expensive data annotation for the unlabeled target domains by fully utilizing the knowledge of existing source domain. In practice, the target data are usually highly heterogeneous that mix multiple latent domains. And sometimes the source data involve the user private information which is forbidden to access directly. To this end, this paper tackles the blending-target data under the source-available setting, and for the first time under the source-free setting. Specifically, we devise a novel Cross-domain Knowledge Collaboration (CdKC) framework, which mainly includes a prediction network and an adaptation network. The complementarity of two networks are exploited to explore the intrinsic structure in targets. Specifically, CdKC is capable of learning domain-invariant space, and disentangling domain-specific feature simultaneously to boost the UDA performance greatly. A total of 12 tasks are conducted on three visual datasets to verify the superior performance of CdKC by comparing with the state-of-the-art models designed under 4 different UDA settings. The experiments demonstrate that the accuracy of CdKC model still exceeds D-CGCT 0.4% on Office dataset and 1.2% on Office–Home dataset although D-CGCT can access source data and domain labels of targets that CdKC cannot do. It verifies the effectiveness of CdKC although under much looser source and target domain restrictions.

Multicentric intelligent cardiotocography signal interpretation using deep semi-supervised domain adaptation via minimax entropy and domain invariance

Background and ObjectiveObstetricians use Cardiotocography (CTG), which is the continuous recording of fetal heart rate and uterine contraction, to assess fetal health status. Deep learning models for intelligent fetal monitoring trained on extensively labeled and identically distributed CTG records have achieved excellent performance. However, creation of these training sets requires excessive time and specialist labor for the collection and annotation of CTG signals. Previous research has demonstrated that multicenter studies can improve model performance. However, models trained on cross-domain data may not generalize well to target domains due to variance in distribution among datasets. Hence, this paper conducted a multicenter study with Deep Semi-Supervised Domain Adaptation (DSSDA) for intelligent interpretation of antenatal CTG signals. This approach helps to align cross-domain distribution and transfer knowledge from a label-rich source domain to a label-scarce target domain. MethodsWe proposed a DSSDA framework that integrated Minimax Entropy and Domain Invariance (DSSDA-MMEDI) to reduce inter-domain gaps and thus achieve domain invariance. The networks were developed using GoogLeNet to extract features from CTG signals, with fully connected, softmax layers for classification. We designed a Dynamic Gradient-driven strategy based on Mutual Information (DGMI) to unify the losses from Minimax Entropy (MME), Domain Invariance (DI), and supervised cross-entropy during iterative learning. ResultsWe validated our DSSDA model on two datasets collected from collaborating healthcare institutions and mobile terminals as the source and target domains, which contained 16,355 and 3,351 CTG signals, respectively. Compared to the results achieved with deep learning networks without DSSDA, DSSDA-MMEDI significantly improved sensitivity and F1-score by over 6%. DSSDA-MMEDI also outperformed other state-of-the-art DSSDA approaches for CTG signal interpretation. Ablation studies were performed to determine the unique contribution of each component in our DSSDA mechanism. ConclusionsThe proposed DSSDA-MMEDI is feasible and effective for alignment of cross-domain data and automated interpretation of multicentric antenatal CTG signals with minimal annotation cost.

GTLNLP: A Mathematical Exploration of Cross-Domain Knowledge Transfer for Text Generation for Generative Transfer Learning in Natural Language Processing

In the field of Cross-Domain Knowledge Transfer generative transfer learning in Natural Language Processing (NLP) used for creating text using generative math. The paper aims to improve the usefulness of text creation models in a variety of areas by using cutting edge deep learning and neural network methods. We come up with a new system that makes it easier for information to move from one domain to another, even when the language and situation are different in each domain. Using domain adaptation techniques to match feature distributions and reduce domain gaps is what our method is based on mathematically. It is a complex version of transfer learning principles. We test our model's abilities on a wide range of tasks by doing a lot of careful experiments. We focus on how well it can share information and write text that makes sense and is relevant to the situation across different areas. This study not only adds to our theoretical understanding of cross-domain knowledge transfer, but it also gives us useful tips on how to make NLP models more flexible and useful in the real world. The results of our study could help improve the state of the art in generative transfer learning and make text generation systems that work better and more reliably in a variety of language settings.

Graph Disentangled Contrastive Learning with Personalized Transfer for Cross-Domain Recommendation

Cross-Domain Recommendation (CDR) has been proven to effectively alleviate the data sparsity problem in Recommender System (RS). Recent CDR methods often disentangle user features into domain-invariant and domain-specific features for efficient cross-domain knowledge transfer. Despite showcasing robust performance, three crucial aspects remain unexplored for existing disentangled CDR approaches: i) The significance nuances of the interaction behaviors are ignored in generating disentangled features; ii) The user features are disentangled irrelevant to the individual items to be recommended; iii) The general knowledge transfer overlooks the user's personality when interacting with diverse items. To this end, we propose a Graph Disentangled Contrastive framework for CDR (GDCCDR) with personalized transfer by meta-networks. An adaptive parameter-free filter is proposed to gauge the significance of diverse interactions, thereby facilitating more refined disentangled representations. In sight of the success of Contrastive Learning (CL) in RS, we propose two CL-based constraints for item-aware disentanglement. Proximate CL ensures the coherence of domain-invariant features between domains, while eliminatory CL strives to disentangle features within each domains using mutual information between users and items. Finally, for domain-invariant features, we adopt meta-networks to achieve personalized transfer. Experimental results on four real-world datasets demonstrate the superiority of GDCCDR over state-of-the-art methods.

Active domain adaptation with mining diverse knowledge: An updated class consensus dictionary approach

Domain adaptation (DA) has recently emerged as an effective paradigm for training the target model with labeled source knowledge. When knowledge transfer in DA encounters the bottleneck, one effective crack way is to introduce the labeled data to guide the DA process. Along this line, many active learning-based DA approaches are emerging to improve the quality of samples selection at the decision border. However, these methods have not preserved and exploited cross-domain common knowledge. In this work, we propose active domain adaptation with mining diverse knowledge: an updated class consensus dictionary approach (UCCDA). Specifically, we firstly initialize the class consensus dictionary by the source prior knowledge. Then, we choose high-confident target pseudo samples through self-training, while assigning labels to those low-confident via oracle annotation. In addition, we design the class consensus dictionary to guide the alignment between the source and target domains, instead of traditional direct cross-domain data alignment. Remarkably, to prevent error accumulation during the consensus dictionary learning, we specially design the anti-forgetting mask matrix to randomly restore the original knowledge. Finally, abundant experiments demonstrate that UCCDA outperforms the related state-of-the-art approaches.

A Method for Inspiring Radical Innovative Design Based on Cross-Domain Knowledge Mining

The reasonable application of cross-domain knowledge tends to promote the generation of radical innovation. However, it is difficult to accurately capture the cross-domain knowledge needed for radical innovation. To solve this problem, this paper proposes a method for inspiring radical innovative design based on FOS and technological distance measurement. First, the functional analysis of the problem product is carried out to determine the target function. Second, the patent sets of problem domain and target domains are constructed based on FOS. Then, this study optimizes the method of technological distance measurement and uses it to determine the optimal target domain. After further categorizing and screening the patents contained in the optimal target domain, specific cross-domain knowledge is pushed to designers. This method can help firms select the most appropriate cross-domain knowledge to design solutions for different problems, thus increasing the possibility of generating radical innovation. In the end, the method is validated in the design of a stovetop cleaning device.

Dual-Teacher Feature Distillation: A Transfer Learning Method for Insomniac PSG Staging.

Insomnia is the most common sleep disorder linked with adverse long-term medical and psychiatric outcomes. Automatic sleep staging plays a crucial role in aiding doctors to diagnose insomnia disorder. Only a few studies have been conducted to develop automatic sleep staging methods for insomniacs, and most of them have utilized transfer learning methods, which involve pre-training models on healthy individuals and then fine-tuning them on insomniacs. Unfortunately, significant differences in feature distribution between the two subject groups impede the transfer performance, highlighting the need to effectively integrate the features of healthy subjects and insomniacs. In this paper, we propose a dual-teacher cross-domain knowledge transfer method based on the feature-based knowledge distillation to improve the performance of sleep staging for insomniacs. Specifically, the insomnia teacher directly learns from insomniacs and feeds the corresponding domain-specific features into the student network, while the health domain teacher guide the student network to learn domain-generic features. During the training process, we adopt the OFD (Overhaul of Feature Distillation) method to build the health domain teacher. We conducted the experiments to validate the proposed method, using the Sleep-EDF database as the source domain and the CAP-Database as the target domain. The results demonstrate that our method surpasses advanced techniques, achieving an average sleep staging accuracy of 80.56% on the CAP-Database. Furthermore, our method exhibits promising performance on the private dataset.

Privacy-preserving Multi-source Cross-domain Recommendation Based on Knowledge Graph

The cross-domain recommender systems aim to alleviate the data sparsity problem in the target domain by transferring knowledge from the auxiliary domain. However, existing works ignore the fact that the data sparsity problem may also exist in the single auxiliary domain, and sharing user behavior data is restricted by the privacy policy. In addition, their cross-domain models lack interpretability. To address these concerns, we propose a novel multi-source cross-domain model based on knowledge graph. Specifically, to avoid the insufficiency of single auxiliary domain, we construct a knowledge graph comprehensively leveraging items from multiple auxiliary domains. To avoid the leakage of user privacy when user information is transferred to multiple domains, we construct graph for information transfer between items to effectively avoid the propagation of users’ private information between different domains. We implicitly integrate the user–item interaction by transferring the learned item embeddings. To improve the interpretability of cross-domain knowledge transfer, we propose a knowledge graph-based retrieval and fusion method to transfer knowledge derived from multiple auxiliary domains. An attention-based fusion network is designed to enhance the representation of the targeted user and items with the transferred item embedding. We perform extensive experiments on three real-world datasets, demonstrating that our model outperforms the states of the art.

Knowledge Graph-Based Reinforcement Federated Learning for Chinese Question and Answering

Knowledge question and answering (Q&A) is widely used. However, most existing semantic parsing methods in Q&A usually use cascading, which can incur error accumulation. In addition, using only one institution’s Q&A data definitely will limit the Q&A performance, while data privacy prevents sharing between institutions. This article proposes a knowledge graph-based reinforcement federated learning (KGRFL)-based Q&A approach to address these challenges. We design an end-to-end multitask semantic parsing model MSP-bidirectional and auto-regressive transformers (BART) that identifies question categories while converting questions into SPARQL statements to improve semantic parsing. Meanwhile, a reinforcement learning (RL)-based model fusion strategy is proposed to improve the effectiveness of federated learning, which enables multi-institution joint modeling and data privacy protection using cross-domain knowledge. In particular, it also reduces the negative impact of low-quality clients on the global model. Furthermore, a prompt learning-based entity disambiguation method is proposed to address the semantic ambiguity problem because of joint modeling. The experiments show that the proposed method performs well on different datasets. The Q&A results of the proposed approach outperform the approach of using only a single institution. Experiments also demonstrate that the proposed approach is resilient to security attacks, which is required for real applications.

Cross-domain Recommendation via Dual Adversarial Adaptation

Data scarcity is a perpetual challenge of recommendation systems, and researchers have proposed a variety of cross-domain recommendation methods to alleviate the problem of data scarcity in target domains. However, in many real-world cross-domain recommendation systems, the source domain and the target domain are sampled from different data distributions, which obstructs the cross-domain knowledge transfer. In this article, we propose to specifically align the data distributions between the source domain and the target domain to alleviate imbalanced sample distribution and thus challenge the data scarcity issue in the target domain. Technically, our proposed approach builds a dual adversarial adaptation (DAA) framework to adversarially train the target model together with a pre-trained source model. Two domain discriminators play the two-player minmax game with the target model and guide the target model to learn reliable domain-invariant features that can be transferred across domains. At the same time, the target model is calibrated to learn domain-specific information of the target domain. In addition, we formulate our approach as a plug-and-play module to boost existing recommendation systems. We apply the proposed method to address the issues of insufficient data and imbalanced sample distribution in real-world Click-through Rate/Conversion Rate predictions on two large-scale industrial datasets. We evaluate the proposed method in scenarios with and without overlapping users/items, and extensive experiments verify that the proposed method is able to significantly improve the prediction performance on the target domain. For instance, our method can boost PLE with a performance improvement of 15.4% in terms of Area Under Curve compared with single-domain PLE on our private game dataset. In addition, our method is able to surpass single-domain MMoE by 6.85% on the public datasets. Code: https://github.com/TL-UESTC/DAA .

Prompt-driven Latent Domain Generalization for Medical Image Classification.

Deep learning models for medical image analysis easily suffer from distribution shifts caused by dataset artifact bias, camera variations, differences in the imaging station, etc., leading to unreliable diagnoses in real-world clinical settings. Domain generalization (DG) methods, which aim to train models on multiple domains to perform well on unseen domains, offer a promising direction to solve the problem. However, existing DG methods assume domain labels of each image are available and accurate, which is typically feasible for only a limited number of medical datasets. To address these challenges, we propose a unified DG framework for medical image classification without relying on domain labels, called Prompt-driven Latent Domain Generalization (PLDG). PLDG consists of unsupervised domain discovery and prompt learning. This framework first discovers pseudo domain labels by clustering the bias-associated style features, then leverages collaborative domain prompts to guide a Vision Transformer to learn knowledge from discovered diverse domains. To facilitate cross-domain knowledge learning between different prompts, we introduce a domain prompt generator that enables knowledge sharing between domain prompts and a shared prompt. A domain mixup strategy is additionally employed for more flexible decision margins and mitigates the risk of incorrect domain assignments. Extensive experiments on three medical image classification tasks and one debiasing task demonstrate that our method can achieve comparable or even superior performance than conventional DG algorithms without relying on domain labels. Our code is publicly available at https://github.com/SiyuanYan1/PLDG/tree/main.

Cross-Domain Mutual-Assistance Learning Framework for Fully Automated Diagnosis of Primary Tumor in Nasopharyngeal Carcinoma.

Accurate T-staging of nasopharyngeal carcinoma (NPC) holds paramount importance in guiding treatment decisions and prognosticating outcomes for distinct risk groups. Regrettably, the landscape of deep learning-based techniques for T-staging in NPC remains sparse, and existing methodologies often exhibit suboptimal performance due to their neglect of crucial domain-specific knowledge pertinent to primary tumor diagnosis. To address these issues, we propose a new cross-domain mutual-assistance learning framework for fully automated diagnosis of primary tumor using H&N MR images. Specifically, we tackle primary tumor diagnosis task with the convolutional neural network consisting of a 3D cross-domain knowledge perception network (CKP net) for excavated cross-domain-invariant features emphasizing tumor intensity variations and internal tumor heterogeneity, and a multi-domain mutual-information sharing fusion network (M2SF net), comprising a dual-pathway domain-specific representation module and a mutual information fusion module, for intelligently gauging and amalgamating multi-domain, multi-scale T-stage diagnosis-oriented features. The proposed 3D cross-domain mutual-assistance learning framework not only embraces task-specific multi-domain diagnostic knowledge but also automates the entire process of primary tumor diagnosis. We evaluate our model on an internal and an external MR images dataset in a three-fold cross-validation paradigm. Exhaustive experimental results demonstrate that our method outperforms the state-of-the-art algorithms, and obtains promising performance for tumor segmentation and T-staging. These findings underscore its potential for clinical application, offering valuable assistance to clinicians in treatment decision-making and prognostication for various risk groups.