Deterrence as a concept is deeply rooted in human nature and for a considerable time it was contested and jilted, yet it resurfaced in one way or the other. Nuclear weapons became the backbone of the concept of Deterrence. Due to the inherent dynamism of Revolution in Military Affairs, the supremacy of Nuclear is being challenged with the advent of the latest technologies which are acting as enablers and disruptors. The concept of Cross DomainDeterrence emerged a decade ago, took shape, and entered the strategic lexicon. It has enablers and drivers, while a gradual shift in this direction is visible. While remaining within the ambit of complex interdependence theory given by Robert O Keohane and Joseph S Nye. This article examines the applicability of Cross-Domain Deterrence in the Asia Pacific and Indian Ocean Region focusing on the US, China, India, and Pak to identify the need to look beyond the horizon and embrace the change.