SUMMARY The Alps are the focus of a wide-ranging discussion. Researchers, scientists, politicians, inhabitants, and people who earn their living in the Alpine region are all confronted with difficult challenges. The main topics are the development in the fields of nature, landscape, tourism and leisure, traffic and transport, and its consequences for the Alps as a living space and economic area. About 30 years ago, a cooperation of tourism and political authorities in 11 countries, regions, provinces, and cantons of Switzerland, Germany, Italy, and Austria has been established. Due to globalization and changing traveling patterns, people have become more and more aware that a new international cooperation of the Alpine tourism regions in the field of destination management and marketing is required. This is necessary in order to react to market changes accordingly. This acknowledgment is instead of small and more or less independent and self-sufficient organizations. It also includes the collaboration concerning one of the most important resources of our time-knowledge-and the establishment of a network where it can be consciously managed. The following paper shows the special qualities of networks, especially knowledge networks at the example of AlpNet. It consists of three parts. The first part deals with the change of Alpine tourism management and marketing, the second part discusses the necessities and challenges of a cross-border cooperation in tourism marketing with a special focus on networks and knowledge networks, and the third part presents the results of an empirical study explaining the problems and perspectives for developing knowledge networks of cross-border destination management in the Alpine region. As far as management and marketing of tourism destinations are concerned, it is shown what possibilities-yet what limits-may result in launching cross-border cooperation projects in the future. For decades cross-border cooperation was used for compensating existing competitive disadvantages on tourism markets. The example of the new project AlpNet shows how important cooperation and member-specific requirements are for tourism and other economic industries when it comes to the establishment of knowledge networks.