CONTEXTUrban expansion(UE) and multiple cropping(MC) are key factors in anthropogenic impacts on global environmental change. However, the multi-scale response patterns of UE and MC have not yet been revealed, and how urbanization affects cropland intensification is still not deeply explored. OBJECTIVEThis study examines the spatial and temporal trends in global UE and MC and analyses the multi-scale response patterns of both. METHODSThe GEE (Google Earth Engine) platform was used to count global cropland cropping intensity (CCI) and impervious surface rasters on an image-by-image basis, while GIS was employed for spatial analyses, and the generalized additive model (GAM) was applied to inscribe variable response trajectories. RESULTS AND CONCLUSIONThe global multiple cropping index(MCI) increased significantly (by 4.1 %) over the period 2001–2019, with growth in double- and triple-cropped cropland dominating this change. Double cropping, as a widespread global farming strategy, has led to a shift towards the intensification of agriculture, with countries in the northern hemisphere contributing more. Global UE significantly expands to twice the baseline level at an average annual growth rate of 2. 42 × 104 km2 over the period 2001–2019, with the expansion of world-class urban agglomerations in China, the United States and Europe dominates this trend. The spatial clustering of MC and UE has continued to intensify, with high-intensity cropping strategies progressively clustering towards areas of significant UE, and this tendency has a clear decreasing urban-rural gradient effect. The global CCI grows significantly and non-linearly with UE, but an important inflection point in the growth trajectory has occurred under the influence of threshold effects. Developed countries tend to be more flexible in their cropping intensity strategies as they move forward with urbanization. There is a clear increasing effect of the urban-rural gradient in the degree of non-linearity in the response of urbanization and cropping intensity. SIGNIFICANCEThe results of the study contribute to the understanding of the complex spatial and temporal coupling mechanisms between UE and MC, and provide useful insights for the development of trade-offs between urbanization and maturity strategies.