Climate change in recent times have presented a scenario of elevated susceptibility of wheat to rising temperatures. Agro-meteorological indices can present a scenario of variable response of wheat to diverse conditions. A field investigation was conducted in rabi season of 2016-17 at Research farm, Department of Agronomy, CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur to evaluate the influence of sowing dates and wheat cultivars on agro-meteorological indices such as growing degree days, photothermal units, Helio thermal units and phenothermal index of wheat crop. The field investigation involved five sowing dates (15th October, 30th October, 15th November, 30th November and 15th December) and wheat cultivars (HPW-349 and HPW-155) which were studied in a factorial randomized block design with three replications. The results of the investigation revealed that timely sown crop i.e., on 15th October recorded the highest values for agro-meteorological indices for both the wheat cultivars such as growing degree days, Helio thermal units, photothermal units and phenothermal index across various wheat development stages such as complete emergence, crown root initiation, tillering, ear emergence and physiological maturity. Therefore, timely sowing of wheat by 15th October was concluded to be the best for optimized agro-meteorological indices such as growing degree days, photothermal units, Helio thermal units and phenothermal index under conditions of North-Western Himalayas.