Critical infrastructure networks, such as transportation and supply chains, are becoming increasingly interdependent. As the operability of network nodes relies on the operability of connected nodes, network disruptions have the potential to spread across entire networks, having catastrophic consequences in the realms of physical network performance and also economic performance. While risk-informed physical network models and economic models have been well-studied in the literature, there is limited study of how physical features of network performance interact with sector-specific economic performance, particularly as these physical networks recover from disruptions of varying durations. In this article, we create a generalizable framework for integrating Functional Dependency Network Analysis (FDNA) and Dynamic Inoperability Input-Output Models (DIIM), to assess the extent to which disruptions to critical infrastructure could degrade its functionality over a period of time. We demonstrate the framework using disruptive scenarios for a critical transportation network in Virginia, USA. We consider scenarios involving: (a) mild case that is relatively more frequent such as recurring traffic conditions; (b) moderate case involving an incident with a multihour delay, and (c) severe case that is relatively less frequent such as evacuation after a major hurricane. The results will be useful for network managers, policymakers, and stakeholders who are seeking to invest in risk mitigation for network functionality and economic activity.