A multisubstructure-based method for assessing the deformation and stress of a fine-meshed model according to a coarse model was proposed. Integrating boundary conditions in a local fine-meshed model, a displacement mapping matrix from the coarse model to the fine-meshed model was constructed. The method was verified by a three-level panel in a fluid–structure interaction (FSI) framework by integrating the steady vortex lattice method (VLM). A comparison between the inner deformation distribution of the coarse model and that of the global fine-meshed model obtained from MSC.Nastran was carried out, and the results showed that the coarse model failed to demonstrate reliable strains and stresses. In contrast, the proposed method in this paper can effectively depict the inner deformation and critical stress distribution. The deformation error was lower than 8%, meeting engineering requirements. Moreover, the results of different working conditions can achieve a similar relative error of displacement for an identical position. The easy storage of the displacement mapping matrix and the convenience of the boundary information transformation among all substructure levels are prominent aspects. As a result, there is a solid foundation for addressing the time-dependent problem in spite of the simultaneity and region.