Critical Developmental Period Research Articles

Early-Life Sodium Restriction Programs Autonomic Dysfunction and Salt- Sensitivity in Male C57BL/6J Mice.

Preterm birth increases the risk of cardiometabolic disease in adulthood. Infants born during the second trimester of pregnancy, a critical period of hypothalamic development, are at risk of sodium (Na) depletion due to renal immaturity and large urine Na losses. We previously demonstrated in male mice that Na restriction during the equivalent mouse hypothalamic development period (PD21-PD42) programs long-term changes in energy balance via increased thermogenic sympathetic nervous activity. We therefore hypothesized that early-life Na restriction programs changes in cardiovascular control via altered autonomic activity. C57BL/6J male mice were supplied a low (0.04%) Na or supplemented (0.30%) Na diet from PD21-PD42, before return to standard (0.15%) Na diet. Hemodynamic and autonomic functions were assessed by radiotelemetry and acute administration of autonomic antagonists before and after all animals were switched to a high Na diet (HSD; 1% Na) at 12 weeks of age. Mice were additionally treated with the angiotensin II type 1 receptor (AT1R) antagonist, losartan, for two weeks. On standard diet, early-life Na restriction resulted in small but significantly different hemodynamic responses to autonomic blockers without effect on systolic blood pressure (SBP) or heart rate (HR). HSD increased SBP in 0.04% but not 0.30% Na mice, accompanied by increased cardiac sympathetic activity. Losartan had a greater BP lowering effect in early life Na-restricted mice. Our findings suggest Na restriction during a critical hypothalamic developmental period programs long-term changes in autonomic control of cardiovascular functions and may offer insight into the increased risk of cardiovascular disease in former preterm infants.

Maternal Characteristics and Iron Intake as a Factors of Iron Deficiency Anemia among Pregnant Women

Pregnancy is a critical period for fetal growth and development, nutritional issues can significantly affect both maternal and fetal health. This phase is marked by increased nutritional needs to support fetal development and maintain maternal well-being. This study investigates the prevalence and risk factors of iron deficiency anemia among pregnant women in Parung Panjang District Health Center, Indonesia. A cross-sectional study was conducted on 92 pregnant women, examining various maternal characteristics and nutrient adequacy levels. The prevalence of anemia was found to be 36%. Parity emerged as a significant factor, with primipara mothers showing a higher anemia rate (46%) compared to multipara mothers (23.8%). Iron intake adequacy was also significantly associated with anemia status (p = 0.050). Women with insufficient iron intake had a higher rate of anemia (45.7%) compared to those with sufficient intake (26.1%). Other factors such as maternal age, education, and vitamin C intake did not show significant associations with anemia. These findings highlight the importance of targeted interventions for primipara mothers and emphasize the crucial role of adequate iron intake during pregnancy. The study underscores the need for comprehensive anemia prevention strategies in prenatal care.

The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.

Oxytocin research is rapidly evolving and increasingly reveals that epigenetic modifications to the oxytocin receptor gene (OXTR) are functional, plastic, and reliable components of oxytocinergic system function. This review outlines how OXTR epigenetics are shaped by the early life environment, impact social-developmental outcomes, and have strong potential to serve as therapeutic targets. We first establish the malleability of OXTR epigenetics in infancy in both animal models and humans through research demonstrating the impact of the early life environment on OXTR DNA methylation (OXTRm) and subsequent social behavior. Next, we detail how OXTRm serves as a predictive mechanism for neurodevelopmental outcomes in animal models of social behavior such as the prairie vole, and summarize the role of OXTRm in psychiatric disorders, emotional processing, and attachment behavior in humans. We discuss the potential of further OXTRm research to improve oxytocin therapeutics by highlighting how a deeper knowledge of OXTRm could improve the therapeutic potential of exogenous oxytocin, how OXTRm may impact additional cellular mechanisms with therapeutic potential including control of the perinatal GABA switch, and how early life therapies may target the tuning of endogenous OXTRm. Finally, we review limitations of previous oxytocin research and make recommendations for future research. IMPACT: Previous research into oxytocin therapeutics has been hampered by methodological difficulties that may be improved by assay of the oxytocin receptor gene (OXTR) and its methylation (OXTRm) Key sites of OXTRm modification link early life exposures to developmental and behavioral outcomes OXTRm appears to have a critical period of development in early life Epigenetic modification of the oxytocin receptor gene could serve as a powerful target for therapeutic interventions.

Prenatal chemical exposures and the methylome: current evidence and opportunities for environmental epigenetics.

Exposure to pollutants and chemicals during critical developmental periods in early life can impact health and disease risk across the life course. Research in environmental epigenetics has provided increasing evidence that prenatal exposures affect epigenetic markers, particularly DNA methylation. In this article, we discuss the role of DNA methylation in early life programming and review evidence linking the intrauterine environment to epigenetic modifications, with a focus on exposure to tobacco smoke, metals, and endocrine-disrupting chemicals. We also discuss challenges and novel approaches in environmental epigenetic research and explore the potential of epigenetic biomarkers in studies of pediatric populations as indicators of exposure and disease risk. Overall, we aim to highlight how advancements in environmental epigenetics may transform our understanding of early-life exposures and inform new approaches for supporting long-term health.

Physical Fitness and Self-Perception in Adolescents: A Public Health Perspective

Adolescence is a critical period for physical and psychological development. The relationship between physical fitness and self-perception, particularly in the context of adolescents, has garnered significant attention due to its implications for long-term health outcomes. This article explores the intersection of physical fitness and self-perception in adolescents, emphasizing the role of physical activity in shaping self- esteem, body image, and mental health. From a public health perspective, promoting physical fitness in this age group can contribute not only to improved physical health but also to better psychological well-being. The article discusses interventions, policy initiatives, and practical recommendations to support adolescents in developing positive physical fitness habits and fostering healthy self-perception.

Abstract 4117594: Fetal Synthetic Glucocorticoid (sGC) Exposure Results in Later Life Cardiac Dysfunction and Ventricular Remodeling in Male Baboon Offspring

The “theory of developmental origins of health and disease” posits that stress in critical developmental periods will program life-course health and may affect cardiovascular (CV) health. Mothers at risk for premature delivery receive synthetic glucocorticoids (sGC) to enhance fetal lung maturation and manage fetal respiratory distress, but sGC exposure is linked to long-term CV dysfunction in offspring. Four groups of male baboons were studied: sGC exposed in utero at middle age (sGC-MA, 13.8±0.2Y), older sGC exposed in utero (sGC-O, 17.1±0.4Y), middle age unexposed (CTR-MA, 13.5±0.6Y), and older, unexposed baboons (CTR-O, 17.4±0.4Y). Gated, breath-hold, cine cardiac magnetic resonance imaging was performed at 3 Tesla (Siemens TIM Trio) to assess left ventricular (LV) function and myocardial strain, analyzed using cvi42® software. Mitochondrial electron transport chain (ETC) complex activity was analyzed using LV tissue from sGC-O and CTR-O euthanized baboons. Protein quantification was used to measure mitochondrial function and RNA-seq assessed differential gene expression and gene ontology (GO) enrichment. Unpaired t-tests were used. Data are reported as mean ± SD. Stroke volume and ejection fraction were similar in the elderly groups (4 sGC-O, 8 CTR-O). However, higher end-systolic and end-diastolic sphericity indexes (SI) and shorter LV axis lengths indicated remodeling. Also, global longitudinal and radial strains were reduced (both p<0.04) in sGC-O vs. CTR-O. Reduced LV cardiac output (p=0.005) was found in 5 sGC-MA animals vs 4 sGC-O animals, but not in 5 CTR-MA vs 8 CTR-O. In sGC-MA vs sGC-O, but not CTR-MA vs CTR-O, significant increases in SI (p=0.001), radial strain (p=0.02), and longitudinal (p=0.03) strain were found, but LV axis length (p=0.03) was reduced. LV mitochondrial analysis in 4 sGC-O vs 4 CTR-O myocardial samples revealed 33.5% less ETC activity (p=0.002) and 19.8% less complex I expression (p=0.048) in sGC. LV RNA-seq identified 63 upregulated and 20 downregulated genes in the sGC-O samples. GO pathway enrichment included changes in heart contraction, wounding responses, and leukocyte regulation pathways. These findings indicate that fetal sGC exposure developmentally programs offspring with LV remodeling and long-term cardiac and gene expression changes in male baboons, the closest available experimental nonhuman primate species to man. Future studies on females will probe sexual dimorphism in developmental programming.

Abstract 4141472: Birthweight is Associated with Left Ventricular Mass Index in Childhood

Introduction/Background: Increased left ventricular mass (LVM) is a risk factor for adult CV disease and is associated with cardiac development in utero. Associations of birthweight with LVM have been demonstrated in young children and adolescence, however, the association between birth weight and LVM in mid-childhood is not well described. Research Questions/Hypothesis: Utilizing an existing longitudinal data set of healthy children, we aimed to determine the association of birthweight to increased LVM at 6-8 years of age. Methods/Approach: A longitudinal cohort of 372 term-born children was enrolled at age 3 and followed until age 6-8 years. Anthropometrics, echocardiography, and maternal recall of birth weight were collected. LVM from echocardiography was indexed to height 2.7 . Multiple linear regression analysis was performed to assess the association of birthweight with LVM index at 6-8 years of age, adjusting for race, sex, body mass index (BMI) z-score, and systolic blood pressure (SBP) percentile collected at the time of echocardiography. Results: 303 children were included in the analysis (21.5% Black and 88.5% White, mean age 7.4 ± 0.3 years at the time of echocardiography, mean birthweight 3.4 ± 0.6 kg, mean SBP percentile 42.7 ± 21.6 percentile). Greater birthweight significantly contributed to greater LVM index (1.2 ± 0.6, p = 0.03), along with Black race (1.9 ± 0.8, p = 0.02) and greater current BMI z-score (2.1 ± 0.3, p < 0.01). Sex and SBP percentile were included in the model but were not significantly related to LVM index (p = 0.23 and 0.51 respectively) in this analysis. Conclusions: Greater birthweight is significantly associated with greater left ventricular mass in childhood, independent of BMI z-score at the time of echocardiography. This suggests a critical period in fetal cardiac development that affects cardiac structure in mid-childhood.

Adolescent mental time travel predicting meaning in life: The potential mediating role of self-continuity.

Knowing who we are and what we are living for helps us to better adjust in everyday life and confront negative life events, especially for adolescents who are going through critical developmental periods when changes in life could bring both psychopathology risk yet opportunity to achieve a better self. The current study focused on mental time travel, the mental visit to the past or future, and examined the impact on adolescents' perceived meaning in life, with the potential mediating factor of self-continuity. A total of 1543 high school students aged 12 to 18 years old (Mage = 15.02, SDage = 1.58, 52% girls) from Jiangsu Province, China were recruited in a two-wave longitudinal survey that separated by an interval of 6 months. Participants reported their proneness to engage in nostalgia or future prospection at T1 and sense of self-continuity at T2, while the perceived meaning in life were reported at both time points. The latent structural equation models were established with items as indicators for all study variables. Mental time travel, including both nostalgia and future prospection, facilitated adolescent meaning in life via increased self-continuity, except that future prospection showed only positive indirect effect, while nostalgia demonstrated direct yet negative impact on meaning in life after accounting for the positive mediation effect. Findings highlighted the distinct effects of the past- and future-oriented mental time travel on adolescent meaning in life, and provided insights for promoting adolescent psychological adjustment.

Adolescent Sleep Quality as Critical Component of Healthy Lifestyle

Background and purpose Adolescence is a critical period for physical, emotional, and cognitive development. High-quality sleep during this phase is essential for healthy growth, emotional well-being, optimal weight, and learning. These factors significantly influence the academic achievements of young people. Purpose: to develop and experimentally justify the methodology of training basketball teams of humanitarian higher educational institutions, taking into account the psychophysiological capabilities of the players. Material and methods The sample consisted of 626 secondary vocational school students aged 17 years from the Central Slovakia region (353 girls and 273 boys). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). The questionnaires were distributed electronically via Google Forms from October 2023 to March 2024. The results were analyzed with an emphasis on gender differences using the chi-square test (χ2), F-test, and independent t-test at significance levels of p<0.01 and p<0.05, respectively. Results The majority of students, both boys and girls, fell asleep between 11:00 PM and midnight. The average bedtime was 10:54 PM for girls and 10:50 PM for boys, with no significant differences between genders. Significant differences were found in wake-up times, with nearly 40% of girls waking up before 6:00 AM, compared to only 24% of boys (p<0.01). Boys experienced fewer difficulties falling asleep, with 21% falling asleep within 15 minutes (p<0.05). The average sleep duration was 6 hours and 28 minutes for girls and 6 hours and 55 minutes for boys, a statistically significant difference (p<0.01). Sleep efficiency was higher in boys (84.25%) compared to girls (78.75%). Sleep problems, daytime dysfunction, and mood changes were more frequent among girls (p<0.01). Only 28.33% of girls and 39.19% of boys had good sleep quality (p<0.01), while 17.00% of girls and 4.40% of boys exhibited severe sleep disturbances Conclusions Our findings indicate significant gender differences in sleep habits and quality, consistent with existing literature. These results highlight the need for increased attention to sleep issues among adolescents and the implementation of preventive and intervention measures to improve sleep quality, which could have a positive impact on their overall health and well-being.

Naringin supplementation during pregnancy alters rat offspring’s brain redox system and mitochondrial function

Naringin supplementation is known to ameliorate oxidative stress in the central nervous system (CNS) and improve cognitive function in disease models using adult rodents. However, if this supplementation is applied during critical periods of development, would it still be beneficial? To address this question, we used pregnant Wistar rats that were supplemented daily with naringin (100 mg/kg) during gestation. After delivery, pups were euthanized on postnatal day (PND) 1, 7, and 21. The prefrontal cortex, hippocampus, striatum, and cerebellum were dissected for redox system and mitochondrial function evaluation. Our data demonstrated that naringin supplementation to pregnant rats during gestation differentially affected the brain structures analyzed, inducing a dysregulation in the redox homeostasis, mainly on PND1. Redox and mitochondrial alterations found in offspring’s cerebellum on PND1 were also observed on PND7, and persisted up to PND21, indicating a higher susceptibility of this structure to the effects triggered by maternal naringin supplementation. In contrast to what was observed in the cerebellum, we found a progressive decline in the number of alterations in the prefrontal cortex, hippocampus, and striatum from PND1 up to PND21, suggesting that these brain structures are not as susceptible as the cerebellum to the naringin’s effects. Thus, our findings demonstrate a possible negative programming effect triggered by maternal naringin supplementation during pregnancy in the offspring’s brain, especially in the cerebellum.

Maternal exercise opportunity before, during, and after pregnancy alters maternal care behavior and offspring development and survival, but has few effects on offspring physical activity or body composition.

Early-life experiences, especially during critical periods of development and growth, can have long-lasting effects on adult phenotypes. Parents are a crucial part of the offspring early-life environment, particularly in mammals (e.g., via pregnancy), and parental behaviors (e.g., maternal exercise) can modify the early-life environment experienced by offspring. Such changes might be beneficial or detrimental, depending on how they affect offspring development and growth or interact with other key parental behaviors (e.g., nursing). We used mice from a long-term artificial selection experiment for high voluntary wheel-running behavior to determine whether maternal exercise opportunity affected (1) maternal physical activity, (2) maternal care behavior, or (3) offspring physical activity and body composition. Eighty prospective dams (40 from 4 selectively bred High Runner [HR] lines and 40 from 4 non-selected Control [CON] lines) were housed with continuous wheel access starting two weeks prior to breeding and ending 10 days postpartum, after which dams were housed without wheels until offspring weaning (21 days postpartum). An additional 100 dams (50 HR, 50 CON) were housed without wheels. Prospective dams from HR lines ran more revolutions/day (mainly by running faster) than those from CON lines when individually housed and in the days leading up to, but not after, birth. During postpartum days 1-5, HR and CON dams with wheels tended to exhibit less maternal behavior than those without (PWheel = 0.0672). During post-partum days 6-10, HR dams with wheels continued to exhibit less maternal behavior than those without, whereas CON dams with wheels exhibited more than those without (PLinetype*Wheel = 0.0218). The proportion of dams giving birth did not differ among groups. However, CON dams with wheels were less likely to have litter death between birth and weaning than those without wheels, whereas the opposite was true for HR dams (PLinetype*Wheel = 0.0447). Both HR and CON dams with wheels had litters with a higher proportion of females at weaning than those without wheels (PWheel = 0.0129). Maternal wheel access had few statistically significant effects on offspring, but may have resulted in developmental delays (e.g., delayed eye opening and decreased lean mass at weaning and sexual maturity). Additionally, maternal wheel access and sex may have interacted to affect wheel-running distance (PSex*Wheel = 0.0683) and duration (PSex*Wheel = 0.0926); female offspring from dams with wheels ran fewer revolutions per day, by running fewer minutes per day, than from dams without wheels, whereas males ran more. However, maternal exercise had no statistically significant effects on offspring food consumption (mass-adjusted), home-cage activity, open-field behavior, the reproductive characteristics of offspring, their adult body composition, nor relative organ masses; nor did maternal wheel access have statistically significant effects on grand-offspring food consumption, body composition or voluntary exercise behavior. Overall, our results provide some support for maternal exercise opportunity altering maternal care behavior. Altered maternal care could explain the observed trends in offspring survival, development, and voluntary exercise behavior. However, these effects did not have apparent long-lasting impacts on offspring or grand-offspring body composition or reproductive characteristics.

Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.

Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN. Healthy adolescents (HC, n = 41) and adolescents with AN or atypical AN (atypAN, n = 76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice-related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice-related activation and psychological assessments among the patient group. Adolescents with AN or atypAN selected fewer high-fat foods than HC (t = -5.92, p < .001). Counter to predictions, there were no significant group differences in choice-related activation in the ROIs. Among individuals with AN or atypAN, choice-related neural activity in the anterior caudate was significantly negatively associated with high-fat food selections in the task (r = -.32, p = .024). In exploratory analyses, choice-related anterior caudate activation was positively associated with psychological measures of illness severity among patients (p's < .05, uncorrected). In this large cohort of adolescents with AN/atypAN, there was no evidence of altered reward system engagement during food choice. While there was no group difference in choice-related caudate activation, the associations with choices and psychological measures continue to suggest that this neural region is implicated in illness. Longitudinal analyses will clarify whether neural variability relates to longer-term course.

Family and Friends: Key Influences on Teenage Traits and Behaviors

The teenage years are a critical period of development, characterized by significant physical, emotional, and psychological changes. During this time, adolescents are particularly impressionable, with their traits and behaviors heavily shaped by the relationships they maintain. Among these relationships, the influences of family and friends are paramount, serving as the primary socializing agents that guide decision-making, value formation, and identity development. The study examines how family dynamics, including parental affection, communication, and behavioral control, influence adolescent development. The study also examines the influence of peer relationships, highlighting how friendships can reduce or exacerbate behavioral problems. By analyzing both direct and indirect effects, the study found that positive family interactions and supportive friendships are important for healthy adolescent development. Conversely, negative influences from any context can lead to increased risk-taking behavior and emotional challenges. The findings highlight the importance of fostering strong, positive relationships within both the family and peer groups to support adolescent development and well-being. The research is conducted by survey with 466 teenagers to find out the influence of family and friends on their adolescence development. The research aims to identify the roles that family and peers play during this crucial period and to provide recommendations for enhancing their positive impact on adolescents.

Research on the Impact of Social Media on Consumer Shopping Behavior:Based on Case Analysis of the Adolescent Population

Starting from the underlying logic of the impact of social media on consumers, this article focuses on analyzing the shopping habits of young consumers and the influence and shaping of social media on their consumption behavior. It analyzes the positive and negative effects of social media and puts forward relevant opinions and suggestions. Compared to the adult consumer group, the adolescent consumer group has not yet formed a relatively fixed consumption value system, and their consumption behavior is more susceptible to various external factors. Adolescents are in a critical period of character development and self-value establishment, so they will pay attention to social trends and seek the unique value of their own existence during this stage. Social media, as a fast channel for transmitting information, is also the main communication platform for adolescents. It provides a huge amount of information, including product purchasing channels, consumer evaluations, etc. These pieces of information constantly influence adolescents’ thoughts and subtly shape their shopping behavior. This article advocates for the correct guidance and shaping of the values of young people, exercising and cultivating their independent thinking ability, to enable them to have healthy and good consumption behavior.

Strategies for Enhancing Young Children's Scientific Inquiry Skills

In recent years, with the continuous advancement of educational reform, the importance of scientific education in early childhood has become increasingly evident. Early childhood is a critical period for cognitive development and interest cultivation. Through scientific inquiry activities, young children’s cognitive development, problem-solving abilities, and curiosity about the surrounding world can be effectively promoted. However, the implementation of early childhood scientific inquiry education still faces numerous challenges, such as a lack of systematic theoretical guidance and insufficient strategies for improvement. This study aims to enhance the existing theoretical foundations of young children's scientific inquiry abilities and proposes specific strategies for improvement to foster the comprehensive development of children's scientific literacy.

Trajectories of depressive symptoms in early to mid-adolescence: associations with school pedagogical and social climate.

Adolescence is a critical period for mental health development, yet research exploring how contextual factors influence the development of depressive symptoms remains limited. This study explored trajectories of depressive symptoms during early to mid-adolescence and their association with various aspects of school climate. The study sample comprised 3671, 7th-grade students (aged 12-13 years) from 101 schools across Sweden, followed longitudinally across three time points spanning grades 7, 8 and 9. Depressive symptom trajectories were identified using latent class growth modelling. The Pedagogical and Social Climate questionnaire assessed school climate, and multinomial logistic regression was employed to predict trajectory membership based on sociodemographic and school climate factors. Four distinct developmental patterns of depressive symptoms emerged: 'Sustained low symptoms' (76.7%), 'Low-increasing' (10.9%), 'Sustained high symptoms' (7.9%), and 'High-decreasing' (4.5%). Gender, parental education and six specific school climate factors, out of the total 19 examined, significantly distinguished these trajectory classes. Positive teacher expectations and strong principal involvement were associated with more favourable trajectories, whereas teaching activities, teacher support and communication between school and home were associated with less favourable trajectories, suggesting a nuanced understanding of their relationship with depressive symptom trajectories. Few school factors were found to be relevant to depressive symptoms, highlighting the importance of considering external factors beyond the school environment in supporting adolescents during this developmental stage. Although the findings are multifaceted, it is primarily positive interpersonal relationships, especially through teacher expectations, that stand out as significant factors in promoting youth mental health.

Associations of fetal and infant growth patterns with behavior and cognitive outcomes in early adolescence

AbstractBackgroundFetal life and infancy might be critical periods for brain development leading to increased risks of neurocognitive disorders and psychopathology later in life. We examined the associations of fetal and infant weight growth patterns and birth characteristics with behavior and cognitive outcomes at the age of 13 years.MethodsPopulation‐based prospective cohort study from fetal life until adolescence. Pregnant women with a delivery date between April 2002 and January 2006 were eligible. Follow‐up measurements were available for 4716 children. Fetal weight was estimated in the second and third trimesters of pregnancy by ultrasonography. Infant weight was measured at birth and at 6, 12, and 24 months. Fetal and infant weight acceleration or deceleration were defined as a change in SD greater than 0.67 between time points. Total, internalizing and externalizing problems and attention‐deficit hyperactivity disorder (ADHD) symptoms were measured using Child Behavior Checklist (CBCL/6–18), autistic traits by the Social Responsiveness Scale (SRS) and intelligence quotient (IQ) by the Wechsler Intelligence Scale for Children‐Fifth Edition (WISC‐V).ResultsOne week longer gestational age at birth was associated with a −0.03 SDS (95% Confidence Interval (CI): −0.04, −0.01) lower total behavior problems score, a −0.02 SDS (95% CI: −0.04, −0.01) lower ADHD symptoms score. Also an increase in birth weight of 500 g was associated with a lower odds of having high externalizing problems (OR 0.92 (95% CI: 0.86, 0.98) and of having a low IQ score (OR 0.79 (95% CI: 0.71, 0.88). Compared to children with normal fetal and infant growth, those with accelerated fetal and infant growth had a 0.27 SDS higher IQ (95% Confidence Interval 0.11, 0.44).ConclusionsBoth fetal and infant weight development are associated with behavioral and cognitive outcomes in early adolescence. Follow‐up studies are needed to assess whether these associations link to later life mental health outcomes.

The long-term intervention effect and persistence analysis of the baduanjin mental sub -health of college students

In recent years, with the rapid development of society and the increase in academic and living pressure of college students, the psychological sub-health problems of college students have become increasingly prominent. Psychological sub -health refers to the state of the state of health and disease, manifested as a diagnostic criteria for poor individual mental state but not reaching the diagnosis of mental illness. As a special group, college students are in a critical period of psychological and physiological development, and facing multiple pressures such as academics, employment, and social networking. Long -term psychological health state will not only affect its academic and life quality, but also may lead to serious psychological problems such as emotional disorders, anxiety, and depression. Therefore, how to effectively intervene and improve the mental sub -health status of college students have become an important issue for the current psychological health education of colleges and universities. The eight -segment brocade of traditional fitness exercises, as part of ancient Chinese qigong, has gradually been widely used in modern health management in recent years. Baduanjin helps individuals to achieve physical and mental balance by regulating physical movements, breathing and mentality, and have the potential to improve mental health. Existing studies have shown that Baduanjin has certain effects on psychological problems such as relieving stress, improving anxiety, and depression, but there are still fewer long -term intervention effects and continuity research on the healthy sub -healthy health of college students. Therefore, this study aims to discuss the long -term intervention effect and its continuity of the eight -stage brocade of the psychological sub -health of college students, and provide new theoretical support and practical basis for colleges and universities' mental health intervention. This study adopts a random control experimental design. The research object is the college student of the School of Huanghe Science and Technology college. It is included in the standard of the SCL-90 (Symptom Self-Evaluation Table). The research objects are divided into the experimental group and control group. The experimental group participated in the two month Baduanjin, 2 times a week, 60 minutes each time; the control group does not perform Baduanjin to maintain daily life. After the experiment, the SCL-90 symptoms of SCL-90 symptoms and CPSS pressure perception table were performed for the experimental group for 1 month and 2 months to evaluate the continuity of the intervention effect. At the end of the intervention, the psychological sub-health symptoms of the experimental group improved significantly, and the overall scores of the SCL-90 decreased significantly. Compared with the control group, the experimental group improved greater improvement in anxiety, depression, and pressure perception. Especially in terms of anxiety and depression, the improvement of the experimental group is particularly significant. In summary, this study provides a wealth of experimental data and theoretical basis for the long -term intervention effect and sustainability of the Baduanjin for the healthy sub -health of college students through random control experiments. The results of the research not only provide an effective means of intervention for colleges and universities, but also open up a new direction for the modern application of traditional fitness methods. In the future practice, Baduanjin is hoping to become an important means of psychological and health intervention in colleges and universities, and provide theoretical basis for college students' physical and mental health.

Pediatric Obesity Pharmacotherapy: State of the Science, Research Gaps, and Opportunities.

Pediatric obesity is a major public health problem, affecting nearly 20% of children and adolescents living in the United States. In 2023, the American Academy of Pediatrics released its first clinical practice guideline for the evaluation and management of child and adolescent obesity and recommended integrating health behavior and lifestyle interventions with pharmacological treatment when medically indicated. However, there is a limited evidence base to guide antiobesity medication treatment decisions in clinical practice and limited data on long-term safety during this critical period of growth and development in youth. Thus, in November of 2023, the National Institute of Diabetes and Digestive and Kidney Diseases sponsored a workshop to identify knowledge gaps and opportunities for research on the use of pharmacotherapy for obesity in children and adolescents. Leading scientific and clinical experts in obesity pathophysiology and treatment, pharmacotherapy, clinical trial design, and health equity and disparities, among others, identified gaps in clinical trial design, guidance for clinical use of medications in children and adolescents, additional treatment outcomes beyond body fat or weight, and improvement in care delivery. Adolescent patients and caregivers with lived experience of obesity and weight management were also invited to participate in a panel discussion, providing personal perspectives on living with obesity, clinical care considerations, and research needs. This article summarizes the workshop proceedings on the state of the science and identifies gaps and opportunities for future research to inform optimal and equitable medical management of children and adolescents with obesity.

Empirical Research on the Impact of Technological Innovation on New Energy Vehicle Sales

In the context of global carbon peak and carbon neutrality goals, researching the driving forces and influencing factors behind the growth in sales of new energy vehicles (NEVs) is particularly urgent and crucial. Although the academic community has extensively explored various factors affecting NEV sales, technological innovation, as the core engine driving industry progress, is yet to receive sufficient and in-depth exploration regarding its potential profound impact on sales. Therefore, this study thoroughly analyzes the mechanism by which technological innovation influences sales, supplementing the existing literature, exploring sustainable industry development, and guiding the optimization of business strategies and precise government policies. This research employs the quality of NEV technology patents as a proxy variable for technological innovation, and conducts an empirical analysis using China’s NEV sales data from 2015 to 2022. The results of the study show the following: (1) the quality of technological innovation significantly contributes to the growth of new energy vehicle sales. This conclusion still holds when the administrative protection of intellectual property rights and the government’s public innovation environment indicators are used as instrumental variables of technological innovation quality. (2) Technological innovations in different links of the new energy vehicle industry chain have a positive impact on sales, especially those in the midstream battery, motor, and downstream charging services. This shows that in the critical period of new energy vehicle development, not only is the breakthrough of key technologies crucial, but also, non-critical technologies can promote sales growth by improving user experience and product performance. (3) Compared with plug-in hybrid electric vehicles (PHEVs), the overall technological innovation of new energy vehicles (NEVs) has a more significant effect on the sales of battery electric vehicles (BEVs). (4) In addition, the study finds that there is no significant difference between high-quality and low-quality technological innovations on the promotion of new energy vehicle sales, which indicates that the market values the overall effect of technological innovations more than the mere level of quality. The study of the impact of technological innovation on sales in different branches of the new energy industry chain can help to clarify the direction of technological innovation, optimize resource allocation, promote the synergistic development of the industry chain, enhance market competitiveness, and provide a scientific basis for policy formulation.