Implications For Critical Care Research Articles

Chimeric antigen receptor T-cell therapy in adults: management of toxicities and implications for critical care

Chimeric antigen receptor (CAR) T-cell therapy is potentially life-changing in patients with haematological malignancies refractory to multiple lines of chemoimmunotherapy and stem cell transplantation. This adoptive cell immunotherapy involves harvesting and engineering patients' own T lymphocytes to express specific antitumour CARs, thereby directing them to target tumour cells. The CAR also has an intracellular, co-stimulatory domain causing in vivo CAR T-cell expansion and persistence. Chimeric antigen receptor T-cells destroy cancer cells but may also induce life-threatening, reversible toxicities that may require support from the critical care team.

Reversibility of total airway closure and alveolar consolidation in a COVID‐19 patient: A case study

Coronavirus disease 2019 (COVID‐19) may be complicated by life‐threatening pneumonia requiring tracheal intubation, mechanical ventilation and veno‐venous extracorporeal membrane oxygenation (vvECMO). It is not yet clear to what extent and after which delay the most severe cases of COVID‐19 pneumonia are reversible. Here, we present a 39‐year‐old patient who developed a severe COVID‐19‐attributed acute respiratory distress syndrome (ARDS) resulting in complete alveolar consolidation and airway closure for several weeks. His remarkable ventilatory pattern was established using ventilator airway pressure curve analysis and computed tomography imaging. The patient was managed with supportive care, mechanical ventilation and vvECMO. He received dexamethasone and tocilizumab as immunomodulatory drugs. Despite multiple complications, he recovered and was weaned from vvECMO, ventilator and oxygen on days 75, 95 and 99 post‐intubation, respectively. He was discharged from hospital on day 113. This case study strongly supports the remarkable potential for reversibility of ARDS in COVID‐19 patients and discusses the implications for critical care nursing regarding mechanical ventilation and ECMO device management in patients who may become entirely dependent on vvECMO for oxygenation and carbon dioxide elimination.

Anesthesiology in Times of Physical Disasters-Earthquakes and Typhoons.

Nepal and Hong Kong both are susceptible to natural disasters due to their geographic locations. Nepal suffers from frequent earthquakes, and Hong Kong regularly experiences typhoons of varying severity. Natural disasters may present acutely or with some advance warning. In either case, it is critical that disaster response plans are well established in advance of any incident. This article discusses the anesthetic and critical care implications of such natural disasters, using Nepal and Hong Kong as case studies.

Continuous Lactate Measurement Devices and Implications for Critical Care: A Literature Review.

The aim of this article is to review the literature on lactate measurements in critical care and the current devices used to measure noninvasively and invasively. Lactate measurements are currently being used as a way to measure the severity of sepsis. Intravascular and subcutaneous devices are some of the ways that these measurements can be continuously gathered as well as point-of-care blood tests. New devices that are being currently used with athletes can measure lactate noninvasively. As the advance of technology continues to move at a fast speed, an evaluation of literature is needed to assess the continued support of lactate and the ability to move to noninvasive devices in critical care. A literature search was conducted in February 2020, using PubMed, CINAHL, MEDLINE, and Cochrane databases. There remains support for the use of lactate and continuous lactate monitoring; however, currently, noninvasive devices are not available for the critical care environment. There are invasive techniques that are being used to measure lactate continuously in critical care and are beneficial for the cardiac surgery population. The review of the literature on continuous lactate measurements produced evidence that supports prediction of morbidity and mortality. There are no current noninvasive lactate measurement devices that can be used in critical care, but they are being currently used in the athletic community. Invasive continuous lactate measurement devices are currently being used and beneficial.

COVID-19: legal implications for critical care.

SummaryThe COVID‐19 pandemic has caused an unprecedented challenge for the provision of critical care. Anticipating an unsustainable burden on the health service, the UK Government introduced numerous legislative measures culminating in the Coronavirus Act, which interfere with existing legislation and rights. However, the existing standards and legal frameworks relevant to critical care clinicians are not extinguished, but anticipated to adapt to a new context. This new context influences the standard of care that can be reasonably provided and yields many human rights considerations, for example, in the use of restraints, or the restrictions placed on patients and visitors under the Infection Prevention and Control guidance. The changing landscape has also highlighted previously unrecognised legal dilemmas. The perceived difficulties in the provision of personal protective equipment for employees pose a legal risk for Trusts and a regulatory risk for clinicians. The spectre of rationing critical care poses a number of legal issues. Notably, the flux between clinical decisions based on best interests towards decisions explicitly based on resource considerations should be underpinned by an authoritative public policy decision to preserve legitimacy and lawfulness. Such a policy should be medically coherent, legally robust and ethically justified. The current crisis poses numerous challenges for clinicians aspiring to remain faithful to medicolegal and human rights principles developed over many decades, especially when such principles could easily be dismissed. However, it is exactly at such times that these principles are needed the most and clinicians play a disproportionate role in safeguarding them for the most vulnerable.

Critical Care Implications of Adrenal Disease States

Adrenal disease in the critically ill patient can present many challenges for the intensivist. Besides primary, secondary, and tertiary adrenal insufficiency, a state known as critical care–related corticosteroid insufficiency (CIRCI) has been described. Adrenal insufficiency can pose many issues to the critically ill patient as it can decrease the patient’s ability to respond to the stress that critical illness presents to the human body. Proper recognition and diagnosis of adrenal insufficiency in the critically ill patient can be extremely important in the treatment of these patients and could be a lifesaving intervention if CIRCI is discovered. A less commonly encountered issue of adrenal disease lies in the area of adrenal hormone excess caused by a pheochromocytoma or extra-adrenal paragangliomas. These tumors can release large amounts of endogenous catecholamines that cause significant patient morbidity and mortality if not recognized early and treated appropriately. Although adrenal insufficiency and adrenal excess are less commonly encountered problems in critically ill patients, the recognition and treatment of these disease states can prevent the morbidity and mortality of critically ill patients that suffer from these disease states. This review contains 5 figures, 5 tables, and 89 references. Key words: adrenal insufficiency, hypothalamic-pituitary axis, critical illness–related corticosteroid insufficiency, pheochromocytoma, steroid replacement therapy

Long-term effects of opioids on the cardiovascular system

Long-term effects of opioids on the cardiovascular system

Genomics and Precision Medicine: Implications for Critical Care.

A new paradigm for disease diagnosis and treatment is emerging that will bring about changes in health care delivery in and out of the hospital setting. Over the past several decades, genomic medicine has been one of the fastest growing fields in acute and chronic health care. This quick growth has created a lag in genomics knowledge and preparation among nurses and health care providers. Genomic medicine may lead to more precise evaluation, diagnosis, and management of selected acute care conditions. This article reviews the current state of genetic and genomics science and looks at the expanding field of genomic medicine's integration into precision medicine. The aim of this article is to raise awareness and spark further inquiry to the remarkable field of genomics and precision medicine.

Critical Care Implications of Thyroid Disease States

Thyroid dysfunction in the critically ill has many causes. In this review, primary and acquired thyroid disease states are discussed. The anatomy, physiology, and pathophysiology of thyroid disorders are addressed, as well as surgical and medical treatment options. Nonthyroidal illness syndrome (sick euthyroid) is also considered. This review contains 3 figures, 7 tables, and 31 references. Key words: agranulocytosis, brain death, hyperthyroidism, hypothyroidism, sick euthyroid

Interventional therapies in stroke management: anaesthetic and critical care implications

### Key points Recent advances in stroke therapy have necessitated new multidisciplinary care pathways. This article will cover interventions used in acute stroke management, including the role of imaging, thrombolysis, interventional radiology, arterial pressure (AP) management, carotid revascularization, haematoma evacuation, and decompressive hemicraniectomy (DHC). The anaesthetic and critical care implications of these interventions are described. Computed tomography (CT) scanners have increased from a single-slice detector to advanced 320-slice scanners capable of performing whole-head imaging in a single rotation. This allows multiple acquisitions during a single contrast injection such that non-contrast CT, angiogram, subtraction cerebral angiography, and perfusion imaging can be performed in a single sitting. With CT perfusion scans, the size of the infarcted core can be seen and also the hypoperfused area around it (the penumbra) which represents brain tissue that may be salvaged if blood flow is restored with reperfusion therapies. Similar advances have been made with magnetic resonance imaging (MRI). MRI with diffusion-weighted imaging (DWI) can differentiate between recent infarction, intracranial masses, and inflammatory disease, and is more sensitive than CT for the detection of acute infarction. It does however have disadvantages in that acutely ill patients may not tolerate it as well and some may even have contra-indications for MRI. Furthermore, MRI may not be readily available in the emergency setting, the acquisition time is longer and MRI is more expensive than CT. Since the primary aim of imaging in acute stroke is to exclude intracranial haemorrhage (which CT is very well suited for), …

Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications.

Vaccine-preventable diseases (VPDs) such as measles and pertussis are becoming more common in the United States. This disturbing trend is driven by several factors, including the antivaccination movement, waning efficacy of certain vaccines, pathogen adaptation, and travel of individuals to and from areas where disease is endemic. The anesthesia-related manifestations of many VPDs involve airway complications, cardiovascular and respiratory compromise, and unusual neurologic and neuromuscular symptoms. In this article, we will review the presentation and management of 9 VPDs most relevant to anesthesiologists, intensivists, and other hospital-based clinicians: measles, mumps, rubella, pertussis, diphtheria, influenza, meningococcal disease, varicella, and poliomyelitis. Because many of the pathogens causing these diseases are spread by respiratory droplets and aerosols, appropriate transmission precautions, personal protective equipment, and immunizations necessary to protect clinicians and prevent nosocomial outbreaks are described.

Critical Care Implications of the Affordable Care Act.

To provide an overview of key elements of the Affordable Care Act. To evaluate ways in which the Affordable Care Act will likely impact the practice of critical care medicine. To describe strategies that may help health systems and providers effectively adapt to changes brought about by the Affordable Care Act. Data sources for this concise review include search results from the PubMed and Embase databases, as well as sources relevant to public policy such as the text of the Patient Protection and Affordable Care Act and reports of the Congressional Budget Office. As all of the Affordable Care Act's provisions will not be fully implemented until 2019, we also drew upon cost, population, and utilization projections, as well as the experience of existing state-based healthcare reforms. The Affordable Care Act represents the furthest reaching regulatory changes in the U.S. healthcare system since the 1965 Medicare and Medicaid provisions of the Social Security Act. The Affordable Care Act aims to expand health insurance coverage to millions of Americans and place an emphasis on quality and cost-effectiveness of care. From models which link pay and performance to those which center on episodic care, the Affordable Care Act outlines sweeping changes to health systems, reimbursement structures, and the delivery of critical care. Staffing models that include daily rounding by an intensivist, palliative care integration, and expansion of the role of telemedicine in areas where intensivists are inaccessible are potential strategies that may improve quality and profitability of ICU care in the post-Affordable Care Act era.

Intensive Care in India: The Indian Intensive Care Case Mix and Practice Patterns Study.

Aims:To obtain information on organizational aspects, case mix and practices in Indian Intensive Care Units (ICUs).Patients and Methods:An observational, 4-day point prevalence study was performed between 2010 and 2011 in 4209 patients from 124 ICUs. ICU and patient characteristics, and interventions were recorded for 24 h of the study day, and outcomes till 30 days after the study day. Data were analyzed for 4038 adult patients from 120 ICUs.Results:On the study day, mean age, Acute Physiology and Chronic Health Evaluation (APACHE II) and sequential organ failure assessment (SOFA) scores were 54.1 ± 17.1 years, 17.4 ± 9.2 and 3.8 ± 3.6, respectively. About 46.4% patients had ≥1 organ failure. Nearly, 37% and 22.2% patients received mechanical ventilation (MV) and vasopressors or inotropes, respectively. Nearly, 12.2% patients developed an infection in the ICU. About 28.3% patients had severe sepsis or septic shock (SvSpSS) during their ICU stay. About 60.7% patients without infection received antibiotics. There were 546 deaths and 183 terminal discharges (TDs) from ICU (including left against medical advice or discharged on request), with ICU mortality 729/4038 (18.1%). In 1627 patients admitted within 24 h of the study day, the standardized mortality ratio was 0.67. The APACHE II and SOFA scores, public hospital ICUs, medical ICUs, inadequately equipped ICUs, medical admission, self-paying patient, presence of SvSpSS, acute respiratory failure or cancer, need for a fluid bolus, and MV were independent predictors of mortality.Conclusions:The high proportion of TDs and the association of public hospitals, self-paying patients, and inadequately equipped hospitals with mortality has important implications for critical care in India.

Quality and safety: reflection on the implications for critical care nursing education

Safe and high quality health care is underpinned by health care professionals possessing the knowledge, skills and professional attributes which are necessary for their specific clinical speciality and area of practice. Education is crucial as it enables clinicians to learn and put into practice their specialist knowledge, skills and attributes. These elements will be based on clinical standards, which set the agenda for quality and safety in health care. The purpose of this paper is to reflect upon how a post-registration, degree-level critical care nursing course provided by an English university facilitates nurses to deliver high quality, safe nursing care for critically ill patients and their families. As a reflective analysis, the process of reflection will be guided and structured according to Rolfe's framework for reflective practice. The reflection is based upon the personal observations and teaching experiences of two university lecturers involved in the delivery of the critical care course. Critical care nursing education can incorporate informed practice, simulation and non-technical skills into post-registration critical-care nursing courses as a way of promoting high-quality, safe clinical practice in the critical care setting. This article provides examples from one course's experience with doing this and ends with specific recommendations for how critical care nursing courses can enhance further the promotion of quality and safety. Educators, mentors and students of post-registration critical care nursing courses are encouraged to explore the relevance of nursing education in promoting safe and high-quality clinical practice.

Courageous Conversations in the End of Life: Implications for Critical Care Nursing

Courageous Conversations in the End of Life: Implications for Critical Care Nursing

Postoperative Nausea and Vomiting in Adults: Implications for Critical Care

Postoperative nausea and vomiting is a dreaded, uncomfortable, and unpleasant patient experience that is also a factor contributing to adverse outcomes in postoperative recovery. The key to management of this concern is to identify high-risk patients and to develop a systematic method of assessment, intervention, and evaluation within the perianesthesia care continuum. This discussion outlines the wide range of pharmacological and alternative therapies that are available in clinical practice with a case study to illustrate incorporation of these interventions in critically ill patients.

Essential Nursing Competencies for Genetics and Genomics: Implications for Critical Care

The implications of genetics and genomics for critical care nurses are becoming more evident, not only in the care provided but also in the numerous medications administered. Genetic causes are being discovered for an increasing number of chronic illnesses and diseases, such as Huntington disease. Because of the scientific and pharmacological advances, leading nursing organizations, such as the American Nurses Association, have established competencies in genetic knowledge for nurses. Such competencies help ensure quality care. Recent advances in the pharmacogenomics of therapy for human immunodeficiency virus disease, cancer, cardiovascular disease, and malignant hyperthermia have indicated a genetic linkage; therefore treatments are targeted toward the genetic aspect of the abnormality. Critical care nurses need knowledge of these genetic conditions and of medications affected by genetic factors.

Communication, swallowing and feeding in the intensive care unit patient

It is not uncommon for patients requiring a period of time in the intensive care unit (ICU) to experience difficulties with communication and/or swallowing, either as a result of their illness or as a result of the treatments they receive. These difficulties can be both short term and long term and require timely and appropriate intervention in order to improve the patient's experience and expedite recovery/rehabilitation. The purpose of this article is to provide critical care nurses with an update on aspects of communication, swallowing and feeding in the ICU. The paper will focus on each area in relation to the current evidence base and factors of 'best practice' (as determined by expert opinion). IMPLICATIONS FOR CRITICAL CARE NURSING PRACTICE: Enabling communication can improve well-being, increase compliance and reduce length of stay; Simple modes of communication, e.g. writing/gesture/pictures can be very effective; Coded eye blinking may be unreliable because of confusion with reflexive blinking; Non-oral nutrition will generally not meet the psychological and physical needs and benefits of oral intake; Not all patients with a tracheostomy in situ will experience dysphagia; however, those considered 'at risk' should have their swallow assessed by an appropriately trained professional, e.g. speech and language therapist/dysphagia trained professional; An inflated tracheostomy cuff will not prevent aspiration. The decision to commence oral intake in the presence of an inflated cuff should be made as a team and take into consideration the patient's medical and psychological status; The use of blue dye to assess the swallow carries a high false-negative rate and cannot be relied on alone to predict either the presence or the absence of aspiration. There is still much more research to be performed and evidence to be gained regarding the input into communication, swallowing and feeding in the ICU; however, a full-team approach to these areas can have very positive effects on the patient's experience.

2020 – Clinical Academic Careers: implications for critical care nursing

2020 – Clinical Academic Careers: implications for critical care nursing

Nurse practitioners and physician assistants in the intensive care unit: An evidence-based review

Advanced practitioners including nurse practitioners and physician assistants are contributing to care for critically ill patients in the intensive care unit through their participation on the multidisciplinary team and in collaborative physician practice roles. However, the impact of nurse practitioners and physician assistants in the intensive care unit setting is not well known. To identify published literature on the role of nurse practitioners and physician assistants in acute and critical care settings; to review the literature using nonquantitative methods and provide a summary of the results to date incorporating studies assessing the impact and outcomes of nurse practitioner and physician assistant providers in the intensive care unit; and to identify implications for critical care practice. We conducted a systematic search of the English-language literature of publications on nurse practitioners and physician assistants utilizing Ovid MEDLINE, PubMed, and the Cumulative Index of Nursing and Allied Health Literature databases from 1996 through August 2007. None. Over 145 articles were reviewed on the role of the nurse practitioner and physician assistant in acute and critical care settings. A total of 31 research studies focused on the role and impact of these practitioners in the care of acute and critically ill patients. Of those, 20 were focused on nurse practitioner care, six focused on both nurse practitioner and physician assistant care, and five were focused on physician assistant care in acute and critical care settings. Fourteen focused on intensive care unit care, and 17 focused on acute care including emergency room, trauma, and management of patients with specific acute care conditions such as stroke, pneumonia, and congestive heart failure. Most studies used retrospective or prospective study designs and nonprobability sampling techniques. Only two randomized control trials were identified. The majority examined the impact of care on patient care management (n = 17), six focused on comparisons of care with physician care, five examined the impact of models of care including multidisciplinary and outcomes management models, and three assessed involvement and impact on reinforcement of practice guidelines, education, research, and quality improvement. Although existing research supports the use of nurse practitioners and physician assistants in acute and critical care settings, a low level of evidence was found with only two randomized control trials assessing the impact of nurse practitioner care. Further research that explores the impact of nurse practitioners and physician assistants in the intensive care unit setting on patient outcomes, including financial aspects of care is needed. In addition, information on successful multidisciplinary models of care is needed to promote optimal use of nurse practitioners and physician assistants in acute and critical care settings.