Sexual assault is a widespread problem among institutions of higher education. Students whose gender and/or sexuality are minoritized (GSM; non-cisgender and/or non-heterosexual) are especially vulnerable to experiencing sexual assault and its negative consequences, including post-traumatic stress disorder (PTSD). A sense of belonging within the campus community can protect victims of sexual assault from negative psychological outcomes; however, no study to date has examined whether this aspect of a positive campus climate protects GSM victims, in particular, from developing more severe PTSD symptoms after sexual assault. We hypothesized that GSM victims would experience more severe PTSD symptoms than non-GSM victims after experiencing sexual assault and that their perceptions of campus climate would moderate this relationship. All undergraduate students from a public liberal arts college on the East Coast were asked to participate in an online survey about their history of sexual assault and emotional well-being. Of those who completed the survey, approximately 18% reported a history of sexual assault (N = 146). GSM victims of sexual assault reported more severe PTSD symptoms than non-GSM victims; however, a significant interaction showed that PTSD symptoms were similar for GSM and non-GSM victims with high ratings of campus climate. Thus, positive perceptions of campus climate protected GSM students from experiencing more severe PTSD symptoms. These findings inform administrative efforts by suggesting the need for more inclusive support resources (i.e., crisis centers and orientation materials), curricula, and community spaces for GSM students.