The article is devoted to the study of the general characteristics and peculiarities of organized crime in the Black Sea region of Ukraine. The relevance and practical significance of research on this type of crime is proven, the essence of the strategic importance of the Black Sea region in the context of the spread of the investigated type of crime is determined. Establishing the specificity of the phenomenon of organizedcrime in the Black Sea region is methodologically carried out through the definition of the concept and signs of organized and regional crime. Socio-economic prerequisites for the determination of crime in the border region of Southern Ukraine are indicated. It is proved that at the present time, organized crime in the South of mainland Ukraine is characterized by professionalization, armed forces, cross-border connections, the presence of well-established corruption schemes of interaction with representatives of the power sector, and a pronounced economic component of self-interest.Statistical data on the spread of organized crime on the territory of Ukraine for the period of the last five years (2018-2022) are analyzed. The primary influence of historical, geographical and cultural systems of territorial factors of crime on the peculiarities of the development of regional crime in the Black Sea region is noted. The author suggests that such factors include geographical location, features of formation, specifics of transportand industrial infrastructure, demographic features, traditions and customs of the local population, etc.It is argued that organized crime in the Black Sea region acts as an independent complex phenomenon, which is characterized by criminal practices of weapons distribution, traffic and distribution of a wide range of narcotic and psychotropic substances, smuggling, economic and corruption criminal offenses.