Creative Commons Attribution Research Articles

Prevalence of developmental dental hard-tissue anomalies among adolescents in southeastern Nigerian rural communities

Background and objectives: Dental anomalies are significant deviation in the normal size, structure, number, root formation or shape of a tooth. It can affect primary and permanent dentition. The aim of the present study was to determine the prevalence of developmental dental hard tissue anomalies in the permanent dentition of adolescents in two southeastern Nigerian rural communities. Materials and methods: This cross-sectional descriptive study was conducted among school children aged 12-13 years attending two public secondary schools. The schools were located in Nkanu-West and Udi Local Government areas in Enugu state. Oral examination for the presence or absence of developmental dental hard tissue anomalies was performed by a single examiner. Statistical analysis was done using SPSS Version 25. Results: A total of 61 (44.9%) males and 75(55.1%) females participated in the study. The age range of the children was 12 to 13 years with mean age of 12.49 ± 0.50 years. The prevalence of developmental dental hard tissue anomalies was 2.2%. Developmental dental hard tissue anomalies were seen only in females, higher among 13-year-old school children and school children from middle socioeconomic status. Enamel hypoplasia was seen more than peg shaped lateral incisor. There was no statistically significant association with sex (p = 0.25), age (p = 0.61), socioeconomic status (p= 0.25) and developmental dental hard tissue anomalies. Conclusion: The prevalence of developmental dental hard tissue anomalies was low in this study. Developmental dental hard tissue anomalies can affect aesthetics and quality of life. A visit to dental clinic for clinical assessment, preventive interventions and management is recommended. January 2025; Vol. 19(1):002. DOI: https://doi.org/10.55010/imcjms.19.002 *Correspondence: Obehi. O Osadolor, Department of Child Dental Health, University of Nigeria Teaching Hospital, Ituku- ozalla, Enugu State. Nigeria. E-mail: osadolorobehi@yahoo.com; © 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0).

Quasinormal Modes of a black hole surrounded by a fluid of strings in Rastall gravity

Abstract In this paper, we explore the quasinormal modes (QNMs) of a black hole surrounded by a fluid of strings within the framework of Rastall gravity. We analyze the behavior of scalar, electromagnetic, and gravitational perturbations, focusing on the influence of the black hole charge $Q$ and angular momentum $l$ on the quasinormal frequencies. Our numerical results reveal a significant dependence on the parameter $\varepsilon$. These trends are consistent across different types of perturbations, emphasizing the relationship between black hole parameters and QNMs behavior.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Fix three dimensional geometries from entanglement entropies of CFT$_2$

Abstract In this paper, we propose an approach to fix the leading behaviors of three dimensional geometries from the dual CFT$_2$ entanglement entropies. We only employ the holographic principle and do not use any assumption about the AdS/CFT correspondence and bulk geometry. Our strategy is to use both UV and IR-like CFT$_2$ entanglement entropies to fix the bulk geodesics. By a simple trick, then the metric can be extracted from the geodesics. As examples, we fix the leading behaviors of the pure AdS$_3$ metric from the entanglement entropies of free CFT$_2$, and more importantly the BTZ black hole from the entanglement entropies of finite temperature CFT$_2$. Consequently, CFT$_2$ with finite size or topological defects can be worked out by simple transformations. Following the same steps, in principle, it is possible to fix the leading behaviors of all three dimensional (topologically distinct) holographic classical geometries from the dual CFT$_2$ entanglement entropies.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Modification of the Sommerfeld effect due to coannihilator decays

Abstract In dark matter coannihilation scenarios, the Sommerfeld effect of coannihilators is usually important in calculations of dark matter thermal relic abundance. Due to decays of coannihilators, two annihilating coannihilators can only approach each other from a finite initial separation. While conventional derivations of Sommerfeld factors essentially assume an infinite initial separation, Sommerfeld factors for a pair of annihilating coannihilators may be different. We find that the Sommerfeld factor for a pair of coannihilators is less prominent than the one obtained without considering decays. The modification of the Sommerfeld factor may result in a change of the dark matter thermal relic abundance well beyond the percent level. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Two-zero textures for Dirac Neutrinos

Abstract We review the two-zero mass matrix textures approach for Dirac neutrinos with the most recent global fit in the oscillation parameters. We found that three of the 15 possible textures are compatible with current experimental data, while the remaining two-zero textures are ruled out. Two textures are consistent with the neutrino masses' normal hierarchy and are CP-conserving. At the same time, the other one is compatible with both mass orderings and allows for CP violation. We also present the correlations between the oscillation parameters for the allowed two-zero textures. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

The resonance effect for the CP asymmetry associated with the process $\omega \rightarrow \pi^{+}\pi^{-}\pi^{0}$

Abstract The direct CP asymmetry in the weak decay process of hadrons is commonly attributed to the weak phase of the CKM matrix and the indeterminate strong phase. We propose a method to generate a significant phase difference through the interference between $\rho$ and $\omega$ mesons, taking into account the G-parity allowed decay process of $\omega \rightarrow \pi^{+}\pi^{-}\pi^{0}$ and the G-parity suppressed decay process of $\rho^{0} \rightarrow \pi^{+}\pi^{-}\pi^{0}$ in B meson decays. 
It can lead to a significant CP asymmetry changes in the interference region. 
Besides, we also calculate the integral results of different phase space regions for the four-body decay process. We hope that our work can offer valuable theoretical guidance for future experimental investigations on CP asymmetry in these decays.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Bexotegrast Shows Dose-dependent Integrin αvβ6 Receptor Occupancy in Lungs of Participants with Idiopathic Pulmonary Fibrosis: A Phase 2, Open-Label Clinical Trial.

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by dyspnea and loss of lung function. Transforming growth factor-beta (TGF-β) activation mediated by αv integrins is central to the pathogenesis of IPF. Bexotegrast (PLN 74809) is an oral, once-daily, dual-selective inhibitor of αvβ6 and αvβ1 integrins under investigation for the treatment of IPF. Positron emission tomography (PET) using an αvβ6-specific PET tracer could confirm target engagement of bexotegrast in the lungs of participants with IPF. Objectives: This Phase 2 study (NCT04072315) evaluated αvβ6 receptor occupancy in the lung, as assessed by changes from baseline in αvβ6 PET tracer uptake, following single dose administration of bexotegrast to participants with IPF. Methods: In this open-label, single-center, single-arm study, adults with IPF received up to 2 single doses of bexotegrast, ranging from 60 to 320 mg with or without background IPF therapy (pirfenidone or nintedanib). At baseline and approximately 4 hours after each orally administered bexotegrast dose, a 60-minute dynamic PET/CT scan was conducted following administration of an αvβ6-specific PET probe ([18F]FP-R01-MG-F2). αvβ6 receptor occupancy by bexotegrast was estimated from the changes in PET tracer uptake following bexotegrast. Pharmacokinetics, safety, and tolerability of bexotegrast were also assessed. Results: Eight participants completed the study. Total and unbound plasma bexotegrast concentrations increased in a dose-dependent manner, and regional PET volume of distribution (VT) values decreased in a dose- and concentration-dependent manner. The VT data fit a simple saturation model, producing an unbound bexotegrast EC50 estimate of 3.32 ng/mL. Estimated maximum receptor occupancy was 35%, 53%, 71%, 88%, and 92% following single 60, 80, 120, 240, and 320-mg doses of bexotegrast, respectively. No treatment-emergent adverse events related to bexotegrast were reported. Conclusions: Dose- and concentration-dependent αvβ6 receptor occupancy by bexotegrast was observed by PET imaging, supporting once-daily 160 to 320 mg dosing to evaluate efficacy in clinical trials of IPF. Trial registration number: NCT04072315 Primary source of funding: Pliant Therapeutics, Inc. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Exotic hybrid pseudopotentials at finite temperature and chemical potential

Abstract Using gauge/gravity duality, we study the exotic hybrid pseudopotentials at finite temperature and chemical potential. The $\Sigma$ hybrid meson can be described by a model including an object called ``defect'' on a string linking the quark and antiquark. It was first proposed by Andreev and perfectly described the $\Sigma_u^-$ hybrid potential at zero temperature and chemical potential. In this paper, we would like to extend this model to finite chemical potential and compare the separate distance and pseudopotentials of $\Sigma_g^+ $ and $\Sigma_u^-$. Unlike $\Sigma_g^+$ ground state, the $\Sigma_u^-$ hybrid pseudopotentials no longer behave as Coulomb-like at short distances. In addition, temperature and chemical potential have a significant impact on the $\Sigma_u^-$ hybrid pseudopotentials. The screen distances and hybrid pseudopotentials of $\Sigma_u^-$ significantly decrease with the increase of temperature and chemical potential. At last, we draw the melting diagram of $\Sigma_g^+ $ and $\Sigma_u^-$ in the $T- \mu$ plane, and confirm that the quark-antiquark pair in $\Sigma_u^-$ excited state is easier to melt than in $\Sigma_g^+$ ground state.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Spectroscopy of excited quarkonium states in the light-front quark model

Abstract We have investigated the ground state ($1S$), radially excited states ($2S$) and ($3S$) along with the orbitally excited state ($1P$) for the heavy charmonia ($c \bar c$) and bottomonia ($b \bar b$) mesons in the light-front quark model (LFQM). The light-front wave functions have been successful in explaining various physical properties of meson states in the past, especially for the $1S$ and $2S$ states. However, studies regarding the radially excited state $3S$ and orbitally excited state $1P$ have hardly been pursued before. In this study, we take up these two excited states and investigate the electromagnetic form factors (EMFFs), charge radii, decay constants, parton distribution functions (PDFs) and the distribution amplitudes (DAs) for the quarkonia system. For the sake of completeness, we have also included the study of the ground and the first excited states of quarkonia mesons. We have also illustrated the 3D wave functions for the radially excited states in order to study their nodal structures. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Asthma and COVID-19: Unveiling Outcome Disparities and Treatment Impact Based on Distinct Endotypes.

Epidemiologic studies on asthmatics and in vitro data suggest a protective role of T2 inflammation in SARS-CoV-2 infection. Using a large, multisite cohort, we studied clinical outcomes following SARS-CoV-2 infection in multiple asthma endotypes and examined the effects of T2-directed biologics in infected asthmatics.in Methods: The National COVID Cohort Collaborative (N3C) Data Enclave was used to identify and stratify asthmatic patients by endotype to include non-T2 and T2 asthmatics, as well as exposure to T2-directed biologic therapy. We evaluated the risk of hospitalization, invasive mechanical ventilation, and 90-day mortality by endotype and exposure to biologics. For this study, 402,376 patients met inclusion criteria, of which 138,142 (34%) were characterized as non-T2 and 264,234 (66%) as T2 asthmatics, a group further divided into 104,823 (26%) atopic, 84,440 (21%) eosinophilic, and 74,971 (19%) T2-high asthmatic endotypes. Compared to non-T2 asthmatics, atopic and T2-high asthmatics experienced decreased odds of hospitalization, and 90-day mortality. Conversely, eosinophilic asthmatics experienced higher odds of hospitalization, intubation, and 90-day mortality. Exposure to T2-directed biologic therapies did not alter outcomes after propensity score matching. In contrast, maximum eosinophil count and recent systemic corticosteroid use were directly correlated with increased odds of all outcomes. COVID-19 outcomes differ depending on asthma endotype, with atopic asthmatics experiencing lower odds and eosinophilic asthmatics experiencing higher odds of deleterious outcomes. T2-directed biologic treatment did not alter these outcomes but recent systemic corticosteroid use predisposes all asthmatics patients to adverse outcomes. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Effectiveness and Safety of an Emergency Department Code Sepsis Protocol: A Pragmatic Clinical Trial.

Rationale: Sepsis care delivery-including the initiation of prompt, appropriate antimicrobials-remains suboptimal. Objectives: This study was conducted to determine direct and off-target effects of emergency department (ED) sepsis care reorganization. Methods: This pragmatic pilot trial enrolled adult patients who presented from November 2019 to February 2021 to an ED in Utah before and after implementation of a multimodal, team-based "Code Sepsis" protocol. Patients who presented to two other EDs where usual care was continued served as contemporaneous control subjects. The primary outcome was door-to-antimicrobial time among patients meeting Sepsis-3 criteria before ED departure. Secondary and safety outcomes included all-cause 30-day mortality, antimicrobial utilization and overtreatment, and antimicrobial-associated adverse events. Multivariable regression analyses used difference-in-differences methods to account for trends in outcomes unrelated to the studied intervention. Results: Code Sepsis protocol activation (N = 307) exhibited 8.5% sensitivity and 66% positive predictive value for patients meeting sepsis criteria before ED departure. Among 10,151 patients who met sepsis criteria during the study, adjusted difference-in-differences analysis demonstrated a 13-minute (95% confidence interval = 7-19) decrease in door-to-antimicrobial time associated with Code Sepsis implementation (P < 0.001). Mortality and clinical safety outcomes were unchanged, but Code Sepsis implementation was associated with increased false-positive presumptive infection diagnoses among patients who met sepsis criteria in the ED and increased antimicrobial utilization. Conclusions: Implementation of a team-based protocol for rapid sepsis evaluation and treatment during the coronavirus disease (COVID-19) pandemic's first year was associated with decreased ED door-to-antimicrobial time but also increased antimicrobial utilization. Measurement of both patient-centered and off-target effects of sepsis care improvement interventions is essential to comprehensive assessment of their value. Clinical trial registered with www.clinicaltrials.gov (NCT04148989).

Detailed derivation of the $\mathbf{^3P_0}$ strong decay model applied to baryons

Abstract We provide an in-detail derivation, through the $^3P_0$ pair creation model, of the transition matrix for a baryon decaying into a meson baryon system. The meson's analysis was successfully conducted in Ref.~\cite{Segovia:2012cd} and we extend the same formalism to the baryon sector, focusing on the $\Delta(1232)\to \pi N$ strong decay width because all hadrons involved in the reaction are very well established, the two hadrons in the final state are stable avoiding further analysis, all quarks are light and so equivalent, and the decay width of the process is relatively well measured. Taking advantage of a very common Rayleigh-Ritz variational method for solving the 2- and 3-body Sch"odinger bound-state equation in which the hadron's radial wave functions are expanded in terms of a Gaussian basis, the expression of the invariant matrix element can be related with the mean-square radii of hadrons involved in the decay. We use their experimental measures in such a way that only the strength of the quark-antiquark pair creation from the vacuum is a free parameter. This is then taken from our previous study of strong decay widths in the meson sector~\cite{Segovia:2012cd}, obtaining a quite compatible result with experiment for the calculated $\Delta(1232)\to \pi N$ decay width and indicating a possible path towards a unified and global description of the baryon and meson strong decay widths within the same constituent quark model framework. Finally, this research work has been developed in setting the stage for a novel raft of applications to exotic hadrons, \emph{i.e.} the description of baryon's coupling to meson-baryon thresholds, one of the mechanism that is thought to be responsible of providing either a large renormalization to naive states or genuine dynamically-generated meson-baryon molecules.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd

Two Texture Zeros for Dirac Neutrinos in a Diagonal charged lepton basis

Abstract A systematic study of the neutrino mass matrix Mν with two texture zeros in a basis where the charged leptons are diagonal, and under the assumption that neutrinos are Dirac particles, is carried through in detail. Our study is done without any approximation, first analytically and then numerically. Current neutrino oscillation data are used in our analysis. Phenomenological implications of Mν on the lepton CP violation and neutrino mass spectrum are explored.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.&amp;#xD;

Strong Coupling from Inclusive Semi-leptonic Decay of Charmed Mesons

Abstract Employing the heavy quark expansion model with the kinetic scheme, we evaluate αS(mc 2), the strong coupling constant at the charm quark mass mc with data on inclusive semileptonic decays of charmed mesons. Using the experimental values of semileptonic decay widths of the D0 and the D+, the value of αS(mc 2) is determined to be 0.445±0.009±0.114, where the first uncertainty is experimental and the second systematic. This reported αS(mc 2) is in good agreement with the value of αS(mc 2) calculated by running αS(mZ 2) at the Z0 boson mass mZ with the renormalization group evolution equation. In addition, values of αS(mc 2) obtained individually from each of the D0, D+, and D+ s mesons are found to be consistent being of the same origin.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Polarization study of the P-wave charmonium radiative decay into a light vector meson at e+e- collider experiment

Abstract In this work, a formalism is presented for the helicity amplitude analysis of the decays ψ(2S) →γ1χcJ, χcJ→γ2V (V=ρ0, Φ, ω) (the subscript 1,2 is used to distinguish the two radiative photons), and the polarization expressions of the P-wave charmonia χcJ and the vector mesons ρ0, Φ, ω for experimental measurements at Electron-Positron Collider. In addition, we derive the formulae of the angular distributions of the χc1,2→γV to extract the degree of transverse polarization PT of e+e- pairs with symmetric beam energy as well as the ratios of two helicity amplitudes x (in χc1 decays) and x, y (in χc2 decays) representing the relative magnitudes of transverse to longitudinal polarization amplitude, and validate it by performing the Monte Carlo simulation. Finally, the statistical sensitivity of PT, x and y are estimated based on the large ψ(2S) data samples collected at the current and proposed future e+e- collider experiment.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must main tain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Sciences and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd

FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in COPD.

Glutathione peroxidase 4 (GPX4) has recently been reported to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Ferroptosis suppressor protein-1 (FSP1) is a protein that defends against ferroptosis in parallel with GPX4, but its role in the pathogenesis of COPD remains unexplored, and further research is needed. Normal and COPD lung tissues were obtained from lobectomy and lung transplant specimens, respectively. FSP1-overexpressing mice were established by monthly transfection with AAV9-FSP1 through modified intranasal administration. The expression of FSP1, GPX4, and prostaglandin-endoperoxide synthase 2 (PTGS2) was measured by Western blotting, immunohistochemistry and other methods. The correlation between FSP1 and ferroptosis and the role of FSP1 in COPD were explored by screening the expression of ferroptosis-related genes in a COPD cell model after the inhibition and overexpression of FSP1. We then explored the underlying mechanism of low FSP1 expression in patients with COPD in vitro by methylated RNA immunoprecipitation (MeRIP)-qPCR. We found that cigarette smoke exposure can lead to an increase in lipid peroxide production and ultimately ferroptosis, which is negatively regulated by FSP1 activity. FSP1 overexpression can prevent ferroptosis and alleviate emphysema. Next, we found that decreased FSP1 expression was caused by increased m6A modification of FSP1 mRNA. Moreover, the level of FSP1 decreased in a YTHDF2-dependent manner. These results indicate that METTL3-induced FSP1 mRNA methylation leading to low FSP1 expression is a potential therapeutic target for COPD. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Probing axion-like particles in leptonic decays of heavy mesons

Abstract We study the possibility to find the axion-like particles (ALPs) through the leptonic decays of heavy mesons. The Standard Model (SM) predictions of the branching ratios of the leptonic decays of heavy mesons are less than corresponding experimental upper limits. This provides some space for the existence of decay channels where the ALP is one of the products. Three scenarios are considered: first, the ALP is only coupled to one single charged fermion, namely, the quark, the antiquark, or the charged lepton; second, the ALP is only coupled to quark and antiquark with the same strength; third, the ALP is coupled to all the charged fermions with the same strength. The constraints of the coupling strength in different scenarios are obtained by comparing the experimental data of the branching ratios of leptonic decays of $B^-$, $D^+$, and $D_s^+$ mesons with the theoretical predictions which are achieved by using the Bethe-Salpeter (BS) method. These constraints are further applied to predict the upper limits of the leptonic decay processes of the $B_c^-$ meson in which the ALP participates.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

ChatGPT as an effective tool for quality evaluation of radiomics research.

This study aimed to evaluate the effectiveness of ChatGPT-4o in assessing the methodological quality of radiomics research using the radiomics quality score (RQS) compared to human experts. Published in European Radiology, European Radiology Experimental, and Insights into Imaging between 2023 and 2024, open-access and peer-reviewed radiomics research articles with creative commons attribution license (CC-BY) were included in this study. Pre-prints from MedRxiv were also included to evaluate potential peer-review bias. Using the RQS, each study was independently assessed twice by ChatGPT-4o and by tworadiologists with consensus. In total, 52 open-access and peer-reviewed articles were included in this study. Both ChatGPT-4o evaluation (average of two readings) and human experts had a median RQS of 14.5 (40.3% percentage score) (p > 0.05). Pairwise comparisons revealed no statistically significant difference between the readings of ChatGPT and human experts (corrected p > 0.05). The intraclass correlation coefficient for intra-rater reliability of ChatGPT-4o was 0.905 (95% CI: 0.840-0.944), and those for inter-rater reliability with human experts for each evaluation of ChatGPT-4o were 0.859 (95% CI: 0.756-0.919) and 0.914 (95% CI: 0.855-0.949), corresponding to good to excellent reliability for all. The evaluation by ChatGPT-4o took less time (2.9-3.5 min per article) compared to human experts (13.9 min per article by one reader). Item-wise reliability analysis showed ChatGPT-4o maintained consistently high reliability across almost all RQS items. ChatGPT-4o provides reliable and efficient assessments of radiomics research quality. Its evaluations closely align with those of human experts and reduce evaluation time. Question Is ChatGPT effective and reliable in evaluating radiomics research quality based on RQS? Findings ChatGPT-4o showed high reliability and efficiency, with evaluations closely matching human experts. It can considerably reduce the time required for radiomics research quality assessment. Clinical relevance ChatGPT-4o offers a quick and reliable automated alternative for evaluating the quality of radiomics research, with the potential to assess radiomics research at a large scale in the future.

The Complex Immune Cell Composition and Cellular Interaction in the Alveolar Compartment of Patients with Acute Respiratory Distress Syndrome.

Acute respiratory distress syndrome (ARDS) is characterized by protein rich edema due to alveolar-capillary barrier dysfunction caused by inflammatory processes. Currently, our understanding of the inflammatory response in patients with ARDS is mainly based on assessment of the systemic compartment and preclinical studies. Investigations into the intricate network of immune cells and their critical functions in the alveolar compartment remain limited. However, with recent improvements in single cell analyses, our comprehensive understanding of the interactions between immune cells in the lungs has improved. In this review, we summarize the current knowledge about the cellular composition and interactions of different immune cell types within the alveolar space of patients with ARDS. Neutrophils and macrophages are the predominant immune cells in the alveolar space of ARDS patients. Yet, all immune cells present, including lymphocytes, participate in complex interactions, coordinate recruitment, modulate the lifespan and control apoptosis through various signaling pathways. Moreover, the cellular composition of alveolar immune cells is associated with clinical outcomes of ARDS patients. In conclusion, this synthesis advances our understanding of ARDS immunology, emphasizing the crucial role of immune cells within the alveolar space. Associations between cellular composition and clinical outcomes highlight the significance of exploring distinct alveolar immune cell subsets. Such exploration holds promise for uncovering novel therapeutic targets in ARDS pathophysiology, presenting avenues for enhancing clinical management and treatment strategies for ARDS patients. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

$\mathcal{R}^2$ curvature-squared corrections on Langevin diffusion coefficients

Abstract The effect of finite coupling corrections to the Langevin diffusion coefficients on a moving heavy quark in the Super Yang-Mills plasma is investigated. &amp;#xD;These corrections are related to curvature squared corrections in the corresponding gravity sector. &amp;#xD;We compare the results of both longitudinal and perpendicular Langevin diffusion coefficients with those in $\mathcal{N}$=4 Super Yang-Mills plasma. It is observed that the curvature-squared corrections influence the Langevin diffusion coefficients, and the corrections for both Langevin diffusion coefficients demonstrate the dependence on the velocity of the moving heavy quark and the specifics of the higher derivative correction.&amp;#xD;In addition, we conduct calculations for the Langevin diffusion coefficients of a moving heavy quark within the Gauss-Bonnet background. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.