Creation Of Database Research Articles

Database, prediction, and antibacterial research of astringency based on large language models

Astringency, a sensory experience causing mouth dryness, significantly impacts the taste of foods such as wine and tea, and astringent molecules may exhibit antibacterial properties. Traditional methods for predicting astringency are costly, and the connection between astringency and antibacterial activity remains largely unexplored. In this study, we present a pioneering computational approach that includes: (1) the creation of the first comprehensive astringency database comprising 238 molecules; (2) the development of a Ligand-Based Prediction (LBP) framework that combines large language models, deep learning, and traditional machine learning for enhanced molecular and peptide prediction; (3) an astringency predictor achieving 0.95 accuracy and 0.90 AUC, validated through electronic tongue measurements; (4) antibacterial predictors for molecules and peptides with accuracies of 0.92 and 0.88, respectively, revealing that 51 % of astringent molecules possess antibacterial properties; (5) accessibility of these predictors via the AstringentPD and ABPD web servers. This work not only enhances the understanding of taste-related molecules but also elucidates the relationship between astringency and antibacterial properties, setting the stage for future explorations in food science and medicinal applications.

ORGANIZATION OF METHODOLOGICAL PRINCIPLES OF THE STATE INNOVATION POLICY IN THE SPHERE OF INFORMATIZATION OF THE HEALTH PROTECTION SYSTEM OF UKRAINE

The article highlights the key issues related to the need to modernize the health care system, globalization and integration into international structures, health care reform. In Ukraine, the process of health care reform is underway, which involves increasing the efficiency of the medical services system, their availability and quality. Innovations can accelerate these processes, in particular through the introduction of digital technologies (e-health, telemedicine), automation of management of medical facilities, development of remote diagnosis and treatment. The state innovation policy will allow to more effectively prepare for similar challenges in the future through the development of new vaccines, diagnostic methods, monitoring systems and management of medical resources. Support from the state (for example, through preferential taxation) to the development of the private medical services sector will reduce the burden on the state budget. In addition, it contributes to the attraction of investments in this area. Therefore, the state innovation policy in the field of health care is a relevant tool for ensuring the sustainable development of the health care system of Ukraine, increasing its efficiency and competitiveness, which meets the modern challenges and needs of society. The authors analyze the key aspects of the state policy aimed at the informatization of medical institutions, in particular, the digitalization of medical services, the introduction of electronic medicine, the creation of unified information platforms and patient databases. The article examines the importance of developing a clear methodology for the implementation of innovative solutions, as well as the role of the state in creating favorable conditions for the informatization of the health care system. The authors also analyze the international experience and the possibilities of its adaptation for Ukrainian realities, emphasizing the need to establish effective cooperation between state bodies, medical institutions and technological companies. The article concludes about the importance of an integrated approach to the informatization of the health care sector in order to improve the quality of medical services and increase the efficiency of medical resource management.

Blockchain in digital notary services

The purpose of the study is to determine the future application of blockchain technology. Protection of rights, as well as legal interests of citizens and legal entities is the main postulate of notary activity. Only through the prism of this provision should one consider the possible application of blockchain technology in the notary. This includes studying the possibilities of the blockchain for verifying the authenticity of documents, automating registration actions. The relevance of the study is related to the need for modern notaries to meet the requirements of the digital world. The research is based on the application of an interdisciplinary approach, civil law and information technology, which combines the analysis of legal aspects with modern technological research. To study legislative aspects, methods of comparative analysis and synthesis were used, which includes an analysis of the legislation of Ukraine and other countries. The empirical method consists in researching existing examples of implementation of blockchain projects in EU and US notary offices. Analysis and modeling were carried out taking into account the architecture of blockchain networks, their capabilities in terms of information protection, authentication and legal validity of digital records. The study found that blockchain technology has significant potential for the notary industry due to its decentralized nature and high level of data protection. It has been established that the implementation of the blockchain allows for the creation of a reliable database for recording notarial actions, ensuring the impossibility of forgery or loss of information. The results of the study confirmed the possibility of using blockchain for digital recording of documents and automation of notarial procedures, which allows to reduce time costs and the risk of human errors. The experience of countries that have already implemented blockchain in the notary office indicates an increase in the level of trust in notary services and a reduction in bureaucratic procedures. The application of blockchain in the notarial sphere can fundamentally change the mechanisms of notarial actions, increasing security, convenience and speed of service. The use of decentralized networks ensures the reliability of data, which makes it impossible to forge them and makes procedures transparent. However, for the full implementation of such decisions, it is necessary to create an appropriate regulatory framework, adapt Ukrainian legislation and ensure the training of specialists for work in the conditions of digital notary.

Peptipedia v2.0: a peptide sequence database and user-friendly web platform. A major update.

In recent years, peptides have gained significant relevance due to their therapeutic properties. The surge in peptide production and synthesis has generated vast amounts of data, enabling the creation of comprehensive databases and information repositories. Advances in sequencing techniques and artificial intelligence have further accelerated the design of tailor-made peptides. However, leveraging these techniques requires versatile and continuously updated storage systems, along with tools that facilitate peptide research and the implementation of machine learning for predictive systems. This work introduces Peptipedia v2.0, one of the most comprehensive public repositories of peptides, supporting biotechnological research by simplifying peptide study and annotation. Peptipedia v2.0 has expanded its collection by over 45% with peptide sequences that have reported biological activities. The functional biological activity tree has been revised and enhanced, incorporating new categories such as cosmetic and dermatological activities, molecular binding, and antiageing properties. Utilizing protein language models and machine learning, more than 90 binary classification models have been trained, validated, and incorporated into Peptipedia v2.0. These models exhibit average sensitivities and specificities of 0.877±0.0530 and 0.873±0.054, respectively, facilitating the annotation of more than 3.6 million peptide sequences with unknown biological activities, also registered in Peptipedia v2.0. Additionally, Peptipedia v2.0 introduces description tools based on structural and ontological properties and user-friendly machine learning tools to facilitate the application of machine learning strategies to study peptide sequences. Database URL: https://peptipedia.cl/.

Концептуально-онтологические аспекты множественности предка в информационных моделях «сущность-связь»

The design of information models in the development of automated systems involves constructing entity-relationship models, which define classes of entities and interclass relationships of the ancestor-descendant type, serving as a conceptual and ontological foundation for the subsequent creation of databases. This article explores aspects of representing the semantic constraints of the subject area imposed on relationships between entities in entity-relationship models. A special type of relationship between classes of entities, termed multiple ancestor (MA) relations, is highlighted, where several instances of the ancestor entity may exist for a single instance of the descendant entity. The article analyses the possible semantic constraints that arise in such cases and the anomalies they generate. Based on the introduced concepts of ascending kinship lines and the MA predicate, a formalisation of MA integrity is presented. Examples of formal MA constraints are provided, including positive (requiring the coincidence of ancestor instances), negative (requiring the mismatch of ancestor instances), and mixed. The mutual influence of several MA constraints with partially intersecting lines of ascending kinship is also examined. Finally, the feasibility of implementing MA constraints in relational database models is evaluated.

Thirty-five years of the French Association of Urologists in Training (AFUF) a scoping review and bibliometric analysis of scientific literature conducted by urologists in training.

The objective of this scoping review was to identify the topics of research and the types of studies published by the French Association of Urologists in Training (AFUF) since it was created, 35 years ago and to perform a bibliometric analysis. A scoping review on PubMed, Google scholar, Excerpta Medica database (EMBASE) was conducted from 1989 until the 31st of December 2023. The PRISMA extended guidelines for scoping reviews were followed. Articles were independently screened and analyzed by two reviewers. The theme type, primary results, language of publication, number of male and female authors and number of citations from each included article were extracted. A total of 32 articles were included among which 17 surveys and 11 cohort studies. There was a median percentage of 20% women among authors. Fifteen articles (47%) were published in French and 17 articles in English. The median number of citations was 4.5. The topics covered were urologist in training's surgical education, well-being, professional practice, and urologic emergencies: renal trauma and spermatic cord torsion. The creation of large national databases enabled the generation of multiple studies focusing on previously under-represented topics. Over the 35 years since it was created, The AFUF has had an interesting and prolific scientific output. It has shown its concerns for urologists in training.

United States Precinct Boundaries and Statewide Partisan Election Results

We describe the creation and verification of databases of all precinct boundaries used in the United States 2016, 2018, and 2020 November general elections, enhanced with election results for all partisan statewide offices. United States election officials report election results in the smallest geographic reporting known as the precinct. Scholars and practitioners find these election results valuable for numerous use cases. However, these data cannot be augmented with other geographically-bound data, such as U.S. Census data, without precinct boundaries. Here we describe the collection of precinct boundary data from state and local election officials, sometimes provided in GIS formats, images, text descriptions, and – in rare cases – verbally. We describe how we verify boundaries with other election data, such as geocoded voter registration files. Our open-source data has appeared in redistricting litigation argued before the United States Supreme Court; and has been used by state and local redistricting authorities, media organizations, advocacy groups, scholars, and a vibrant community of mapping enthusiasts.

20 Co-occurring behaviours of concern and sleep problems in children with neurodevelopmental disorders

Abstract Background Many children with neurodevelopmental disorders (NDDs) have behaviours of concern (BoC). These behaviours, such as aggression and self-injury, can impair functioning, cause distress to the child and caregivers, and threaten physical safety. This population also commonly experiences chronic and frequent sleep problems including issues falling asleep and staying asleep. Studies in sub-populations of NDDs suggest insufficient sleep is related to worsening BoC. Therefore, sleep may be a modifiable risk factor in children with NDDs and BoC. However, no studies have systematically characterized co-occurring behaviour and sleep problems in the general NDD population. To our knowledge this is the first study to take a transdiagnostic approach in assessing the co-occurrence of sleep problems and BoC in children with NDDs, and systematically characterizing BoC and sleep problems by their type and severity. Objectives To assess the co-occurrence of BoC and sleep problems in a population of children with diverse NDDs and systematically characterize both BoC and sleep problems. Design/Methods A literature review and clinical experience informed the creation of a REDCap database. Medical information, the nature, frequency, and severity of BoC and sleep problems, and other relevant information (e.g., demographics, medications) were included. Charts from children ages 2-18 years who visited the Child Development Centre for consultation from May – October 2022 and had confirmation of an NDD diagnosis were manually reviewed. Results 241 children met eligibility criteria. Of children with data available for both sleep and behaviour, 55% had co-occurring behaviour and sleep problems. These children displayed aggression (75%) and self-injury (49%) more frequently than children who had behaviours but no sleep problems (66% and 34%, respectively). Children with co-occurring behaviours and sleep problems were more likely to have severe BoC, including severe aggression (48%) and self-injury (45%), compared to children who had behavioural concerns but no sleep problems (21% and 20%, respectively). Conclusion The majority of children with NDDs have co-occurring BoC and sleep problems. This co-occurrence was related to increased frequency and severity of BoC in children with NDDs. Addressing sleep problems may represent a previously underrecognized therapeutic target to address BoC in this population.

Innovating Through Public–Private Partnership

The article titled Innovating through Public-Private Partnership, explores the potential of public-private partnerships (PPP) as a means to foster innovation, economic stabilization, and sustainable community development. It highlights how the collaboration between public administration authorities and private or non-governmental sectors can address pressing societal challenges, including global warming, healthcare modernization, and technological advancements. The research outlines the essential components of PPPs, including financial models, management frameworks, and project evaluation criteria, with a particular focus on innovation-driven initiatives. Various stages of establishing a successful PPP are examined, from project conceptualization and partner selection to implementation and performance monitoring. Furthermore, the paper delves into the importance of funding methods and risk management, demonstrating how a well-structured PPP can combine public and private resources to deliver public goods effectively. The article also provides insights into sector-specific innovation strategies, such as digitalization and renewable energy projects. The case for renewable energy production through PPPs, involving solar and wind energy, is highlighted as a sustainable development model that strengthens collaboration between public and private sectors. By analyzing a five-year history of PPP projects in Europe and providing forecasts for the future, the paper underscores the growing relevance of PPPs in achieving long-term goals for economic and infrastructural development. The study concludes with recommendations for fostering a conducive environment for PPPs, such as legislative reform, the creation of national databases, and investment in education and training to enhance the success and innovation potential of PPPs.

THI1 Gene Evolutionary Trends: A Comprehensive Plant-Focused Assessment via Data Mining and Large-Scale Analysis.

Molecular evolution analysis typically involves identifying selection pressure and reconstructing evolutionary trends. This process usually requires access to specific data related to a target gene or gene family within a particular group of organisms. While recent advancements in high-throughput sequencing techniques have resulted in the rapid accumulation of extensive genomics and transcriptomics data and the creation of new databases in public repositories, extracting valuable insights from such vast datasets remains a significant challenge for researchers. Here, we elucidated the evolutionary history of THI1, a gene responsible for encoding thiamine thiazole synthase. The thiazole ring is a precursor for vitamin B1 and a crucial cofactor in primary metabolic pathways. A thorough search of complete genomes available within public repositories reveals 702 THI1 homologs of Archaea and Eukarya. Throughout its diversification, the plant lineage has preserved the THI1 gene by incorporating the N-terminus and targeting the chloroplasts. Likewise, evolutionary pressures and lifestyle appear to be associated with retention of TPP-riboswitch sites and consequent dual post-transcriptional regulation of the de novo biosynthesis pathway in basal groups. Multicopy retention of THI1 is not a typical plant pattern, even after successive genome duplications. Examining cis-regulatory sites in plants uncovers two shared motifs across all plant lineages. A data mining of 484 transcriptome datasets supports the THI1 homolog expression under a light/dark cycle response and a tissue-specific pattern. Finally, the work presented brings a new look at public repositories as an opportunity to explore evolutionary trends to THI1.

Estimasi Sumberdaya Bauksit Menggunakan Metode Ordinary Kriging Pada PT. Wahana Petra Sejahtera Kabupaten Bengkayang Provinsi Kalimantan Barat

PT. Wahana Petra Sejahtera, which operates in the bauxite mining sector, requires resource calculations as a basis for carrying out its mining activities. This research aims to determine the levels and distribution of Al2O3, SiO2, and Fe2O3 and estimate bauxite resources using the ordinary kriging method. This research uses secondary data in coordinates, elevation, test pit depth, and slope data. Data processing uses software in database creation, statistical analysis, block and composite modeling, variogram analysis, resource estimation, and model validation. The calculation results for the Jirak block show that the Al2O3 waste content is 1,488,000 tons, low-grade 4,532,000 tons, medium-grade 1,824,000 tons, and high-grade 32,000 tons. For SiO2 the average content is 13.54% and the average Fe2O3 content is 13.50%. Meanwhile, in the Sindu block the Al2O3 waste content is 64,000 tons, medium-grade 1,188,000 tons, and high-grade 3,056,000 tons. Meanwhile, the average SiO2 content is 9.13% and the average Fe2O3 content is 12.06%. The total resources in the Jirak block are 7,696,000 tons with the amount meeting the COG of 800 tons. Meanwhile, in the Sindu block, the total resources are 5,008,000 tons with an amount that meets the COG of 1,280,000 tons.

Systematic review on oral antibacterial relay therapy for acute staphylococcal prosthetic joint infections treated with debridement, antibiotics and implant retention (DAIR).

The management of acute prosthetic joint infections (PJIs) often involves a debridement, antibiotics and implant retention (DAIR) strategy. Our objective was to conduct a systematic review and a network meta-analysis (NMA) to assess the comparative effectiveness of available oral antimicrobial regimens for the treatment of acute staphylococcal PJIs treated with DAIR. We conducted a systematic review searching articles from databases creation until 31 December 2023. We included articles on acute staphylococcal PJIs managed with DAIR with an oral antibiotic regimen relaying the initial management. The primary outcome was the remission rate. Out of the 2421 studies screened, six studies completed the systematic review criteria: one randomized controlled trial and five observational studies. There was heterogeneity in patients' populations, duration and posology of treatments, definition of outcome and length of follow-up. Studies revealed 10 antibiotic regimens and most data focusing on five combinations recommended by the IDSA's guidelines: rifampicin associated to fluoroquinolone, clindamycin, cycline, linezolid or trimethoprim-sulfamethoxazole. Treatment comparisons were often secondary, without adjustment for confounding factors, resulting in a high risk of bias. Owing to inconsistencies a complete analysis, including an NMA was not possible. The available data highlight five companions to rifampicin, however, there is insufficient evidence to compare them. The literature does not provide a basis for rationalizing alternatives when rifampicin cannot be used.

Unravelling the molecular mechanism underlying drought stress tolerance in Dinanath (Pennisetum pedicellatum Trin.) grass via integrated transcriptomic and metabolomic analyses

Dinanath grass (Pennisetum pedicellatum Trin.) is an extensively grown forage grass known for its significant drought resilience. In order to comprehensively grasp the adaptive mechanism of Dinanath grass in response to water deficient conditions, transcriptomic and metabolomics were applied in the leaves of Dinanath grass exposed to two distinct drought intensities (48-hour and 96-hour). Transcriptomic analysis of Dinanath grass leaves revealed that a total of 218 and 704 genes were differentially expressed under 48- and 96-hour drought conditions, respectively. The genes that were expressed differently (DEGs) and the metabolites that accumulated in response to 48-hour drought stress mainly showed enrichment in the biosynthesis of secondary metabolites, particularly phenolics and flavonoids. Conversely, under 96-hour drought conditions, the enriched pathways predominantly involved lipid metabolism, specifically sterol lipids. In particular, phenylpropanoid pathway and brassinosteroid signaling played a crucial role in drought response to 48- and 96-hour water deficit conditions, respectively. This variation in drought response indicates that the adaptation mechanism in Dinanath grass is highly dependent on the intensity of drought stress. In addition, different genes associated with phenylpropanoid and fatty acid biosynthesis, as well as signal transduction pathways namely phenylalanine ammonia-lyase, putrescine hydroxycinnamoyl transferase, abscisic acid 8’-hydroxylase 2, syntaxin-61, lipoxygenase 5, calcium-dependent protein kinase and phospholipase D alpha one, positively regulated with drought tolerance. Combined transcriptomic and metabolomic analyses highlights the outstanding involvement of regulatory pathways related to secondary cell wall thickening and lignin biosynthesis in imparting drought tolerance to Dinanath grass leaves. These findings collectively contribute to an enhanced understanding of candidate genes and key metabolites relevant to drought response in Dinanath grass. Furthermore, they establish a groundwork for the creation of a transcriptome database aimed at developing abiotic stress-tolerant grasses and major crop varieties through both transgenic and genome editing approaches.

Promotion and Tenure Database Creation and Utilization: A 12-Year History.

Trends in faculty demographic composition, promotion success, and retention are important considerations in Academic Health Centers (AHC). This paper reviews the design, implementation, and utility of a faculty promotion and tenure (P&T) database (PROMO/TE©) over 12years in a large southwestern academic health center. Review of the system design, portfolio creation, P&T tracking, interface with other faculty databases, and lessons learned will be offered. PROMO/TE© was developed to improve the P&T packet creation, application, and review process in one College and was expanded to other colleges at the AHC. The PROMO/TE© system is integrated with Workday® and FACFACTS© to track trends in recruitment, attrition, and P&T trends across gender, underrepresented minorities, and other subgroups. PROMO/TE© has several advantages including improving communication, transparency, uniformity, and efficiency in the P&T packet creation, application, and review process. Increased cost savings ($217,198 annually) were noted with elimination of hard copy packets and decreased time spent. The first college reviewed 743 dossiers in the PROMO/TE© system since its creation in 2012 and there has been on average a 10% increase in P&T approvals since its inception. PROMO/TE© facilitates and tracks trends in the P&T process and has many benefits as well as significant cost savings. PROMO/TE© serves as a potential model for other institutions.

Acupuncture treatment of diabetic peripheral neuropathy: an overview of systematic reviews based on evidence mapping.

The study attempted to evaluate the meta-analyses (MAs) of the acupuncture treatment of diabetic peripheral neuropathy (DPN) to provide a basis for clinical decision-making. Eight databases, such as PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data, CQVIP, and CBM, were searched from database creation to December 22, 2023. The MAs of DPN treatment using acupuncture or acupuncture combined with conventional Western medicine were included. AMSTAR-2 and PRISMA 2020 helped evaluate the methodological and reporting quality of the included studies. The GRADE methodology helped assess the evidence quality of outcome indicators. Evidence mapping was performed to display evaluation results. A total of 18 MAs involving 23,240 DPN patients were included. Based on the methodological quality evaluation, four MAs were of "moderate" quality, seven had a quality grade of "low," and another seven were of "critically low" quality. The evidence quality evaluation showed that among studies of acupuncture vs. conventional Western medicine, four had an evidence quality of "moderate," 18 had an evidence quality of "low," and 17 had an evidence quality of "critically low" and that among studies of acupuncture + conventional Western medicine vs. conventional Western medicine, 12 had an evidence quality of "moderate," 29 had an evidence quality of "low," and 33 had an evidence quality of "critically low." Compared with conventional Western medicine, simple acupuncture and acupuncture + conventional Western medicine significantly improved total effective rate (TER) and nerve conduction velocity (NCV). Acupuncture treatment of DPN significantly improves TER and NCV with proven safety. However, the MAs of the acupuncture treatment of DPN must strictly refer to relevant standards and specifications regarding methodological and reporting quality, along with the design, execution, and reporting of primary randomized controlled trials (RCTs).

An automatic workflow for the quantitative evaluation of bit wear based on computer vision

As global oil exploration ventures into deeper and more complex territories, drilling bit wear and damage have emerged as significant constraints on drilling efficiency and safety. Despite the publication of official bit wear evaluation standards by the International Association of Drill Contractors (IADC), the current lack of quantitative and scientific evaluation techniques means that bit wear assessments rely heavily on engineers' experience. Consequently, forming a standardized database of drilling bit information to underpin the mechanisms of bit wear and facilitate optimal design remains challenging. Therefore, an efficient and quantitative evaluation of bit wear is crucial for optimizing bit performance and improving penetration efficiency.This paper introduces an automatic standard workflow for the quantitative evaluation of bit wear and the design of a comprehensive bit information database. Initially, a method for acquiring images of worn bits at the drilling site was developed. Subsequently, the wear classification and grading models based on computer vision were established to determine bit status. The wear classification model focuses on the positioning and classification of bit cutters, while the wear grading model quantifies the extent of bit wear. After that, the automatic evaluation method of the bit wear is realized. Additionally, bit wear evaluation software was designed, integrating all necessary functions to assess bit wear in accordance with IADC standards. Finally, a drilling bit database was created by integrating bit wear data, logging data, mud-logging data, and basic drilling bit data.This workflow represents a novel approach to collecting and analyzing drilling bit information at drilling sites. It holds potential to facilitate the creation of a large-scale information database for the entire lifecycle of drilling bits, marking the inception of intelligent analysis, design, and manufacture of drilling bits, thereby enhancing performance in challenging drilling conditions.

Towards a national life cycle database: an LCA case study from the Czech Republic

Abstract The building sector in the Czech Republic faces several challenges, including limited availability of Life Cycle Assessment (LCA) data for building materials and products, insufficient market incentives, little institutional capacity, and some resistance from governmental entities. Therefore, this study also outlines the creation of an internal environmental dataset database designed to conduct Whole Life Carbon (WLC) assessments for 50 case studies. The database primarily sources Environmental Product Declarations (EPDs) and generic data from the Ecoinvent database, which are stored within the OneClick LCA software (OCLCA). The Global Warming Potential (GWP) is calculated for the whole life cycle of each building, using the EU Level(s) methodology. As a baseline, the datasets for materials and products with the highest GWP values were used. A sensitivity analysis was performed on the main resulting hotspots to produce results for both the so-called realistic (average GWP values) and optimistic (lowest GWP values) scenarios. The application of this methodology is demonstrated through a detailed example of one of the case studies, within the framework of the INDICATE international project. This work represents a significant step toward defining a Czech national methodology for establishing benchmarks that can be readily used by Czech practitioners and practitioners.

The Weakening of Taxpayer Rights in the Exchange of Information between Tax Authorities

Developments in international legislation and the growing digitalization of tax law support the development of global networks between tax authorities. We are witnessing an integration of databases that will lead to increasingly intense coordination of the fight against tax evasion at a supranational level. As in social networks and digital commerce, databases are increasingly enriched, contain increasingly precise information on the individual taxpayer and use common languages that allow for automated exchanges of information. While waiting for the creation of a global database – not conditioned by the constraints of reciprocity and abstractly usable by all authorized entities who need it – the first risks of limitation of the taxpayer’s rights are emerging. In fact, these phenomena have dark sides that are starting to emerge in use, at a national level and with respect to individual taxpayers, of interpolated databases. Moreover, a growing amount of information flows from heterogeneous and increasingly widespread sources, sometimes not protected by the requirements of professionalism, legality and public trust since data collection and entry can be delegated to economic entities, intermediaries and consultants. The absence of an authority responsible for the unitary management of global databases and for the resolution of their conflicts, the slow and timid affirmation (only in some national systems) of the taxpayer’s right of access to information concerning them, the difficult configuration of the faculty to request the correction of erroneous data and of the specular public power to remove the reported inaccuracies, weaken the system of protections gradually erected to protect the taxpayer’s position. In this way, the coordination of national systems that contemporary tax law creates is strongly unbalanced on the side of the protection of tax interests. International and European tax law should instead provide greater guarantees in favor of the taxpayers, defending their right to fair taxation.

THE IMPACT OF DIGITALIZATION ON THE DEVELOPMENT OF THE AGRO-FOOD SPHERE

The agro-food sphere is one of the key industries in the country's economy and plays a major role in ensuring food security. The development of the agro-food sphere requires the development and implementation of innovative projects in this field. The creation and implementation of such innovative projects require the availability of information support, which includes complete and up-to-date information about the objects and processes related to the project. It has been proven that the innovative development of the agro-food sphere is closely related to the digitalization process in this field. It is noted that digitalization in the management of agriculture and the agro-food sphere opens up new opportunities for increasing the efficiency, transparency, and sustainability of this industry. The main directions of implementing digitalization in the agro-food sphere have been studied, including the creation of electronic registers and databases, and the development of decision support systems. The integration of e-government services in the agro-food sphere offers significant opportunities for improving the efficiency of public administration, enhancing service delivery, improving interaction between public authorities and agricultural market entities, and ensuring sustainable agricultural development. The author has developed a methodology for the integral assessment of the level of e-government development in the country. The integral assessment is based on initial indicators, including those defined by the United Nations Department of Economic and Social Affairs. The method of the modified principal component was used to determine the weighting coefficients of these indicators in the integral assessment. Integral assessments of the components of the agro-food sphere have been determined: the food industry, retail trade in food products, and indicators related to the protection and preservation of the environment associated with the agro-food sphere. A significant correlation has been found between these integral assessments and the integral assessment of digitalization

International experience of using expert opinions in criminal proceedings

The article is devoted to the important issue of international standards integration into the national system of forensic examination. The influence of international legal norms on the regulation of expert activity in Ukraine is analysed and the prospects for the development of this area are outlined. Particular attention is paid to the importance of forensic examination in legal proceedings, and the key role of experts in establishing objective truth and ensuring justice through their specialised knowledge is emphasised. Foreign experience in the field of forensic examination is considered, taking into account the use of specialised knowledge and methods of conducting examinations in other countries. It is indicated that in the context of crime globalisation, forensic examination in Ukraine should meet the highest international standards. To achieve this, it is necessary not only to update the legislative framework, but also to expand the capabilities of experts, introduce modern research methods and ensure close cooperation with international expert institutions. This will improve the quality of investigations and the effectiveness of the fight against crime. International cooperation in the field of forensic science, regulated by Section 4 of the Law of Ukraine “On Forensic Science”, is a key tool for ensuring effective judicial proceedings. It allows for the involvement of highly qualified specialists from different countries in the investigation of complex criminal cases and the use of modern research methods, which contributes to the establishment of objective truth. To ensure the high quality of forensic examinations and their international recognition, it is necessary to unify approaches and standards. International cooperation in this area facilitates the exchange of experience, the introduction of the latest techniques and the creation of common databases, which increases the reliability of expert opinions and their recognition around the world.