Creatine Phosphokinase Changes Research Articles

Bioelectrical Impedance Vector and Creatine Phosphokinase Changes Induced by a High-Intensity Training Session in Rink Hockey Players

This study aimed to analyze anthropometric and whole-body/muscle-localized bioelectrical impedance vector analysis (BIVA) adaptations and their relation to creatine kinase (CK) as a biomarker of muscle damage in a group of seven male players in the maximum category of professional rink hockey. There were three checkpoint assessments in relation to a high-intensity training session: pre-session (PRE), post-session (POST), and 24 h-post-session (POST24H). The resistance, reactance, and impedance module were adjusted by height (R/h, Xc/h, and Z/h, respectively). The Wilcoxon signed-rank test was used to compare the data at baseline and follow-up, while Spearman correlation was used to explore the relationship between CK and the rest of the parameters. The results registered a decrease in body mass at POST (p = 0.03) and a reestablishment at POST24H (p = 0.02). Whole-body BIVA registered a significant increase in R/h between PRE–to–POST (p = 0.02) and returned to baseline values at POST24H (p = 0.02), which was expected since this parameter is related to hydration processes. Muscle-localized BIVA in the rectus femoris muscle showed an increase in both Xc/h and phase angle in POST (p = 0.04 and p = 0.03, respectively) and a decrease in Xc/h at POST24H (p = 0.02). CK correlated with R/h in the rectus femoris at all the checkpoints (PRE–to–POST: r = 0.75, p = 0.05; PRE–to–POST24H: r = 0.81, p = 0.03; POST–to–POST24H: r = 0.82, p = 0.02). Our results indicate that BIVA is a sensitive methodology to assess general and muscle-localized hydration induced by a high-intensity training session in rink hockey players. A correlation between BIVA and CK was also reported.

Factors associated with changes in creatine phosphokinase (CPK) in trauma patients submitted to the "Red Wave", with evolution to rhabdomyolysis.

to identify and analyze factors associated with plasma creatine phosphokinase (CPK) levels in trauma victims with progression to rhabdomyolysis. we conducted a prospective, longitudinal study, with 50 patients submitted to the "Red Wave" protocol, with evolution to rhabdomyolysis after hospital admission. We studied the variables age, gender, trauma scores, mechanism and outcome, CPK at admission and final, intervals of days between laboratory evaluations, surgery and complications. We stratified CPK values in <500U/L, ≥500 - <1000 U/L, and ≥1000U/L, with calculation of the difference between the initial and final values. at admission, 83% of patients (n=39) had CPK≥1000U/L, with predominance of blunt trauma and thoracic injury (p<0.05), as well as orthopedic fracture, acute renal failure and gastrointestinal bleeding, CPK being lower in those without acute renal injury, with a trend towards statistical significance. There were no differences in final CPK stratification. Factors that were independently associated with the greater CPK variation were, positively, hospitalization time greater than one week and compartment syndrome, and negatively, acute renal injury. the CPK level of 1000U/L remains the lower limit, with importance for early intervention in worsening conditions such as digestive hemorrhage, acute renal injury and compartment syndrome, which implied greater absolute differences between initial and final CPK, in addition to blunt trauma, thoracic injury and orthopedic fracture.

Testing of an oral dosing technique for double-crested cormorants, Phalacocorax auritus, laughing gulls, Leucophaeus atricilla, homing pigeons, Columba livia, and western sandpipers, Calidris mauri, with artificially weather MC252 oil

Scoping studies were designed to determine if double-crested cormorants (Phalacocorax auritus), laughing gulls (Leucophaues atricilla), homing pigeons (Columba livia) and western sandpipers (Calidris mauri) that were gavaged with a mixture of artificially weathered MC252 oil and food for either a single day or 4–5 consecutive days showed signs of oil toxicity. Where volume allowed, samples were collected for hematology, plasma protein electrophoresis, clinical chemistry and electrolytes, oxidative stress and organ weigh changes. Double-crested cormorants, laughing gulls and western sandpipers all excreted oil within 30min of dose, while pigeons regurgitated within less than one hour of dosing. There were species differences in the effectiveness of the dosing technique, with double-crested cormorants having the greatest number of responsive endpoints at the completion of the trial. Statistically significant changes in packed cell volume, white cell counts, alkaline phosphatase, alanine aminotransferase, creatine phosphokinase, gamma glutamyl transferase, uric acid, chloride, sodium, potassium, calcium, total glutathione, glutathione disulfide, reduced glutathione, spleen and liver weights were measured in double-crested cormorants. Homing pigeons had statistically significant changes in creatine phosphokinase, total glutathione, glutathione disulfide, reduced glutathione and Trolox equivalents. Laughing gulls exhibited statistically significant decreases in spleen and kidney weight, and no changes were observed in any measurement endpoints tested in western sandpipers.

Evaluation of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin therapy in a southern Brazilian cohort.

Background Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. Sex differences in the pharmacokinetics and pharmacodynamics of statins contribute to interindividual variations in drug efficacy and toxicity. Objective To evaluate the presence of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin treatment. Methods Lipid levels of 495 patients (331 women and 164 men) were measured at baseline and after 6 ± 3 months of simvastatin/atorvastatin treatment to assess the efficacy and safety profiles of both drugs. Results Women had higher baseline levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) compared with men (p < 0.0001). After treatment, women exhibited a greater decrease in plasma TC and LDL-C levels compared with men. After adjustment for covariates, baseline levels of TC and LDL-C influenced more than 30% of the efficacy of lipid-lowering therapy (p < 0.001), regardless of sex. Myalgia [with or without changes in creatine phosphokinase (CPK) levels] occurred more frequently in women (25.9%; p = 0.002), whereas an increase in CPK and/or abnormal liver function was more frequent in in men (17.9%; p = 0.017). Conclusions Our results show that baseline TC and LDL-C levels are the main predictors of simvastatin/atorvastatin therapy efficacy, regardless of sex. In addition, they suggest the presence of sexual dimorphism in the safety of simvastatin/atorvastatin. The effect of sex differences on receptors, transporter proteins, and gene expression pathways needs to be better evaluated and characterized to confirm these observations.

Pharmacokinetics and Tolerability of Single-Dose Daptomycin in Young Infants

Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants. Subjects < 120 days of age with suspected systemic infections were eligible for inclusion. Each subject was given a single 6 mg/kg intravenous dose of daptomycin. An average of 4 postdose concentrations per infant was obtained. Data from 20 infants are presented. Median gestational age at birth and postnatal age were 32 weeks (range: 23, 40) and 3 days (1, 85), respectively. The median area under the concentration curve at 24 hours, volume of distribution, total body clearance and half-life of daptomycin were 262.4 mg×h/L (166.7, 340.2), 0.21 L/kg (0.11, 0.34), 0.021 L/h/kg (0.016, 0.034) and 6.2 hours (3.7, 9.0), respectively. No adverse events related to daptomycin were observed, including changes in creatine phosphokinase concentrations. Daptomycin clearance in young infants was similar to that in children 2-6 years of age and higher than that observed in adolescents and adults.

Poster 302: Elevated Creatinine Phosphokinase in the First Week of Inpatient Rehabilitation: Are We Stretching Too Aggressively?

Objective: To assess changes in creatine phosphokinase (CPK) levels during acute care and early rehabilitation in persons with acute, motor complete spinal cord injury (SCI). Design: Prospective, longitudinal study. Setting: Level 1 trauma center with attached inpatient rehabilitation unit. Participants: 16 consecutive patients (75% men; mean age, 35.4±16.4y; age range, 14−65y; 56% Hispanic, 44% white; 75% had tetraplegia, 25% paraplegia) admitted to the trauma center with motor complete SCI. Neurologic levels ranged from C2-T12.

Changes in creatine phosphokinase (CK) concentrations after minor and major surgeries in children

During surgery, damage occurs to muscles in the area of the operation. The few studies that have examined creatine phosphokinase (CK) values after surgery have been in adults. The only study in children was after cardiac surgery. Understanding the normal enzyme pattern of change may help to differentiate malignant hyperthermia, anaesthesia-induced rhabdomyolysis and elevated CK values resulting from inherited muscle disease in cases in which these are suspected. The aim of this study was to delineate the normal rise of CK after minor and major surgery in children. A total of 71 patients aged 1 month-17 yr were studied. From the cohort of 71 patients, 46 underwent elective surgery (14 major, 32 minor) and in 25 the surgery was designated as an emergency surgery (21 major, 4 minor). The anaesthesia protocol was similar for both groups with halothane induction and isoflurane maintenance. Owing to its possible effect on CK, succinylcholine was avoided during the study. The mean values of CK concentration before and after surgery were 63.1 iu litre(-1) and 151.5 iu litre(-1), respectively. The median CK elevation (range) for the major and minor surgery groups was 43 iu litre(-1) (4-647) and 10 iu litre(-1) (-28 to 122), respectively (P<0.0001). CK concentrations in the major surgery group were significantly higher than the minor surgery group. This profile can contribute to the evaluation of patients who present with the possibility of malignant hyperthermia, anaesthesia-induced rhabdomyolysis and underlying muscle disease. Any rise of CK concentration above what is expected should prompt further investigation.

Muscle Damage Is Linked To Cytokine Changes Following A 160-km Race

PURPOSE To determine whether or not creatine phosphokinase (CPK) release during ultramarathon race competition is related to changes in plasma cytokines. METHODS Subjects included 60 ultramarathoners (mean±SE, age 45.3±1.1 yr) who had been training for 13.9±1.3 yr, and finished the 160-km race in under 30 h (26.3±0.4 h). Subjects provided training information through questionnaires, and recorded perceptions of muscle soreness during the week following the race using a 10-point Likert scale (DOMS) (1=no soreness, 4=slight soreness, 7=sore, and 10=unbearably sore). Blood samples were collected the morning prior to and immediately following the 2004 160-km Western States Endurance Run. Complete blood counts and 7 plasma cytokines and chemokines were measured (IL-6, IL-10, IL-8, IL-1ra, granulocyte colony-stimulating factor or G-CSF, monocyte chemotactic protein 1 or MCP-1, and macrophage inflammatory protein 1 beta or MIP-1β). Changes in these plasma cytokines/chemokines were correlated with changes in CPK and the DOMS scale. RESULTS Significant increases were measured for all 7 cytokines/chemokines, with the greatest fold increase seen for IL-6 (125×), and then IL-10 (24×), G-CSF (12×), IL-1ra (7×), IL-8 (4×), MCP-1 (3×), and MIP-1β(1.2×). CPK increased from 159±21 to 17,833±2,883 U/L, and change in CPK was significantly correlated with changes in IL-6 (r=0.68, P<0.001), G-CSF (r=0.67, P<0.001), IL-10 (r=0.53, P<0.001), IL-1ra (r=0.50, P<0.001), and MCP-1 (r=0.49, P<0.001), but not IL-8 or MIP-1β. DOMS averaged 7. 1±0.3 the day after the race, and 5.0±0.3, 2.5±0.2, and 1.6±0.1 3-d, 5-d, and 7-d post-race, respectively, and each was significantly correlated with CPK (r=0.40 to 0.63, P<0.001) and changes in IL-6, G-CSF, IL-10, and MCP-1 (r=0.28 to 0.77, P<0.05). Use of NSAIDS during the race was reported by 72% of the athletes. A comparison of NSAID users and nonusers showed no differences in CPK or DOMS, but did reveal significantly greater increases in IL-6, IL-8, G-CSF, MCP-1, and MIP-1β in the NSAID users (P<0.05). Self-selected use of antioxidant supplements either in the months before (70%) or during the race (18%) had no effect on CPK, DOMS, or changes in cytokines/chemokines. CONCLUSION Muscle damage in athletes competing in a 160-km race was significantly correlated with post-race DOMS and increases in 5 of 7 cytokines/chemokines. Ultramarathoners using NSAIDS did not experience a reduction in muscle damage or DOMS, but did have higher post-race levels in 5 of 7 cytokines/chemokines. Supported by the 160-km Western States Endurance Run Medical Board, and the Gatorade Sports Science Institute.

Muscle Damage Is Linked To Cytokine Changes Following A 160-km Race

PURPOSE To determine whether or not creatine phosphokinase (CPK) release during ultramarathon race competition is related to changes in plasma cytokines. METHODS Subjects included 60 ultramarathoners (mean±SE, age 45.3±1.1 yr) who had been training for 13.9±1.3 yr, and finished the 160-km race in under 30 h (26.3±0.4 h). Subjects provided training information through questionnaires, and recorded perceptions of muscle soreness during the week following the race using a 10-point Likert scale (DOMS) (1=no soreness, 4=slight soreness, 7=sore, and 10=unbearably sore). Blood samples were collected the morning prior to and immediately following the 2004 160-km Western States Endurance Run. Complete blood counts and 7 plasma cytokines and chemokines were measured (IL-6, IL-10, IL-8, IL-1ra, granulocyte colony-stimulating factor or G-CSF, monocyte chemotactic protein 1 or MCP-1, and macrophage inflammatory protein 1 beta or MIP-1β). Changes in these plasma cytokines/chemokines were correlated with changes in CPK and the DOMS scale. RESULTS Significant increases were measured for all 7 cytokines/chemokines, with the greatest fold increase seen for IL-6 (125×), and then IL-10 (24×), G-CSF (12×), IL-1ra (7×), IL-8 (4×), MCP-1 (3×), and MIP-1β(1.2×). CPK increased from 159±21 to 17,833±2,883 U/L, and change in CPK was significantly correlated with changes in IL-6 (r=0.68, P<0.001), G-CSF (r=0.67, P<0.001), IL-10 (r=0.53, P<0.001), IL-1ra (r=0.50, P<0.001), and MCP-1 (r=0.49, P<0.001), but not IL-8 or MIP-1β. DOMS averaged 7. 1±0.3 the day after the race, and 5.0±0.3, 2.5±0.2, and 1.6±0.1 3-d, 5-d, and 7-d post-race, respectively, and each was significantly correlated with CPK (r=0.40 to 0.63, P<0.001) and changes in IL-6, G-CSF, IL-10, and MCP-1 (r=0.28 to 0.77, P<0.05). Use of NSAIDS during the race was reported by 72% of the athletes. A comparison of NSAID users and nonusers showed no differences in CPK or DOMS, but did reveal significantly greater increases in IL-6, IL-8, G-CSF, MCP-1, and MIP-1β in the NSAID users (P<0.05). Self-selected use of antioxidant supplements either in the months before (70%) or during the race (18%) had no effect on CPK, DOMS, or changes in cytokines/chemokines. CONCLUSION Muscle damage in athletes competing in a 160-km race was significantly correlated with post-race DOMS and increases in 5 of 7 cytokines/chemokines. Ultramarathoners using NSAIDS did not experience a reduction in muscle damage or DOMS, but did have higher post-race levels in 5 of 7 cytokines/chemokines. Supported by the 160-km Western States Endurance Run Medical Board, and the Gatorade Sports Science Institute.

The Effect of Diazepam and Midazolam Pretreatment on Succinylcholine Induced Fasciculation , Muscle Relaxation and Serum Potassium and Creatine Phosphokinase Changes

The Effect of Diazepam and Midazolam Pretreatment on Succinylcholine Induced Fasciculation , Muscle Relaxation and Serum Potassium and Creatine Phosphokinase Changes

Evaluation of the Myotoxicity of Bupivacaine in Bier Blocks???A Biochemical and Electron Microscopic Study

The possible myotoxic effect of bupivacaine in combination with tourniquet ischemia was evaluated in 11 patients who underwent surgery of an arm under intravenous regional anesthesia. Eleven patients with the same kind of surgery and tourniquet who had general anesthesia served as controls. Venous blood bupivacaine concentrations in the anesthetized arm were high at the end of tourniquet time (27.2-202 micrograms/m1) and varied from 2.3 to 12.3 micrograms/ml 10 min after tourniquet release. Changes in blood-gas tensions and plasma potassium and lactate concentrations before and just after tourniquet release correlated with the ischemia time. Changes in creatine phosphokinase, lactate dehydrogenase and aspartate aminotransferase activities, possible indices of loss of integrity of muscle cell membranes, varied considerably and did not correlate with the ischemia time. There were no significant differences between the two groups in any of the parameters. Electron microscopy revealed no evidence of muscle degeneration 24 hr after the use of tourniquet with either bupivacaine intravenous regional (n = 4) or general anesthesia (n = 3).

Augmentation of serum CPK activity by digitalis in patients with acute myocardial infarction.

The effect of acetyl strophanthanin on the rate of creatine phosphokinase (CPK) efflux was evaluated in 59 predominantly class I and II patients randomly allocated between treated and control. Therapy (0.5 mg) was begun 11-15 hours after the onset of symptoms and repeated four hours later (0.25 mg). Accumulated CPK activity (ACA) was determined from serial serum CPK changes sampled every two hours and compared to predicted CPK activity (PCA) determined from the first seven hours of CPK changes. In the control group, ACA was not significantly different from PCA. Digitalis consistently resulted in an augmentation of CPK efflux into serum which was temporally related to drug administration and resulted in a corresponding increase in ACA (P less than 0.001). Thus acetyl strophanthanin appears to increase apparent CPK activity in serum in class I and II patients.

Protection of Jeopardized Ischemic Myocardium by Reduction of Ventricular Afterload

Abstract To determine whether reduction of ventricular afterload protects ischemic myocardium, we studied 38 patients with acute myocardial infarction. Serial serum creatine phosphokinase values were used to estimate ischemic myocardial injury (i.e., infarct size). In addition, infarct size was predicted by nonlinear least-squares approximation from creatine phosphokinase changes during the first seven hours after admission. In 10 hypertensive and 14 normotensive patients infarct size as actually observed and as predicted was virtually identical. Another group of 14 patients, hypertensive on admission, were given trimethaphan to lower blood pressure, decrease ventricular afterload, and presumably diminish myocardial oxygen requirements. In these patients, observed infarct size was 24 per cent less than that predicted (p<0.01). Mortality within one month was less in the treated than in untreated patients matched for predicted infarct size. The results suggest that reduction of ventricular afterlo...

Enzyme activities in skeletal muscle after contractile activity in vitro

1. 1. Changes in muscle enzyme activities following isometric and isotonic contractile activity of electrically stimulated plantaris longus from frog were studied in vitro. The effect of contractile activity under hypoxic conditions and the time-course of changes in enzyme activities after exercise were also investigated. 2. 2. Isometric contractile work caused decreased activities in creatine phosphokinase, phosphorylase and phosphofructokinase and increased activities in hexokinase and cytochrome oxidase. The activity levels of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, pyruvate kinase, lactate dehydrogenase and fumarase were not significantly different from control values. 3. 3. After isotonic contraction no significant changes in creatine phosphokinase, phosphorylase and phosphofructokinase activities were seen. Besides hexokinase and cytochrome oxidase, fumarase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate deh ydrogenase activities were also increased. 4. 4. There were no significant differences between the enzyme response obtained after isometric contractions in deoxygenated or oxygenated medium. 5. 5. After a recovery period for 5 hours following isometric work the activities of hexokinase, the hexose monophosphate shunt dehydrogenases, fumarase and cytochrome oxidase showed increased activities. These declined to control values after 20 hours recovery except for hexokinase and 6-phosphogluconate dehydrogenase. The activity levels of creatine phosphokinase, phosphorylase and phosphofructokinase were progressively decreased during the recovery period. Pyruvate kinase and lactate dehydrogenase also showed decreased activity values after 20 hours recovery.

Deleterious effects due to hemorrhage after myocardial reperfusion

The effect of coronary reperfusion on evolving myocardial infarction was examined in 16 conscious dogs. Coronary arterial occlusion was produced by inflating an exteriorized balloon cuff, and reperfusion was initiated 5 hours later by deflating the cuff. Infarct size calculated from 24 hour serial serum creatine phosphokinase (CPK) values was compared to infarct size predicted from log normal curves best fit to initial 5 hour serial CPK changes. With sustained occlusion, predicted and observed infarct size correlated closely ( r = 0.94, no. = 11). Reperfusion produced two disparate effects. In nine dogs, observed infarct size was less than predicted, reflecting 42 ± 6 percent (standard error) salvage of myocardium. In seven dogs, observed infarct size exceeded predicted size by more than 100 percent. Thus, reperfusion resulted in extension of myocardial infarction in 44 percent of the animals. Extension of infarction was associated with myocardial hemorrhage. Hemoglobin content in biopsy specimens from the center of the infarct was 10 times greater in the animals with extension of infarction than in those with myocardial salvage. Thus, reperfusion is not without hazard during evolving infarction in the conscious dog; although it frequently diminishes ischemic injury, it may precipitate myocardial hemorrhage and extension of infarction.

Early estimation of myocardial damage in conscious dogs and patients with evolving acute myocardial infarction.

To estimate the ultimate extent of myocardial damage during evolving myocardial infarction in conscious dogs and patients, we analyzed early serum creatine phosphokinase (CPK) changes with nonlinear curve-fitting techniques. In experiments with dogs, serial serum CPK changes were fit to a log-normal function by the least squares method; the extent of the completed infarct was calculated by analysis of observed serum CPK changes and verified by measurement of myocardial CPK depletion 24 h after coronary occlusion. Early prediction of myocardial damage was based on projected serum CPK values from best fit curves based on data obtained during the first 5 h after initial elevation of enzyme activity. The correlation between predicted and observed values was close (r > 0.96, n = 11). In 11 additional conscious animals subjected to coronary occlusion, isoproterenol was administered continuously as soon as damage had been estimated from projected serum CPK values. The extent of the completed infarct was assessed by analysis of all serial serum CPK values and verified by analysis of myocardial CPK depletion 24 h after coronary occlusion. In each experiment the calculated completed infarct size exceeded infarct size projected before administration of isoproterenol (average increase = 44+/-10 [SE]%). When similar calculations were applied in experiments with eight dogs treated with propranolol, myocardial salvage was detected in 50% of the animals. In 30 patients with uncomplicated acute myocardial infarction the extent of the completed infarct, measured by analysis of CPK activity in serum samples obtained every 2 h, was compared with damage estimated from CPK values projected by the best fit log-normal curve derived from data obtained during the first 7 h after the initial serum CPK elevation. The estimate of damage based on early data correlated closely with the extent of infarction calculated from all available serial serum CPK values (r = 0.93, n = 30). Thus, the extent of the completed infarct could be estimated accurately during the early evolution of infarction. In patients with spontaneous extension of infarction manifested by chest pain and electrocardiographic changes, the calculated extent of the completed infarct exceeded that predicted. Conversely, salvage of myocardium, after reduction of myocardial oxygen requirements by administration of trimethaphan, was reflected by reduction of the extent of the calculated completed infarct with respect to that predicted from early serum CPK changes.

Estimation of infarct size in man and its relation to prognosis.

Infarct size was assessed quantitatively in 33 patients with acute myocardial infarction with a new technic based on analysis of serial serum creatine phosphokinase (CPK) changes to determine its relationship to prognosis. We have recently measured infarct size in the conscious dog with this method which takes into account CPK distribution space, fractional disappearance rate, proportion degraded in myocardium, and proportion released into the circulation, and we have validated the method by measurement of myocardial CPK depletion in the same animals. In the present study, CPK activity (determined spectrophotometrically) and isoenzyme profiles (assayed electrophoretically) were measured in patient serum samples obtained every 2 hours. Infarct size was estimated by mathematical analysis of serial CPK changes utilizing the method previously developed in the conscious dog model. CPK isoenzyme profiles demonstrated prominent anodal bands, absent from normal serum, indicating that enzyme elevations reflected CPK released from heart rather than skeletal muscle. In 19 class I-II survivors (New York Heart Association) estimated infarct size was 31 ± 4 CPK-gram-equivalents (CPK-g-Eq). It was significantly larger ( P &lt; 0.01), 103 ± 14, in nine patients who died and in four class III or IV survivors (91 ± 8). Estimation of cumulative infarct size differentiated patients with electrocardiographic changes and clinical sequelae from complications such as pericarditis from those patients with extension of infarction. Thus, infarct size can be assessed quantitatively in patients with acute myocardial infarction and provide a useful diagnostic and prognostic index based on the extent of myocardial damage.

Serum creatine phosphokinase changes in psychotic illness.

Serum creatine phosphokinase changes in psychotic illness.

Myocardial infarct size in man assessed by serial serum creatine phosphokinase changes

Myocardial infarct size in man assessed by serial serum creatine phosphokinase changes

Plasma creatine phosphokinase changes induced by freezing injury and adaptation to cold.

ArticlePlasma creatine phosphokinase changes induced by freezing injury and adaptation to cold.J H Petajan, M T Vogwill, and M B MurrayJ H Petajan, M T Vogwill, and M B MurrayPublished Online:01 Oct 1969https://doi.org/10.1152/jappl.1969.27.4.528MoreSectionsPDF (851 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByCreatine phosphokinase in serum and cerebrospinal fluid, and microscopic findings in brain and heart in hypothermic rabbitsForensic Science International, Vol. 39, No. 3The effect of cold stress on the fasted, water-deprived, neonate chicken (Gallus domesticus)Journal of Thermal Biology, Vol. 4, No. 2Changes of Functional State of Liver, Thymus and Adrenals, in Cold Acclimatized White Rats13 May 2010 | Zentralblatt für Veterinärmedizin Reihe A, Vol. 23, No. 6Increased plasma creatine kinase activity in rabbits: Effect of systematically repeated blood samplingExperientia, Vol. 32, No. 4Effects of high altitude exposure on components of blood and urine in mountaineersInternational Journal of Biometeorology, Vol. 18, No. 1Serum creatine phosphokinase levels in rats following cold injuryInternational Journal of Biometeorology, Vol. 17, No. 2 More from this issue > Volume 27Issue 4October 1969Pages 528-30 https://doi.org/10.1152/jappl.1969.27.4.528PubMed5347345History Published online 1 October 1969 Published in print 1 October 1969 Metrics