To study the mode-I failure and mechanical behavior of rock under cyclic loading, the cracked chevron notched Brazilian disc (CCNBD) of sandstone was employed in this paper, and thus three different upper-limit loads cyclic tests were carried out, including 95 %SUL(static ultimate load) ∼ 35 %SUL, 85 %SUL ∼ 25 %SUL, 75 %SUL ∼ 15 %SUL. The 3D discrete element model of CCNBD specimen was built to study mechanical properties and cracking behavior at a meso-scale. Meanwhile, the effect of cyclic loading on microstructure characteristics and fracture process zone (FPZ) was discussed. The results show that cyclic loading has a weakening effect on fracture toughness, and a modified fracture toughness calculation method was proposed considering the effect of irreversible plastic deformation under cyclic loading. There are obvious stages of microcracking behavior under cyclic loading, specific for the condition of 85 %SUL ∼ 25 %SUL, and the microcrack density is positively correlated with the number of cycles. Meanwhile, the effect of cyclic load on sandstone microstructure contains weak-structure fracture effect and compaction effect, and they exist simultaneously and work together. In addition, cyclic loading has a great influence on the length of FPZ, and the length of FPZ under cyclic loading is greater than that under monotonic loading.