COVID-19 Infection In Pregnant Women Research Articles

Covid-19 infection in pregnant women: Auditory evaluation in infants.

Recent studies showed that COVID-19 infection can affect cochleo-vestibular system. The possibility of a vertical transmission is controversial. Some studies suggested that it is possible but unlikely, others find no evidence of vertical transmission. The objective of this study was to investigate whether exposure to COVID-19 during pregnancy or at birth has an impact on the hearing of the offspring. As part of the national hearing screening program, we performed in all newborns between January 2022 and February 2023, TEOAEs (Transient Evoked Otoacoustic Emissions) at birth and at 3 months. For those "REFER" at the third month test, we performed aABR (Automatic Auditory Brainstem Response) at 6 months. We analysed separately result between infants born to COVID-positive mothers during pregnancy and those born to COVID-negative mothers. To statistical verify differences we performed "Chi-square test". We enrolled a total of 157 infants, of whom 16 were born to mothers who had a molecular PCR test positive for COVID-19. In the latter we tested a total of 32 ears and only 1 ear (3,1%) resulted "REFER". On the other hand, in the control group we tested a total of 282 ears and 22 (7,8%) were found to be "REFER". Our study showed no significant differences in audiological assessment between newborns exposed to COVID-19 infection during pregnancy or at birth compared to the unexposed group. However, further studies with a larger patient's sample will be necessary for a more comprehensive evaluation.

Risk Factor of Vitamin-D Deficiency in Pregnant Women with COVID-19 Infection: Comprehensive Meta-Analysis and Systematic Review

Introduction: It has been suggested that coronavirus infection (COVID-19) in pregnant women may be influenced by vitamin D deficiency (VDD). The physiological changes brought on by pregnancy, and the body's partial immune suppression make pregnant women more susceptible to vitamin D deficiency and viral infections. Therefore, this review aims to synthesize the current information on the link between vitamin D levels and the risk of COVID-19 in pregnant women. Material and Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. Articles retrieved were screened based on the PRISMA 2020 guidelines. Studies that assessed the effect of vitamin D levels on pregnant women with COVID-19 infection were considered for the review. Odds ratios with their 95 percent confidence intervals (CI) from a meta-analysis using a random-effects model were reported. Results: Three eligible studies were relevant to the relationship between vitamin D deficiency and COVID-19 infection in pregnant women (n=1005). The metanalysis showed that vitamin D deficiency in pregnant women was 1.8 times (95% confidence interval, OR 1.72 to 1.88; p=0.0005) more likely to be infected with COVID-19. Conclusion: According to our results, vitamin D deficiency in pregnant women may increase the risk of COVID-19 infection. Therefore, we recommend adequate vitamin D levels to prevent COVID-19 and its severity.

COVID-19 enfeksiyonu doğurganlık çağındaki kadınlar için risk oluşturur mu?

Objectives: This study aims to investigate the potential differential impact of COVID-19 infection on pregnant women compared to non-pregnant individuals of childbearing age by evaluating laboratory findings from both inpatient and outpatient cases. Material and Methods: From the onset of COVID-19 in Turkey in March 2020 until the commencement of vaccination, a total of 94 COVID-19 patients were included in three separate groups: pregnant women and non-pregnant individuals with COVID-19 (with and without pneumonia). Sociodemographic data and examination findings were retrospectively retrieved from the hospital information system. Results: The study revealed that pregnant women, with a mean age of 28.87±1.38, experienced a significantly shorter mean length of hospital stay of 5.03±0.49 days compared to the other groups (p<0.001). Notably, pregnant women exhibited significant variations in urea, creatinine, white blood cell count, neutrophil count, hemoglobin, and hematocrit values in comparison to the other groups (p<0.001). Moreover, there were significant differences among the three groups concerning neutrophil and lymphocyte percentage values (p<0.001). Conclusion: The study suggests that COVID-19 infection in pregnant women is associated with more favorable clinical outcomes, shorter length of hospital stay, and relatively moderate alterations in laboratory findings when accounting for pregnancy-induced changes. It is implied that pregnancy might not pose as substantial a risk factor for severe COVID-19 infection as advanced age or underlying chronic conditions such as diabetes, asthma, COPD, and malignancy.

The Association of Laboratory Parameters with COVID-19 Severity in Pregnancy

Background Pregnant women were one of the most susceptible groups because they are vulnerable to respiratory infection. They may get more severe symptoms due to their physiological changes during pregnancy including the immunological response. This study was performed to find whether there is an association between laboratory parameters (Hb, leukocytes, platelet, neutrophils, lymphocyte, monocyte, NLR, PLR and CRP) and the severity of Covid-19 infection in pregnant women. Methods This study is a retrospective cohort study using secondary data from patient’s medical records at Persahabatan General Hospital, Jakarta from March to June 2021. Results Pregnancy cases with COVID-19 in this study were in the mean of 29 year age. Most of them are in the third trimester of pregnancy. 80.5% from 67 patients have no- mild symptom while 19.5% have moderate to severe symptom. There are no difference in vital sign nor oxygen saturation at first admission. Lower level was found in the parameter of leukocyte, lymphocyte and monocyte. Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein increase as the degree of severity increase. The mean neutrophil in pregnant women with moderate to severe COVID-19 symptom was 80.49±7.47 while median NLR value was of 6.76 (2.73-18.71) . Conclusions Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein has associate significantly to severity symtomps of COVID-19 in pregnancy.

Effectiveness of Covid-19 Vaccine in Pregnant Women: A Systematic Review

The newly developed COVID-19 vaccine faces public's concerns in terms of its effectiveness and safety as an approach in combating COVID-19 pandemic. It is well-established that COVID-19 vaccine is effective alongside being the most promising approach against COVID-19 infection in both general and vulnerable populations. This study aims to evaluate the effectiveness of COVID-19 vaccine in pregnant women as a subgroup of vulnerable population by analysing several important immunological parameters in pregnant women. Specifically, it investigates how effective the COVID-19 vaccine will reduce the infection rate and how it will affect the mothers' antibody levels against SARS-CoV-2. In this study, the immunological parameters investigated are maternal antibody response against SARS-CoV-2 and the transplacental transfer of the antibody. To test the hypothesis that COVID-19 vaccine is effective in pregnant women, a systematic review was conducted on previous studies regarding COVID-19 vaccine and its outcomes in pregnancy. Results were narratively analysed. The results showed reduced COVID-19 infection rate, elevated maternal antibody titre against SARS-CoV-2 and positive transplacental anti-SARS-CoV-2 IgG antibody transfer in vaccinated pregnant women in comparison to unvaccinated pregnant women. These results suggest that COVID-19 vaccine is highly effective against COVID-19 infection in pregnant women. Furthermore, COVID-19 vaccine not only elicits sufficient maternal antibody response as an immunity for mothers against COVID-19 infection but also provides similar protection for infants via passive immunity by means of transplacental antibody transfer. In conclusion, the uptake of COVID-19 vaccine and future booster dose by pregnant women should be strongly encouraged due to its favourable outcomes and protection against COVID-19 disease.

Factors related to maternal mortality rate in covid-19 patients - a cross-sectional study from an Indonesian covid-19 referral hospital.

The covid-19 pandemic may cause severe clinical manifestations in a vulnerable population, such as pregnant women. Based on Indonesian Obstetrics and Gynecology Association (POGI), the number of maternal deaths due to covid-19 from April 2020 to April 2021 reached 3% and increased to 9% since the delta variant of covid-19 emerged. This research was expected to identify factors that are related to the mortality rate of pregnant women with covid-19. This was a cross-sectional study using secondary data collected from June 2020 to August 2021. The study was conducted in Universitas Indonesia Hospital, a national covid-19 referral hospital. Patient characteristics, pregnancy profile, comorbidities, laboratory results, chest X-ray examination, treatment options, and the severity of symptoms were evaluated. In addition, bivariate data analysis was carried out using the SPSS device. Out of 114 research subjects, seven patients (6.1%) died, and 107 patients (93.9%) survived. The risk of mortality was significantly (P < 0.05) related to patients' age, duration of hospitalization, gestational age, severity rate of covid-19, the level of hemoglobin, leukocyte count, platelet count, lymphocytes, the levels of D-dimer, C-reactive protein, transaminase enzymes, urea, creatinine, eGFR, sodium, potassium, and procalcitonin. In addition, significant differences (P < 0.05) related to maternal mortality rate were also shown in the presence of comorbidities (type 2 diabetes, congestive heart failure, coronary artery disease/acute coronary syndrome, and urinary tract infection), and the use of steroids and tocilizumab. Various factors significantly related to the mortality rate of pregnant women with covid-19. This study may become the basis for a further study with a larger number of subjects, adjustment of assessment and management of covid-19 infected pregnant women, thus hopefully reducing the risk of mortality in pregnant women with covid-19.

The Impact of COVID-19 on Birth Weight during Pregnancy

Introduction: Coronavirus is a viral pathogen that can be transmitted through respiratory droplets, leading to severe infectious diseases. This study aimed to ascertain the influence of the COVID-19 pandemic on birth weight during pregnancy. Methods: This study used secondary data and a retrospective case-control approach for observational analysis. The case and control groups each had 153 samples. The case group was further separated into symptomatic and asymptomatic categories. Statistical analyses were performed to determine how COVID-19 infection in pregnant women affected birth weight. Fisher’s exact test was used to evaluate data for the subgroups of asymptomatic and symptomatic individuals, while the Mann-Whitney test was used to compare the infection's impact. Results: Most participants were 21–35 years old (78.2%). The findings showed that 85% of pregnant COVID-19 patients were in their third trimester. Mothers diagnosed with COVID-19 had infants with birth weights of >4,000 grams (3.3%), 2,500–4,000 grams (43.1%), and <2,500 grams (53.6%). Birth weight distribution in women unaffected by COVID-19 was >4,000 grams (14.4%), 2,500–4,000 grams (67.3%), and <2,500 grams (18.3%). The Mann-Whitney statistical test was performed using SPSS. It yielded a p-value of 0.001, less than the significance level of 0.05, indicating a correlation between confirmed COVID-19 infection in pregnant women and birth weight. Conclusion: This study found that the presence of COVID-19 infection during pregnancy significantly affects infants' birth weight.

Need for Neonatal Resuscitation: Does Maternal COVID-19 Affect It?

Background Maternal COVID-19 infection acquired during late pregnancy carries a potential risk for adverse neonatal outcomes. There is still a paucity of data on its effect on the transition from intrauterine to extrauterine life. Objectives The objectives of this study were to determine the impact of maternal COVID-19 infection on neonates for the risk and need for resuscitation at birth, Apgar scores at 1- and 5-minutes, and the need of NICU admission during early neonatal period. Materials and method In this hospital-based prospective matched cohort study, 100 COVID-positive pregnant women presenting for delivery were enrolled. We also included 100 non-COVID pregnant women after the best possible matching of their major baseline parameters with the study group. Neonates of both groups were followed-up till 7 days of life. Results The two groups were comparable for all baseline variables except for the mode of delivery. The requirement of neonatal resuscitation was 30% and 21% in the study and control groups (RR = 1.429; 95% CI 0.88–2.32; p = 0.149). Apgar scores at 1- and 5- minutes were also unaffected by maternal COVID-19 infection with mean scores of 8.8 ± 0.651 vs. 8.87 ± 0.562 (p = 0.42) in the study and control groups, respectively. COVID-exposed neonates had a higher incidence of NICU admission when compared with the unexposed group (RR =1.616; 95% CI 1.002–2.606; p = 0.047). Among neonates born to COVID-positive mothers, 11% demonstrated evidence of SARS-CoV-2 positivity within first 5 days of life. The risk for need of resuscitation and mean Apgar scores were comparable among SARS-CoV-2 positive and negative neonates (p > 0.05). Conclusion COVID-19 infection in pregnant women is not associated with an increased risk of neonatal resuscitation.

(066) STI Co-infection Among Pregnant Women with SARS-CoV-2

Abstract Introduction Although information on COVID-19 infection during pregnancy is still limited, existing evidence does not support increased susceptibility to infection or increased risk of developing severe disease during pregnancy, and the occurrence of intrauterine transmission has not been proven conclusively. However, to our knowledge, there is even less information available on co-infection with sexually transmitted infections in pregnant patients with COVID-19. The prevalence of any curable STI (gonorrhea, chlamydia, trichomoniasis, or syphilis) during pregnancy is estimated to be 3.3% (95% CI 2.9-3.7). Objectives STIprevalence may be correlated with COVID-19 infection in pregnant women, since both are influenced by risk-taking behaviors (i.e. condom use, mask-wearing, handwashing, and social distancing). On the other hand, an upregulated immune response in the setting of COVID-19 infection may in fact provide immunological protection against co-infection with STI’s or Group B Streptococcus (GBS), a non-sexually transmitted infection with a prevalence of 17.9% (95% CI 16.2-19.7) in pregnant patients. Our goal was to further explore this relationship. Methods We conducted a chart review of 34 pregnant patients with COVID-19, specifically looking at the incidence of antenatal STI’s and GBS. Results The mean age of the participants was 28.9 (SD 5.7) years, the mean gestational age at infection was 33.9 (SD 7.3) weeks, and the mean gestational age at delivery was 37.2 (SD 4.4) weeks. 26.5% (n=9) of patients tested positive for an STI, including gonorrhea (n=3), chlamydia (n=3), HPV (n=3), and trichomoniasis (n=2). 23.5% (n=8) tested positive for GBS infection. Conclusions The increased incidence of STI’s among pregnant women with COVID-19 compared to the expected incidence for any pregnant woman may suggest increased risks to this particular population that are worth investigating further. Disclosure No.

Giving Birth By Caesarean Section in Women Infected With Covid-19 and The Incidence of Covid-19 in Newborn. A Systematic Review

Labor method by caesarean section in Covid-19 infected pregnant women had higher ratio than vaginal delivery. The use of Caesarean section is adjusted to the condition of the mother or/and the baby. However, the literature on labor method and its relation to Covid-19 infection in newborn is rare. We conducted a review about association between giving birth by caesarean section in women infected with Covid-19 and the incidence of Covid-19 in the newborn. This research was an analytic systematic review and guided by PICO. Studies from NCBI and ScienceDirect were used to locate full text articles, written in English, published from 2019-2021. The search strategy included terms for (Cesarean Section or Delivery, Obstetric) and (Covid-19 or Sars-Cov-2) and infant, newborn and infectious disease vertical transmission. Articles were included when met the inclusion and exclusion criteria, then analysed with RevMan 5.4. The search yielded 205 records. After full text screening, 3 studies were found to meet all criteria and 3 studies were obtained from manual search. Six studies using cohort designs were based in the United States, China, Morocco, Spain, and Turkey. Sample sizes ranged from 15 to 125 participants. Overall effect z=0.81 (p value=0.42) showed that the caesarean section had no significant protective factor from Covid-19 infection in newborn. Our finding indicated that babies who were born from mothers with Covid-19 infection. However, there was possible publication bias and samples collected were minimum. More studies are needed to advance this emerging literature.

EPH166 The Effect of COVID-19 on Maternal and Neonatal Outcomes in a Large Tertiary Health System in Saudi Arabia

There is a scarcity of data comparing the rates of maternal and neonatal outcomes in pregnant women with and without COVID-19 infection. Our aim was to assess the effect of COVID-19 on maternal outcomes (stillbirths and miscarriage) and neonatal outcomes (low birth weight <2500 gm Apgar-1 minute score < 7, and Apgar-5 minute score < 7). This is a multicenter retrospective cohort study that included pregnant women who were followed and delivered at three National Guard health System hospitals between March 2020 and October 2021. A laboratory test confirmed the diagnosis of COVID-19 during pregnancy. Multivariable Logistic regression was conducted to assess the risks of maternal and neonatal outcomes. The study included 644 pregnant women with a confirmed COVID-19 infection and 654 pregnant women with no COVID-19 infection. There was no statistically significant difference in the risk of stillbirth (adjusted odds ratio, aOR1.93, 95% CI 0.55, 8.12) or miscarriage (aOR 0.52, 95% CI 0.23, 1.10) between COVID-19 infected pregnant women and non-infected pregnant women. COVID-19 infection, on the other hand, was associated with increased odds of low birth weight (aOR 1.5, 95%CI 1.06, 2.14), Apgar score-1 minute <7 (aOR 2.14, 95%CI 1.53, 3.03), and Apgar score-5 Minutes <7 (aOR 2.8, 95%CI 1.91, 4.17). Infants born to pregnant women with COVID-19 infection were more likely to have low birth weight and low Apgar scores than those born to uninfected mothers.

Study neonate’s complications in COVID-19 infected pregnant women in early period of pandemic in Ardabil province, Iran

Background: Pregnant women and neonates are considered as high-risk groups of population. Due to higher risk of COVID-19 in pregnant women, the aim of this study was to determine neonates' complications in COVID-19 infected pregnant women in early period of pandemic in Ardabil province. Methods: This prospective cross-sectional study was conducted on 21 infected pregnant women and their neonates from Feb to June 2020 in Alavi Hospital, Ardabil. Mother’s clinical and laboratory findings and their neonates were registered in a checklist. Neonates’ complications were assessed and infants 'growth and developmental disorders followed up at 28 days, 6 months, and 12 months. Collected data were analysed by statistical methods in SPSS version 24. Results: In terms of clinical symptoms, the most prevalence symptoms were shortness of breath, fever, chills and dry cough. 15 infected mothers had a cesarean section and there was no maternal and neonatal mortality in this study. Of the 21 neonates, 13 were boys and 8 girls. Five neonates had respiratory distress and were admitted to the intensive care unit for 1 week. In these 5 neonates, arterial pH was low and neonatal CRP was high and the blood culture was negative for them. Also, all neonates were negative for COVID-19. None of the newborns had problems with feeding and poor reflexes and other symptoms. All newborns had negative PCR. 19 neonates were born over 2500 grams. Conclusions: Results showed that suffering to COVID-19 had not relation with growth disorder in neonates and mother's clinical symptoms had not different with other symptoms. So we can use similar investigations to control of COVID-19 in all pregnant women. Also, COVID-19 infection in newborns was not associated with growth and developmental disorders in 1 year fallow up.

An Observational Study of COVID-19 Infection in Pregnant Women at a Tertiary Care Center

An Observational Study of COVID-19 Infection in Pregnant Women at a Tertiary Care Center

Blood Type Associated with the Risk of COVID-19 Infection in Pregnant Women

COVID-19 forced us to investigate risk factors to provide the best medical attention, especially in vulnerable groups, such as pregnant patients. Studies in other populations have analyzed blood groups in relation to infection, complications, and death. The present study aimed to analyze the association of blood groups with the risk of infection and complications in pregnant women and newborns from the Mexican-Mestizo population. We studied 1906 individuals. Quantitative variables were analyzed through the Student's t-test. Categorical variables were analyzed through Pearson's chi-square test, and logistic regression was used to analyze the association between categorical variables and outcomes. No significant association was observed between blood groups and infection risk. Individuals with the AB blood type are at higher risk for developing severe disease, although blood groups do not seem to be involved in the risk of SARS-CoV-2 infection. However, the AB blood group could be considered a risk factor for developing severe COVID-19 in the Mexican population.

Evaluation of maternal serum and umbilical cord brain-derived neurotrophic factor (BDNF) levels in COVID-19-infected pregnancies.

COVID-19 is a disease that affects and damages the neurological system. The aim of this study was to evaluate the fetal neurodevelopmental status through maternal serum and umbilical cord BDNF levels. In this prospective study, 88 pregnant women were evaluated. Demographic and peripartum characteristics of the patients were recorded. Samples were collected from pregnant women for maternal serum and the umbilical cord BDNF levels during delivery. In this study, 40 pregnant women hospitalized with COVID-19 formed the infected group and 48 pregnant women without COVID-19 formed the healthy control group. Demographic and postpartum characteristics were similar in both groups. Maternal serum BDNF values were significantly lower in the COVID-19 infected group (1597.0 ± 337.3 pg/ml) than in the healthy group (1783.2 ± 394.1 pg/ml) (p=0.019). Fetal BDNF levels were 1794.9 ± 440.3 pg/ml in the healthy group and 1691.0 ± 368.6 pg/ml in COVID-19 infected pregnant women group and statistically similar between groups (p=0.232). Results showed that while maternal serum BDNF levels decreased in the presence of COVID-19, there was no difference in umbilical cord BDNF levels. This may be an indication that the fetus is not affected and is protected.

Impact of the Presence Anti-SARS-CoV-2 IgA in the Colostrum of Women Infected by COVID-19 During the Pregnancy in Neonatal Clinical Outcomes: A Cross-Sectional Study.

To describe the presence of anti-SARS-CoV-2 IgA and IgG in the blood and colostrum of women with COVID-19 infection during pregnancy and associate the presence of anti-SARS-CoV-2 IgA in colostrum with clinical symptoms of their newborns. A cross-sectional study was developed with 165 participants with COVID-19 infection during pregnancy and their newborns. characteristics COVID-19 infection in pregnant women, gestational age, and clinical symptoms in their newborns (fever, hypothermia, respiratory distress, hypotonia, hypoactivity, hypoglycemia, cyanosis, vomiting/regurgitation, abdominal distention, and jaundice). Maternal blood and colostrum samples were collected postpartum to to detect the presence of IgA and IgG anti-SARS-CoV-2. The median interval between COVID-19 diagnosis and delivery was 37.5days (IQ = 12.0, 73.0days). Clinical symptoms during hospitalization were observed in 55 newborns (33.3%), and two (1.6%) tested RT-PCR positive for COVID-19. Positive colostrum for anti-SARS-CoV-2 IgA was found in 117 (70.9%) women. The presence of anti-SARS-CoV-2 IgA in colostrum was associated independently with lower clinical symptoms in their newborns (OR = 0.42; 95% CI 0.202 to 0.84; p = 0.015). The presence of anti-SARS-CoV-2 IgA in colostrum was detected in more than two-thirds of the women evaluated and was associated with a lower frequency of clinical symptoms in their newborns.

COVID-19 Vaccine During Pregnancy and Perinatal Outcomes.

Introduction When COVID-19 vaccination started, there was little data on the safety of immunization against COVID-19 infection in pregnant women. Previous studies revealed no safety concerns for pregnant women or newborns who received a messenger ribonucleic acid (mRNA) COVID-19 vaccine during pregnancy. This study aimed to investigate the effects of COVID-19 vaccination on pregnant women and on perinatal outcomes. Methods This cross-sectional study was conducted in a maternity hospital in King Saud Medical City. It started in January 2022 and ended in June 2022. The questionnaire was developed and validated by experts. This study included all women admitted to the postpartum ward who were more than 18 years old and had received the COVID-19 vaccine. The study excluded women who had no proof of their vaccination status or who could not complete the questionnaire. The primary outcome was the effect of COVID-19 vaccination on gestational age and birth weight. The secondary outcomes included the development of polyhydramnios, oligohydramnios, mode of delivery, Apgar score, postpartum hemorrhage, and neonatal intensive care unit admission. Results A total of 365 pregnant women participated in this study. The mean gestational age of the unvaccinated women was 38.83 ± 1.62 weeks, which was significantly (p < 0.001) higher than that of vaccinated women (37.69 ± 2.9 weeks). In addition, the average birth weight for the unvaccinated women was 2.96 ± 0.4 kg, which did not differ significantly (p = 0.89) from that of vaccinated women (2.97 ± 0.66 kg). Conclusion COVID-19 vaccination, regardless of the type of vaccine received before, during, or after pregnancy, is not associated with any unfavorable perinatal outcomes for pregnant women or neonates.

Complications Of Severe and Very Severe Variants of Covid-19 Infection in Pregnant Women

Complications Of Severe and Very Severe Variants of Covid-19 Infection in Pregnant Women

Maternal and Foetal Outcome among Pregnant Women Infected with COVID-19 in Three Referral Hospitals in Cameroon

Introduction: Pregnancy is generally known to be an immune compromised state, thus placing pregnant women at risk of SARS-COV-2 infection. We therefore carried out this study to assess the maternal and foetal outcomes among pregnant women infected with COVID-19 in three referral hospitals in Cameroon. Methodology: This was a hospital-based retrospective case control study covering a two-year period. Data collection was done over a duration of four months at the Yaoundé Central Hospital, Douala Gynaeco-Obstetric and Paediatric Hospital and the Bamenda Regional Hospital. Cases were pregnant women who gave birth after a confirmed COVID-19 infection, matched 1:2 by age (±1 year) and parity (±1) to pregnant women not infected by COVID-19, who gave birth at the three hospitals within the same period. Results: The rate of caesarean section delivery among our cases was 52.4% as compared to 44.3% among controls (OR, 1.38, 95% CI, 0.74 - 2.60, P = 0.296). Maternal mortality rate in our cases was at 8.2% as compared to 6.6% in controls (OR, 1.60, 95% CI, 0.50 - 5.12, P = 0.422). The rate of preterm delivery in our cases was 24.6% as compared to 11.5% in the control group (OR, 2.39, 95% CI, 1.05 - 5.42, P = 0.025). Perinatal death rate in our study was recorded at 8.2% as compared to 3.4% in the controls (OR, 2.63, 95% CI, 0.68 - 10.18, PS = 0.162) Conclusion: Pregnant women infected with COVID-19 were found to have higher risks of preterm delivery and acute foetal distress as compared to pregnant women who were not infected. Caesarean section deliveries, maternal and foetal mortality were higher in COVID-19 infected pregnant women as compared to those not though these findings were not statistically significant.

Assessment on knowledge and practice regarding management of COVID-19 infected pregnant women among the staff nurses, JNIMS hospital, Porompat, Imphal, Manipur

Assessment on knowledge and practice regarding management of COVID-19 infected pregnant women among the staff nurses, JNIMS hospital, Porompat, Imphal, Manipur